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compositionComposition:REGORAFENIB-40MG
prescription
Prescription Medicine
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Regonat 40 mg Tablet is used to treat colorectal carcinoma. It contains Regorafenib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells. This medicine is not recommended for use in pregnant and breastfeeding mothers due to embryo-fetal toxicity.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

REGORAFENIB-40MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Regonat 40 mg Tablet

Regonat 40 mg Tablet is a prescription medicine used to treat adults with certain types of advanced cancers of the colon, rectum, stomach, and liver. It is typically prescribed after other standard treatments have already been tried. This medicine helps manage the growth and spread of these specific tumours.

To get the best results, you must take Regonat 40 mg Tablet consistently at the same time each day exactly as your doctor instructs. It is taken as a daily dose for a specific number of weeks followed by a break period. Always take your dose after a low-fat meal, such as a light breakfast, to help your body absorb the medicine properly.

While taking this medicine, you may experience common side effects such as fatigue, diarrhoea, or a specific skin reaction on your hands and feet. However, you should contact your doctor immediately if you develop signs of serious issues, including severe bleeding, unusual bruising, or persistent stomach pain.

Before starting treatment, let your doctor know if you have high blood pressure, heart problems, or upcoming surgeries. Do not take this medicine if you have severe liver disease or are currently suffering from active, severe bleeding.

Certain prescription medications, herbal supplements, and even grapefruit juice can change how this medicine works, potentially causing dangerous side effects or reducing its effectiveness. If you are pregnant, planning to become pregnant, or breastfeeding, you must avoid taking this medicine because it can harm an unborn baby.

Uses of Regonat 40 mg Tablet

Regonat 40 mg Tablet is used to treat adults with certain types of advanced cancers of the colon, rectum, stomach, and liver. The detailed uses of Regonat 40 mg Tablet are as follows:

  • Colorectal cancer: Used for advanced colon or rectal cancer that has spread to other parts of the body and has been treated with other chemotherapy medicines.
  • Gastrointestinal stromal tumours (GIST): Used for a rare type of stomach or bowel cancer that cannot be removed with surgery or has spread, after other treatments have stopped working.
  • Liver cancer: Used for people with advanced liver cancer who have been previously treated with another specific cancer medicine.

Key Benefits

Regonat 40 mg Tablet helps treat certain advanced cancers by slowing the growth and spread of cancer cells. When used as prescribed, it helps control disease progression, supports ongoing cancer management, and may improve overall treatment outcomes in patients whose cancer has not responded to standard therapies.

  • Slows Cancer Progression: By blocking pathways that promote tumour growth and the formation of new blood vessels, this medicine helps slow or temporarily stop the progression of advanced cancers.
  • Helps Control Advanced Disease: This medicine provides an important treatment option for patients whose cancer has progressed despite previous therapies, helping to stabilise the disease and support continued cancer management.
  • Supports Quality of Life: By helping keep the cancer under control, this medicine may reduce disease-related symptoms, maintain physical functioning, and provide more stable periods during treatment.
Side effects of Regonat 40 mg Tablet
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • If you experience symptoms such as mouth ulcers, redness, difficulty in swallowing or talking, abdominal pain, and painful bowel movements as a drug side effect, consult your doctor as they may adjust the dose if necessary or prescribe alternative medication.
  • Practice good hygiene, such as washing your hands regularly, to prevent infection.
  • Drink plenty of water to keep your mucous membranes hydrated and promote healing.
  • Avoid spicy or acidic foods, which can irritate the mucous membranes and exacerbate inflammation.
  • Increase your intake of omega-3 fatty acids, found in fatty fish, nuts, and seeds, to reduce inflammation.
  • Follow a soft food diet to reduce discomfort and promote healing.
  • Weight loss without physical activity needs immediate medical attention.
  • Get a physical examination and blood tests done to identify factors causing weight loss that could be related to metabolism and thyroid function.
  • Avoid smoking and alcohol intake as it can alter your liver condition and increase your weight loss.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes of weight loss.
  • Talk to your dietician and consume food which can maintain ideal weight.
  • Wash your hands regularly with soap and water or use a hand sanitizer to prevent the spread of infections.
  • Wear masks, gloves and other protective clothing.
  • Cover sneezes and coughs with a medical mask or tissue or your elbow.
  • Take vaccinations to enhance your immunity to specific diseases.
  • Clean your utensils, linen and surfaces regularly.

