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  3. Valrest-500 mg ER Tablet 10's

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Valrest-500 mg ER Tablet 10's, Pack of 10 TabletS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Valrest-500 mg ER Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat bipolar disorder and prevent symptoms of migraine (like a headache). It contains Sodium valproate, which decreases the excessive and abnormal nerve activity in the brain. Thereby, helps in controlling seizures. It helps block the nerve transmission across the brain and provides a calming effect. In some cases, you may experience certain common side effects, such as stomach pain, nausea, vomiting, dry mouth, tremors, tiredness, sleepiness, headache, weight gain, and hair loss. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

SODIUM VALPROATE-500MG

Manufacturer/Marketer :

Sbs Biotech

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Valrest-500 mg ER Tablet

Valrest-500 mg ER Tablet is used to treat epilepsy/seizures/fits. Additionally, Valrest-500 mg ER Tablet is also used to treat bipolar disorder and prevent symptoms of migraine (like a headache). Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures, sometimes leading to an unconscious state. 
­ 
Valrest-500 mg ER Tablet contains 'Sodium valproate', which decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures. Valrest-500 mg ER Tablet increases the amount of a chemical substance called GABA; this helps block the nerve transmission across the brain and provides a calming effect. Thereby helps treat bipolar disorder. 
 
You can take Valrest-500 mg ER Tablet with or without food. You are advised to take Valrest-500 mg ER Tablet as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as stomach pain, nausea, vomiting, dry mouth, tremors, tiredness, sleepiness, headache, weight gain, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Please do not stop taking Valrest-500 mg ER Tablet without consulting your doctor to avoid worsening of seizures. Contact your doctor if your child gets her first period whilst on treatment with Valrest-500 mg ER Tablet . Do not take Valrest-500 mg ER Tablet if you are pregnant, as it could cause serious congenital disabilities. If you are of childbearing age, use effective contraception while taking Valrest-500 mg ER Tablet . Consult your doctor before taking Valrest-500 mg ER Tablet if you are breastfeeding. Do not drive or operate machinery as Valrest-500 mg ER Tablet may cause drowsiness and dizziness. Avoid consuming alcohol along with Valrest-500 mg ER Tablet as it could lead to increased dizziness and sleepiness.

Uses of Valrest-500 mg ER Tablet

Valrest-500 mg ER Tablet is used in the treatment of epilepsy, bipolar disorder, and migraine. The detailed uses of Valrest-500 mg ER Tablet are as follows:

  • Seizure Management: Valrest-500 mg ER Tablet is primarily used to manage various types of seizures in individuals with epilepsy, helping to stabilise electrical activity in the brain.
  • Bipolar Disorder Treatment: Valrest-500 mg ER Tablet can be utilized in the treatment of bipolar disorder, aiding in mood stabilization and reducing the frequency of mood swings.
  • Migraine Prevention: Valrest-500 mg ER Tablet may also be prescribed to prevent migraines, providing relief from recurrent headaches.

Have a query?

Directions for Use

  • Valrest-500 mg ER Tablet can be taken with or without food.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Valrest-500 mg ER Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

Valrest-500 mg ER Tablet belongs to a group of anticonvulsants or anti-epileptics used to treat epilepsy (fits). Additionally, Valrest-500 mg ER Tablet is also used to treat bipolar disorder and prevent migraine headaches. Valrest-500 mg ER Tablet decreases the excessive and abnormal nerve activity in the brain, thereby controlling seizures. Valrest-500 mg ER Tablet is used to treat both localized (seizures which affect only a part of the brain) and generalized seizures (seizures which affect the entire brain).

How Valrest-500 mg ER Tablet Works

Valrest-500 mg ER Tablet contains 'Sodium valproate', which decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures. Valrest-500 mg ER Tablet increases the amount of a chemical substance called GABA; this helps block the nerve transmission across the brain and provides a calming effect. Thereby helps treat bipolar disorder.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Valrest-500 mg ER Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

What if I have taken an overdose of Valrest-500 mg ER Tablet

Do not take more than the prescribed dose of Valrest-500 mg ER Tablet as it may cause an overdose. The symptoms of overdose include headache, dizziness, confusion, memory loss, tiredness, feeling sick or being sick, blurred vision due to pupil of the eye becoming smaller, poor reflexes, weak or floppy muscles, fits, loss of consciousness, behavioural changes and breathing difficulties such as fast breathing, shortness of breath or chest pain. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Valrest-500 mg ER Tablet if you are allergic to any of its contents; if you have liver problems, porphyria, urine-related problems (like urea cycle disorder), diabetes, an immune system disorder or kidney problems. Consult your doctor immediately if you experience suicidal tendencies while taking Valrest-500 mg ER Tablet . Contact your doctor if your child gets her first period during the treatment with Valrest-500 mg ER Tablet . Do not take Valrest-500 mg ER Tablet if you are pregnant unless prescribed by the doctor, as it is a pregnancy category C medicine and can cause serious congenital disabilities. Consult your doctor before taking Valrest-500 mg ER Tablet if you are breastfeeding. Valrest-500 mg ER Tablet may cause drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol along with Valrest-500 mg ER Tablet as it could lead to increased dizziness and sleepiness. 

