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  3. Retol-Plus Tablet 10's

Retol-Plus Tablet 10's, Pack of 10
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Retol-Plus Tablet 10's is indicated to treat and prevent migraine. It is used to relieve the symptoms at the first sign of a migraine attack and to prevent the worsening of the attack. It narrows the blood vessels in the brain and also affects the blood flow patterns associated with headaches. Also, it prevents nausea and vomiting associated with migraine. It may cause common side effects, such as stomach upset, dizziness, dry mouth, constipation, and insomnia (trouble sleeping).

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Composition :

CAFFEINE-100MG + ERGOTAMINE-1MG + PARACETAMOL-250MG + PROCHLORPERAZINE-2.5MG

Manufacturer/Marketer :

Olcare Laboratories Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Retol-Plus Tablet 10's

Retol-Plus Tablet 10's is indicated to treat and prevent migraine. Retol-Plus Tablet 10's is used to relieve the symptoms at the first sign of a migraine attack and to prevent the worsening of the attack. Migraine is a neurological condition which is characterised by an intense pulsating, throbbing, pounding, debilitating headache which usually occurs on one side of the head; however, it can occur on both sides or shift.

Retol-Plus Tablet 10's is a combination of four drugs, namely: Ergotamine (ergot alkaloid), caffeine (methylxanthine), prochlorperazine (anti-emetic) and paracetamol (analgesic). Ergotamine works by narrowing the blood vessels in the brain and also affects the blood flow patterns associated with headaches. Caffeine enhances the vasoconstrictive effect, which is the narrowing of blood vessels. Prochlorperazine prevents nausea and vomiting associated with migraine by modifying the effects of neurotransmitters. Paracetamol blocks the release of prostaglandins that cause pain.

You are advised to take Retol-Plus Tablet 10's as directed by your doctor, depending on your medical condition. In some cases, you may experience specific common side effects, such as stomach upset, dizziness, dry mouth, constipation, and insomnia (trouble sleeping). Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Retol-Plus Tablet 10's contains paracetamol; do not take other medicines containing paracetamol along with Retol-Plus Tablet 10's unless prescribed. Do not take Retol-Plus Tablet 10's if you are pregnant or breastfeeding. Retol-Plus Tablet 10's may cause drowsiness and dizziness, so drive with caution. Retol-Plus Tablet 10's should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol with Retol-Plus Tablet 10's as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your health condition and any medications you're taking to rule out any side effects or interactions.

Uses of Retol-Plus Tablet 10's

Retol-Plus Tablet 10's is used in the treatment of migraine. The detailed uses of Retol-Plus Tablet 10's are as follows:

  • Migraine Relief: Retol-Plus Tablet 10's, mainly used to relieve the headache, nausea, and light and sound sensitivity that come with migraines.
  • Pain management: By reducing moderate to severe migrainous pain, this medication can help patients feel more comfortable during an attack.
  • Preventive Treatment: In certain situations, Retol-Plus Tablet 10's may be used to help people who experience frequent migraines by reducing the frequency and severity of their attacks.
  • Symptomatic Management: After an episode, it can help people quickly resume their regular activities by managing their acute migraine symptoms.

Directions for Use

• Take Retol-Plus Tablet 10's with or without food as advised by a doctor. • Follow your doctor’s recommendations on the dosage and timing of this medication based on your medical conditions to achieve optimal results. • Swallow it as a whole with a glass of water. • Do not crush, chew, or break it.

Medicinal Benefits

Retol-Plus Tablet 10's is a combination of four drugs, namely: Ergotamine, caffeine, prochlorperazine, and paracetamol. Retol-Plus Tablet 10's is indicated to treat and prevent migraine. Ergotamine is an ergot alkaloid that works by narrowing the blood vessels in the brain and also affects the blood flow patterns associated with headaches. Caffeine is a methylxanthine that enhances the vasoconstrictive effect (narrowing of blood vessels). Prochlorperazine is an anti-emetic that prevents nausea and vomiting associated with migraine by modifying the effects of neurotransmitters. Paracetamol is an analgesic that blocks the release of prostaglandins that cause pain. Retol-Plus Tablet 10's is used to relieve the symptoms at the first sign of a migraine attack and to prevent the worsening of the attack.

