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compositionComposition:ATAZANAVIR-300MG+RITONAVIR-100MG
prescription
Prescription Medicine
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SYNTHIVAN TABLET is used to treat HIV infection. It contains Atazanavir and Ritonavir which work by inhibiting the protease enzyme production that is required by the HIV-infected cells to make new viruses. In some cases, this medicine may cause side effects such as stomachache, diarrhoea, nausea, vomiting, headache, dizziness, indigestion, and tiredness. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

ATAZANAVIR-300MG+RITONAVIR-100MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About SYNTHIVAN TABLET

SYNTHIVAN TABLET is a prescription medicine used, in combination with other antiretroviral medicines, to treat Human Immunodeficiency Virus type 1 (HIV-1) infection. It contains atazanavir, which helps prevent HIV from multiplying, and ritonavir, which increases the amount of atazanavir in your body so that it works more effectively. Together, they help lower the amount of HIV (viral load), which can help protect your immune system and reduce the risk of HIV-related complications.
Although SYNTHIVAN TABLET helps control HIV infection, it does not cure HIV or prevent the virus from spreading to others. Continue following your doctor's advice and practise safer sex to help reduce the risk of HIV transmission.

Take SYNTHIVAN TABLET exactly as prescribed, at the same time every day and with food, as food helps improve the absorption of atazanavir. Before starting treatment, your doctor may perform blood tests, including resistance testing, to help determine whether this medicine is suitable for your HIV strain and to guide treatment decisions.

Missing doses or stopping treatment without medical advice may allow HIV to become resistant to treatment, making the medicine less effective. Eating a balanced diet, staying physically active, avoiding smoking, and attending regular follow-up appointments may help support your overall health during treatment.

Like all medicines, SYNTHIVAN TABLET may cause side effects, although not everyone experiences them. Contact your doctor promptly if you develop a severe skin rash, persistent abdominal pain, symptoms of liver problems, a slow or irregular heartbeat (called PR interval prolongation), or symptoms of kidney stones, such as severe pain in your side or back, pain while passing urine, or blood in the urine.

Before taking SYNTHIVAN TABLET , tell your doctor if you have liver disease, kidney disease, diabetes, haemophilia, or heart rhythm problems. Also inform your doctor about all prescription medicines, over-the-counter medicines, herbal products, and supplements you are taking, as some may interact with this medicine. If you have an existing heart condition or are taking medicines that affect heart rhythm, your doctor may recommend an electrocardiogram (ECG) before starting treatment and during follow-up. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, consult your doctor before taking this medicine.

Uses of SYNTHIVAN TABLET

SYNTHIVAN TABLET is prescribed as part of combination antiretroviral therapy to help control HIV infection. It is commonly used for: 

  • HIV-1 Infection: SYNTHIVAN TABLET is prescribed to control HIV-1 infection by lowering the viral load in your blood. This protects your immune cells (CD4 cells) and prevents the virus from causing further damage to your body's natural defence system.

Key Benefits

Taking SYNTHIVAN TABLET exactly as prescribed helps control HIV infection and supports long-term health. The primary benefits include:

  • Reduces viral load: Helps lower the amount of HIV in your body.
  • Protects your immune system: Helps preserve CD4 cells, allowing your immune system to function more effectively.
  • Lowers the risk of HIV-related complications: Reducing the viral load helps decrease the risk of opportunistic infections and other HIV-related illnesses.
  • Supports long-term HIV management: Regular treatment helps keep the virus under control as part of your overall HIV care plan.
Side effects of Synthivan Tablet

Directions for Use

  • SYNTHIVAN TABLET should be taken with food.
  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Swallow SYNTHIVAN TABLET as a whole with a glass of water.
  • Do not crush, break, or chew it.

How SYNTHIVAN TABLET Works

SYNTHIVAN TABLET contains two active components, atazanavir and ritonavir, which work together to help control HIV infection. Atazanavir belongs to a group of medicines called protease inhibitors. HIV needs an enzyme called protease to produce mature virus particles that can infect new cells. By blocking this enzyme, atazanavir helps stop the virus from multiplying and spreading within the body. Ritonavir helps increase the amount of atazanavir in your body by slowing its breakdown in the liver. This helps atazanavir remain effective for longer and improves its ability to control HIV when used as part of combination antiretroviral therapy.
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Alcohol

Caution

Consumption of alcohol may increase the risk of side-effects.

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Pregnancy

Caution

SYNTHIVAN TABLET should be used with caution in pregnant women. It is given only if clinically needed and when benefits outweigh the risk.

