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compositionComposition:TOFACITINIB-5MG
prescription
Prescription Medicine
info
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Tofaciz-5Mg Tab is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. It contains Tofacitinib which works by lowering inflammation and symptoms associated with arthritis. In some cases, this medicine may cause side effects such as diarrhoea, headache, upper respiratory tract infection, nausea, and vomiting. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TOFACITINIB-5MG

Manufacturer/Marketer :

Assentus Biogenics Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Tofaciz-5Mg Tab

Tofaciz-5Mg Tab is a prescription medicine used to manage moderate to severe autoimmune inflammatory conditions, including rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. It is also prescribed to treat moderate to severe ulcerative colitis, an inflammatory bowel disease. By targeting key inflammatory pathways in the body, this medicine helps reduce painful swelling and prevents further damage to your joints and tissues.

To achieve the best results, you must take Tofaciz-5Mg Tab consistently every day exactly as prescribed by your doctor. It is typically taken once or twice daily, and you can take it either with or without food. Along with taking your medicine regularly, adopting a balanced, anti-inflammatory diet and incorporating gentle physical exercise can significantly improve your mobility and overall treatment outcomes.

While taking Tofaciz-5Mg Tab , you may experience some common, mild side effects such as headaches, diarrhoea, or cold-like symptoms. However, because this medicine affects your immune system, it is crucial to consult your doctor immediately if you develop any signs of serious infections, unusual bruising, high fever, or shingles.

Talk to your doctor before starting this medicine if you have a history of tuberculosis, chronic infections, liver damage, kidney issues, or heart problems. Do not take this if you currently have a severe active infection, severe liver problems, or if you are allergic to any of its ingredients.

This medicine can interact with other drugs that suppress your immune system or certain medications processed by your liver, which can increase the risk of severe side effects or reduce how well the treatment works. You should avoid drinking excess alcohol, stop smoking, and consult your doctor before starting treatment if you are pregnant, planning a pregnancy, breastfeeding, or are an older adult.

Uses of Tofaciz-5Mg Tab

The following are the common conditions for which Tofaciz-5Mg Tab may be prescribed:

  • Rheumatoid Arthritis: Helps reduce joint pain, stiffness, and swelling in adults when other standard therapies have not worked well.
  • Psoriatic Arthritis: Lowers active joint inflammation and helps improve physical function in daily activities.
  • Ankylosing Spondylitis: Targets inflammation in the spine to reduce chronic back pain and stiffness.
  • Ulcerative Colitis: Reduces chronic inflammation in the lining of the large intestine to help achieve and maintain symptom-free periods.
     

Key Benefits

Tofaciz-5Mg Tab helps control excessive immune system activity that causes inflammation in autoimmune conditions. By reducing ongoing inflammation, it helps relieve symptoms, improve daily function, and lower the risk of long-term damage associated with these diseases.

Key benefits include:

  • Easier Daily Movement: By reducing inflammation in the joints, Tofaciz-5Mg Tab helps restore flexibility, making daily tasks like walking, bending, and reaching much more comfortable.
  • Long-Term Control Over Flares: Regular use helps keep your immune system from overreacting, which reduces the frequency and severity of painful symptom flare-ups.
  • Improved Bowel Comfort: For those managing ulcerative colitis, this medicine helps calm gut inflammation, leading to fewer urgent bathroom trips, less cramping, and healthier digestion.
     
Side effects of Tofaciz 5 mg Tablet
  • Practice good hygiene by washing hands frequently when touching any wounds.
  • Apply creams or lotions to the dry skin and moisturize it.
  • Wear the proper clothing and footwear when working outside.
  • Cover the wounds with bandage and change it daily.
  • Avoid baths at swimming pools, lakes and rivers.
  • Drink a lot of water to control diarrhoea and prevent dehydration.
  • Avoid spicy, fatty, or high-fiber foods that may irritate the colon.
  • Reduce stress through methods such as deep breathing or meditation.
  • Include probiotics or supplements containing live bacteria to maintain the health of the gut.
  • Quit smoking since smoking makes colitis symptoms worse.
  • See your doctor right away if you experience extreme inflammation, bleeding stools, or abdominal pain.
  • To promote overall health, drink plenty of water and consume hydrating foods like watermelon and leafy greens.
  • Support gut health with probiotic-rich foods such as yoghurt and sauerkraut.
  • Eat antioxidant-rich foods like berries and green tea, while limiting sugary drinks, alcohol, and processed foods.
  • Additionally, reduce stress through relaxation techniques like deep breathing and meditation.
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.

