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compositionComposition:VALGANCICLOVIR-450MG
prescription
Prescription Medicine
info
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Valcip Tablet is used to treat cytomegalovirus retinitis (viral infection of the retina). It contains Valganciclovir, which works by inhibiting viral replication. In some cases, this medicine may cause side effects such as diarrhoea, loss of appetite, cough, headache, stomach pain, nausea, fever, and tiredness. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

VALGANCICLOVIR-450MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Valcip Tablet

Valcip Tablet is a prescription medicine used to treat cytomegalovirus (CMV) infection of the retina in people with acquired immunodeficiency syndrome (AIDS). It is also used to help prevent CMV disease in patients who have received an organ transplant, such as a kidney, heart, or pancreas, and are at high risk of getting this infection. This medicine helps manage viral growth to protect vital organs and preserve vision.

You should take Valcip Tablet exactly as prescribed by your doctor, keeping a consistent daily schedule to maintain steady levels of the medication in your body. It is highly recommended to take this oral medicine with food, as eating a meal significantly helps your body absorb the drug. Adopting a diet rich in nutrients and getting sufficient rest can also support your immune system during treatment.

Common side effects of Valcip Tablet include diarrhoea, fever, nausea, and low blood cell counts, which can leave you feeling tired or more vulnerable to new infections. If you experience severe side effects such as unusual bruising, pale skin, unexplained fever, or sudden changes in your vision, you must contact your doctor immediately.

Before starting this medication, talk to your doctor if you have kidney problems, a history of blood cell disorders, or are receiving bone marrow treatments. Do not take this if you are allergic to this medication or other similar antiviral drugs. Individuals with severe kidney impairment or severely low blood cell counts may not be able to take this medicine.

Valcip Tablet can interact with other medicines that affect your kidneys or bone marrow, and drinking alcohol while on this medication can increase your risk of severe side effects. Pregnant women, breastfeeding mothers, and elderly individuals must consult their healthcare provider before using this medicine, as it can carry serious risks for these specific groups.

Uses of Valcip Tablet

Valcip Tablet is used to treat and prevent cytomegalovirus (CMV) infections in specific high-risk patients. It is mainly used for:

  • Cytomegalovirus (CMV) retinitis in AIDS patients: Valcip Tablet helps control the virus in the eye, preventing the infection from spreading and protecting your vision from permanent damage.
  • Prevention of CMV disease in organ transplant recipients: Valcip Tablet prevents the virus from active replication in high-risk kidney, heart, liver, or kidney-pancreas transplant patients, reducing the risk of CMV disease after transplantation. 
     

Key Benefits

Valcip Tablet helps control CMV infection and reduces the risk of serious complications. Key benefits of using Valcip Tablet include:

  • Protects your vision: Valcip Tablet helps stabilise your sight and reduces the risk of blindness by controlling CMV infection in the eye. This allows you to maintain your daily activities and independence.
  • Supports recovery after organ transplantation: This medicine provides critical protection for your immune system and organs by keeping cytomegalovirus under control. This helps you recover more safely after a major transplant.
  • Helps prevent the return of severe viral symptoms: Taking this medicine consistently helps prevent the return of severe viral symptoms. This gives you peace of mind and supports your overall physical recovery. 
     
Side effects of Valcip Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Limit sugary drinks and foods to reduce yeast growth.
  • Avoid yeast-rich foods like beer, wine, and sourdough bread.
  • Include probiotic-rich foods like yogurt, kefir, kimchi, and sauerkraut.
  • Eat antifungal foods like garlic, onions, cinnamon, and coconut oil.
  • Focus on nutrient-rich foods high in vitamins C and E.
  • Use a warm saltwater rinse in your mouth several times daily.
  • Practice excellent oral hygiene through regular brushing, flossing, and denture cleaning.
  • Stay hydrated by drinking plenty of water.
  • To manage stress, try relaxation methods like deep breathing exercises, meditation, or yoga to help calm your mind and body.
  • Avoid smoking and tobacco to prevent immune function impairment.
  • Consult a doctor for proper diagnosis and treatment.

