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  3. Rasilez 300 mg Tablet 7's

Rasilez 300 mg Tablet 7's, Pack of 7 TabletS
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Rasilez 300 mg Tablet is used to treat essential hypertension. It contains Aliskiren, which works by inhibiting the action of renin, an enzyme that helps the body make angiotensin I, which is converted to angiotensin II (tightens and narrows blood vessels, increasing blood pressure). Thus, it reduces the production of angiotensin I and II. This helps to relax, widen the blood vessels, and lower blood pressure.

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Composition :

ALISKIREN-300MG

Manufacturer/Marketer :

Novartis India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Rasilez 300 mg Tablet

Rasilez 300 mg Tablet belongs to the class of drugs called direct renin inhibitors used in the treatment of essential hypertension. Essential hypertension is high blood pressure without a known secondary cause. 

Rasilez 300 mg Tablet contains Aliskiren which works by inhibiting the action of renin, an enzyme that helps the body to make angiotensin I, which is converted to angiotensin II (tightens and narrows blood vessels which increases the blood pressure). Thus, it reduces the production of angiotensin I and II. This helps to relax and widen the blood vessels and lower blood pressure. 

Take Rasilez 300 mg Tablet as prescribed. Your doctor will advise how often you take Rasilez 300 mg Tablet based on your medical condition. Sometimes, Rasilez 300 mg Tablet may cause common side effects such as dizziness, headache, back pain, diarrhoea, high levels of potassium in the blood or tiredness. Most of these side effects of Rasilez 300 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Aliskiren or any other ingredients of Rasilez 300 mg Tablet or if you have ever had a reaction called angioedema (swelling of the face, lips, tongue, throat, arms, and legs, and may cause difficulty breathing) to an ACE inhibitor medicine, inform your doctor. Rasilez 300 mg Tablet is not recommended for pregnant women, especially in the second and third trimesters, as it may cause injury and death to the developing fetus. Therefore, pregnant or breastfeeding women are advised to consult a doctor before taking Rasilez 300 mg Tablet. Rasilez 300 mg Tablet is not recommended for children below 18 years as the safety and effectiveness were not established. 

Uses of Rasilez 300 mg Tablet

Rasilez 300 mg Tablet is sued in the treatment of Essential hypertension (high blood pressure). The detailed uses of Rasilez 300 mg Tablet are as follows:<br/>• High Blood Pressure (Hypertension): Rasilez 300 mg Tablet is primarily used to treat essential hypertension, a condition where blood pressure is consistently elevated without a known secondary cause. It helps relax and widen blood vessels, allowing blood to flow more easily and reducing strain on the heart.<br/>• Cardiovascular Risk Reduction: Rasilez 300 mg Tablet lowers blood pressure, which in turn helps reduce the risk of serious complications such as heart attack, stroke, and heart failure. It supports long-term heart health by improving circulation and easing the workload on the heart.<br/>• Renin Inhibition Therapy: Rasilez 300 mg Tablet acts as a direct renin inhibitor, blocking the enzyme responsible for producing angiotensin I and II—hormones that constrict blood vessels. This mechanism helps maintain stable blood pressure and prevents vascular damage over time.<br/>

Directions for Use

• Rasilez 300 mg Tablet can be taken with or without food as advised by the doctor.• Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.• Swallow Rasilez 300 mg Tablet as a whole with a glass of water.• Do not chew, crush or break it.

Medicinal Benefits

Rasilez 300 mg Tablet contains Aliskiren used in the treatment of essential hypertension (high blood pressure). It inhibits the action of renin, an enzyme that helps the body to produce angiotensin II (tightens and narrows blood vessels which increases blood pressure). Thus, it reduces the production of angiotensin II. This helps to relax and widen the blood vessels and lower blood pressure. Thereby, it helps to reduce the risk of heart failure, stroke, heart attack or kidney failure.

How Rasilez 300 mg Tablet Works

Rasilez 300 mg Tablet contains Aliskiren which works by inhibiting the action of renin, an enzyme that helps the body to make angiotensin I, which is converted to angiotensin II (tightens and narrows blood vessels which increases the blood pressure). Thus, it reduces the production of angiotensin I and II. This helps to relax and widen the blood vessels and lower blood pressure.

