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compositionComposition:TRIHEXYPHENIDYL-5MG
prescription
Prescription Medicine
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Trihexol 5mg Tablet is used to treat Parkinson’s disease and drug-induced movement disorders. It restores the balance of brain chemicals, helping relax muscles and improve control. It reduces symptoms such as stiffness, tremors, spasms, restlessness, and slurred speech, thereby supporting smoother movement and improved quality of life.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TRIHEXYPHENIDYL-5MG

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Trihexol 5mg Tablet

Trihexol 5mg Tablet is used alone or with other medications to treat Parkinson’s disease (a brain disorder that affects movements) and extrapyramidal symptoms (drug-induced movement disorders).

Trihexol 5mg Tablet contains Trihexyphenidyl, which works by relaxing muscles and regulating the nerve impulses that control muscle function. It also restores balance among brain chemicals (neurotransmitters), thereby improving muscle control and reducing stiffness and tremors, thereby helping the body move more smoothly.

Take Trihexol 5mg Tablet exactly as prescribed by your doctor. Swallow it whole with a glass of water, and do not crush or chew it. In some cases, Trihexol 5mg Tablet may cause common side effects, including nausea, vomiting, dizziness, constipation, weakness, headache, dry mouth, decreased urination, drowsiness, and nervousness or restlessness. Please consult your doctor if these side effects persist or worsen.

Before taking Trihexol 5mg Tablet, consult your doctor if you are pregnant or breastfeeding. Trihexol 5mg Tablet should not be given to children, as its safety and effectiveness have not been established. Avoid consuming alcohol while taking Trihexol 5mg Tablet, as it may lead to increased drowsiness and dizziness. Keep your doctor informed about all your medications and health conditions to rule out any side effects or interactions.

Uses of Trihexol 5mg Tablet

Trihexol 5mg Tablet is used in the management of Parkinson’s disease and certain drug-induced movement disorders. The detailed uses of Trihexol 5mg Tablet are as follows:

  • Treatment of Parkinson’s disease: Trihexol 5mg Tablet is used alone or with other medications to treat the symptoms of Parkinson’s disease (such as muscle stiffness, tremors, and spasms).
  • Treatment of extrapyramidal symptoms: Trihexol 5mg Tablet is also used to manage extrapyramidal symptoms (such as involuntary spasms, restlessness, and slurred speech) caused by antipsychotic medications.

Key Benefits

Trihexol 5mg Tablet offers the following medicinal benefits for people with Parkinson’s disease and certain movement disorders:

  • Restores the balance of brain chemicals (neurotransmitters) involved in movement (motor) control.
  • Promotes muscle relaxation, reducing stiffness and making movement easier.
  • Controls tremors and improves steadiness.
  • Decreases involuntary movements, helping to manage drug-induced extrapyramidal symptoms such as spasms, restlessness, and slurred speech.
  • Supports smoother, more comfortable movement, making daily activities easier to perform.
  • Helps manage muscle contractions and abnormal postures associated with various dystonia types.
  • Contributes to a better overall quality of life for patients with movement disorders.
Side effects of Trihexol 5mg Tablet
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
Here are the steps to manage medication-triggered Nervousness:
  • Tell your doctor immediately if you experience symptoms of Nervousness, such as anxiety, jitteriness, or an increased heart rate, after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen to alleviate symptoms of Nervousness. This can include switching to a different medication, reducing the dosage, or temporarily stopping the medication. Your doctor may also recommend alternative techniques like relaxation, mindfulness meditation, or journaling. These techniques can help reduce anxiety and Nervousness.
  • Practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling, to help manage Nervousness.
  • Engage in regular physical activity, such as walking or jogging, to help reduce anxiety and improve mood.
  • Your doctor may advise considering cognitive-behavioural therapy (CBT) or other forms of talk therapy to address underlying anxiety or Nervousness.
  • You should maintain regular follow-up appointments with your doctor to monitor nervousness symptoms, adjust treatment plans as needed, and discuss any concerns or questions.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Directions for Use

  • Trihexol 5mg Tablet can be taken with or without food.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow it as a whole with a glass of water.
  • Do not crush, chew, or open it.