Directions for Use

  • Valcip Tablet can be taken with food to minimise stomach discomfort or as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Valcip Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Valcip Tablet Works

Valcip Tablet is an inactive medicine (prodrug) that is converted inside the body into its active antiviral form. Once converted, Valganciclovir mimics the natural building blocks of the virus's DNA and inserts itself into the viral DNA chain, preventing the cytomegalovirus from replicating and multiplying. This helps control the spread of the infection, allowing your body's immune system or your transplant therapy to manage the virus more effectively.
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Alcohol

Consult your doctor

The interaction of alcohol with Valcip Tablet is unknown. Please consult a doctor before consuming alcohol while using Valcip Tablet .

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Pregnancy

Unsafe

Valcip Tablet is not recommended for pregnant women as it may cause birth defects. Please consult a doctor if you are pregnant.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Valcip Tablet as it may pass into breast milk. Therefore, please consult a doctor if you are breastfeeding.

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Driving

Unsafe

Valcip Tablet may cause dizziness, tiredness, drowsiness, shakiness or confusion in some people. Therefore, avoid driving or operating heavy machinery if you experience any of these symptoms after taking Valcip Tablet .

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Liver

Caution

Take Valcip Tablet with caution, especially if you have a history of liver disease. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Valcip Tablet with caution, especially if you have a history of kidney disease. The dose may be adjusted by your doctor as required.

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Children

Consult your doctor

Valcip Tablet should be used in children only if recommended by a doctor.

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Heart

Caution

Valcip Tablet should be used with caution in patients with heart problems. Inform your doctor about any heart-related conditions before taking Valcip Tablet .

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Geriatrics

Caution

Limited data is available regarding the use of Valcip Tablet in elderly patients. If you have any concerns about the usage of Valcip Tablet in geriatrics, please consult your doctor.

What if I have taken an overdose of Valcip Tablet

If you take too much Valcip Tablet , call emergency services (108/112) or go to the nearest emergency department immediately. An overdose can cause serious damage to your kidneys and blood-producing organs.

Diet & Lifestyle Advise

  • Stay well-hydrated: Drink plenty of fluids throughout the day to help protect your kidneys, as this medicine is cleared from your body through your urine.
  • Practice strict food safety: Since your immune system may be weakened, avoid raw or undercooked meats, unpasteurised dairy products, and unwashed produce to prevent foodborne infections.
  • Protect yourself from germs: Wash your hands frequently with soap and water, and avoid close contact with people who have active infections like colds or flu.
     
health query

Have a query?

How Soon It Starts Working

  • The time required for Valcip Tablet to start to work: Valcip Tablet ideally shows its action within 2 hours after administration.
  • The time for which the effects of Valcip Tablet last: The effect of Valcip Tablet lasts for 4 hours.

What if you forget to take Valcip Tablet

If you miss a dose, take it as soon as you remember with food. However, if it is almost time for your next scheduled dose, skip the missed one and return to your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store Valcip Tablet tablets at room temperature, between 20°C and 25°C (68°F to 77°F), in a dry place away from direct heat and moisture. Do not store them in the bathroom cabinet. •If you are using the oral solution, store the liquid in the refrigerator betw

Drug Warnings

  • Avoid handling broken or crushed tablets: Especially if you are pregnant or planning to become pregnant, as the active substance can be absorbed through the skin and may cause birth defects.
  • Wash exposed areas immediately: If the powder from a broken tablet or the liquid medicine touches your skin or eyes, wash the area immediately and thoroughly with soap and water.
  • Get regular blood tests: This medicine can lower your white blood cells, red blood cells, and platelets, which must be monitored closely as directed by your doctor.
  • Use effective birth control:  During treatment and for at least 90 days after your last dose (for men) or 30 days (for women) to prevent pregnancy, as this medicine can cause birth defects and affect fertility.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Medicines that can damage the kidneys: Taking Valcip Tablet with other medicines that can damage the kidneys (such as certain antibiotics or pain relievers) can increase the risk of kidney damage.
  • Bone marrow-suppressing medicines: Combining this medicine with drugs that suppress your bone marrow (such as certain cancer therapies or other antivirals) can severely lower your blood cell counts.
  • Medicines used for gout (such as probenecid): Taking it alongside medications used for gout (like probenecid) can increase the levels of Valcip Tablet in your blood, raising the risk of side effects.
  • Imipenem-cilastatin: Avoid using this medicine with Valcip Tablet , as the combination may increase the risk of seizures. 
ValganciclovirCidofovir
Critical
ValganciclovirAdalimumab
Severe

Drug-Drug Interactions

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ValganciclovirCidofovir
Critical
How does the drug interact with Valcip Tablet:
Taking cidofovir with Valcip Tablet can increase the risk of kidney problems.