Storage

• Store in a cool and dry place away from sunlight.
• Keep Rasilez 300 mg Tablet out of reach and sight of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Rasilez 300 mg Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • Increased creatinine levels must be corrected immediately with the help of a doctor.
  • Reduce strenuous activities that can lead to muscle breakdown and production of creatinine.
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding tissue.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
  • Avoid smoking and drinking alcohol.
  • Limit fruit intake to two servings a day, choose a low-potassium options like apples and strawberries.
  • Restrict starchy vegetables like potatoes and pumpkin to half a cup daily.
  • Avoid or limit foods like tomato products, high-bran cereals, and salty or sugary snacks.
  • Limit dairy products to 200g of yoghurt or 300ml of milk per day.

What if I have taken an overdose of Rasilez 300 mg Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Rasilez 300 mg Tablet may include blurred vision, dizziness, fainting, and nausea. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

If you are allergic to Aliskiren or any other ingredients of Rasilez 300 mg Tablet or if you have ever had a reaction called angioedema (swelling of the face, lips, tongue, throat, arms, and legs, and may cause difficulty breathing) to an ACE inhibitor medicine, inform your doctor. Rasilez 300 mg Tablet is not recommended for pregnant women, especially in the second and third trimesters, as it may cause injury and death to the developing fetus. Therefore, pregnant or breastfeeding women are advised to consult a doctor before taking Rasilez 300 mg Tablet. Rasilez 300 mg Tablet is not recommended for children below 18 years as the safety and effectiveness were not established. Do not consume alcohol with Rasilez 300 mg Tablet as it may worsen dizziness. Avoid potassium supplements with Rasilez 300 mg Tablet as they may lead to high potassium levels in the blood. If you have severe and persistent diarrhoea, you are recommended to stop taking Rasilez 300 mg Tablet.

Drug-Drug Interactions

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AliskirenLisinopril
Critical
AliskirenValsartan
Critical

Drug-Drug Interactions

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AliskirenLisinopril
Critical
How does the drug interact with Rasilez 300 mg Tablet:
Combining Rasilez 300 mg Tablet with Lisinopril can increase the potassium levels in the blood.

How to manage the interaction:
Although taking Rasilez 300 mg Tablet and lisinopril together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor if you experience symptoms including weakness, tiredness, confusion, numbness or tingling, and irregular heartbeats. Do not discontinue any medications without a doctor's advice.
AliskirenValsartan
Critical
How does the drug interact with Rasilez 300 mg Tablet:
Using Rasilez 300 mg Tablet together with Valsartan may increase the risk of serious side effects (kidney problems, low blood pressure, or high potassium levels).

How to manage the interaction:
Taking Valsartan with Rasilez 300 mg Tablet is not advised as it can result in an interaction, it can be taken if a doctor has advised it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
AliskirenTelmisartan
Critical
How does the drug interact with Rasilez 300 mg Tablet:
Co-administration of Rasilez 300 mg Tablet with Telmisartan can increase the risk of hyperkalemia (high potassium levels in the blood).

How to manage the interaction:
Taking Telmisartan with Rasilez 300 mg Tablet can possibly lead to an interaction, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.
AliskirenEnalapril
Critical
How does the drug interact with Rasilez 300 mg Tablet:
Using Rasilez 300 mg Tablet together with enalapril may increase the risk of serious side effects such as kidney problems, low blood pressure, and high potassium levels in the blood.

How to manage the interaction:
Taking enalapril with Rasilez 300 mg Tablet is not recommended, but it can be taken together if your doctor advises. However, contact your doctor if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, or feelings of heaviness in the legs. Do not stop taking any medications without consulting a doctor.
AliskirenOlmesartan medoxomil
Critical
How does the drug interact with Rasilez 300 mg Tablet:
Using Rasilez 300 mg Tablet together with olmesartan may increase the risk of serious side effects (kidney problems, low blood pressure, and high potassium levels in the blood).

How to manage the interaction:
Taking Olmesartan medoxomil with Rasilez 300 mg Tablet is not recommended as it can cause an interaction, they can be taken if advised by a doctor. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat.It is crucial that you continue to consume enough fluids while taking these medications. Do not stop using any medications without consulting a doctor.
AliskirenRamipril
Critical
How does the drug interact with Rasilez 300 mg Tablet:
Taking Rasilez 300 mg Tablet together with ramipril may increase the risk of serious side effects such as kidney problems, low blood pressure, and high potassium levels in the blood. High levels of potassium can develop into a condition known as hyperkalemia, which in severe cases can lead to kidney problems, muscle paralysis and irregular heart rhythm.

