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compositionComposition:HYDROCHLOROTHIAZIDE-12.5MG+RAMIPRIL-5MG
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Prescription Medicine
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Ramistar H 5 mg Capsule 15's is used to treat high blood pressure. It contains Ramipril and Hydrochlorothiazide, which relax the blood vessels and increase the amount of urine passed out from the kidneys. Sometimes, you may experience side effects such as headaches, tiredness, a slow heart rate, and nausea. Inform your doctor if you are pregnant, breastfeeding, taking any other medicines or have pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

HYDROCHLOROTHIAZIDE-12.5MG+RAMIPRIL-5MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Ramistar H 5 mg Capsule 15's

Ramistar H 5 mg Capsule 15's is a prescription tablet used to treat high blood pressure (hypertension). It is typically prescribed when a single medication is not enough to control your blood pressure. By lowering high blood pressure, it helps prevent serious cardiovascular issues like strokes, heart attacks, and kidney problems.

Managing high blood pressure can sometimes feel overwhelming because it often requires long-term treatment and lifestyle changes. Ramistar H 5 mg Capsule 15's combines two blood pressure-lowering medicines into a single tablet, helping simplify treatment while supporting better blood pressure control. 

To get the most benefit, you should take Ramistar H 5 mg Capsule 15's consistently once every day, preferably at the same time, or as directed by your healthcare provider. You can take this tablet with or without food, but taking it in the morning is often recommended to avoid waking up during the night to urinate. Combining this medicine with a low-salt diet, regular exercise, and maintaining a healthy weight will greatly improve your results.

While taking Ramistar H 5 mg Capsule 15's, some people may experience mild side effects like dizziness, a dry cough, or feeling tired. These are common as your body adjusts, but you must contact your doctor immediately if you develop serious symptoms such as swelling of your face, lips, or throat, or severe stomach pain.

Before starting Ramistar H 5 mg Capsule 15's, tell your doctor if you have kidney disease, liver damage, diabetes, or gout. Do not take this if you are pregnant, as it can cause serious harm to an unborn baby, or if you have ever had a severe allergic reaction (angioedema) to similar blood pressure medicines.

This medication can interact with lithium, potassium supplements, and certain pain relievers, which can alter its effects or increase your risk of side effects. Avoid drinking alcohol while taking Ramistar H 5 mg Capsule 15's because it can worsen dizziness and make you feel faint. Pregnant women, breastfeeding mothers, and elderly individuals should consult their doctor before using this medicine to ensure it is safe for them.

Uses of Ramistar H 5 mg Capsule 15's

Ramistar H 5 mg Capsule 15's may be prescribed for the following conditions: 

  • High Blood Pressure (Hypertension): Ramistar H 5 mg Capsule 15's helps by relaxing your blood vessels and removing excess fluid, which lowers your blood pressure and reduces the workload on your heart.
  • Reduction of Cardiovascular Risks: By keeping your blood pressure within a healthy range, Ramistar H 5 mg Capsule 15's helps lower your long-term risk of experiencing a stroke, heart attack, or kidney failure.
     

Key Benefits

Ramistar H 5 mg Capsule 15's combines two blood pressure-lowering medicines that work together to help control hypertension and support long-term cardiovascular health. Its benefits may include: 

  • Controls Blood Pressure Effectively: The combination of two active ingredients helps lower and maintain blood pressure within a healthy range.
  • Reduces Strain on the Heart: By lowering blood pressure, it helps reduce the workload on the heart and supports better cardiovascular function.
  • Protects Vital Organs: Long-term blood pressure control may help reduce the risk of complications affecting the heart, brain, kidneys, and blood vessels.
  • Lowers the Risk of Cardiovascular Events: Maintaining healthy blood pressure levels may help reduce the risk of heart attack, stroke, and heart failure.
  • Offers Convenient Combination Therapy: Combining two medicines into a single tablet simplifies treatment and may improve adherence to the prescribed therapy.
     

Directions for Use

Take Ramistar H 5 mg Capsule 15's exactly as prescribed by your doctor. Follow these steps for safe use:

  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet.
  • Take your dose at the same time each day to maintain a steady level of medicine in your body. Taking it in the morning is highly recommended so you do not have to get up in the middle of the night to urinate.
  • You may take this medicine with or without food.