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
DivalproexEsketamine
Severe

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
How does the drug interact with Valrest-500 mg ER Tablet:
Coadministration of Glycerol phenylbutyrate and Valrest-500 mg ER Tablet can increase ammonia levels in the blood.

How to manage the interaction:
Taking Glycerol phenylbutyrate and Valrest-500 mg ER Tablet together is generally avoided as it can lead to an interaction, it can be taken when your doctor advises. If you experience any symptoms like sudden dizziness, headaches, vomiting, and visual disturbances, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexEsketamine
Severe
How does the drug interact with Valrest-500 mg ER Tablet:
Coadministration of Esketamine and Valrest-500 mg ER Tablet can increase the side effects of esketamine.

How to manage the interaction:
Although taking Valrest-500 mg ER Tablet and Esketamine together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience any symptoms like drowsiness and impaired motor coordination, consult the doctor immediately. Do not stop using any medications without talking to your doctor.
DivalproexKetoconazole
Severe
How does the drug interact with Valrest-500 mg ER Tablet:
Coadministration of Ketoconazole and Valrest-500 mg ER Tablet may increase the risk of liver damage.

How to manage the interaction:
Although taking Ketoconazole and Valrest-500 mg ER Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain, fatigue, nausea, vomiting, stomach pain, dark urine, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexMipomersen
Severe
How does the drug interact with Valrest-500 mg ER Tablet:
Co-administration of Valrest-500 mg ER Tablet and mipomersen can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Valrest-500 mg ER Tablet and mipomersen can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult the doctor immediately. Avoid alcohol consumption, and Do not stop using any medications without a doctor's advice.
DivalproexSodium oxybate
Severe
How does the drug interact with Valrest-500 mg ER Tablet:
Co-administration of Sodium oxybate and Valrest-500 mg ER Tablet can increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Sodium oxybate and Valrest-500 mg ER Tablet can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like dizziness, sweating, palpitations, and shortness of breath, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexSodium phenylbutyrate
Severe
How does the drug interact with Valrest-500 mg ER Tablet:
Co-administration of Sodium phenylbutyrate and Valrest-500 mg ER Tablet can increase ammonia levels in the blood and is generally not recommended for patients with urea cycle disorders.

How to manage the interaction:
Co-administration of Valrest-500 mg ER Tablet with Sodium phenylbutyrate can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without first consulting your doctor.
DivalproexKetamine
Severe
How does the drug interact with Valrest-500 mg ER Tablet:
Co-administration of Valrest-500 mg ER Tablet and Ketamine can increase the risk of side effects.

How to manage the interaction:
Co-administration of Valrest-500 mg ER Tablet and Ketamine can lead to an interaction, it can be taken if advised by your doctor. If you have any symptoms such as dizziness, drowsiness, shortness of breath, or impairment in thinking and motor coordination, make sure to contact your doctor right away. Do not stop using any medications without a doctor's advice.
DivalproexTeriflunomide
Severe
How does the drug interact with Valrest-500 mg ER Tablet:
Co-administration of Valrest-500 mg ER Tablet and teriflunomide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Valrest-500 mg ER Tablet and teriflunomide can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexMeropenem
Severe
How does the drug interact with Valrest-500 mg ER Tablet:
Co-administration of Valrest-500 mg ER Tablet and Meropenem can reduce the blood levels of Valrest-500 mg ER Tablet sodium.

How to manage the interaction:
Co-administration of Valrest-500 mg ER Tablet with Meropenem can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without a doctor's advice.
DivalproexVorinostat
Severe
How does the drug interact with Valrest-500 mg ER Tablet:
Coadministration of Valrest-500 mg ER Tablet and Vorinostat can increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Valrest-500 mg ER Tablet and Vorinostat, you can take these medicines together if prescribed by your doctor. If you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult the doctor immediately. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilizing fat instead of glucose for the generation of energy.
  • Atkins diet (high fat and controlled carbohydrates) is recommended for adolescents and adults.
  • Exercising regularly helps maintain weight and improve overall health. 
  • Rest well; get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity and improve coping skills.
  • Have a seizure response plan that helps those around you know what to do.
  • Prepare your living area; small changes may help reduce the risk of physical injury during a seizure.
  • Understand what triggers seizures and try reducing or avoiding them.
  • Please pay attention to overall health, as it can help reduce seizure activity.
  • Install an alarm or emergency device to get assistance during a seizure attack.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Valrest-500 mg ER Tablet as it may cause increased dizziness and sleepiness.