How Trihexol 5mg Tablet Works

Trihexol 5mg Tablet contains Trihexyphenidyl, which works by relaxing muscles and regulating the nerve impulses that control muscle function. It also restores balance between brain chemicals (neurotransmitters), thereby improving muscle control and reducing stiffness and tremors, which helps the body to move more smoothly.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Trihexol 5mg Tablet, as it may cause increased dizziness and drowsiness.

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Pregnancy

Caution

Trihexol 5mg Tablet belongs to pregnancy category C. Please consult your doctor if you are pregnant or planning to become pregnant. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

It is unknown whether Trihexol 5mg Tablet passes into breastmilk. Consult your doctor if you are breastfeeding.

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Driving

Unsafe

Trihexol 5mg Tablet may cause dizziness, drowsiness and blurred vision. Avoid driving and handling machinery if you experience these symptoms.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Trihexol 5mg Tablet is not recommended for use in children, as its safety and effectiveness have not been established.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems

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Geriatrics

Consult your doctor

Limited information available for use of Trihexol 5mg Tablet in elderly patients. Please consult your doctor.

What if I have taken an overdose of Trihexol 5mg Tablet

Do not take more than the prescribed dose of Trihexol 5mg Tablet, as it may cause serious side effects. If you suspect you have taken an overdose or notice any unusual symptoms, please consult a doctor immediately.

Diet & Lifestyle Advise

Dietary recommendations:

  • Include a diet rich in iron, folate and magnesium.
  • Eat berries, leafy greens, nuts, fish, whole grains, and olive oil in your meals.
  • Avoid processed foods, sugary drinks, fried snacks, and high-sodium foods.
  • Increase fibre intake and drink plenty of water.

Physical activity:

  • Do aerobic exercises, such as swimming or walking, to improve blood flow to muscles.
  • Include strength and balance training to help reduce the risk of falls.
  • Consider physiotherapy to maintain muscle strength and coordination.
  • Try to avoid stress by practising meditation or yoga.

Mental well-being:

  • Engage in mentally stimulating activities such as puzzles and reading.
  • Stay connected with family and friends to improve cognitive health.
  • Regularly attend therapy sessions.
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How Soon It Starts Working

  • The time required for Trihexol 5mg Tablet to start to work: The time required for Trihexol 5mg Tablet to start to work is 1 hour after administration.
  • The time for which the effects of Trihexol 5mg Tablet last: The effect of Trihexol 5mg Tablet lasts for 6 to 12 hours.

What if you forget to take Trihexol 5mg Tablet

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and take the next dose at the scheduled time. Do not take a double dose.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Do not take Trihexol 5mg Tablet if you are allergic to any of its ingredients or if you have narrow-angle glaucoma (high eye pressure).
  • Do not discontinue Trihexol 5mg Tablet on your own, as it may cause withdrawal symptoms or worsen your condition.
  • Talk to your doctor immediately if you experience hallucinations.
  • Inform your doctor before taking Trihexol 5mg Tablet if you have prostate problems, urination problems, stomach ulcers, acidity, myasthenia gravis (muscle problems), tardive dyskinesia (involuntary facial movements), alcoholism, high blood pressure, or heart, liver or kidney problems.
  • Consult your doctor before taking Trihexol 5mg Tablet if you are pregnant or breastfeeding.
  • Trihexol 5mg Tablet should not be given to children, as its safety and effectiveness have not been established.
  • Trihexol 5mg Tablet may cause drowsiness and dizziness, do not drive unless you are alert.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions: Trihexol 5mg Tablet may interact with certain medicines, potentially increasing side effects or altering their effectiveness. Inform your doctor if you are taking any of the following:

  • Electrolyte supplements (Potassium citrate, Potassium chloride)
    • Potential effect: May increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.
  • Antidepressants (Esketamine)
    • Potential effect: May increase the risk of side effects.
  • Drugs used to treat epilepsy (Zonisamide, Topiramate)
    • Potential effect: May increase the risk of severity or side effects such as increased body temperature and decreased sweating, especially in warm weather.
  • Drugs used for treatment-resistant depression (Ketamine)
    • Potential effect: May increase the risk of side effects.
  • Drugs used to treat Parkinson’s disease (Amantadine)
    • Potential effect: May increase the risk of side effects such as heat tolerance, dry mouth, confusion, constipation, difficulty urinating, and blurred vision, especially in the elderly or those with a debilitating (physically weak) condition.

Drug-Food Interactions: Do not consume alcohol while taking Trihexol 5mg Tablet, as it may lead to increased dizziness and drowsiness.

Drug-Disease Interactions: Trihexol 5mg Tablet should be avoided or used with caution in people with:

  • Arrhythmia (irregular heartbeats)
  • Autonomic neuropathy (nerve damage)
  • Gastrointestinal obstruction
  • Glaucoma (high eye pressure)
  • Urinary obstruction
  • Infectious diarrhoea and fever
  • Tardive dyskinesia (involuntary facial movements)
  • Hypertension (high blood pressure)
TrihexyphenidylPotassium citrate
Critical
TrihexyphenidylPotassium chloride
Critical

Drug-Drug Interactions

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TrihexyphenidylPotassium citrate
Critical
How does the drug interact with Trihexol 5mg Tablet:
Co-administration of Trihexol 5mg Tablet with potassium citrate may increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Trihexol 5mg Tablet with potassium citrate is not recommended as it can possibly result in an interaction, it can be taken if prescribed by a doctor. However, if you experience abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, or black stools contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TrihexyphenidylPotassium chloride
Critical
How does the drug interact with Trihexol 5mg Tablet:
Co-administration of Trihexol 5mg Tablet with potassium chloride can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Trihexol 5mg Tablet with potassium chloride is not recommended as it can possibly result in an interaction, it can be taken if prescribed by a doctor. However, if you experience abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, black stools contact a doctor immediately. Do not discontinue any medications without consulting to a doctor.
TrihexyphenidylAmantadine
Severe
How does the drug interact with Trihexol 5mg Tablet:
Coadministration of Allopurinol with Trihexol 5mg Tablet may increase side effects such as heat intolerance, dry mouth, confusion, constipation, difficulty urinating, and blurred vision especially in the elderly or those with a debilitating (physically weak) condition.

How to manage the interaction:
If you are supposed to take Allopurinol and Trihexol 5mg Tablet together, your doctor may adjust the dose or monitor you more frequently to safely use both medications.
TrihexyphenidylTopiramate
Severe
How does the drug interact with Trihexol 5mg Tablet:
Taking Trihexol 5mg Tablet with topiramate can increase the risk of increase body temperature and reduced sweating.

How to manage the interaction:
Co-administration of Trihexol 5mg Tablet with Topiramate can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience dizziness or lightheaded, increase body temperature contact your doctor right away. Do not discontinue any medications without first consulting your doctor.
TrihexyphenidylEsketamine
Severe
How does the drug interact with Trihexol 5mg Tablet:
Taking Trihexol 5mg Tablet with esketamine can increase the risk of other side effects.

How to manage the interaction:
Although there is a interaction between Trihexol 5mg Tablet and esketamine, but can be taken together if prescribed by your doctor. However, if you experience drowsiness, confusion, difficulty concentrating, and impairment in thinking contact your doctor right away. Do not stop using any medications without talking to your doctor.
TrihexyphenidylZonisamide
Severe
How does the drug interact with Trihexol 5mg Tablet:
Coadministration of Trihexol 5mg Tablet with Zonisamide can increase the risk or severity of Zonisamide side effects like increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Trihexol 5mg Tablet with Zonisamide together is not recommended as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience increased heart rate, fever, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.
TrihexyphenidylKetamine
Severe
How does the drug interact with Trihexol 5mg Tablet:
Taking Trihexol 5mg Tablet with Ketamine can increase the risk of side effects.