How to manage the interaction:
Taking Ramipril with Rasilez 300 mg Tablet is not recommended, but can be taken if prescribed by a doctor. However, consult your doctor if you feel nausea, vomiting, weakness, confusion, tingling in the hands and feet, a sensation of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. You must drink enough fluids while taking these medications. It is advised to reduce the intake of foods high in potassium, including tomatoes, raisins, figs, potatoes, lima beans, bananas, plantains, papayas, pears, cantaloupes, mangoes. Do not discontinue any medications without a doctor's advice.
AliskirenAzilsartan medoxomil
Critical
How does the drug interact with Rasilez 300 mg Tablet:
Taking Rasilez 300 mg Tablet with Azilsartan medoxomil can increase the risk of low blood pressure and high potassium levels in the body.

How to manage the interaction:
Taking Azilsartan medoxomil with Rasilez 300 mg Tablet is generally avoided as it may lead to an interaction, it can be taken if prescribed by the doctor. Consult the doctor if you experience vomiting, weakness, tingling in your hands and feet, or palpitations. Make sure to hydrate while taking these medications. It is advised to reduce the intake of potassium-rich foods. Do not discontinue any medications without a doctor's advice.
AliskirenPerindopril
Critical
How does the drug interact with Rasilez 300 mg Tablet:
Combining Rasilez 300 mg Tablet with Perindopril can increase the risk of low blood pressure, high potassium levels, and kidney damage.

How to manage the interaction:
Taking Perindopril with Rasilez 300 mg Tablet is not recommended, but can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
AliskirenItraconazole
Severe
How does the drug interact with Rasilez 300 mg Tablet:
Coadministration of Itraconazole and Rasilez 300 mg Tablet can significantly increase the blood levels and effects of Rasilez 300 mg Tablet.

How to manage the interaction:
Itraconazole and Rasilez 300 mg Tablet may interact, however if prescribed by a physician, they can be used together. Consult a doctor if you have any of the following symptoms: weakness, confusion, tingling in the hands and feet, weak pulse, slow or irregular heartbeat. Without consulting a doctor, never stop taking any medication.
AliskirenCiclosporin
Severe
How does the drug interact with Rasilez 300 mg Tablet:
The combined use of Rasilez 300 mg Tablet and ciclosporin can significantly increase the blood levels and effects of Rasilez 300 mg Tablet, which may lead to low blood pressure, hyperkalemia (high potassium levels) in the body. High potassium levels can cause hyperkalemia, which can lead to kidney failure, muscular paralysis, abnormal heart rhythms. If you are elderly, dehydrated, or have kidney disease, diabetes, or severe heart failure, you are more prone to develop hyperkalemia while taking these medications.

How to manage the interaction:
Taking Rasilez 300 mg Tablet and ciclosporin will lead to an interaction, they can be taken together if your doctor has prescribed them. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. It is important to maintain proper fluid intake while taking these medications. It is advised to reduce intake of potassium-rich foods such as tomatoes, raisins, figs, potatoes, lima beans, bananas, plantains, papayas, pears, cantaloupes, mangoes, and potassium-containing salt substitutes.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a low-salt diet and minimize eating processed foods as they contain more sodium. Try to replace salt with spices or herbs to add flavour to the food.
  • Do regular exercise such as cycling, walking, jogging, dancing or swimming for a minimum of 30 minutes per day.
  • Chronic stress may also cause high blood pressure. Therefore, avoid stress triggers and make time for yourself to relax and do activities that you enjoy.
  • Maintain a diet that is rich in fruits, vegetables, whole grains and low-fat dairy products.
  • Avoid smoking and alcohol intake.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES
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Alcohol

Unsafe

Avoid consumption of alcohol while on treatment with Rasilez 300 mg Tablet as it may worsen dizziness.

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Pregnancy

Unsafe

Rasilez 300 mg Tablet is not recommended for use during pregnancy, especially in the second and third trimesters, as it may cause injury and death to the developing fetus. So when pregnancy is detected, Rasilez 300 mg Tablet should be discontinued as soon as possible.

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Breast Feeding

Caution

It is unknown whether Rasilez 300 mg Tablet passes into breast milk. You are recommended to avoid breastfeeding while taking Rasilez 300 mg Tablet. However, if you have any concerns regarding this, please discuss them with your doctor.