Directions for Use

  • Tofaciz-5Mg Tab can be taken with or without food.
  • It is recommended to take Tofaciz-5Mg Tab 1-2 times a day, depending on your medical condition, or as prescribed by your doctor.
  • Swallow Tofaciz-5Mg Tab as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Tofaciz-5Mg Tab Works

Tofaciz-5Mg Tab contains tofacitinib, a Janus kinase (JAK) inhibitor that helps reduce inflammation caused by an overactive immune system. Tofaciz-5Mg Tab works by blocking Janus kinase (JAK) pathways inside immune cells. These pathways transmit signals that stimulate the production of inflammatory proteins. By blocking these signals, Tofaciz-5Mg Tab reduces the immune system's excessive inflammatory response and helps prevent it from attacking healthy tissues. Together, these actions help reduce inflammation, relieve symptoms such as pain, swelling, and stiffness, protect joints from further damage, and promote healing of the intestinal lining in conditions such as ulcerative colitis.
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Alcohol

Caution

It is not known if alcohol interacts with Tofaciz-5Mg Tab , so please consult a doctor.

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Pregnancy

Unsafe

Tofaciz-5Mg Tab must not be taken during pregnancy. If you are a woman of child-bearing potential, use effective contraception during the treatment with Tofaciz-5Mg Tab and for 4 weeks after discontinuation.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Tofaciz-5Mg Tab . Please consult a doctor if you have any concerns.

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Driving

Safe

Tofaciz-5Mg Tab generally does not affect your ability to drive. However, drive or operate machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this. Tofaciz-5Mg Tab is not recommended for patients with severe liver problems.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Tofaciz-5Mg Tab is not recommended for children below 18 years as safety and effectiveness were not established.

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Heart

Caution

No serious side effects were observed. But it requires careful consideration and monitoring due to increased risks of heart-related problems, particularly in patients with existing cardiovascular risk factors.

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Geriatrics

Caution

No serious adverse effects were observed; however, it requires careful consideration and caution due to the increased risk of certain adverse events, particularly infections.

What if I have taken an overdose of Tofaciz-5Mg Tab

If you accidentally take more than your prescribed dose of Tofaciz-5Mg Tab , seek immediate medical attention or call a poison control centre right away. Do this even if you do not feel any symptoms of illness.

Diet & Lifestyle Advise

  • Anti-inflammatory diet: Focus on eating a diet rich in anti-inflammatory foods, such as olive oil, leafy green vegetables, and fish rich in omega-3 fatty acids, to support your joints and gut health.
  • Protect your joints: Keep active with low-impact physical activities like swimming, walking, or stationary cycling. This helps maintain joint flexibility and muscle strength without putting too much strain on your joints.
  • Manage gut triggers: If you are taking this medicine for ulcerative colitis, keep a food journal to identify and avoid foods that trigger your symptoms (such as highly spiced, greasy, or high-fibre foods during active flares).
  • Practise strict hand hygiene: Since Tofaciz-5Mg Tab dampens your immune system, wash your hands frequently with soap and water, and avoid close contact with people who have contagious illnesses like the cold or flu.
  • Schedule non-live vaccinations: Talk to your doctor about keeping your vaccinations up to date, such as the flu or pneumonia vaccines, ensuring you only receive non-live versions while on this treatment.
     
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How Soon It Starts Working

  • The time required for Tofaciz-5Mg Tab to start to work: The time required for Tofaciz-5Mg Tab to show its action is unknown.
  • The time for which the effects of Tofaciz-5Mg Tab last: The duration of action for Tofaciz-5Mg Tab is clinically unknown.