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Breast Feeding

Caution

If SYNTHIVAN TABLET is prescribed during breastfeeding, the doctor may advise you to stop breastfeeding as this medicine can pass into breastmilk.

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Driving

Caution

SYNTHIVAN TABLET may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

SYNTHIVAN TABLET should be used with caution in patients with liver diseases. The dose may have to be adjusted by your doctor.

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Kidney

Caution

SYNTHIVAN TABLET should be used with caution in patients with kidney diseases. The dose may have to be adjusted by your doctor.

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Children

Caution

This medicine is not recommended for children below 3 months. However, please consult your doctor for more information.

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Heart

Consult your doctor

SYNTHIVAN TABLET should be avoided if you have heart problems, especially conduction issues like prolonged PR interval or arrhythmias. It may increase the risk of heart rhythm changes, including irregular heartbeat and fainting. Always consult your doctor for safer alternatives tailored to your cardiac condition.

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Geriatrics

Caution

SYNTHIVAN TABLET can be used in geriatric patients, but older adults may face increased risks of heart rhythm issues and kidney problems. Careful monitoring and dose adjustments by a doctor are essential for safe use.

What if I have taken an overdose of SYNTHIVAN TABLET

If you take more than your prescribed dose, seek immediate medical attention right away. An overdose can cause serious health complications, and medical monitoring may be necessary.

Diet & Lifestyle Advise

  • Take with food: Always take this medication with a full meal, as dietary fat and protein help your body absorb the medicine effectively.
  • Manage cholesterol and blood sugar: Since protease inhibitors can affect your lipid and glucose levels, focus on a diet rich in vegetables, whole grains, and lean proteins, and monitor your levels regularly with your doctor.
  • Stay hydrated: Drink plenty of water throughout the day to support kidney function and overall health.
  • Avoid certain supplements: Do not take herbal supplements like St. John’s Wort, as they can significantly lower the level of the medicine in your body, making it less effective.
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How Soon It Starts Working

The time required for SYNTHIVAN TABLET to start to work: The effect of SYNTHIVAN TABLET is observed within 2 to 4 hours of administration. The time for which the effects of SYNTHIVAN TABLET last: SYNTHIVAN TABLET effect lasts for 24 hours.

What if you forget to take SYNTHIVAN TABLET

If you miss a dose, check how much time has passed since your scheduled dose. If it is within the safe window discussed with your doctor, take it immediately with food. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store SYNTHIVAN TABLET at room temperature, between 15°C and 30°C (59°F to 86°F), in a dry place.

Drug Warnings

  • Take it on time: Take SYNTHIVAN TABLET at the same time every day. Missing doses may make HIV treatment less effective and increase the risk of drug resistance.
  • Take with food: Always take this medicine with food to help your body absorb atazanavir properly.
  • Do not stop treatment: Continue taking SYNTHIVAN TABLET unless your doctor advises you to stop, even if you feel well.
  • Regular monitoring: Keep all follow-up appointments and blood tests. Your doctor may monitor your viral load, CD4 cell count, liver function, blood sugar, cholesterol levels, and kidney function during treatment.
  • Heart monitoring: If you have a heart condition or take medicines that affect heart rhythm, your doctor may recommend an electrocardiogram (ECG) before starting treatment and during follow-up.
  • Inform your healthcare providers: Tell your doctor, dentist, surgeon, and pharmacist that you are taking SYNTHIVAN TABLET before starting any new medicine or undergoing a medical or dental procedure.
  • Stay hydrated: Drink plenty of water during treatment, as this may help reduce the risk of kidney stones.
  • Watch for new symptoms: Tell your doctor if you develop new or worsening symptoms after starting treatment. This may be due to immune reconstitution inflammatory syndrome (IRIS), which can occur when your immune system begins to recover and responds to infections already present in your body.
  • Prevent HIV transmission: Continue practising safer sex and avoid sharing needles or other injection equipment, as SYNTHIVAN TABLET helps control HIV but does not prevent HIV transmission.