How Retol-Plus Tablet 10's Works

Retol-Plus Tablet 10's is a combination of four drugs, namely: Ergotamine (ergot alkaloid), caffeine (methylxanthine), prochlorperazine (anti-emetic) and paracetamol (analgesic). Ergotamine works by narrowing the blood vessels in the brain and also affects the blood flow patterns associated with headaches. Caffeine enhances the vasoconstrictive effect, which is the narrowing of blood vessels. Prochlorperazine prevents nausea and vomiting associated with migraine by modifying the effects of neurotransmitters. Paracetamol blocks the release of prostaglandins that cause pain.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Retol-Plus Tablet
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in white blood cells which may lead to impaired immunity.
  • Identify the medicine causing acidosis and talk to your doctor whether it can be discontinued or substituted with other medicine.
  • If you experience symptoms of acidosis like rapid breathing, confusion, overtiredness or nausea, contact your doctor immediately.
  • Your doctor may recommend dietary changes like changes in potassium intake based on the type of acidosis.
  • Consume more fruits, vegetables, and cruciferous foods like cabbage, kale, and broccoli.
  • Reduced alcohol intake can enhance liver enzyme function.
  • Oxidative stress can be managed by eating foods rich in antioxidants, such as vitamins C and E.
  • Liver function tests regularly can help manage increased levels of AST.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.

What if I have taken an overdose of Retol-Plus Tablet 10's

Do not take more than the prescribed dose of Retol-Plus Tablet 10's as it may cause an overdose. If you suspect you have taken an overdose, please consult a doctor immediately.

Drug Warnings

Do not take Retol-Plus Tablet 10's if you are allergic to any of its contents; if you have/had heart problems, blood circulation problems or if you are taking antibiotics, anti-fungal, anti-HIV or other anti-migraine medicines. Retol-Plus Tablet 10's, when taken along with antibiotics, anti-fungal, anti-HIV drugs, could lead to unpleasant side-effects such as poor blood flow to hands, feet, or brain. Retol-Plus Tablet 10's contains paracetamol, do not take other medicines containing paracetamol along with Retol-Plus Tablet 10's unless prescribed. Inform your doctor before taking Retol-Plus Tablet 10's if you have/had high blood pressure, heart problems, high cholesterol, diabetes, asthma, liver and kidney problems. Do not take Retol-Plus Tablet 10's if you are pregnant or breastfeeding. Retol-Plus Tablet 10's may cause drowsiness and dizziness, so drive only if you are alert. Retol-Plus Tablet 10's is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol with Retol-Plus Tablet 10's as it could lead to increased drowsiness. Do not take any other NSAIDs for pain relief along with Retol-Plus Tablet 10's unless prescribed.

Drug-Drug Interactions

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ProchlorperazineMetoclopramide
Critical
ProchlorperazineMesoridazine
Critical

Drug-Drug Interactions

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ProchlorperazineMetoclopramide
Critical
How does the drug interact with Retol-Plus Tablet:
Coadministration of metoclopramide and Retol-Plus Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Metoclopramide with Retol-Plus Tablet together is generally avoided as it can possibly result in an interaction, they can be taken together if advised by your doctor. However, if you experience muscle spasm or movements that you can't stop or control, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping, consult the doctor. Do not stop taking any medications without consulting a doctor.
ProchlorperazineMesoridazine
Critical
How does the drug interact with Retol-Plus Tablet:
Coadministration of mesoridazine and Retol-Plus Tablet can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking mesoridazine with Retol-Plus Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or an irregular heartbeat. Do not stop taking any medications without consulting a doctor.
CaffeinePhenelzine
Critical
How does the drug interact with Retol-Plus Tablet:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Retol-Plus Tablet with Phenelzine is not recommended, please consult your doctor before taking it. They can be taken if your doctor advises it. Do not stop taking any medication without consulting your doctor.
CaffeineTranylcypromine
Critical
How does the drug interact with Retol-Plus Tablet:
Coadministration of tranylcypromine with Retol-Plus Tablet can in cause severe high blood pressure.