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Pregnancy

Unsafe

Valrest-500 mg ER Tablet belongs to pregnancy category D. Avoid taking Valrest-500 mg ER Tablet if you are pregnant as it could lead to serious birth defects.

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Breast Feeding

Consult your doctor

Valrest-500 mg ER Tablet may pass into breastmilk. Consult your doctor before taking Valrest-500 mg ER Tablet if you are breastfeeding.

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Driving

Unsafe

Valrest-500 mg ER Tablet causes dizziness, sleepiness and tiredness. Do not drive or operate machinery unless you are alert.

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Liver

Unsafe

Valrest-500 mg ER Tablet should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Safe if prescribed

Valrest-500 mg ER Tablet can be given to children if prescribed by the doctor. The dose will be adjusted by the doctor depending upon the child's body weight.

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Heart

Consult your doctor

It is unknown whether Valrest-500 mg ER Tablet is safe for use in cardiac patients or not. Please consult your physician.

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Geriatrics

Caution

Valrest-500 mg ER Tablet should be given with caution in elderly patients due to age-related side effects. Seek medical advice before using Valrest-500 mg ER Tablet .

FAQs

Valrest-500 mg ER Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat bipolar disorder and prevent symptoms of migraine (like a headache).

Valrest-500 mg ER Tablet decreases the excessive and abnormal nerve activity in the brain. It balances the brain's chemical messenger and prevents overactivity of the brain, thereby controlling seizures episodes.

Valrest-500 mg ER Tablet helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA; this helps in blocking the nerve transmission across the brain and provides a calming effect.

Valrest-500 mg ER Tablet limits the transmission of nerve pain, thereby prevents migraine headache. Migraine is a neurological condition which is characterized by intense headaches.

Do not discontinue Valrest-500 mg ER Tablet without consulting your doctor. To treat your condition effectually, continue taking Valrest-500 mg ER Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Valrest-500 mg ER Tablet ; your doctor will reduce the dose gradually to avoid worsening of seizures.

Birth-control pills like oestrogen-containing products may affect the way Valrest-500 mg ER Tablet works. It is better to consult the doctor if you are using birth control pills to avoid pregnancy.

Valrest-500 mg ER Tablet may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a proper diet and exercising regularly.

Valrest-500 mg ER Tablet might cause fertility issues in both men and women. However, it can be reversible upon discontinuation of Valrest-500 mg ER Tablet . In rare cases, Valrest-500 mg ER Tablet can be a contributing factor in male infertility.

Limit caffeine intake, avoid smoking and mouthwashes containing alcohol, drink water regularly, and chew sugar-free gum/candy might prevent dry mouth.

Valrest-500 mg ER Tablet may change the results of liver enzymes, and urine and blood tests. Inform the person doing the tests that you are taking Valrest-500 mg ER Tablet .

Store Valrest-500 mg ER Tablet at room temperature, in a dry place. Keep out of sight and reach of children.

Valrest-500 mg ER Tablet may cause side effects like stomach pain, nausea, vomiting, dry mouth, tremors, tiredness, sleepiness, headache, weight gain, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

No, avoid consumption of alcohol while taking Valrest-500 mg ER Tablet as it may cause increased dizziness and sleepiness.

Yes, Valrest-500 mg ER Tablet causes dizziness, sleepiness and tiredness. Do not drive or operate machinery unless you are alert.

No, taking higher than the recommended dose of Valrest-500 mg ER Tablet will not be more effective and may cause unpleasant side effects. Do not take more than the prescribed dose of Valrest-500 mg ER Tablet as it may cause an overdose.

Country of origin

India

Manufacturer/Marketer address

Nanhera, Kala Amb Industrial Area, Sirmaur, Himachal Pradesh
Other Info - VAL0255

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Dec 3, 2025 | 7:34 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.1500.pdf
  2. https://www.nhs.uk/medicines/sodium-valproate/http://mri.cts-mrp.eu/download/DE_H_0642_002_FinalPI_2of4.pdf
  3. https://www.drugs.com/cons/valproate-sodium-intravenous.html
  4. https://www.medsafe.govt.nz/consumers/cmi/e/Epilim.pdf

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