Drug-Drug Interactions

verifiedApollotooltip

The following medicines may interact with SYNTHIVAN TABLET and may require dose adjustments, careful monitoring, or should be avoided:

  • Hormonal contraceptives: SYNTHIVAN TABLET may reduce the effectiveness of some hormonal birth control methods. Your doctor may recommend an alternative or additional contraceptive method.
  • Certain cholesterol-lowering medicines: Medicines such as simvastatin and lovastatin can increase the risk of muscle-related side effects when taken with SYNTHIVAN TABLET .
  • Acid-reducing medicines: Medicines such as omeprazole, famotidine, antacids, and other acid-reducing medicines can reduce the absorption of atazanavir, making SYNTHIVAN TABLET less effective.
  • Herbal supplements: St. John's Wort should not be taken with SYNTHIVAN TABLET because it can reduce the amount of the medicine in your body and make HIV treatment less effective.
Atazanavir + RitonavirDihydroergotamine
Critical
Atazanavir + RitonavirTolvaptan
Critical

Drug-Drug Interactions

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Atazanavir + RitonavirDihydroergotamine
Critical
How does the drug interact with Synthivan Tablet:
Taking Dihydroergotamine with Atazanavir and Ritonavir may increase the risk of side effects.

How to manage the interaction:
Although taking Atazanavir and Ritonavir with Dihydroergotamine together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
Atazanavir + RitonavirTolvaptan
Critical
How does the drug interact with Synthivan Tablet:
When Tolvaptan and Atazanavir and Ritonavir are taken together, may significantly increase the blood levels and effects of Tolvaptan.

How to manage the interaction:
Taking Tolvaptan with Ritonavir and Atazanavir is generally not recommended, as it possibly results in an interaction, but it can be taken if prescribed by a doctor. If you notice any of these symptoms -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
Atazanavir + RitonavirSildenafil
Critical
How does the drug interact with Synthivan Tablet:
Taking Atazanavir and Ritonavir with Sildenafil can increase the blood levels and side effects of sildenafil.

How to manage the interaction:
Taking Atazanavir and Ritonavir with Sildenafil together is avoided as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, shortness of breath, dizziness, lightheadedness, fainting, visual disturbances, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
Atazanavir + RitonavirFlibanserin
Critical
How does the drug interact with Synthivan Tablet:
Taking Flibanserin with Atazanavir and Ritonavir may increase the risk of side effects.

How to manage the interaction:
Taking Atazanavir and Ritonavir with Flibanserin is generally not recommended, as it results in an interaction, it can be taken if prescribed by doctor. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
Atazanavir + RitonavirEplerenone
Critical
How does the drug interact with Synthivan Tablet:
Co-administration of Eplerenone with Atazanavir and Ritonavir may significantly increase the blood levels of Eplerenone.

How to manage the interaction:
Taking Ritonavir and Atazanavir with Eplerenone together is not recommended as it can lead to an interaction. However, it can be taken if a doctor advises it. If you experience any unusual symptoms like headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
Atazanavir + RitonavirAlfuzosin
Critical
How does the drug interact with Synthivan Tablet:
Concomitant use of Alfuzosin with Atazanavir and Ritonavir can increase the risk of low blood pressure.

How to manage the interaction:
Coadministration of Alfuzosin with Atazanavir and ritonavir is not recommended, however, it can be taken if your doctor has advised it. Contact your doctor immediately if you experience dizziness, palpitations, difficulty swallowing, or sweating. It is recommended to monitor your blood pressure regularly. Do not discontinue any medications without first consulting your doctor.
Atazanavir + RitonavirMethysergide
Critical
How does the drug interact with Synthivan Tablet:
Taking Methysergide with Atazanavir and Ritonavir may increase the risk of side effects.

How to manage the interaction:
Taking Atazanavir and Ritonavir with Methysergide is generally not recommended, as it results in an interaction, it can be taken if prescribed by doctor. You should seek immediate medical attention if you develop severe abdominal pain, nausea, vomiting, pale or cold skin, chest pain or tightness, irregular heartbeat, severe headache. Do not stop using any medications without talking to a doctor.
Atazanavir + RitonavirRanolazine
Critical
How does the drug interact with Synthivan Tablet:
Taking Ritonavir and Atazanavir with Ranolazine may significantly increase the blood levels and effects of Ranolazine.

How to manage the interaction:
Co-administration of Ranolazine with Atazanavir and Ritonavir can possibly result in an interaction, but it can be taken if a doctor has advised it. In case you experience any symptoms like feeling lightheaded, fainting, or rapid heartbeats, consult a doctor. Do not stop using any medications without a doctor's advice.
Atazanavir + RitonavirNevirapine
Critical
How does the drug interact with Synthivan Tablet:
When Atazanavir and Ritonavir is taken with Nevirapine, it can reduce the levels and side effects of atazanavir & increase the blood levels and effects of nevirapine.