How to manage the interaction:
Taking Retol-Plus Tablet with Tranylcypromine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience headache, confusion, blurred vision, problems with speech or balance, nausea, vomiting, chest pain, convulsions, and sudden numbness or weakness (especially on one side of the body). Do not discontinue any medications without consulting a doctor.
CaffeineIsocarboxazid
Critical
How does the drug interact with Retol-Plus Tablet:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Retol-Plus Tablet with Isocarboxazid is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. Do not stop taking any medication without consulting your doctor.
CaffeineLinezolid
Critical
How does the drug interact with Retol-Plus Tablet:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Retol-Plus Tablet with Linezolid is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. Do not stop taking any medication without consulting your doctor.
ErgotamineClarithromycin
Critical
How does the drug interact with Retol-Plus Tablet:
When Retol-Plus Tablet is taken with Clarithromycin, the amount of Retol-Plus Tablet in the blood can go up.

How to manage the interaction:
Taking Clarithromycin with Retol-Plus Tablet can result in an interaction, it should be taken only if a doctor has advised it. However, if you experience abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, irregular heartbeat, severe headache, shortness of breath, blurred vision, confusion, and/or slurred speech, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ErgotamineVoriconazole
Critical
How does the drug interact with Retol-Plus Tablet:
The serum concentration of Ergometrine can be increased when it is combined with Voriconazole.

How to manage the interaction:
Taking Retol-Plus Tablet with Voriconazole is not recommended, please consult your doctor before taking it.
ErgotamineSafinamide
Critical
How does the drug interact with Retol-Plus Tablet:
Taking Safinamide with Retol-Plus Tablet can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Safinamide with Retol-Plus Tablet is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
ErgotamineRasagiline
Critical
How does the drug interact with Retol-Plus Tablet:
Taking Retol-Plus Tablet and Rasagiline together can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Rasagiline and Retol-Plus Tablet is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm, stomach cramp, nausea, vomiting, and diarrhea contact your doctor right away. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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CAFFEINE-100MG+ERGOTAMINE-1MG+PARACETAMOL-250MG+PROCHLORPERAZINE-2.5MGFruit juices, Fruits
Moderate

Drug-Food Interactions

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CAFFEINE-100MG+ERGOTAMINE-1MG+PARACETAMOL-250MG+PROCHLORPERAZINE-2.5MGFruit juices, Fruits
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consumption of grape juice or grape fruit can increase the blood levels of ergotamine in the body. Consumption of grape juice increases the effect of caffeine. Limit your consumption of grapefruit and grapefruit juice during treatment with ergotamine and caffeine.

Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly, as it helps in improving overall health and boosts self-esteem.
  • Avoid bright lights, loud noises, and extreme temperatures.
  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.
  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.
  • Massage your scalp to ease the pain.
  • Lie down in a quiet, dark room.
  • Avoid smoking, alcohol, and caffeinated drinks. 
  • Learn what triggers your migraine and try avoiding them.
  • Stay hydrated. Drink plenty of fluids.
  • Learn relaxation skills, as they help reduce stress.

Habit Forming

No

Therapeutic Class

ANTIMIGRAINE AGENTS

Retol-Plus Tablet 10's Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Retol-Plus Tablet 10's as it may cause increased drowsiness.

bannner image

Pregnancy

Unsafe

Avoid taking Retol-Plus Tablet 10's if you are pregnant or planning for pregnancy. Please consult your doctor if you are pregnant or if you have any concerns regarding this.

bannner image

Breast Feeding

Unsafe

Retol-Plus Tablet 10's may pass into breastmilk. Avoid taking Retol-Plus Tablet 10's if you are breastfeeding.

bannner image

Driving

Caution

Retol-Plus Tablet 10's may cause dizziness and drowsiness. Do not drive or operate machinery unless you are alert.

bannner image

Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

bannner image

Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Unsafe

Retol-Plus Tablet 10's should not be given to children as the safety and effectiveness were not established.