How to manage the interaction:
Taking Valcip Tablet with Cidofovir is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
ValganciclovirAdalimumab
Severe
How does the drug interact with Valcip Tablet:
The combined use of adalimumab and Valcip Tablet can increase the risk of serious infections.

How to manage the interaction:
There may be a possibility of interaction between Valcip Tablet and Adalimumab, but it can be taken if prescribed by a doctor. If you notice any of the following symptoms - fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain or burning while peeing - reach out to your doctor right away. Do not stop using any medications without talking to your doctor.
ValganciclovirZidovudine
Severe
How does the drug interact with Valcip Tablet:
Combining Valcip Tablet with Zidovudine can increase the risk of side effects.

How to manage the interaction:
Although taking Valcip Tablet and Zidovudine together can cause an interaction, it can be taken if your doctor has suggested it. If you experience any complications or symptoms, make sure to contact your doctor right away. Do not stop using any medications without a doctor's advice.
ValganciclovirInfliximab
Severe
How does the drug interact with Valcip Tablet:
The combined use of infliximumab and Valcip Tablet can increase the risk of infections.

How to manage the interaction:
Co-administration of Valcip Tablet with Infliximab can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
ValganciclovirCladribine
Severe
How does the drug interact with Valcip Tablet:
The combined use of cladribine and Valcip Tablet can increase the risk of infections.

How to manage the interaction:
Taking Cladribine with Valcip Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, or burning while urinating - contact your doctor right away. Do not discontinue any medications without consulting your doctor.
ValganciclovirTenofovir alafenamide
Severe
How does the drug interact with Valcip Tablet:
When Valcip Tablet is taken with Tenofovir alafenamide it may increase the risk of kidney problems.

How to manage the interaction:
Although taking Tenofovir alafenamide and Valcip Tablet together can cause an interaction, it can be taken if your doctor has suggested it. However, consult your doctor immediately if you experience symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without talking to your doctor.
ValganciclovirDeferiprone
Severe
How does the drug interact with Valcip Tablet:
Taking Valcip Tablet and Deferiprone may increase the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between Valcip Tablet and Deferiprone, but it can be taken if prescribed by a doctor. If you're having any of these symptoms - like infection, fever, chills, diarrhea, sore throat, trouble breathing, losing weight, or pain while peeing - contact your doctor right away. Do not stop using any medications without a doctor's advice.
ValganciclovirClozapine
Severe
How does the drug interact with Valcip Tablet:
Taking Clozapine and Valcip Tablet may increase the risk of severe infections.

How to manage the interaction:
Taking Clozapine with Valcip Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're having any of these symptoms - like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - contact your doctor right away. Do not stop using any medications without a doctor's advice.
ValganciclovirCertolizumab
Severe
How does the drug interact with Valcip Tablet:
Taking Valcip Tablet and Certolizumab may increase the risk of serious infection.

How to manage the interaction:
Although there is a possible interaction between Valcip Tablet and Certolizumab, you can take these medicines together if prescribed by your doctor. If you notice any of the following symptoms - fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, or burning while urinating - contact your doctor right away. Do not discontinue any medications without consulting your doctor.
ValganciclovirGolimumab
Severe
How does the drug interact with Valcip Tablet:
The combined use of golimumab and Valcip Tablet can increase the risk of infections.

