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compositionComposition:CYPROHEPTADINE-2MG
prescription
Prescription Medicine
info
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Step-Up Syrup is used to treat allergy symptoms and loss of appetite. It contains cyproheptadine, which works by blocking the action of histamine, a substance responsible for causing allergic reactions. This medicine may sometimes cause side effects such as drowsiness, dizziness, constipation, blurred vision, restlessness, dry mouth, nose, or throat. Inform the doctor if your child is taking any other medication, or has any pre-existing medical conditions.

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Written By ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CYPROHEPTADINE-2MG

Manufacturer/Marketer :

Emcee Pharmaceuticals (P) Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Step-Up Syrup

Step-Up Syrup contains cyproheptadine, a medicine used in children to manage allergy symptoms such as runny nose, sneezing, watery eyes, and itchy skin. It is also prescribed to help stimulate appetite and promote healthy weight gain in paediatric patients who struggle to eat enough. By targeting specific natural chemicals in the body, this medicine provides relief from allergy symptoms and helps support normal growth.

For best results, parents should give Step-Up Syrup consistently at the same times each day as directed by the doctor. It can be taken with or without food, though giving it with food or milk may help prevent mild stomach upset. Alongside this medicine, offering your child frequent, small, nutrient-dense meals and keeping them hydrated can significantly improve their overall progress.

While taking Step-Up Syrup , your child may experience common mild side effects like drowsiness or dry mouth. If you notice any serious side effects, such as extreme sleepiness, a rapid heart rate, or severe mood changes, stop giving the medicine and consult your doctor immediately.

Do not give this medicine if your child has certain health conditions, such as narrow-angle glaucoma, a blocked stomach or bowel, or difficulty urinating. Always talk to your doctor before starting this medicine if your child has asthma, heart problems, or thyroid issues. This medication is not recommended for newborn or premature infants.

Tell your doctor about all other medicines your child is taking, especially other allergy medicines, anti-seizure drugs, or medicines that cause sleepiness, as they can interact with Step-Up Syrup and increase the risk of side effects. Avoid giving your child any alcohol-containing cough syrups or preparations while they are on this treatment.

Uses of Step-Up Syrup

Your doctor may prescribe Step-Up Syrup to help manage the following conditions:

  • Allergy relief: Helps reduce symptoms of seasonal and year-round allergies, such as sneezing, runny nose, itchy throat, and watery eyes.
  • Skin allergy symptoms: Relieves hives, swelling, and severe itching associated with skin rashes or insect bites.
  • Appetite stimulation: Used to help increase appetite and encourage healthy weight gain in paediatric patients experiencing poor eating habits or weight loss due to chronic illness.

Key Benefits

When used as directed as part of your treatment plan, Step-Up Syrup may provide the following benefits:

  • Symptom relief: Provides prompt relief from uncomfortable allergy symptoms, helping your child play, study, and sleep without constant itching or sneezing.
  • Skin healing: By blocking the triggers of allergic reactions, it helps the skin heal faster and reduces the discomfort of hives.
  • Nutritional support: For children struggling with a poor appetite, this medicine helps stimulate their natural desire to eat. This makes it easier for parents to introduce a balanced diet, helping the child regain strength, improve energy levels, and meet vital growth milestones.
Side effects of Step-Up Syrup 200 ml
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.

Directions for Use

  • Step-Up Syrup can be given with or without food as advised by your doctor.
  • Follow your doctor’s instructions regarding the dosage and duration of the medication.
  • Administer the advised dose to the child using the measuring cup/measuring spoon/dropper.
  • Avoid using regular household spoons, as they may not measure the dose correctly. Shake well before use.

How Step-Up Syrup Works

Step-Up Syrup contains cyprohaptadine. It works by blocking two main active substances in your child's body: histamine and serotonin. Histamine is a natural chemical released during an allergic reaction that causes symptoms like itching, swelling, runny nose, and watery eyes. By blocking histamine receptors, this medicine stops these allergy symptoms at their source. At the same time, this medicine acts as a serotonin blocker in a specific part of the brain that controls appetite. Serotonin can sometimes signal to the body that it is full; by blocking these signals, Step-Up Syrup helps stimulate the urge to eat, encouraging a healthy and consistent appetite in children who need to gain weight.
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Alcohol

Not applicable

-

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Pregnancy

Not applicable

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Breast Feeding

Not applicable

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Driving

Not applicable

-

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Liver

Caution

Give Step-Up Syrup with caution if your child has a history of liver diseases or conditions. Your doctor may adjust the dose as needed based on your child’s medical condition.

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Kidney

Consult your doctor

Give Step-Up Syrup with caution if your child has a history of kidney diseases or conditions. Your doctor may adjust the dose as needed based on your child’s medical condition.

