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  3. Valrest-500 mg ER Tablet 10's

Valrest-500 mg ER Tablet 10's, Pack of 10 TabletS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Valrest-500 mg ER Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat bipolar disorder and prevent symptoms of migraine (like a headache). It contains Sodium valproate, which decreases the excessive and abnormal nerve activity in the brain. Thereby, helps in controlling seizures. It helps block the nerve transmission across the brain and provides a calming effect. In some cases, you may experience certain common side effects, such as stomach pain, nausea, vomiting, dry mouth, tremors, tiredness, sleepiness, headache, weight gain, and hair loss. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

SODIUM VALPROATE-500MG

Manufacturer/Marketer :

Sbs Biotech

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Valrest-500 mg ER Tablet

Valrest-500 mg ER Tablet is used to treat epilepsy/seizures/fits. Additionally, Valrest-500 mg ER Tablet is also used to treat bipolar disorder and prevent symptoms of migraine (like a headache). Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures, sometimes leading to an unconscious state. 
­ 
Valrest-500 mg ER Tablet contains 'Sodium valproate', which decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures. Valrest-500 mg ER Tablet increases the amount of a chemical substance called GABA; this helps block the nerve transmission across the brain and provides a calming effect. Thereby helps treat bipolar disorder. 
 
You can take Valrest-500 mg ER Tablet with or without food. You are advised to take Valrest-500 mg ER Tablet as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as stomach pain, nausea, vomiting, dry mouth, tremors, tiredness, sleepiness, headache, weight gain, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Please do not stop taking Valrest-500 mg ER Tablet without consulting your doctor to avoid worsening of seizures. Contact your doctor if your child gets her first period whilst on treatment with Valrest-500 mg ER Tablet . Do not take Valrest-500 mg ER Tablet if you are pregnant, as it could cause serious congenital disabilities. If you are of childbearing age, use effective contraception while taking Valrest-500 mg ER Tablet . Consult your doctor before taking Valrest-500 mg ER Tablet if you are breastfeeding. Do not drive or operate machinery as Valrest-500 mg ER Tablet may cause drowsiness and dizziness. Avoid consuming alcohol along with Valrest-500 mg ER Tablet as it could lead to increased dizziness and sleepiness.

Uses of Valrest-500 mg ER Tablet

Valrest-500 mg ER Tablet is used in the treatment of epilepsy, bipolar disorder, and migraine. The detailed uses of Valrest-500 mg ER Tablet are as follows:<br/>• Seizure Management: Valrest-500 mg ER Tablet is primarily used to manage various types of seizures in individuals with epilepsy, helping to stabilise electrical activity in the brain.<br/>• Bipolar Disorder Treatment: Valrest-500 mg ER Tablet can be utilized in the treatment of bipolar disorder, aiding in mood stabilization and reducing the frequency of mood swings.<br/>• Migraine Prevention: Valrest-500 mg ER Tablet may also be prescribed to prevent migraines, providing relief from recurrent headaches.<br/>

Directions for Use

  • Valrest-500 mg ER Tablet can be taken with or without food.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Valrest-500 mg ER Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

Valrest-500 mg ER Tablet belongs to a group of anticonvulsants or anti-epileptics used to treat epilepsy (fits). Additionally, Valrest-500 mg ER Tablet is also used to treat bipolar disorder and prevent migraine headaches. Valrest-500 mg ER Tablet decreases the excessive and abnormal nerve activity in the brain, thereby controlling seizures. Valrest-500 mg ER Tablet is used to treat both localized (seizures which affect only a part of the brain) and generalized seizures (seizures which affect the entire brain).

How Valrest-500 mg ER Tablet Works

Valrest-500 mg ER Tablet contains 'Sodium valproate', which decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures. Valrest-500 mg ER Tablet increases the amount of a chemical substance called GABA; this helps block the nerve transmission across the brain and provides a calming effect. Thereby helps treat bipolar disorder.

Storage

Keep Valrest-500 mg ER Tablet out of reach and sight of children.
Side effects of Valrest-500 mg ER Tablet
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
  • Do not stand up suddenly. Lie down and get up slowly only when you feel better.
  • Avoid alcohol and large meals.
  • Drink enough water before standing for long periods.
  • Exercise regularly; however, avoid exercising in extreme heat.
  • Eat small, low-carb meals.
  • Wear compression stockings.
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.
  • Regular exercise increases nitric oxide, relaxing blood vessels and improving circulation.
  • Avoid smoking and alcohol consumption as they can damage blood vessels and worsen vasodilation.
  • Foods high in omega-3 fatty acids such as walnuts, flaxseeds and fatty fish improve cardiovascular health and lower inflammation.
  • Limit the amount of salt in your regular diet.
  • Avoid triggers like alcohol, caffeine, and energy drinks.
  • Try relaxation techniques such as yoga, meditation, or deep breathing.
  • Exercise regularly as it helps maintain heart health.
  • Follow a nutritious and balanced diet.
  • Hallucination is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control hallucinations. You can share what is being seen with a therapist to know whether they are real or imaginary.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your imagination.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes of hallucinations.
  • Talk to your dietician and consume food that can improve your mental health.

