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compositionComposition:PRUCALOPRIDE-1MG
prescription
Prescription Medicine
info
Pruwel 1 Tablet 10's
Pruwel 1 Tablet 10's
Pruwel 1 Tablet 10's
Pruwel 1 Tablet 10's
Pruwel 1 Tablet 10's

Pruwel 1 Tablet is used to treat chronic idiopathic constipation(long-term constipation with no known cause). It contains prucalopride, which works on the muscles of the gut to increase movement and help restore normal bowel function. In some cases, this medicine may cause side effects, such as headache, diarrhoea, nausea, and abdominal pain. Before using Pruwel 1 Tablet , tell your doctor if you are pregnant, breastfeeding, taking other medications, or have any existing health conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PRUCALOPRIDE-1MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Pruwel 1 Tablet

Pruwel 1 Tablet is used to treat chronic idiopathic constipation (long-term constipation). Chronic idiopathic constipation is a condition where a person has infrequent, difficult, or incomplete bowel movements lasting for three months or more, without any known cause such as disease or medication.

Pruwel 1 Tablet contains prucalopride, which works on the muscle walls of the gut to increase bowel movement, helping to restore normal bowel function and relieve chronic constipation.

Take Pruwel 1 Tablet for as long as your doctor has prescribed it to you. In some cases, you may experience certain common side effects, such as headache, diarrhoea, nausea, and abdominal pain. Most of these side effects will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Avoid taking Pruwel 1 Tablet if you are pregnant, breastfeeding, or under 18 years old, as its safety is not established; Pruwel 1 Tablet may cause dizziness and tiredness, so only drive if you feel alert, and always inform your doctor about your health and any medications you are using to prevent side effects or interactions.

Uses of Pruwel 1 Tablet

Pruwel 1 Tablet is used in the treatment of Chronic idiopathic constipation. The detailed use of Pruwel 1 Tablet is as follows:

  • Chronic Idiopathic Constipation (CIC): Pruwel 1 Tablet stimulates bowel movements and improves colonic transit and gastric emptying.
  • When Other Laxatives Fail: Pruwel 1 Tablet is prescribed for adults who have not found relief from constipation despite using other laxatives.
  • Relieving Symptoms: Pruwel 1 Tablet helps to reduce symptoms related to constipation, such as bloating, discomfort, and straining during bowel movements.

Key Benefits

  • Pruwel 1 Tablet belongs to the group of medicines called gastrointestinal prokinetics, used to treat chronic idiopathic constipation (long-term constipation with no known cause).
  • Pruwel 1 Tablet acts on the muscle walls of the gut and increases bowel motility. 
  • It helps restore normal bowel function and treats constipation.
  • Pruwel 1 Tablet helps to treat chronic constipation in adults in whom laxatives do not work well. 
Side effects of Pruwel 1 Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Directions for Use

  • Pruwel 1 Tablet can be taken with or without food.
  • It is recommended to take Pruwel 1 Tablet once daily or as advised by your doctor.
  • Swallow Pruwel 1 Tablet as a whole with a glass of water.
  • Do not break, chew, or crush it.

How Pruwel 1 Tablet Works

Pruwel 1 Tablet contains prucalopride, which acts on the muscle walls of the gut and increases bowel motility. This helps restore normal bowel function and treats constipation. Pruwel 1 Tablet helps treat chronic constipation in adults in whom laxatives do not work well.
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Alcohol

Consult your doctor

It is not known if alcohol interacts with Pruwel 1 Tablet . Please consult your doctor if you have any concerns regarding this.

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Pregnancy

Unsafe

Pruwel 1 Tablet is not recommended during pregnancy. Use a reliable method of contraception while taking Pruwel 1 Tablet . Inform your doctor if you are pregnant, think you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Pruwel 1 Tablet might pass into breastmilk. Avoid breastfeeding while taking Pruwel 1 Tablet .

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Driving

Caution

Pruwel 1 Tablet is unlikely to affect your ability to drive. However, sometimes Pruwel 1 Tablet might cause dizziness and tiredness, so drive only if you are alert.

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Liver

Consult your doctor

Please consult your doctor if you have liver impairment/liver disease.

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment/kidney disease.

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Children

Unsafe

Pruwel 1 Tablet is not recommended for children below 18 years as safety and effectiveness have not been established.

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Heart

Caution

Pruwel 1 Tablet should be used with caution in patients with heart problems. Inform your doctor about any heart-related conditions before taking Pruwel 1 Tablet .

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Geriatrics

Caution

Pruwel 1 Tablet should be given with caution in elderly patients due to an increased risk of side effects. Dose adjustment may be required based on their health condition.

