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  3. VOLIBRIS 5MG TABLET

VOLIBRIS 5MG TABLET, Pack of 10 TABLETS
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

VOLIBRIS 5MG TABLET is used to treat pulmonary arterial hypertension (high blood pressure in the lungs). It contains Ambrisentan, which works by widening the blood vessels and improving blood flow. In some cases, this medicine may cause side effects such as headache, dizziness, breathlessness, runny nose, feeling sick, diarrhoea, and fatigue. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition :

AMBRISENTAN-5MG

Manufacturer/Marketer :

GlaxoSmithKline Consumer Healthcare Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About VOLIBRIS 5MG TABLET

VOLIBRIS 5MG TABLET is used to treat high blood pressure in the arteries of the lungs (pulmonary arterial hypertension). Hypertension is a medical condition in which the blood exerts high pressure (force exerted by circulating blood) against the walls of blood vessels. This condition makes the heart work harder in pumping blood to the whole body. Pulmonary hypertension affects the arteries in the lungs and the right side of the heart.

VOLIBRIS 5MG TABLET contains ‘Ambrisentan,’ which belongs to the class of ‘endothelin receptor blockers’. Ambrisentan works by inhibiting the action of Endothelin, a natural substance that constricts blood vessels and raises blood pressure. VOLIBRIS 5MG TABLET widens the constricted pulmonary arteries (blood vessels that carry blood from the heart to the lungs) and increases blood supply to the lungs, thus lowering the blood pressure.

In some cases, VOLIBRIS 5MG TABLET can cause side effects like headache, dizziness, palpitations, breathlessness, runny nose, feeling sick, diarrhoea, and fatigue. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Please inform your doctor if you are using any prescription or non-prescription drugs, including vitamins and herbal products. Let your doctor know if you have any allergic reactions to VOLIBRIS 5MG TABLET or any other medicines before starting VOLIBRIS 5MG TABLET. Inform your doctor if you have low blood pressure, lung, heart, kidney or liver problems, and anaemia (lack of blood cells). It is advised to consult a doctor if you are a pregnant or breastfeeding mother. Do not stop taking VOLIBRIS 5MG TABLET without consulting your doctor, since it may worsen your condition and increase the risk of future heart problems. Do not consume alcohol with VOLIBRIS 5MG TABLET as it may increase the risk of low blood pressure.

Uses of VOLIBRIS 5MG TABLET

VOLIBRIS 5MG TABLET is used in the treatment of Pulmonary arterial hypertension. The detailed uses of VOLIBRIS 5MG TABLET are as follows:<br/> • Treatment of Pulmonary Arterial Hypertension: VOLIBRIS 5MG TABLET is used to treat Pulmonary Arterial Hypertension (PAH) by increasing blood supply to the lungs, thus lowering the blood pressure.<br/> • Decreases High Blood Pressure in Lung Arteries: VOLIBRIS 5MG TABLET helps reduce high pressure in the arteries between the heart and lungs.<br/> • Improves Exercise Tolerance: VOLIBRIS 5MG TABLET improves stamina and physical activity capacity in PAH patients.<br/> • Lowers Disease Progression: VOLIBRIS 5MG TABLET slows the advancement of symptoms linked to PAH. <br/> • Reduces Heart Strain: VOLIBRIS 5MG TABLET reduces the workload on the heart by widening blood vessels in the lungs.<br/>

Directions for Use

  • Take VOLIBRIS 5MG TABLET with or without food, or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to improve effectiveness.
  • Swallow VOLIBRIS 5MG TABLET as a whole with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

VOLIBRIS 5MG TABLET is an anti-hypertensive medicine that treats high blood pressure in the arteries of the lungs (pulmonary arterial hypertension (PAH)). It contains ‘Ambrisentan,’ an endothelin receptor blocker. VOLIBRIS 5MG TABLET works by inhibiting the action of Endothelin, a natural substance that constricts blood vessels and raises blood pressure. In people with PAH, the pulmonary arteries get narrower, making the heart work harder to pump blood through them. VOLIBRIS 5MG TABLET widens these constricted arteries and makes it easier for the heart to pump blood, thus lowering the blood pressure.

