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  1. Home
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  3. Sorafenat 200 mg Tablet 60's

Prescription drug
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Sorafenat 200 mg Tablet 60's, Pack of 1 TABLET
Sorafenat 200 mg Tablet 60's, Pack of 1 TABLET
Sorafenat 200 mg Tablet 60's, Pack of 1 TABLET
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Composition :

SORAFENIB-200MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Sorafenat 200 Tablet

Sorafenat 200 Tablet belongs to the group of medicine called ‘anti-cancer’ that is primarily indicated in the treatment of kidney, liver, and thyroid cancer.  Kidney cancer is also known as renal cancer is a disease in which healthy cells of the kidney become malignant (cancerous), grow in an uncontrolled manner, and forms a tumour. Cancer of the liver is known as liver cancer. When cancer occurs in the liver, it destroys healthy cells of the liver and affects the ability of the liver to function normally. Thyroid cancer occurs when cells start multiplying in the thyroid gland and form a tumour. The tumour is a collection of abnormal cells.

Sorafenat 200 Tablet contains 'Sorafenib' that falls in the category of medicines known as 'kinase inhibitors'. It works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. In this way, it stops the spread of cancerous cells.

Take Sorafenat 200 Tablet as prescribed by your doctor. You are suggested to take Sorafenat 200 Tablet as long as your doctor has prescribed it after checking your medical condition.  In some cases, you may experience certain common side-effects such as itching or skin rash, acne, dry skin, vomiting, diarrhoea, and loss of appetite. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

To treat your condition effectually, continue taking Sorafenat 200 Tablet for as long as your doctor has prescribed. Do not take Sorafenat 200 Tablet if you are pregnant or planning for pregnancy as Sorafenat 200 Tablet causes serious birth defects. Sorafenat 200 Tablet should not be taken by breastfeeding mothers as it passes into breast milk and may cause a possible risk to the infant. Elderly people are more sensitive to the medicine so the doctor may adjust the dosage according to the condition. Avoid consuming alcohol along with Sorafenat 200 Tablet as it could lead to increased dizziness.

Uses of Sorafenat 200 Tablet

Sorafenat 200 Tablet is used in the treatment of kidney, liver, and thyroid cancer. The detailed uses of Sorafenat 200 Tablet are as follows:

  • Treats Advanced Renal Cell Carcinoma (Kidney Cancer): Sorafenat 200 Tablet is prescribed for advanced kidney cancer in patients who have not responded to previous treatment with interleukin-2 or interferon-alpha, or those who are not suitable for such treatments.
  • Treats Hepatocellular Carcinoma (Liver Cancer): Sorafenat 200 Tablet is effective in treating liver cancer, especially in patients who cannot undergo surgery. It helps slow the growth and spread of cancer cells in the liver.
  • Treats Differentiated Thyroid Carcinoma (Thyroid Cancer): Sorafenat 200 Tablet is used to treat thyroid cancer that has spread to other parts (metastatic) and is no longer responding to radioactive iodine therapy.

Have a query?

Directions for Use

  • Take Sorafenat 200 Tablet without food on an empty stomach, at least 1 to 2 hours before a meal.
  • Follow your doctor’s recommendations on the dosage and timing of this medication to achieve optimal results.
  • Swallow it as a whole with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

Sorafenat 200 Tablet is a ' tyrosine kinase inhibitor (TKI)', that stops the uncontrolled growth and spread of cancerous cells. Sorafenat 200 Tablet is effective in treating thyroid, liver and kidney cancer. It acts by stopping the action of the abnormal protein that is responsible for the multiplication of cancerous cells. Whenever a new healthy cell is formed it undergoes a usual process of maturity. Cancerous cells form new cells more quickly so Sorafenat 200 Tablet targets cancerous cells and block the action of Tyrosine kinases enzymes (responsible for causing cancer). In this way, Sorafenat 200 Tablet stops the production, spread and growth of cancerous cells in the body.

How Sorafenat 200 Tablet Works

Sorafenat 200 Tablet contains 'Sorafenib' that falls in the category of medicines known as 'kinase inhibitors'. It works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. In this way, it stops the spread of cancerous cells.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Sorafenat 200 mg Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
  • Apply moisturizer immediately after showering or bathing.
  • Use a moisturizer containing lanolin, petroleum jelly, glycerine, hyaluronic acid or jojoba oil.
  • Do not use hot water for bathing. Instead use warm water and limit showers and bath to 5 to 10 minutes.
  • Apply a sunscreen with SPF-30 or higher.
  • Avoid harsh soaps, detergents and perfumes.
  • Do not scratch or rub the skin.
  • Drink adequate water to prevent dehydration.
  • Wear pants, full sleeves and a wide-brimmed hat while going out in the sun.