What if I have taken an overdose of Valrest-500 mg ER Tablet

Do not take more than the prescribed dose of Valrest-500 mg ER Tablet as it may cause an overdose. The symptoms of overdose include headache, dizziness, confusion, memory loss, tiredness, feeling sick or being sick, blurred vision due to pupil of the eye becoming smaller, poor reflexes, weak or floppy muscles, fits, loss of consciousness, behavioural changes and breathing difficulties such as fast breathing, shortness of breath or chest pain. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Valrest-500 mg ER Tablet if you are allergic to any of its contents; if you have liver problems, porphyria, urine-related problems (like urea cycle disorder), diabetes, an immune system disorder or kidney problems. Consult your doctor immediately if you experience suicidal tendencies while taking Valrest-500 mg ER Tablet . Contact your doctor if your child gets her first period during the treatment with Valrest-500 mg ER Tablet . Do not take Valrest-500 mg ER Tablet if you are pregnant unless prescribed by the doctor, as it is a pregnancy category C medicine and can cause serious congenital disabilities. Consult your doctor before taking Valrest-500 mg ER Tablet if you are breastfeeding. Valrest-500 mg ER Tablet may cause drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol along with Valrest-500 mg ER Tablet as it could lead to increased dizziness and sleepiness. 

Drug-Drug Interactions

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Sodium ValproateSodium phenylbutyrate
Critical
Sodium ValproateBuprenorphine
Severe

Drug-Drug Interactions

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Sodium ValproateSodium phenylbutyrate
Critical
How does the drug interact with Valrest-500 mg ER Tablet:
Combining Sodium phenylbutyrate and Valrest-500 mg ER Tablet can increase ammonia levels in the blood.

How to manage the interaction:
Taking Sodium phenylbutyrate with Valrest-500 mg ER Tablet is not recommended, but it can be taken if prescribed by a doctor. If you experience any symptoms like sudden dizziness, lightheadedness, fainting, headache, shortness of breath, nausea, vomiting, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateBuprenorphine
Severe
How does the drug interact with Valrest-500 mg ER Tablet:
Using buprenorphine together with Valrest-500 mg ER Tablet may increase the risk of severe side effects, including respiratory problems and loss of consciousness.

How to manage the interaction:
Although the administration of buprenorphine alongside Valrest-500 mg ER Tablet can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateMeropenem
Severe
How does the drug interact with Valrest-500 mg ER Tablet:
Co-administration of Meropenam and Valrest-500 mg ER Tablet together can reduce the effect of Valrest-500 mg ER Tablet.

How to manage the interaction:
Co-administration of Meropenam and Valrest-500 mg ER Tablet can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any unusual symptoms, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateKetamine
Severe
How does the drug interact with Valrest-500 mg ER Tablet:
Co-administration of Ketamine and Valrest-500 mg ER Tablet can increase side effects and cause respiratory depression.

How to manage the interaction:
Co-administration of Ketamine and Valrest-500 mg ER Tablet can lead to an interaction, but it can be taken if your doctor advises. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, difficulty concentrating, excessive sedation, impaired thinking, judgment, and motor coordination. Avoid driving or operating hazardous machinery until you know how these medications affect you. Do not discontinue any medications without consulting the doctor.
Sodium ValproateLeflunomide
Severe
How does the drug interact with Valrest-500 mg ER Tablet:
Co-administration of Leflunomide and Valrest-500 mg ER Tablet can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Leflunomide and Valrest-500 mg ER Tablet can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateLithium
Severe
How does the drug interact with Valrest-500 mg ER Tablet:
Co-administration of Lithium with Valrest-500 mg ER Tablet can increase the risk irregular heart rhythm.

How to manage the interaction:
Co-administration of Lithium and Valrest-500 mg ER Tablet can lead to an interaction, but it can be taken if advised by your doctor. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, and difficulty concentrating. Do not discontinue any medications without consulting a doctor.
Sodium ValproateDoripenem
Severe
How does the drug interact with Valrest-500 mg ER Tablet:
Co-administration of Valrest-500 mg ER Tablet with doripenem can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Doripenam and Valrest-500 mg ER Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, involuntary muscle movements, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateErtapenem
Severe
How does the drug interact with Valrest-500 mg ER Tablet:
The combined use of Ertapenem and Valrest-500 mg ER Tablet can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Ertapenem and Valrest-500 mg ER Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like loss of seizure control or changes in behavior, consult your doctor immediately. Do not discontinue any medications without consulting the doctor.
Sodium ValproateVorinostat
Severe
How does the drug interact with Valrest-500 mg ER Tablet:
Co-administration of Vorinostat with Valrest-500 mg ER Tablet can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Vorinostat and Valrest-500 mg ER Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateTeriflunomide
Severe
How does the drug interact with Valrest-500 mg ER Tablet:
Co-administration of Teriflunomide and Valrest-500 mg ER Tablet can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Teriflunomide and Valrest-500 mg ER Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and yellowing of the skin or eyes. Avoid alcohol while taking these medications, and consult your doctor immediately. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilizing fat instead of glucose for the generation of energy.
  • Atkins diet (high fat and controlled carbohydrates) is recommended for adolescents and adults.
  • Exercising regularly helps maintain weight and improve overall health. 
  • Rest well; get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity and improve coping skills.
  • Have a seizure response plan that helps those around you know what to do.
  • Prepare your living area; small changes may help reduce the risk of physical injury during a seizure.
  • Understand what triggers seizures and try reducing or avoiding them.
  • Please pay attention to overall health, as it can help reduce seizure activity.
  • Install an alarm or emergency device to get assistance during a seizure attack.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