What if you forget to take Tofaciz-5Mg Tab

If you miss a dose of Tofaciz-5Mg Tab , take it as soon as you remember. However, if your next scheduled dose is only a few hours away, skip the missed dose and return to your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Tofaciz-5Mg Tab tablets at controlled room temperature, ideally between 20°C and 25°C (68°F to 77°F). •Keep the tablets in their original blister pack or bottle to protect them from light and moisture. Do not store them in humid environments like the bathr

Drug Warnings

  • Complete recommended screening tests: Your doctor should screen you for tuberculosis (TB) and perform blood tests before you start Tofaciz-5Mg Tab .
  • Avoid live vaccines during treatment: Do not receive live vaccines, such as certain shingles vaccines or the nasal spray influenza vaccine, unless your doctor advises otherwise, as your immune system may be weakened.
  • Attend regular monitoring appointments: Keep all scheduled blood tests so your doctor can monitor your blood cell counts, liver function, kidney function, and cholesterol levels throughout treatment.
  • Watch for signs of infection or shingles: Contact your doctor immediately if you develop fever, persistent cough, unexplained skin rashes, or painful blisters on one side of your body.
  • Seek emergency medical care for serious symptoms: Stop taking Tofaciz-5Mg Tab and get immediate medical attention if you experience sudden chest pain, difficulty breathing, swelling or pain in one leg, or symptoms suggestive of a blood clot.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Other immunosuppressants: Taking Tofaciz-5Mg Tab with medicines such as cyclosporine, azathioprine, tacrolimus, or biologic therapies can greatly increase the risk of serious infections and is generally not recommended.
  • Medicines affecting liver enzymes: Strong CYP3A4 inhibitors (such as ketoconazole) may increase Tofaciz-5Mg Tab levels, while strong CYP3A4 inducers (such as rifampicin) may reduce its effectiveness. Your doctor may adjust your dose if necessary.
     
TofacitinibBelimumab
Severe
TofacitinibLenalidomide
Severe

Drug-Drug Interactions

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TofacitinibBelimumab
Severe
How does the drug interact with Tofaciz 5 mg Tablet:
Taking Belimumab with Tofaciz 5 mg Tablet may increase the risk of infections.

How to manage the interaction:
Taking Tofaciz 5 mg Tablet with Belimumab together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
TofacitinibLenalidomide
Severe
How does the drug interact with Tofaciz 5 mg Tablet:
Taking Tofaciz 5 mg Tablet together with lenalidomide may increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction between lenalidomide and Tofaciz 5 mg Tablet, it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TofacitinibCiclosporin
Severe
How does the drug interact with Tofaciz 5 mg Tablet:
Co-administration of Tofaciz 5 mg Tablet with cyclosporine may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction, Tofaciz 5 mg Tablet can be taken with ciclosporin if prescribed by the doctor. Consult the prescriber if you experience side effects such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue the medication without a doctor's advice.
TofacitinibBortezomib
Severe
How does the drug interact with Tofaciz 5 mg Tablet:
Taking Tofaciz 5 mg Tablet and bortezomib may increase the risk of infections.

How to manage the interaction:
Although using Bortezomib and Tofaciz 5 mg Tablet together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.
TofacitinibSaquinavir
Severe
How does the drug interact with Tofaciz 5 mg Tablet:
When Tofaciz 5 mg Tablet is taken with Saquinavir, it may increase the risk of side effects..

How to manage the interaction:
There may be a possibility of interaction between Tofaciz 5 mg Tablet and Saquinavir, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms such as paleness, fatigue, dizziness, fainting, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without first talking to your doctor.
TofacitinibPhenobarbital
Severe
How does the drug interact with Tofaciz 5 mg Tablet:
Taking Tofaciz 5 mg Tablet with phenobarbital, may decrease Tofaciz 5 mg Tablet blood levels and effects.

How to manage the interaction:
Although taking phenobarbital and Tofaciz 5 mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. Do not stop using any medications without a doctor's advice.
TofacitinibImatinib
Severe
How does the drug interact with Tofaciz 5 mg Tablet:
Taking Imatinib and Tofaciz 5 mg Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Imatinib can be taken with Tofaciz 5 mg Tablet if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without consulting a doctor.
TofacitinibEnzalutamide
Severe
How does the drug interact with Tofaciz 5 mg Tablet:
Co-administration of Enzalutamide and Tofaciz 5 mg Tablet may decrease the blood levels of Tofaciz 5 mg Tablet, which may make Tofaciz 5 mg Tablet less effective.