Always follow your doctor's exact instructions regarding your dose and how long you should continue taking this medication.
 

How Ramistar H 5 mg Capsule 15's Works

Ramistar H 5 mg Capsule 15's contains two active components that work in different ways to lower your blood pressure. The first component, ramipril, is an ACE inhibitor. It works by blocking a natural substance in the body that causes blood vessels to tighten. By relaxing and widening these blood vessels, it allows blood to flow more easily, which lowers your blood pressure. The second component, hydrochlorothiazide, is a diuretic, often called a 'water pill'. It works by helping your kidneys remove extra salt and water from your body through your urine. This reduces the total volume of fluid circulating in your blood vessels, which further lowers blood pressure. Together, these two mechanisms provide a more comprehensive and effective way to manage hypertension than either would alone.
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Alcohol

Caution

Ramistar H 5 mg Capsule 15's may enhance the hypotensive (low blood pressure) effect if alcohol is taken along with it. For better advice, you should consult your doctor about whether you can take Ramistar H 5 mg Capsule 15's with alcohol.

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Pregnancy

Unsafe

The use of Ramistar H 5 mg Capsule 15's or any ACE inhibitors (Ramipril) is usually contraindicated during the second and third trimesters of pregnancy. It may cause harm to the developing fetus. Hence, you should always consult your doctor before using Ramistar H 5 mg Capsule 15's.

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Breast Feeding

Caution

Use of Ramistar H 5 mg Capsule 15's is not recommended during the breastfeeding stage.

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Driving

Caution

Drive with caution, Ramistar H 5 mg Capsule 15's may cause blurry vision, and dizziness or weariness may occur.

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Liver

Caution

Rare elevation in the liver enzymes (like bilirubin) has been observed while taking Ramistar H 5 mg Capsule 15's, so it must be taken with caution. If you have a history of liver diseases/conditions, the dose may have to be adjusted by your doctor.

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Kidney

Caution

Ramistar H 5 mg Capsule 15's to be taken with caution, especially in case of severe kidney disease. The dose may have to be adjusted by your doctor. Ramistar H 5 mg Capsule 15's should be given with precaution in hemodialysis conditions.

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Children

Caution

Ramistar H 5 mg Capsule 15's is not recommended for children. The safety and effectiveness of Ramistar H 5 mg Capsule 15's have not been established in children due to limited testing of this drug on children by competent authorities worldwide. If necessary, your doctor will decide whether to give Ramistar H 5 mg Capsule 15's or not.

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Heart

Safe if prescribed

Ramistar H 5 mg Capsule 15's is safe for use in heart patients if recommended by the physician.

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Geriatrics

Caution

Ramistar H 5 mg Capsule 15's should be used under caution in geriatric patients. Please consult your physician.

What if I have taken an overdose of Ramistar H 5 mg Capsule 15's

An overdose of Ramistar H 5 mg Capsule 15's may cause unpleasant side effects. If you suspect you have taken an overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Reduce Salt Intake: Limit your sodium intake as it can raise your blood pressure and reduce the effectiveness of Ramistar H 5 mg Capsule 15's. Use herbs and spices instead of table salt to flavour food.
  • Stay Hydrated Responsibly: While the water pill component helps remove excess fluid, severe dehydration can cause your blood pressure to drop too low. Drink a moderate, consistent amount of water daily as advised by your doctor.
  • Eat Potassium-Balanced Foods: This medicine can affect your potassium levels. Talk to your doctor before drastically changing your intake of potassium-rich foods (like bananas and spinach) or using salt substitutes containing potassium.
  • Avoid Sudden Posture Changes: To minimise dizziness or lightheadedness, rise slowly from a sitting or lying position.
     
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How Soon It Starts Working

The time required for Ramistar H 5 mg Capsule 15's to start to work: Ramistar H 5 mg Capsule 15's ideally shows its action within 1 to 2 hours after administration.

The time for which the effects of Ramistar H 5 mg Capsule 15's last: The effect of Ramistar H 5 mg Capsule 15's lasts for 24 hours.