Directions for Use

  • Take Regonat 40 mg Tablet after a low-fat meal for best results.
  • Regonat 40 mg Tablet should be taken once daily for the first 21 days of each 28-day cycle or as advised by your doctor.
  • Swallow the medicine as a whole with a glass of water.
  • Do not break, chew or crush Regonat 40 mg Tablet .

How Regonat 40 mg Tablet Works

Regonat 40 mg Tablet contains regorafenib, which is a type of medicine known as a kinase inhibitor. It works by blocking several proteins (called kinases) that are found on the surface of both cancer cells and nearby blood vessel cells. These proteins act like switches that tell cancer cells to grow, divide, and multiply. By blocking these switches, the medicine helps stop the cancer cells from multiplying. Additionally, it cuts off the signal that allows new blood vessels to grow toward the tumour, effectively starving the tumour of the oxygen and nutrients it needs to survive.
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Alcohol

Unsafe

Avoid alcohol consumption while taking Regonat 40 mg Tablet .

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Pregnancy

Unsafe

Regonat 40 mg Tablet is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Regonat 40 mg Tablet . You should not become pregnant while you are taking Regonat 40 mg Tablet and for at least two weeks after your treatment. Using effective birth control methods while on treatment with Regonat 40 mg Tablet is suggested.

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Breast Feeding

Unsafe

Regonat 40 mg Tablet should not be taken if you are breastfeeding as it passes into breast milk and may harm your infant.

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Driving

Unsafe

Regonat 40 mg Tablet may cause dizziness in some patients. Hence, do not drive, operate machinery, or engage in any activity that needs concentration until you are confident that you can do so safely while you are on treatment with Regonat 40 mg Tablet .

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Liver

Caution

If you have a pre-existing or a history of liver problems, tell your doctor before taking this medicine. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney diseases, inform your doctor before taking Regonat 40 mg Tablet . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Regonat 40 mg Tablet is not recommended for use in children below 18 years of age as the safety and efficacy is not established.

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Heart

Consult your doctor

Please consult your doctor before receiving Regonat 40 mg Tablet if you have pre-existing heart problems. Your doctor will prescribe Regonat 40 mg Tablet if the benefits outweigh the risks.

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Geriatrics

Caution

Regonat 40 mg Tablet should be used with caution in geriatric patients. Therefore, please consult your doctor before giving Regonat 40 mg Tablet to elderly individuals.

What if I have taken an overdose of Regonat 40 mg Tablet

If you accidentally take more than your prescribed dose, seek emergency medical care or contact a nearby hospital immediately.

Diet & Lifestyle Advise

  • Eat a low-fat breakfast before your dose to ensure the medicine is absorbed safely and effectively.
  • Avoid drinking grapefruit juice or eating grapefruit while on this medicine, as it can dangerously increase the drug levels in your body.
  • Moisturise your hands and feet regularly with a thick cream, and wear loose, comfortable socks and shoes to help prevent skin cracking and blistering.
  • Avoid exposing your hands and feet to very hot water or friction (like heavy scrubbing or intense physical activities) during the first few weeks of treatment.
  • Monitor your blood pressure daily at home, keeping a log to share with your doctor.
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Have a query?

How Soon It Starts Working

The time required for Regonat 40 mg Tablet to start to work: The time required for Regonat 40 mg Tablet to show its action is not clinically established. The time for which the effects of Regonat 40 mg Tablet last: The duration of action for Regonat 40 mg Tablet is not clinically established.

What if you forget to take Regonat 40 mg Tablet

If you miss a dose, take it as soon as you remember on the same day. If you do not realise until the next day, skip the missed dose entirely and take your next dose at your regularly scheduled time. Do not take two doses at once to make up for a missed dose.