Have a query?

FAQs

Retol-Plus Tablet 10's is used to treat and prevent migraine. It is used to relieve the symptoms at the first sign of a migraine attack and to prevent the worsening of the attack.

Retol-Plus Tablet 10's contains Ergotamine, caffeine, prochlorperazine, and paracetamol. Ergotamine works by narrowing the blood vessels in the brain and also affects the blood flow patterns associated with headaches. Caffeine enhances the vasoconstrictive effect (narrowing of blood vessels). Prochlorperazine prevents nausea and vomiting associated with migraine by modifying the effects of neurotransmitters. Paracetamol blocks the release of prostaglandins that cause pain.

Dry mouth could be a side-effect of Retol-Plus Tablet 10's. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.

Orthostatic hypotension could be a side-effect of Retol-Plus Tablet 10's. Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking, instead, lie down and get up slowly only when you feel better.

Do not discontinue Retol-Plus Tablet 10's without consulting your doctor as it could lead to recurring or worsening of symptoms. To treat your condition effectually, continue taking Retol-Plus Tablet 10's for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Retol-Plus Tablet 10's.

Do not take Retol-Plus Tablet 10's along with antibiotics (clarithromycin, erythromycin, troleandomycin), antifungal (itraconazole, ketoconazole) and anti-HIV medicines (indinavir, nelfinavir, ritonavir). Retol-Plus Tablet 10's contains ergotamine and caffeine, which, when taken along with these drugs, could lead to unpleasant side effects such as poor blood flow to the hands, feet, or brain.

Retol-Plus Tablet 10's may cause constipation. Eat high-fibre foods and drink plenty of fluids if you experience constipation. Talk to your doctor if the condition persists or worsens.

When used responsibly and under medical guidance, Retol-Plus Tablet 10's can be a highly effective treatment option. However, the long-term side effects are not well established. If you experience difficulties or concerns, consult your doctor promptly to discuss appropriate measures.

No, Retol-Plus Tablet 10's is not a blood thinner. It is a medication used to treat migraine headaches and contains a combination of ergotamine, caffeine, paracetamol, and prochlorperazine.

No, taking a higher-than-recommended dose may not be more effective; instead, it may increase the risk of serious side effects and toxicity. Therefore, follow your doctor’s instructions and please consult your doctor. If you are experiencing increased severity of migraine attacks, which are not relieved by the recommended dose of this medicine, please consult your doctor for re-evaluation.

Yes, Retol-Plus Tablet 10's can expire. Please check the expiration date on the medicine pack. Do not use the Retol-Plus Tablet 10's after the expiry date.

A migraine is a severe headache that causes throbbing, pulsing pain on one side of the head. The headache phase usually lasts at least four hours, but it can also last for days.

Migraine attacks can be triggered by various factors, including hormonal changes (especially around menstruation), stress, lack of sleep or too much sleep, certain foods and drinks like alcohol, caffeine, aged cheeses, bright lights, loud noises, strong smells, weather changes, dehydration, and sudden physical exertion. However, each person may have unique triggers that vary depending on their sensitivity.

The common side effects of Retol-Plus Tablet 10's are stomach upset, dizziness, dry mouth, constipation, and insomnia (trouble sleeping). Please consult your doctor if any of these side effects persist or worsen.

Country of origin

India

Manufacturer/Marketer address

504/A, 505/A, G.I.D.C. Estate, Wadhwan 363 035., Dist. Surendranagar. Gujarat.
Other Info - RET0264

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 5, 2025 | 1:15 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.lagaay.com/Catalogus/Product%20information/032870/Ergotamine%20tablets%20leaflet.pdf
  2. https://www.drugs.com/cdi/ergotamine-and-caffeine-tablets.html
  3. https://www.medicines.org.uk/emc/files/pil.99.pdf
  4. https://www.medicines.org.uk/emc/files/pil.1958.pdf

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