What if you forget to take Ramistar H 5 mg Capsule 15's

If you miss a dose of Ramistar H 5 mg Capsule 15's, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

Store Ramistar H 5 mg Capsule 15's tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F). •Keep the medication in its original packaging to protect it from moisture and light.

Drug Warnings

  • Take it consistently: Continue taking Ramistar H 5 mg Capsule 15's exactly as prescribed, even if you feel well or your blood pressure readings improve. Do not stop or change your dose without medical advice.
  • Monitor your blood pressure regularly: Keep track of your blood pressure readings and share them with your doctor during follow-up visits to help assess your treatment response.
  • Stay alert to fluid loss: Contact your doctor if you develop prolonged vomiting, severe diarrhoea, or excessive sweating, as these conditions can increase the risk of dehydration, low blood pressure, and electrolyte imbalances.
  • Attend scheduled blood tests: Regular monitoring of kidney function and electrolyte levels helps ensure the medicine remains safe and effective during long-term treatment.
  • Protect your skin from sunlight: Hydrochlorothiazide may increase sensitivity to sunlight. Wear protective clothing and use sunscreen when spending extended periods outdoors.
  • Check before taking new medicines: Some over-the-counter medicines, particularly pain relievers such as ibuprofen or naproxen, may reduce the effectiveness of this treatment or increase the risk of kidney problems. Consult your doctor or pharmacist before starting any new medication.
     

Drug-Drug Interactions

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Drug-Drug Interactions

The following medicines may interact with Ramistar H 5 mg Capsule 15's and may require dose adjustments, additional monitoring, or special precautions: 

  • Lithium: Combining this with Ramistar H 5 mg Capsule 15's can cause dangerous levels of lithium to build up in your body.
  • Potassium Supplements: Taking these alongside this medicine can lead to dangerously high levels of potassium in your blood.
  • NSAIDs (like Ibuprofen or Naproxen): These pain relievers can lower the effectiveness of your blood pressure medicine and increase your risk of kidney damage.
  • Other Blood Pressure Medications: Taking multiple blood pressure drugs together can increase the risk of excessively low blood pressure and kidney issues.

Drug-Food Interactions

The following food and drink interactions may affect the safety or effectiveness of Ramistar H 5 mg Capsule 15's: 

  • Alcohol: Drinking alcohol while taking this medicine can increase the risk of dizziness, lightheadedness, and fainting by dropping your blood pressure too quickly.
  • Salt Substitutes: Many salt substitutes contain potassium, which can lead to unsafe levels of potassium in your blood when combined with this medicine.

Drug-Disease Interactions

Inform your doctor if you have a history of the following conditions before taking Ramistar H 5 mg Capsule 15's, as it may worsen your condition or require closer monitoring:

  • Kidney Disease: This medicine can affect kidney function and may need careful monitoring if you have pre-existing kidney problems.
  • Diabetes: The diuretic component may affect your blood sugar levels, requiring you to monitor your blood glucose more closely.
  • Gout: This medication can raise uric acid levels in your blood, which may trigger or worsen painful gout attacks.
     
Ramipril + HydrochlorothiazideAliskiren
Critical
Ramipril + HydrochlorothiazideDofetilide
Critical

Drug-Drug Interactions

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Ramipril + HydrochlorothiazideAliskiren
Critical
How does the drug interact with Ramistar H 5mg Cap:
Taking aliskiren together with ramipril may increase the risk of serious side effects (kidney problems, low blood pressure, and high potassium levels in the blood).

How to manage the interaction:
Taking Ramipril with Aliskiren is not recommended but can be taken if prescribed by a doctor. However, consult a doctor if you feel nausea, vomiting, weakness, confusion, tingling in the hands and feet, a sensation of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
Ramipril + HydrochlorothiazideDofetilide
Critical
How does the drug interact with Ramistar H 5mg Cap:
Taking Dofetilide and Hydrochlorothiazide can increase the risk of an irregular heart rhythm which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Combining Dofetilide and Hydrochlorothiazide together is not recommended as it can result in an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Ramipril + HydrochlorothiazideCisapride
Critical
How does the drug interact with Ramistar H 5mg Cap:
Taking Cisapride and Hydrochlorothiazide can increase the risk of an irregular heart rhythm which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Combining Cisapride and Hydrochlorothiazide together is generally avoided as it can result in an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, or fast or pounding heartbeats, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Ramipril + HydrochlorothiazideTrimethoprim
Severe
How does the drug interact with Ramistar H 5mg Cap:
Taking Ramipril with Trimethoprim can increase the amount of potassium in blood (known as hyperkalemia) which can increase the risk of kidney problems.