Storage

•Store Regonat 40 mg Tablet at room temperature between 20°C to 25°C (68°F to 77°F) in its original container.

Drug Warnings

  • Write the date you first open the bottle directly on the label so you know when to safely discard any remaining tablets.
  • Always check the appearance of your tablets; do not use them if they appear damaged or altered.
  • Use a reliable form of birth control during treatment and for at least 2 months after your final dose to prevent pregnancy.
  • Notify your surgical team or dentist that you are taking this medicine, as you must stop taking it at least 2 weeks before any planned surgery or dental procedure to ensure proper wound healing.
  • Attend all scheduled blood work appointments so your healthcare provider can closely monitor your liver function and blood counts.

Drug-Drug Interactions

verifiedApollotooltip
  • Strong Antibiotics and Antifungal Medicines: Certain antibiotics, such as clarithromycin, and antifungal medicines, such as ketoconazole, can increase the levels of Regonat 40 mg Tablet in your bloodstream, raising the risk of side effects. Your doctor may recommend dose adjustments or closer monitoring during treatment.
  • Medicines for Seizures or Tuberculosis: Medicines used to treat seizures, such as carbamazepine, and tuberculosis treatments, such as rifampin, can speed up the breakdown of Regonat 40 mg Tablet , reducing its effectiveness. Inform your doctor if you are taking these medicines so your treatment can be adjusted if necessary.
RegorafenibDexamethasone
Critical
RegorafenibClarithromycin
Critical

Drug-Drug Interactions

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RegorafenibDexamethasone
Critical
How does the drug interact with Regonat 40 mg Tablet:
When Regonat 40 mg Tablet is taken with Dexamethasone, may significantly reduce the blood levels of Regonat 40 mg Tablet.

How to manage the interaction:
Co-administration of Regonat 40 mg Tablet and Dexamethasone can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
RegorafenibClarithromycin
Critical
How does the drug interact with Regonat 40 mg Tablet:
When Regonat 40 mg Tablet is taken with Clarithromycin, may alter the blood levels and effects of Regonat 40 mg Tablet.

How to manage the interaction:
Co-administration of Clarithromycin and Regonat 40 mg Tablet can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
RegorafenibKetoconazole
Critical
How does the drug interact with Regonat 40 mg Tablet:
When Regonat 40 mg Tablet is taken with Ketoconazole, it can increase the levels of Regonat 40 mg Tablet, which may lead to side effects.

How to manage the interaction:
Taking Regonat 40 mg Tablet with Ketoconazole is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
RegorafenibCarbamazepine
Critical
How does the drug interact with Regonat 40 mg Tablet:
When Regonat 40 mg Tablet is taken with Carbamazepine, it may decrease the blood levels of Regonat 40 mg Tablet, which may make Regonat 40 mg Tablet less effective in treating your condition.

How to manage the interaction:
Taking Regonat 40 mg Tablet with Carbamazepine is generally not advised, but it can be taken if prescribed by the doctor. Without consulting a doctor, never stop taking any drugs.
RegorafenibEnzalutamide
Critical
How does the drug interact with Regonat 40 mg Tablet:
Taking Enzalutamide with Regonat 40 mg Tablet may decrease the blood levels of Regonat 40 mg Tablet, which may make Regonat 40 mg Tablet less effective in treating your condition.

How to manage the interaction:
Taking Enzalutamide with Regonat 40 mg Tablet is not recommended, as it may lead to an interaction, it can be taken if prescribed by the doctor. Do not discontinue any medications without a doctor's advice.
RegorafenibBosentan
Critical
How does the drug interact with Regonat 40 mg Tablet:
Taking Regonat 40 mg Tablet with bosentan it can increases the risk of side effects.

How to manage the interaction:
Taking Regonat 40 mg Tablet with Bosentan is not recommended, please consult your doctor before taking it. They can be taken together if advised by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
RegorafenibIsoniazid
Critical
How does the drug interact with Regonat 40 mg Tablet:
When Isoniazid is taken with Regonat 40 mg Tablet, it can increase the levels of Regonat 40 mg Tablet leading to side effects.