How to manage the interaction:
Taking Nevirapine with Atazanavir and Ritonavir is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience a rash on any parts of your body, loss of appetite, nausea, vomiting, jaundice (yellowing of the skin and/or eyes), contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Atazanavir + RitonavirRegorafenib
Critical
How does the drug interact with Synthivan Tablet:
Taking Atazanavir and Ritonavir with Regorafenib may alter the blood levels and effects of regorafenib.

How to manage the interaction:
Although taking Atazanavir and Ritonavir with Regorafenib is generally not recommended as it possibly results in an interaction, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

Certain foods or drinks may affect how SYNTHIVAN TABLET should be taken. Important considerations include:

  • Food: Take SYNTHIVAN TABLET with food, as food helps improve the absorption of atazanavir and supports the medicine's effectiveness.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIRETROVIRAL AGENTS]

FAQs

No. SYNTHIVAN TABLET should always be taken with a full meal or a substantial snack, as food is necessary for your body to absorb the medicine properly and ensure it works effectively against HIV. Do not take it on an empty stomach. If you have difficulty taking it with food, speak with your doctor or pharmacist.
No. SYNTHIVAN TABLET does not cure HIV or AIDS. It is an antiretroviral medicine that helps control the virus by reducing the amount of HIV in your body (viral load), supporting your immune system, and lowering the risk of opportunistic infections. Continue taking it exactly as prescribed and discuss your long-term treatment plan with your doctor.
Yellowing of the skin and the whites of your eyes is a common, usually harmless side effect of this medicine. However, you should still contact your doctor right away to confirm that it is not a sign of liver damage, especially if you also experience dark urine, pale stools, or abdominal pain. Talk to your doctor to monitor your health.
Certain acid-reducing medications can prevent your body from absorbing SYNTHIVAN TABLET properly, making it less effective. You should discuss all your current medications with your healthcare provider, as you may need to space out your doses or avoid certain heartburn drugs entirely. Talk to your doctor or pharmacist for specific guidance.
It is highly recommended to limit or avoid alcohol while taking this medicine. Alcohol can increase stress on your liver and worsen some of the common side effects of the medication, such as nausea and dizziness. Talk to your doctor about safe alcohol consumption limits.
You must discuss your pregnancy plans or current pregnancy status with your healthcare provider. Managing your HIV treatment during pregnancy is vital to protect both your health and to prevent transmitting the virus to your baby, but your doctor may need to adjust your treatment plan. Talk to your doctor for personalised advice.
If you miss a dose, take it with food as soon as you remember, unless it is almost time for your next scheduled dose. Never take two doses at the same time to make up for a missed one, as this can increase your risk of severe side effects. Talk to your doctor or pharmacist if you frequently miss doses.
Yes, this medicine can lower the effectiveness of hormonal contraceptives, increasing the risk of unplanned pregnancy. It is recommended to use a reliable, non-hormonal backup birth control method, such as condoms, while using this medication. Talk to your doctor to find the best contraceptive option for you.
Not everyone needs to change their HIV treatment. However, your doctor may recommend switching to a different treatment regimen if the virus becomes resistant to the medicine, troublesome side effects develop, important drug interactions occur, or another treatment is better suited to your health needs. Your HIV specialist will determine the most appropriate treatment based on your medical history, treatment response, and test results. Do not stop or switch your HIV medicines without your doctor's advice.

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Reference

  1. Ritonavir Ritonavir. 1996. [Accessed on 10 Apr. 2019]Check here
  2. Zentiva Pharma UK Limited. Atazanavir 150 mg hard capsules Atazanavir 200 mg hard capsules Atazanavir 300 mg hard capsules. Electronic Medicines Compendium (EMC) [Revised in December 2020] [Accessed on 20th January 2023].Check here
  3. AbbVie Deutschland GmbH & Co. KG. Norvir 100 mg film-coated tablets ritonavir. Electronic Medicines Compendium (EMC) [Revised in August 2022] [Accessed on 20th January 2023].Check here
  4. Matrix Laboratories Limited. Atazanavir Sulfate and Ritonavir Tablets, 300 mg/100 mg. U.S. Food and Drug Administration. [Revised in November 2011]. [Accessed on 20th January 2023]. docs/pepfar/022282PI.pdfCheck here
  5. Central Drugs Standard Control Organization. Atazanavir 150mg + Ritonavir 50mg capsules. December 2006. Atazanavir + Ritonavir (300mg + 100mg) FC Tablets. November 2008. [Accessed on 20th January 2023].Check here
  6. Clinical Reference Document. [Accessed on 02 Jun. 2026]Check here

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - SYN0117
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