How VOLIBRIS 5MG TABLET Works

VOLIBRIS 5MG TABLET contains Ambrisentan, which belongs to the class of endothelin receptor blockers. Ambrisentan works by inhibiting the action of Endothelin, a natural substance that constricts blood vessels and raises blood pressure. VOLIBRIS 5MG TABLET widens the constricted pulmonary arteries (blood vessels that carry blood from the heart to the lungs) and increases blood supply to the lungs, thus lowering the blood pressure.

Storage

• Store in a cool and dry place away from sunlight.• Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Volibris 5mg Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • A blocked nose can be relieved by drinking more water, which helps clear fluids.
  • Use saline nasal spray available over the counter to relieve blockage or blow harder to remove the mucus.
  • Use nasal strips that can be placed on the nose to widen nostrils and increase airflow.
  • Keep a humidifier around to moisten air at home/workplace.
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
  • Avoid diet rich in salt and carbohydrates
  • Drink plenty of water and stay hydrated.
  • Exercise regularly and maintain a healthy lifestyle.
  • Take potassium rich foods like potatoes, spinach, tomatoes, sea food and dairy products.
  • Take beverages containing caffeine like coffee and tea.
  • Red rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Managing Medication-Related Skin Allergies: A Step-by-Step Guide
  • If you experience signs of skin allergies such as redness, itching, or irritation after taking medication, contact your doctor right away.
  • To alleviate skin allergy symptoms, your doctor may change your medication regimen or offer tailored medication management advice.
  • Your doctor may recommend or prescribe drugs to relieve discomfort.
  • Cool compresses or calamine lotion can help relieve redness and itching on the afflicted skin area.
  • Staying hydrated by consuming plenty of water can help relieve discomfort.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.

What if I have taken an overdose of VOLIBRIS 5MG TABLET

Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include sweating, confusion, blurred vision, dizziness, light-headedness when getting up suddenly from a sitting/lying position, or faintness. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Brief your medical history if you have heart failure, liver or kidney diseases, lung conditions (pulmonary fibrosis), anaemia, oedema (fluid retention) and hypotension (low blood pressure) before starting VOLIBRIS 5MG TABLET. VOLIBRIS 5MG TABLET is contraindicated during pregnancy since it has harmful effects on the foetus. Consult your doctor before using VOLIBRIS 5MG TABLET if you are a breastfeeding mother. Complete the course strictly as suggested by the doctor, even if you feel better, to avoid disease recurrence. Do not drive or operate machinery since VOLIBRIS 5MG TABLET may cause side effects like dizziness and weakness, affecting your ability to concentrate and drive. Avoid consumption of alcohol with VOLIBRIS 5MG TABLET as it may increase the risk of low blood pressure. VOLIBRIS 5MG TABLET is not recommended in patients younger than 18 years of age.

Drug-Drug Interactions

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AmbrisentanCiclosporin
Severe
AmbrisentanTizanidine
Severe

Drug-Drug Interactions

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AmbrisentanCiclosporin
Severe
How does the drug interact with Volibris 5mg Tablet:
When Volibris 5mg Tablet is taken with cyclosporine, this increases the blood levels of Volibris 5mg Tablet. This can increase the risk of serious side effects such as liver problems, anemia, and fluid accumulation (particularly in the lungs).

How to manage the interaction:
Co-administration of ciclosporin with Volibris 5mg Tablet can result in an interaction, but it can be taken if a doctor has advised it. If you experience any of these symptoms such as fever with shivering, pain in your joints, swelling, bleeding or bruising easily, a rash or itchy skin, not feeling hungry, feeling tired, dark color urine, looking pale, dizziness, gaining weight suddenly, or breathing problem, consult a doctor. Do not stop using any medications without talking to a doctor.
AmbrisentanTizanidine
Severe
How does the drug interact with Volibris 5mg Tablet:
Coadministration of Tizanidine with Volibris 5mg Tablet may increase the risk or severity of developing low blood pressure.

How to manage the interaction:
Although there is a possible interaction between Volibris 5mg Tablet and Tizanidine, you can take these medicines together if your doctor advises. If you notice any symptoms like headache, dizziness, shortness of breath, chest pain, or sweating, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
AmbrisentanTeriflunomide
Severe
How does the drug interact with Volibris 5mg Tablet:
When Volibris 5mg Tablet and Teriflunomide are taken together, the risk or severity of developing liver injury increases.