How to manage the interaction:
Although taking Enzalutamide and Tofaciz 5 mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. Do not stop using any medications without consulting a doctor.
TofacitinibPralatrexate
Severe
How does the drug interact with Tofaciz 5 mg Tablet:
Taking Tofaciz 5 mg Tablet with Pralatrexate may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction between Pralatrexate and Tofaciz 5 mg Tablet, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting your doctor.
TofacitinibBudesonide
Severe
How does the drug interact with Tofaciz 5 mg Tablet:
Using Tofaciz 5 mg Tablet together with budesonide may increase the risk of serious infections.

How to manage the interaction:
Co-administration of budesonide along with Tofaciz 5 mg Tablet can lead to an interaction but can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Tofaciz-5Mg Tab can be taken with or without food. However, excessive alcohol intake may increase the risk of liver problems, so discuss alcohol consumption with your doctor.
     
TOFACITINIB-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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TOFACITINIB-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit, Grapefruit Juice

How to manage the interaction:
Consuming grapefruit products while taking Tofaciz 5 mg Tablet can increase the risk of side effects. Avoid consuming grapefruit products while being treated with Tofaciz 5 mg Tablet, as it can lead to an interaction.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIRHEUMATICS, DISEASE MODIFYING ANTIRHEUMATIC DRUGS (DMARDs)]

FAQs

Tofaciz-5Mg Tab is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.
Tofaciz-5Mg Tab works by blocking Janus kinase enzyme, thereby lowers inflammation and symptoms associated with rheumatoid and psoriatic arthritis.
Hypertension/high blood pressure could be a side-effect of Tofaciz-5Mg Tab . Consult your doctor before taking Tofaciz-5Mg Tab if you have high blood pressure or if you are taking anti-hypertensive medicines.
Diarrhoea might be a side-effect of Tofaciz-5Mg Tab . Eat non-spicy meals and drink plenty of fluids to prevent dehydration if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.
Tofaciz-5Mg Tab might impair fertility in females of reproductive potential. It is not known if the effect is reversible. Therefore, talk to a doctor before starting Tofaciz-5Mg Tab if you are trying to become pregnant or if you have any concerns regarding this.
Tofaciz-5Mg Tab affects the immune system and might lower the ability of the immune system to fight infections. Inform your doctor if you have an active infection, if you have a condition that increases the chance of having infections, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids.
Tofaciz-5Mg Tab is not recommended for patients with severe liver impairment. Dose adjustment may be needed in patients with mild to moderate liver impairment. Please consult the doctor if you have liver problems.
Tofaciz-5Mg Tab may increase the risk of cancer by changing the way the immune system works. Inform the doctor if you ever had any type of cancer.
Tofaciz-5Mg Tab may begin working within 2-8 weeks after starting the treatment.
Tofaciz-5Mg Tab should not be taken along with tocilizumab as it might increase the risk of infections. Before starting Tofaciz-5Mg Tab , inform the doctor if you are taking tocilizumab.
Prior to starting Tofaciz-5Mg Tab , active or latent tuberculosis test, CBC (complete blood count), LFT (liver function test), and lipid profile tests should be done.
No, Tofaciz-5Mg Tab is not a steroid. It belongs to a group of medicines known as JAK inhibitors, which specifically target and block certain inflammatory signals inside cells. Talk to your doctor to learn more.
You can receive non-live vaccines, such as the standard flu shot, while taking Tofaciz-5Mg Tab . However, you should avoid live vaccines because your immune system is less active and you could develop an infection from the vaccine itself. Talk to your doctor or pharmacist before getting any vaccine.
It is not recommended to take Tofaciz-5Mg Tab during pregnancy, as it may cause harm to an unborn baby. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor to discuss safer treatment options.
Alcohol does not directly interfere with how Tofaciz-5Mg Tab works, but both substances are processed by the liver. Consuming alcohol while on this medication can increase the risk of liver damage, so it is best to limit your intake. Talk to your doctor for personalised advice.
Because Tofaciz-5Mg Tab can affect your immune system and how your body heals, you may need to temporarily stop taking it before and after a planned surgical procedure. Talk to your doctor and surgeon to create a safe plan.
Since Tofaciz-5Mg Tab lowers your ability to fight germs, watch closely for a fever, chills, persistent cough, burning when you urinate, or extreme tiredness. If you experience any of these symptoms, contact your doctor immediately for medical advice. Do not stop taking Tofaciz-5Mg Tab on your own unless your doctor tells you to do so.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

41B/5, Gariahat Road (South) Kolkata Kolkata Wb 700031 In
Other Info - TOF0055
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