How to manage the interaction:
Taking Regonat 40 mg Tablet with Isoniazid is not recommended, it taken can be taken if prescribed by the doctor.
RegorafenibImatinib
Critical
How does the drug interact with Regonat 40 mg Tablet:
When Regonat 40 mg Tablet is taken with Imatinib, it may increase the level of imatinib which may lead to side effects.

How to manage the interaction:
Taking Regonat 40 mg Tablet with Imatinib is not recommended, it can be taken if prescribed by your doctor. However, if you experience any unusual symptoms, consult the doctor.
RegorafenibDabigatran etexilate
Severe
How does the drug interact with Regonat 40 mg Tablet:
Taking Dabigatran etexilate with Regonat 40 mg Tablet can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Dabigatran etexilate with Regonat 40 mg Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
RegorafenibApixaban
Severe
How does the drug interact with Regonat 40 mg Tablet:
Coadministration of Regonat 40 mg Tablet and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Regonat 40 mg Tablet and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and Grapefruit Juice: Do not consume grapefruit or grapefruit juice while taking Regonat 40 mg Tablet , as they can slow the breakdown of the medicine, leading to excessively high levels in your bloodstream and increasing the risk of side effects.
  • High-Fat Foods: Avoid taking Regonat 40 mg Tablet with high-fat meals, as they can significantly alter the absorption of the medicine and affect how well it works. Follow your doctor's instructions regarding meal timing.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Regonat 40 mg Tablet is used to treat Colorectal Cancer.
Regonat 40 mg Tablet contains Regorafenib, which works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells.
Regonat 40 mg Tablet is safe to be taken by a diabetic person. However, take Regonat 40 mg Tablet only after consulting with a doctor, as they may adjust the dosing according to your condition.
You should know that this medicine may reduce fertility in both men and women. Discuss the risks of taking an irinotecan injection with your doctor.
Yes, Regonat 40 mg Tablet is a chemotherapy agent used in the treatment of colon and rectal cancer.
Regonat 40 mg Tablet should be taken with a low-fat breakfast. Swallow it as a whole with a glass of water. Do not crush, break, or chew the medicine.
Yes, Regonat 40 mg Tablet works by shrinking the tumours or stopping their growth. Thereby, it helps treat colorectal cancer.
Regonat 40 mg Tablet may cause side effects such as diarrhoea, rash, tiredness, decreased appetite, nausea, weight loss, fatigue, stomach pain, loss of appetite, hoarseness, and dizziness. Consult the doctor if any of these side effects persist or worsen.
No, you should not take Regonat 40 mg Tablet on an empty stomach. It must be taken with a low-fat meal, like a light breakfast containing less than 30% fat, to make sure it is absorbed correctly by your body. Talk to your doctor or pharmacist if you need examples of low-fat meals.
This medicine can cause serious liver damage in some patients. Your doctor will perform regular blood tests to check how well your liver is functioning, especially during the first few months of treatment. If you notice yellowing of your skin or dark urine, contact your doctor immediately. Talk to your doctor if you have any concerns about your liver.
No, you must swallow the tablets whole with a glass of water. Do not crush, chew, split, or break them, as this can affect how the medicine is absorbed and increase your risk of side effects. Talk to your doctor if you have trouble swallowing pills.
This medicine can cause a common side effect known as hand-foot skin reaction, which causes redness, pain, and peeling. Keep your skin moisturised, avoid hot water, and contact your doctor right away, as they may need to adjust your dose. Talk to your doctor for advice on managing skin changes.
No, this medicine can cause severe harm or birth defects to an unborn baby. Both men and women should use highly effective birth control during treatment and for at least 2 months after the final dose. Talk to your doctor immediately if you or your partner suspect a pregnancy.
Yes, this medicine can cause a significant increase in blood pressure, often within the first week of starting treatment. You should monitor your blood pressure regularly at home. Talk to your doctor if your blood pressure readings are higher than normal.
You should avoid or severely limit alcohol while taking this medicine. Alcohol can place extra stress on your liver, which is already at risk for damage during this treatment. Talk to your doctor for personalised advice regarding alcohol use.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - REG0179
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