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Driving

Caution

Rasilez 300 mg Tablet may cause dizziness or drowsiness. So, drive only if you are alert after taking Rasilez 300 mg Tablet.

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Liver

Consult your doctor

If you have a pre-existing or a history of liver disease, inform your doctor before taking Rasilez 300 mg Tablet.

bannner image

Kidney

Caution

If you have a pre-existing or a history of kidney diseases, inform your doctor before taking Rasilez 300 mg Tablet. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

bannner image

Children

Unsafe

Rasilez 300 mg Tablet is not recommended for children below 18 years as the safety and effectiveness were not established.

Have a query?

FAQs

Rasilez 300 mg Tablet is used to treat Essential hypertension (high blood pressure).

Rasilez 300 mg Tablet contains Aliskiren which works by inhibiting the action of renin, an enzyme that helps the body to produce angiotensin II (tightens and narrows blood vessels which increases blood pressure). Thus, it reduces the production of angiotensin II. This helps to relax and widen the blood vessels and lower blood pressure.

You are not recommended to take potassium supplements with Rasilez 300 mg Tablet as it may increase the levels of potassium in the blood (hyperkalaemia). However, please consult a doctor before taking other medicines or supplements with Rasilez 300 mg Tablet.

You are not recommended to take ibuprofen with Rasilez 300 mg Tablet as co-administration of these two medicines may reduce the effect of Rasilez 300 mg Tablet and increase the risk of impaired kidney function. However, if you experience loss of appetite, sudden weight loss or weight gain, weakness, muscle cramps, vomiting, nausea, decreased or increased urination, irregular heart rhythm and fluid retention, please consult a doctor immediately. If you are supposed to use these medicines together, you are advised to contact your doctor so that the dose may be adjusted to use safely.

Rasilez 300 mg Tablet usually starts working within two weeks after starting the treatment. However it may take 4 weeks to see full benefits. Therefore, it's important to continue taking Rasilez 300 mg Tablet as prescribed by your doctor and monitor your blood pressure regularly.

Yes, Rasilez 300 mg Tablet can cause fluid and electrolyte imbalance. Symptoms of fluid and electrolyte imbalance include dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, and gastrointestinal disturbances such as nausea and vomiting. If you experience any of these symptoms, consult your doctor immediately. Therefore, It's important to monitor your electrolyte levels and stay hydrated while taking Rasilez 300 mg Tablet.

Yes, Rasilez 300 mg Tablet can cause hyperkalemia (high potassium levels in the blood). Therefore, monitor your potassium levels and kidney function while taking Rasilez 300 mg Tablet. If you experience symptoms like muscle weakness, irregular heartbeat, or numbness, consult your doctor immediately.

Joint pain is a common side effect of Rasilez 300 mg Tablet. To manage this side effect, do light exercise or physical therapy to strengthen the muscles around the affected joint. Maintain a healthy weight to reduce stress on your joints. If the joint pain persists, please consult your doctor.

Serious side effects of Rasilez 300 mg Tablet include severe allergic reaction with symptoms such as rash, itching, swelling of face or lips or tongue, difficulty breathing. If you experience any of these symptoms, please consult your doctor immediately.

Yes, Rasilez 300 mg Tablet can cause dizziness as a side effect. If you experience dizziness, it's important to sit or lie down until the symptoms disappear. Always carry some sugary food or fruit juice with you in case you experience dizziness while traveling. And also avoid such as driving or operating heavy machinery or activities that requires mental alertness until you know how the Rasilez 300 mg Tablet affects you.

Avoid taking Rasilez 300 mg Tablet with fruit juices and drinks containing plant extracts (including herbal teas), as they can decrease the effectiveness of Rasilez 300 mg Tablet. Avoid high-sodium foods, as they can counteract the blood pressure-lowering effects and also alcohol, as it can increase the risk of drowsiness and other side effects. Avoid high-fat meals, especially close to the time you take Rasilez 300 mg Tablet.

The common side effects of Rasilez 300 mg Tablet are dizziness, headache, back pain, diarrhoea, high levels of potassium in the blood or tiredness. If any of these side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India.
Other Info - RAS0006

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 9:23 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.ema.europa.eu/en/documents/product-information/rasilez-epar-product-information_en.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021985s023lbl.pdf
  3. https://medlineplus.gov/druginfo/meds/a607039.html

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