How to manage the interaction:
Although there is a interaction between Trihexol 5mg Tablet and ketamine, but it can be taken together if prescribed by your doctor. However, if you experience drowsiness, confusion, difficulty concentrating, and impairment in thinking contact your doctor right away. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIPARKINSON AGENTS]

FAQs

Trihexol 5mg Tablet belongs to a group of medicines called anti-spasmodic agents used as an adjunct to treat Parkinson's disease and extrapyramidal symptoms (drug-induced movement disorders).
Trihexol 5mg Tablet works by relaxing the muscles and nerve impulses that control muscle functioning. It improves muscle control and reduces stiffness, helping muscles move more naturally.
Dry mouth may be a side effect of Trihexol 5mg Tablet. Limiting caffeine intake, avoiding smoking and alcohol-containing mouthwashes, drinking water regularly, and chewing sugar-free gum or candy may help stimulate saliva and prevent dry mouth.
Trihexol 5mg Tablet should be used with caution in hot weather, as it may increase the risk of heat stroke. Inform your doctor if you have heat intolerance or fever.
Antidepressants should be avoided while taking Trihexol 5mg Tablet, as it might increase sedative effects. Consult your doctor before taking Trihexol 5mg Tablet if you are using depressants.
Hallucination is a medical condition in which the person may feel, hear or believe things that are not true, see things that are not there, or feel unusually suspicious or confused. Trihexol 5mg Tablet may cause hallucinations in some cases if taken for a prolonged time. So, if you experience hallucinations while taking Trihexol 5mg Tablet, please talk to your doctor immediately.
Constipation may occur as a side-effect of Trihexol 5mg Tablet. Try eating foods that encourage a bowel movement. Consult your doctor if you experience excessive constipation.
Consult your doctor before taking Trihexol 5mg Tablet if you have glaucoma. Trihexol 5mg Tablet is contraindicated in patients with narrow-angle glaucoma. Trihexol 5mg Tablet may cause blindness on long-term use in case of patients with narrow-angle glaucoma.
The dosage and frequency of taking Trihexol 5mg Tablet depend on various factors, including age, weight, medical condition, severity of symptoms, and other medications being taken. So, it's essential to follow the specific instructions provided by your doctor.
Don't stop taking Trihexol 5mg Tablet without consulting your doctor. Stopping suddenly can cause withdrawal symptoms and worsen your condition. If you're doing well, report to your doctor for further guidance. Contact your doctor immediately for appropriate treatment if you experience any difficulties or side effects. Your doctor will help you adjust your medication safely and effectively.
Before starting Trihexol 5mg Tablet, it's crucial to have a thorough consultation with your doctor. Share your comprehensive medical history, including any existing conditions or past illnesses. Also, provide a detailed list of your medications and supplements. Inform your doctor about any medication allergies or sensitivities. Furthermore, discuss your lifestyle habits, such as smoking, alcohol consumption, or recreational drug use. If you're pregnant, breastfeeding, or planning to become pregnant, be sure to disclose this information. This will enable your doctor to determine whether Trihexol 5mg Tablet suits you and provide personalised care.
Swallow it whole with a glass of water. Do not chew or crush the tablet or capsule. It's important to follow your doctor's exact directions, including the recommended dose and duration of treatment.
The common side effects of Trihexol 5mg Tablet include nausea, vomiting, dizziness, constipation, weakness, headache, dry mouth, decreased urination, drowsiness, and feeling nervous or restless. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if the side effects persist or worsen.

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Country of origin

India
Other Info - TR80429
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