Valrest-500 mg ER Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Valrest-500 mg ER Tablet as it may cause increased dizziness and sleepiness.

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Pregnancy

Unsafe

Valrest-500 mg ER Tablet belongs to pregnancy category D. Avoid taking Valrest-500 mg ER Tablet if you are pregnant as it could lead to serious birth defects.

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Breast Feeding

Consult your doctor

Valrest-500 mg ER Tablet may pass into breastmilk. Consult your doctor before taking Valrest-500 mg ER Tablet if you are breastfeeding.

bannner image

Driving

Unsafe

Valrest-500 mg ER Tablet causes dizziness, sleepiness and tiredness. Do not drive or operate machinery unless you are alert.

bannner image

Liver

Unsafe

Valrest-500 mg ER Tablet should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have any concerns regarding this.

bannner image

Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Safe if prescribed

Valrest-500 mg ER Tablet can be given to children if prescribed by the doctor. The dose will be adjusted by the doctor depending upon the child's body weight.

Have a query?

FAQs

Valrest-500 mg ER Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat bipolar disorder and prevent symptoms of migraine (like a headache).

Valrest-500 mg ER Tablet decreases the excessive and abnormal nerve activity in the brain. It balances the brain&amp;#039;s chemical messenger and prevents overactivity of the brain, thereby controlling seizures episodes.

Valrest-500 mg ER Tablet helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA; this helps in blocking the nerve transmission across the brain and provides a calming effect.

Valrest-500 mg ER Tablet limits the transmission of nerve pain, thereby prevents migraine headache. Migraine is a neurological condition which is characterized by intense headaches.

Do not discontinue Valrest-500 mg ER Tablet without consulting your doctor. To treat your condition effectually, continue taking Valrest-500 mg ER Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Valrest-500 mg ER Tablet ; your doctor will reduce the dose gradually to avoid worsening of seizures.

Birth-control pills like oestrogen-containing products may affect the way Valrest-500 mg ER Tablet works. It is better to consult the doctor if you are using birth control pills to avoid pregnancy.

Valrest-500 mg ER Tablet may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a proper diet and exercising regularly.

Valrest-500 mg ER Tablet might cause fertility issues in both men and women. However, it can be reversible upon discontinuation of Valrest-500 mg ER Tablet . In rare cases, Valrest-500 mg ER Tablet can be a contributing factor in male infertility.

Limit caffeine intake, avoid smoking and mouthwashes containing alcohol, drink water regularly, and chew sugar-free gum/candy might prevent dry mouth.

Valrest-500 mg ER Tablet may change the results of liver enzymes, and urine and blood tests. Inform the person doing the tests that you are taking Valrest-500 mg ER Tablet .

Store Valrest-500 mg ER Tablet at room temperature, in a dry place. Keep out of sight and reach of children.

Valrest-500 mg ER Tablet may cause side effects like stomach pain, nausea, vomiting, dry mouth, tremors, tiredness, sleepiness, headache, weight gain, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

No, avoid consumption of alcohol while taking Valrest-500 mg ER Tablet as it may cause increased dizziness and sleepiness.

Yes, Valrest-500 mg ER Tablet causes dizziness, sleepiness and tiredness. Do not drive or operate machinery unless you are alert.

No, taking higher than the recommended dose of Valrest-500 mg ER Tablet will not be more effective and may cause unpleasant side effects. Do not take more than the prescribed dose of Valrest-500 mg ER Tablet as it may cause an overdose.

Country of origin

India

Manufacturer/Marketer address

Nanhera, Kala Amb Industrial Area, Sirmaur, Himachal Pradesh
Other Info - VAL0255

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:42 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.1500.pdf
  2. https://www.nhs.uk/medicines/sodium-valproate/http://mri.cts-mrp.eu/download/DE_H_0642_002_FinalPI_2of4.pdf
  3. https://www.drugs.com/cons/valproate-sodium-intravenous.html
  4. https://www.medsafe.govt.nz/consumers/cmi/e/Epilim.pdf

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