What if I have taken an overdose of Pruwel 1 Tablet

Take Pruwel 1 Tablet only as prescribed by the physician. Please make sure not to take more than the recommended dose as it could lead to serious side effects such as headache, nausea, and diarrhoea. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Diet & Lifestyle Advise

  • Try maintaining a balanced diet that includes fresh fruits and vegetables.
  • Stay hydrated, drink enough water and fluids.
  • Exercise regularly, and stay fit.
  • Get enough sleep.
  • Try making time to empty your bowels whenever the body tells you to.
  • Eat food rich in fibre such as whole-wheat bread, oatmeal, flaxseed, nuts, beans, lentils, fruits (berries, apples, oranges, bananas, pears, figs), and vegetables (broccoli, spinach, sweet potatoes, avocados).

Have a query?

How Soon It Starts Working

  • The time required for Pruwel 1 Tablet to start to work: Pruwel 1 Tablet ideally shows its action within 2 to 3 hours of administration. 
  • The time for which the effects of Pruwel 1 Tablet last: Pruwel 1 Tablet effect lasts for 24 hours.

What if you forget to take Pruwel 1 Tablet

If you miss a dose of Pruwel 1 Tablet , take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose.

Storage

• Store in a cool and dry place away from sunlight.• Keep Pruwel 1 Tablet out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Do not take Pruwel 1 Tablet if you are allergic to any of its components
  • Also, avoid taking Pruwel 1 Tablet if you are on renal dialysis, have perforation/obstruction of the gut wall, inflammation of the intestinal tract, Crohn’s disease, toxic megacolon/megarectum, or ulcerative colitis.
  • Inform your doctor if you have AIDS, hormonal problems, neurological disease, suicidal tendency, mood disorder, cancer, heart, kidney, or liver problems.
  • Avoid taking Pruwel 1 Tablet if you are pregnant or breastfeeding.
  • Pruwel 1 Tablet is not recommended for children below 18 years, as safety and effectiveness have not been established. 
  • Pruwel 1 Tablet may cause dizziness and tiredness, so drive only if you are alert.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions: Pruwel 1 Tablet may interact with an antihistamine (diphenhydramine).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have renal dialysis, perforation/obstruction of the gut wall, inflammation of the intestinal tract, Crohn’s disease, toxic megacolon/megarectum, ulcerative colitis, mood disorders, or suicidal tendency.

No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

Pruwel 1 Tablet is used to treat chronic idiopathic constipation.
Pruwel 1 Tablet acts on the muscle walls of the gut and increases bowel motility. Thereby, helps restore the normal functioning of the bowel and treats constipation.
Diarrhoea might occur if Pruwel 1 Tablet is taken in larger doses. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. Contraceptive pills might become ineffective in case of severe diarrhoea. In such conditions, use an extra method of contraception.
Do not take Pruwel 1 Tablet for longer durations unless advised by the doctor, as it might lead to dependency on Pruwel 1 Tablet for a bowel movement. Consult your doctor if your bowel movement is irregular even after taking Pruwel 1 Tablet for four weeks.
Drink plenty of fluids and consume fibre-rich food, whole-grain bread, unprocessed bran, fruits and vegetables. Try to exercise regularly.
If you miss a dose, try to take it as soon as you remember. However, if it is almost time for the scheduled dose, skip the missed dose and take the scheduled dose instead. Avoid taking the double dose as it might cause unpleasant side effects or overdose.
Pruwel 1 Tablet may cause side effects such as vomiting, nausea, diarrhoea, headache, tiredness and stomach cramps/pain. If these side effects persist or worsen, please consult your doctor.
Pruwel 1 Tablet has been shown to act quickly but the effect varies from person to person. This is because each patient reacts differently to particular medication. Generally, Pruwel 1 Tablet causes a bowel movement within 2-3 hours. However, it may take about 4-5 days to show full effect and rapid bowel movements.
Pruwel 1 Tablet is not recommended during pregnancy. Use a reliable method of contraception while taking Pruwel 1 Tablet . Inform your doctor if you are pregnant, think you are pregnant or are planning a pregnancy.
Take Pruwel 1 Tablet as advised by your doctor. It can be taken at any time of the day. It is typically administered once daily orally, with or without food.
Pruwel 1 Tablet has been proven to be beneficial in cases of gastroparesis and constipation. Gastroparesis is a disorder that stops or slows the food movement from stomach to small intestine, even though there is no blockage in the intestines or stomach.
You should avoid taking Pruwel 1 Tablet if you are allergic to it, if you have a tear in your intestinal or stomach wall, a bowel blockage or inflammatory conditions of the intestinal wall like ulcerative colitis or Crohn’s disease. Always consult your doctor before starting Pruwel 1 Tablet .

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.584 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  2. U.S. Food and Drug Administration (FDA). 210166S000Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026] Check here
  3. Drugs.com Clinical Review Team. Prucalopride Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  4. MedlinePlus. A619011 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026] Check here
  5. Prucalopride succinate [EMC SmPC]. 2022. [Accessed on 28 Jan. 2019] Check here
  6. Prucalopride [EMC SmPC]. 2022. [Accessed on 28 Mar. 2019] Check here
  7. Information H, Diseases D. Constipation - NIDDK [Internet]. National Institute of Diabetes and Digestive and Kidney Diseases. 2021 [Accessed on 7 March 2022]Check here

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - PRU0053

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