What if I have taken an overdose of Sorafenat 200 Tablet

Do not take more than the prescribed dose of Sorafenat 200 Tablet as it may cause overdose. The adverse reactions observed were mainly diarrhoea and dermatologic. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Sorafenat 200 Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding, or bruising. Your doctor may advise you to undergo regular blood tests, kidney and liver tests to monitor your condition. Inform your doctor about your health condition and medicines to rule out any unpleasant side-effects. Before your doctor prescribes you Sorafenat 200 Tablet , tell them if you have heart problems, high blood pressure, bleeding issues, surgery, or an electrolyte imbalance (like abnormal levels of magnesium, calcium,  or potassium in the blood). Sorafenat 200 Tablet is restricted to use in persons who are sensitive to any of its constituent or have squamous cell lung cancer or already taking carboplatin and paclitaxel.
 

Drug-Drug Interactions

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SorafenibMesoridazine
Critical
SorafenibPimozide
Critical

Drug-Drug Interactions

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SorafenibMesoridazine
Critical
How does the drug interact with Sorafenat 200 mg Tablet:
Using mesoridazine together with Sorafenat 200 mg Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Mesoridazine with Sorafenat 200 mg Tablet can cause an interaction, please consult a doctor before taking it. However, if you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations call a doctor. Do not stop using any medications without consulting a doctor.
SorafenibPimozide
Critical
How does the drug interact with Sorafenat 200 mg Tablet:
Using Pimozide together with Sorafenat 200 mg Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Sorafenat 200 mg Tablet with Pimozide can cause an interaction, consult a doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
SorafenibCarboplatin
Critical
How does the drug interact with Sorafenat 200 mg Tablet:
Co-administration of Sorafenat 200 mg Tablet with Carboplatin can increase the risk or severity of serious side effects.

How to manage the interaction:
Taking Sorafenat 200 mg Tablet with Carboplatin together is not recommended as it can cause an interaction, consult a doctor before taking it. However if you experience any unusual symptoms, consult the doctor. Do not stop using any medications without consulting a doctor.
SorafenibThioridazine
Critical
How does the drug interact with Sorafenat 200 mg Tablet:
Using thioridazine together with Sorafenat 200 mg Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Sorafenat 200 mg Tablet with Thioridazine together is not recommended as it can cause an interaction, consult a doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
SorafenibZiprasidone
Critical
How does the drug interact with Sorafenat 200 mg Tablet:
Co-administration of Sorafenat 200 mg Tablet with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Sorafenat 200 mg Tablet with Ziprasidone together can result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
SorafenibSaquinavir
Critical
How does the drug interact with Sorafenat 200 mg Tablet:
Using saquinavir together with Sorafenat 200 mg Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although Sorafenat 200 mg Tablet and Saquinavir is not recommended as it leads to an interaction, contact a doctor before you take Sorafenat 200 mg Tablet. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
SorafenibDronedarone
Critical
How does the drug interact with Sorafenat 200 mg Tablet:
Using dronedarone together with Sorafenat 200 mg Tablet can increase the risk of an irregular heart rhythm. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Sorafenat 200 mg Tablet with Dronedarone is generally avoided as it can cause an interaction, consult a doctor before taking it. However, if you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations call a doctor. Do not stop using any medications without consulting a doctor.
SorafenibSparfloxacin
Critical
How does the drug interact with Sorafenat 200 mg Tablet:
Coadministration of Sorafenat 200 mg Tablet with Sparfloxacin can prolong the QT interval (QT interval is a measurement made on an electrocardiogram used to assess some of the electrical properties of the heart) may result in additive effects and increased risk of ventricular arrhythmias (abnormal heart rhythm).

How to manage the interaction:
Co-administration of Sumatriptan with Sparfloxacin can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
SorafenibIvabradine
Severe
How does the drug interact with Sorafenat 200 mg Tablet:
Coadministration of Ivabradine with Sorafenat 200 mg Tablet can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Ivabradine with Sorafenat 200 mg Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
SorafenibLeflunomide
Severe
How does the drug interact with Sorafenat 200 mg Tablet:
Coadministration of leflunomide with Sorafenat 200 mg Tablet can increase the risk of liver problems.

How to manage the interaction:
Taking Sorafenat 200 mg Tablet with Leflunomide together can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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SORAFENIB-200MGHigh fat foods
Moderate

Drug-Food Interactions

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SORAFENIB-200MGHigh fat foods
Moderate
Common Foods to Avoid:
Frozen Meals, Cheese, Red Meat, Potato Chips, Hamburgers, Hot Dogs, Ice Cream

How to manage the interaction:
Food may reduce the oral absorption and bioavailability of Sorafenat 200 mg Tablet. Avoid taking Sorafenat 200 mg Tablet with high fat foods.