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Children

Safe if prescribed

Step-Up Syrup is safe to use in children if prescribed by a doctor. The doctor will decide the dose of this medicine based on your child's age, body weight, and condition.

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Heart

Caution

Please give Step-Up Syrup with caution under the doctor's advice if the child has a history of heart diseases/conditions.

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Geriatrics

Not applicable

Step-Up Syrup is for paediatric patients only.

What if I have taken an overdose of Step-Up Syrup

If you suspect an overdose, seek immediate medical attention or go to the nearest hospital right away. Symptoms of an overdose in children can include extreme drowsiness, confusion, fever, flushed skin, dry mouth, or unusual excitement and seizures.

Diet & Lifestyle Advise

  • Offer small, frequent meals: If using this medicine to boost appetite, serve 5 to 6 small, nutrient-rich meals or snacks throughout the day instead of three large meals.
  • Focus on calorie-dense foods: Include healthy fats and proteins like nut butters, whole milk, yoghurt, and cheese in your child’s diet to support healthy weight gain.
  • Stay hydrated: Encourage your child to drink water regularly throughout the day to help relieve dry mouth, which is a common side effect of this medicine.
  • Minimise allergy triggers: Keep windows closed during high-pollen seasons, dust your home regularly, and keep pets out of your child's sleeping area to manage allergy symptoms naturally.
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How Soon It Starts Working

The time required for Step-Up Syrup to start to work: The time required for Step-Up Syrup to show its action is unknown. The time for which the effects of Step-Up Syrup last: The duration of action for Step-Up Syrup is unknown.

What if you forget to take Step-Up Syrup

If you miss a dose, give it as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed one and continue with the regular schedule. Do not give a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight. • Keep it away from children's reach. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Check the liquid: Always inspect the solution or drops before giving a dose. Do not use the medicine if the liquid is cloudy, contains floating particles, or has changed colour.
  • Watch for paradoxical excitement: Keep in mind that while this medicine causes drowsiness in many children, it can sometimes cause some young children to become unusually excited, hyperactive, or restless instead.
  • Limit outdoor activities during peak heat: This medicine can decrease sweating, making your child more sensitive to hot weather. Ensure they stay cool and hydrated during play.
  • Avoid other sedating products: Do not give other over-the-counter cold, cough, or allergy medicines that cause sleepiness while using Step-Up Syrup unless specifically advised by your doctor.

Drug-Drug Interactions

verifiedApollotooltip
  • Other antihistamines: Taking this with other allergy medications can increase the risk of severe drowsiness and dry mouth.
  • Sedatives and sleep medications: Combining this medicine with drugs that cause sleepiness can lead to extreme drowsiness and slow breathing.
  • MAO Inhibitors (MAOIs): Do not use this medicine if your child is taking or has recently taken MAO inhibitors, as this can prolong and intensify the side effects of Step-Up Syrup .
CyproheptadineLinezolid
Critical
CyproheptadineProcarbazine
Critical

Drug-Drug Interactions

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CyproheptadineLinezolid
Critical
How does the drug interact with Step-Up Syrup 200 ml:
Using linezolid together with Step-Up Syrup 200 ml may increase side effects of Step-Up Syrup 200 ml.

How to manage the interaction:
Taking Step-Up Syrup 200 ml with Linezolid is not recommended, consult a doctor before taking it. Contact a doctor if you experience dizziness, drowsiness, blurred vision, dry mouth, constipation, heat intolerance, flushing, decreased sweating, difficulty urinating, palpitation, rapid heartbeat, confusion, disorientation, and memory problems. Do not stop using any medications without talking to a doctor.
CyproheptadineProcarbazine
Critical
How does the drug interact with Step-Up Syrup 200 ml:
Using procarbazine together with Step-Up Syrup 200 ml may increase side effects.

How to manage the interaction:
Taking Step-Up Syrup 200 ml with Procarbazine is not recommended, please consult your doctor before taking it. Call a doctor if you experience dizziness, drowsiness, blurred vision, dry mouth, constipation, heat intolerance, flushing, decreased sweating, difficulty urinating, palpitation, rapid heartbeat, confusion, disorientation, and memory problems.
CyproheptadinePotassium chloride
Critical
How does the drug interact with Step-Up Syrup 200 ml:
Taking Step-Up Syrup 200 ml with Potassium chloride can increase the risk of stomach ulcers.

How to manage the interaction:
Taking Step-Up Syrup 200 ml with Potassium chloride is not recommended, as it can lead to an interaction, can be taken if your doctor has prescribed it. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, dark, tarry stools, consult the doctor immediately. Do not stop any medication without talking to a doctor.
CyproheptadinePotassium citrate
Critical
How does the drug interact with Step-Up Syrup 200 ml:
Taking Step-Up Syrup 200 ml and Potassium citrate (in tablet or capsule form) together can increase the risk of stomach ulcers.