How to manage the interaction:
Although taking Valcip Tablet and Golimumab together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any of the following symptoms - fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain or burning while peeing - contact your doctor right away. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Food: Taking this medicine with food increases its absorption into your body, making it more effective. Do not take it on an empty stomach unless directed by your doctor.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIVIRALS]

FAQs

Valcip Tablet is used to treat cytomegalovirus (CMV) infection of the retina of the eye in adult AIDS patients. Also, it is used to prevent CMV infection in patients who received an organ transplant from a donor infected with CMV.
Valcip Tablet contains Valganciclovir that works by getting converted to ganciclovir in the body and inhibits the multiplication of the virus. Thereby, it helps to control the infection.
Valcip Tablet may cause diarrhoea as a temporary side effect. However, if the condition persists or worsens, please consult a doctor.
Valcip Tablet should be used with caution in patients with kidney problems and only in doses as prescribed by a doctor. However, regular blood tests are recommended while taking Valcip Tablet to monitor kidney functioning.
You are not recommended to take Valcip Tablet with tacrolimus (immunosuppressant) as it may increase the risk of kidney or nerve damage, cause side effects affecting bone marrow function leading to a low number of blood cells. Therefore, please consult a doctor before taking Valcip Tablet with other medicines.
Valcip Tablet is classed as a cytotoxic medicine and will therefore require special handling.
Common side effects of Valcip Tablet may include diarrhoea, loss of appetite, cough, headache, stomach pain, nausea, fever, tiredness, or sinusitis (sinus infection). Most of the side effects of Valcip Tablet do not require medical attention and resolve gradually over time. However, if the side effects persist or worsen, please consult your doctor.
Yes, it also has activity against the alpha herpesviruses. But it should be taken only if recommended by the healthcare professional.
It is a viral infection of the retina (light-sensing cells) caused by cytomegalovirus. In serious cases, it may lead to blindness. CMV retinitis is more likely to affect people with a weakened immune system from HIV/AIDS. The symptoms include blurred vision, a blind spot in vision, floaters in the eye, loss of peripheral vision or flashes in the eye.
Valcip Tablet is not recommended for pregnant women as it may cause birth defects. Please consult a doctor if you are pregnant or have any concerns.
If you are breastfeeding, do not take Valcip Tablet as it may be excreted in human milk and cause adverse effects in the baby.
Valcip Tablet may cause dizziness, tiredness, drowsiness, shakiness or confusion in some people. Therefore, avoid driving or operating heavy machinery if you experience these symptoms after taking Valcip Tablet .
No, you should not crush, chew, or break Valcip Tablet tablets. They must be swallowed whole to ensure the medicine is released correctly and to prevent the drug powder from irritating your skin, eyes, or throat. If you have trouble swallowing tablets, consult your healthcare provider for alternatives.
Yes, you should always take Valcip Tablet with food. Taking this medicine with a meal significantly increases the amount of the drug your body absorbs, making the treatment much more effective. Your doctor can advise you further if you have trouble eating.
Yes, Valcip Tablet can cause serious birth defects. Both men and women taking this medicine must use reliable birth control during treatment and for a specified period after stopping the medication. If you plan to start a family or suspect you are pregnant, reach out to your physician.
You should contact your healthcare provider right away if you notice unusual bruising or bleeding. This can be a sign that Valcip Tablet is lowering your blood platelet counts, which requires medical evaluation and a potential adjustment of your treatment.
It is best to avoid or strictly limit alcohol while taking Valcip Tablet . Alcohol can worsen side effects like dizziness, nausea, and headache, and can place additional stress on your liver and kidneys. Your doctor can provide more specific guidance based on your health.
Your doctor will schedule regular blood tests, often weekly at the start of your treatment, to monitor your complete blood count and kidney function. These tests are essential to ensure the medication is working safely and has not dropped your blood cell levels too low.
Yes, clinical evidence suggests that Valcip Tablet may temporarily or permanently affect fertility in both men and women, potentially reducing sperm production or affecting egg development. If you are concerned about your future fertility, discuss this directly with your specialist.

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.8177 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.6508 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Alganciclovir [Prescribing Information]. 2010. [Accessed on 01 Apr. 2019]Check here
  4. Valgaciclovir [Prescribing Information]. 2025. [Accessed on 09 Mar. 2025]Check here
  5. Fda.gov. 2020. VALCYTE (valganciclovir hydrochloride tablets) [Accessed on 19 March 2025]Check here
  6. Valganciclovir 450 mg Film-coated Tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. [Accessed on 19 March 2025]Check here
  7. Valganciclovir 450 mg Film-coated Tablets -PIL-Electronic Medicines Compendium (EMC). Electronic Medicines Compendium (eMC) [Internet]. Medicines.org.uk. 2019. [Accessed on 2025 Mar 19]Check here

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - VAL0302
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