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles reduce fatigue, helps in weight loss, and give strength. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga and other relaxation techniques may also help in improving physical and mental health and may reduce your stress levels.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting helps in improving your health, mental ability, and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listen to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains,  nuts, and seeds.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Sorafenat 200 Tablet Substitute

Substitutes safety advice
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption with Sorafenat 200 Tablet as it may increase the risk of side effects such as dizziness, drowsiness, or difficulty in concentrating.

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Pregnancy

Unsafe

Sorafenat 200 Tablet is restricted to use in pregnancy. A woman needs to have a negative pregnancy test before starting treatment with this medicine. It is better to use effective birth control methods to prevent pregnancy while taking this medicine or for at least 6 months after taking the last dose of Sorafenat 200 Tablet .

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Breast Feeding

Unsafe

Sorafenat 200 Tablet should not be taken by breastfeeding mothers as it passes into breast milk and may cause a possible risk to the infant.

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Driving

Caution

It is not known if Sorafenat 200 Tablet may affect your driving ability or not.

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Liver

Safe if prescribed

Sorafenat 200 Tablet is safe to take by patients dealing with liver cancer as prescribed by their doctor. The dose may be adjusted by the doctor according to the medical condition of the patient.

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Kidney

Safe if prescribed

Sorafenat 200 Tablet is safe to take by patients dealing with kidney cancer as prescribed by their doctor. The dose may be adjusted by the doctor according to the medical condition of the patient.

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Children

Caution

Sorafenat 200 Tablet is not recommended for children below 18 years as the safety and effectiveness were not established.

FAQs

Sorafenat 200 Tablet is used in the treatment of kidney, liver, and thyroid cancer.

Sorafenat 200 Tablet is safe to be taken by a diabetic person. However, take Sorafenat 200 Tablet only after asking with a doctor as they may adjust the dosing according to the condition of the patient.

Sorafenat 200 Tablet is restricted to use in pregnancy. A woman needs to have a negative pregnancy test before starting treatment with this medicine. It is better to use effective birth control methods to prevent pregnancy while taking this medicine or for at least 6 months after taking the last dose of Sorafenat 200 Tablet .

Sorafenat 200 Tablet should be stopped in cases where a person faces a serious side effect that affects the quality of life. Otherwise, you need to keep taking Sorafenat 200 Tablet until your doctor asks you to stop it.

Liver cancer may spread fast depending upon the type of cancer. Hemangiosarcoma and angiosarcoma (the type of liver cancer) spread quickly while hepatocellular carcinoma spreads slowly in the disease.

Before your doctor prescribes you Sorafenat 200 Tablet , tell them if you have heart problems, high blood pressure, bleeding issues, surgery, or an electrolyte imbalance (like abnormal levels of magnesium, calcium, or potassium in the blood).

Sorafenat 200 Tablet is restricted to use in persons who are sensitive to any of its constituents or have squamous cell lung cancer or already taking carboplatin and paclitaxel.

If you are going for surgery tell your dentist ahead that you are taking this medicine. You need to stop taking it at least 10 days after having surgery.

Sorafenat 200 Tablet should be taken as advised by the doctor. It is usually taken without food at least 1 hour before or 2 hours after food. Swallow it as a whole with water. Do not crush, break or chew it.

You are advised to take Sorafenat 200 Tablet for as long as it is prescribed by your doctor based on your medical condition. Do not stop taking Sorafenat 200 Tablet even if you feel better till the treatment is completed as the symptoms may reoccur.

No, taking treatment along with Sorafenat 200 Tablet is not recommended. It is used alone rather than in combination with other treatments to avoid the unwanted side-effects. However, consult the doctor before the treatment.

You will know if Sorafenat 200 Tablet is working if you notice the changes in the symptoms, decrease in the tumour size, or if the blood test shows positive changes. Your doctor will regularly check to know the condition.

The severe side-effects associated with Sorafenat 200 Tablet include heart attack, heart failure, increased risk of bleeding, liver problem, allergic reactions, gastro-intestinal perforations (a tear in wall of stomach or intestine).

Yes, Sorafenat 200 Tablet may decrease the blood sugar levels, which may sometimes lead to fainting. Diabetic patients should check their blood sugar regularly. Consult the doctor if this condition worsens.

No, this isn’t dangerous.Hand-foot reactions (refers to palms and soles) are the most common adverse reactions of Sorafenat 200 Tablet . You should consult the doctor if this condition persists for longer durations or worsens.

Country of origin

India

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - SOR0083

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 10, 2025 | 3:15 PM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021923s008s009lbl.pdf
  2. https://www.drugs.com/nexavar.html
  3. https://www.ema.europa.eu/en/documents/product-information/nexavar-epar-product-information_en.pdf

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