How to manage the interaction:
Taking Step-Up Syrup 200 ml with Potassium citrate is not recommended, as it may lead to an interaction but can be taken if prescribed by the doctor. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
CyproheptadineEsketamine
Severe
How does the drug interact with Step-Up Syrup 200 ml:
Combining Step-Up Syrup 200 ml with Esketamine can increase the side effects.

How to manage the interaction:
Although there is a possible interaction between Step-Up Syrup 200 ml and Esketamine, you can take these medicines together if prescribed by your doctor. If you're having trouble with feeling tired, confused or finding it hard to focus, consult a doctor. Do not stop using any medications without talking to a doctor.
CyproheptadineSodium oxybate
Severe
How does the drug interact with Step-Up Syrup 200 ml:
Taking Step-Up Syrup 200 ml with sodium oxybate can enhance the risk of negative effects.

How to manage the interaction:
Although there is a possible interaction between Step-Up Syrup 200 ml and Sodium oxybate, you can take these medicines together if prescribed by your doctor. If you notice any symptoms like feeling tired, dizzy, confused or having low blood pressure or difficulty breathing, make sure to contact your doctor right away. Do not discontinue any medications without first consulting your doctor.
CyproheptadineZonisamide
Severe
How does the drug interact with Step-Up Syrup 200 ml:
Coadministration of Step-Up Syrup 200 ml with Zonisamide can lead to increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Step-Up Syrup 200 ml with Zonisamide together is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience changes in blood pressure, increased heart rate, fever, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.
CyproheptadineKetamine
Severe
How does the drug interact with Step-Up Syrup 200 ml:
Using ketamine together with Step-Up Syrup 200 ml may increase side effects.

How to manage the interaction:
Although taking Ketamine and Step-Up Syrup 200 ml together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you feel dizzy, sleepy, confused, have trouble focusing, lazy, or have trouble breathing, make sure to contact your doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Step-Up Syrup when used as directed. 
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIALLERGIC]

FAQs

Step-Up Syrup is used to treat symptoms of allergies such as itching, runny nose, sneezing, or watery eyes. It also helps stimulate appetite.
Step-Up Syrup contains cyproheptadine, an anti-allergic drug that works by blocking the action of histamine, a substance responsible for causing allergic reactions. Thereby, helps to provide relief from symptoms of allergy such as sneezing, running nose, watery eyes, itching, swelling, and congestion or stiffness.
You are recommended to give Step-Up Syrup to your child for as long as your doctor has prescribed it. However, if the symptoms persist or worsen, such as rash, fever, or persistent headache, after one week of using Step-Up Syrup , please consult your doctor.
The common side effects of Step-Up Syrup may include drowsiness, dizziness, constipation, blurred vision, restlessness, dry mouth, nose, or throat. Most of these side effects of Step-Up Syrup do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor immediately.
No, you should never use Step-Up Syrup as a sleep aid for children. Although drowsiness is a common side effect, using this medication solely to induce sleep is unsafe. Talk to your doctor if your child is having sleep difficulties.
This medicine should not be given to newborn or premature infants. For older babies and toddlers, it must only be given under the direct supervision and prescription of a paediatrician. Talk to your doctor to see if it is safe for your child.
Yes, Step-Up Syrup can be taken with or without food. If the medicine causes your child to have a mild stomach upset, giving it with a meal or a glass of milk can help prevent this.
Some children, especially very young ones, may experience an unusual reaction where they become hyperactive or excited instead of sleepy. If this happens, do not give any more doses and talk to your doctor for guidance.
No, you should never use a regular kitchen spoon to measure this medicine. Kitchen spoons are not accurate and can lead to giving too much or too little medicine. Always use the dropper, syringe, or cup that came with the product.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 087056S045Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Cyproheptadine Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. MedlinePlus. Cyproheptadine. [Accessed on 11-Sep-2020]Check here
  4. WebMD. Cyproheptadine. [Accessed on 11-Sep-2020]Check here
  5. Lactmed. Cyproheptadine. [Accessed on 11-Sep-2020]Check here
  6. Bertrand, Valérie et al. Safety of Cyproheptadine, an Orexigenic Drug. Analysis of the French National Pharmacovigilance Data-Base and Systematic Review. National Library of Medicine. (PMC). [Accessed on 18th June 2022]Check here
  7. Najib, Khadijehsadat et al. Beneficial effect of cyproheptadine on body mass index in undernourished children: a randomized controlled trial. National Library of Medicine. (PMC). [Accessed on 18th June 2022]Check here

Country of origin

INDIA

Manufacturer/Marketer address

DB-107, Ground Floor, Sector-I, Salt Lake City, Kolkata- 700064
Other Info - STE0065
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