How to manage the interaction:
Although taking Ramipril together with Trimethoprim can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you feel weakness, confusion, numbness or tingling, and uneven heartbeats. You must drink enough fluids while taking these medications. Do not stop taking any medication without consulting a doctor.
Ramipril + HydrochlorothiazideLeflunomide
Severe
How does the drug interact with Ramistar H 5mg Cap:
Taking leflunomide with ramipril can increase the risk of liver problems.

How to manage the interaction:
Although taking Ramipril with Leflunomide can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Ramipril + HydrochlorothiazidePotassium iodide
Severe
How does the drug interact with Ramistar H 5mg Cap:
Taking Potassium Iodide with Ramipril may significantly increase potassium levels in the blood. (High levels of potassium can develop into a condition known as hyperkalemia, which can lead to kidney problems, muscle paralysis and irregular heart rhythm).

How to manage the interaction:
Although there is an interaction between Potassium iodide and Ramipril, you can take these medicines together if prescribed by a doctor. However, if you notice any nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, or irregular heartbeat, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Ramipril + HydrochlorothiazideKetoconazole
Severe
How does the drug interact with Ramistar H 5mg Cap:
Coadministration of ramipril with ketoconazole may increase the risk of liver damage.

How to manage the interaction:
Although taking Ramipril with Ketoconazole can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, tiredness, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue using any medications without consulting a doctor.
Ramipril + HydrochlorothiazideAmiloride
Severe
How does the drug interact with Ramistar H 5mg Cap:
Taking Ramipril with Amiloride may increase the risk of side effects (low blood pressure, kidney problems, and increased potassium levels in the blood).

How to manage the interaction:
Although taking amiloride along with ramipril can result in an interaction, they can be taken together if prescribed by a doctor. However, consult the doctor if you feel weakness, confusion, numbness or tingling, and uneven heartbeats. Do not stop taking any medication without consulting a doctor.
Ramipril + HydrochlorothiazidePotassium acetate
Severe
How does the drug interact with Ramistar H 5mg Cap:
Taking ramipril with potassium acetate may significantly increase potassium levels in the blood. High levels of potassium can develop into a condition known as hyperkalemia, which can lead to kidney problems, muscle paralysis and irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between Ramipril and Potassium acetate, but it can be taken if prescribed by a doctor. However, if you notice any nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, or irregular heartbeat, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Ramipril + HydrochlorothiazideTizanidine
Severe
How does the drug interact with Ramistar H 5mg Cap:
The combined use of Tizanidine and Hydrochlorothiazide can increase the risk of low blood pressure.

How to manage the interaction:
Taking Tizanidine and Hydrochlorothiazide together can result in an interaction, but they can be taken if advised by a doctor. However, if you experience any symptoms like headache, dizziness, lightheadedness, fainting, and changes in pulse or heart rate, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTI- HYPERTENSIVES]

FAQs

Ramistar H 5 mg Capsule 15's is used to treat hypertension (high blood pressure).
Ramistar H 5 mg Capsule 15's contains Ramipril (blood pressure-lowering agent) and Hydrochlorothiazide (diuretic or water pill). Ramipril is an angiotensin-converting enzyme or ACE inhibitor that lowers high blood pressure by blocking a naturally occurring substance known as angiotensin II (which tightens your blood vessels). It allows these constricted blood vessels to relax and, therefore, helps lower high blood pressure. On the other hand, Hydrochlorothiazide works by increasing the amount of urine passed out from the kidneys. It effectively reduces excess fluid overload in the body and treats oedema (swelling) associated with heart, liver, kidney, or lung disease. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Thus, both help lower high blood pressure and reduce the chances of heart attacks or strokes.
Yes, Ramistar H 5 mg Capsule 15's can cause dizziness. It is advised to avoid driving or operating any heavy machinery while taking Ramistar H 5 mg Capsule 15's. In case you feel dizzy or lightheaded, it is recommended to rest for some time until you feel better.
It is advised to continue your medicine even after your blood pressure is under control or becomes normal, as blood pressure can shoot up at any time. If you have any discomfort, please consult your doctor immediately.
If you forget to take Ramistar H 5 mg Capsule 15's at any time, take it as soon as you remember, then continue to take it at the usual times. Do not take a double dose to make up for a forgotten dose.
No, it is a prescribed drug given by a physician to prevent specific medical conditions. Taking it on your own can cause unwanted side effects.
Yes, in some cases, Ramistar H 5 mg Capsule 15's may affect your serum potassium level, so consult your doctor before using potassium supplements or its salt substitutes.
Ramistar H 5 mg Capsule 15's should not be used if you have a history of a serious allergic reaction, including swelling of the face/lips/tongue/throat (angioedema) and an inability to pass urine. Before going outdoor in the sun, try to wear sunscreen (SPF) and avoid sunlamps and tanning booths as prolonged intake of Ramistar H 5 mg Capsule 15's may cause your skin to be sensitive to the sunlight.
Yes, if you have diabetes, Ramistar H 5 mg Capsule 15's may change your blood sugar level, so check your blood sugar regularly as directed. Tell your doctor if you have high blood sugar (hyperglycemia) symptoms like increased thirst/urination or signs of low blood sugar (hypoglycemia) such as sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. Your doctor might adjust your dose of Ramistar H 5 mg Capsule 15's.
The common side effects of Ramistar H 5 mg Capsule 15's include headaches, tiredness, slow heart rate, and nausea. Most of these side effects gradually resolve over time; however, if they persist, please inform your doctor.
Yes, you can take Ramistar H 5 mg Capsule 15's every day if advised by the doctor. Just make sure to follow your doctor’s instructions regarding how long to use it. Taking it for years on your own without your doctor’s approval could be fatal.
No, Ramistar H 5 mg Capsule 15's is not to be taken during pregnancy. If you are pregnant or think you may be pregnant, contact your doctor immediately. This medicine is not recommended during pregnancy because it can seriously harm the developing baby. Do not stop or change your medication without medical advice, as your doctor will advise you on the safest alternative treatment.
This medicine contains a diuretic component that works by helping your kidneys remove excess salt and water. This is a normal effect that helps lower your blood pressure. Talk to your doctor if this becomes bothersome.
It is generally recommended to take Ramistar H 5 mg Capsule 15's in the morning. This prevents you from needing to wake up during the night to urinate. Talk to your doctor or pharmacist to find the best schedule for you.
You should avoid or severely limit alcohol while taking Ramistar H 5 mg Capsule 15's. Alcohol can worsen side effects like dizziness, drowsiness, and lightheadedness. Talk to your doctor for personalised advice.
A dry, persistent cough is a well-known side effect of one of the active components in this medicine. If this cough is bothersome or does not go away, do not take cough medicine without consulting your healthcare provider. Talk to your doctor about alternative treatment options.
Most salt substitutes contain potassium instead of sodium. Using these while taking Ramistar H 5 mg Capsule 15's can cause potassium to build up to dangerous levels in your blood. Talk to your doctor before using any salt substitutes.
Dizziness can happen, especially when you first start taking this medicine. Try getting up slowly from sitting or lying down. If the dizziness persists or causes you to faint, talk to your doctor right away.
Ramistar H 5 mg Capsule 15's starts working within a few hours to help lower blood pressure, but it may take several weeks of consistent daily use to see the full benefits. Talk to your doctor if you do not notice an improvement in your blood pressure readings over time.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 019901S060Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. National Health Service (NHS). Ramipril - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  3. National Health Service (NHS). Safety In Lactation Diuretics - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Drugs.com Clinical Review Team. Hydrochlorothiazide Patient Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  5. Watson Pharma Private Limited. U.S. Food & Drug Administration. [Revised in August 2020] [Accessed on 8th April 2022] docs/label/2020/020504s026lbl.pdfCheck here
  6. Cipla Ltd. RAMIPRES-H Tablets (Ramipril + Hydrochlorothiazide). Ciplamed.com [Revised on April 2017] [Accessed on 8th April 2022]Check here

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd Floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India
Other Info - RAM0027
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