How to manage the interaction:
Although taking Volibris 5mg Tablet and Teriflunomide together can cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms - fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, liver damage, or bleeding - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
AmbrisentanMipomersen
Severe
How does the drug interact with Volibris 5mg Tablet:
Taking Volibris 5mg Tablet with Mipomersen can increase the risk or severity of liver problems.

How to manage the interaction:
Taking Volibris 5mg Tablet with Mipomersen together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
AmbrisentanLomitapide
Severe
How does the drug interact with Volibris 5mg Tablet:
Taking Volibris 5mg Tablet with Lomitapide can lead to or increase the risk or severity of developing liver problems.

How to manage the interaction:
Although there is a possible interaction, Volibris 5mg Tablet can be taken with Lomitapide if prescribed by the doctor. Consult the prescriber if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
AmbrisentanLeflunomide
Severe
How does the drug interact with Volibris 5mg Tablet:
Taking leflunomide and Volibris 5mg Tablet can lead to or increase the risk or severity of developing liver problems.

How to manage the interaction:
Although there is an interaction between leflunomide and Volibris 5mg Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Reduce sodium intake in your diet to maintain your blood pressure.
  • Eat natural and healthy foods by cutting down on high-sodium processed foods.
  • Lose those extra pounds, since being obese can be a risk factor for hypertension.
  • Exercise regularly to maintain good heart health.
  • Avoid smoking and alcohol intake.
  • Chronic stress may also cause high blood pressure. Therefore, avoid stress triggers and make time for yourself to relax and do activities that you enjoy.
  • Try to include heart-healthy omega-3 fatty acids in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil and coconut oil to lower your elevated blood pressure.
  • Limit sodium chloride intake (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

VOLIBRIS 5MG TABLET Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

It is advised to limit alcohol intake, since alcohol consumption may increase the risk of low blood pressure and cause adverse effects, such as dizziness, fainting, light-headedness or headache.

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Pregnancy

Unsafe

VOLIBRIS 5MG TABLET is not recommended and unsafe in pregnancy. It can affect and harm the developing baby. You are advised to get a pregnancy test done before starting VOLIBRIS 5MG TABLET. You should get a negative pregnancy test for sure before using VOLIBRIS 5MG TABLET. Also, please use reliable forms of birth control if you are undergoing treatment with VOLIBRIS 5MG TABLET to avoid pregnancy.

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Breast Feeding

Caution

It is not known if VOLIBRIS 5MG TABLET is excreted into the breast milk. Please consult your doctor for more information before taking VOLIBRIS 5MG TABLET if you are a nursing mother.

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Driving

Caution

VOLIBRIS 5MG TABLET may cause side effects like dizziness and weakness, affecting your ability to concentrate and drive. Hence, it is recommended not to drive or operate machinery until you are mentally alert.

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Liver

Caution

Let your doctor know if you have any history of liver disease before taking VOLIBRIS 5MG TABLET. VOLIBRIS 5MG TABLET may cause an increase in liver enzymes. If you are using VOLIBRIS 5MG TABLET and experience any nausea, vomiting, loss of appetite, dark-coloured urine and yellowing of the skin, please see your doctor immediately.

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Kidney

Caution

VOLIBRIS 5MG TABLET should be used with caution in cases of renal impairment. It is recommended to seek a doctor's advice before starting VOLIBRIS 5MG TABLET if you have any kidney problems.

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Children

Unsafe

Safety and effectiveness of VOLIBRIS 5MG TABLET have not been established in patients below 18 years of age.

Have a query?

FAQs

VOLIBRIS 5MG TABLET is used to treat Pulmonary arterial hypertension.

VOLIBRIS 5MG TABLET consists of Ambrisentan. It is an anti-hypertensive medicine that lowers blood pressure by widening the pulmonary arteries and making the heart pump blood efficiently.

Yes, VOLIBRIS 5MG TABLET can make you feel dizzy. Dizziness usually occurs when you suddenly stand up from a lying or sitting position. Try rising slowly when you change your posture to relieve dizziness. If the side effect persists longer, please seek medical help.

Do not stop using VOLIBRIS 5MG TABLET even if you feel better. It should be strictly used as advised by your doctor to avoid the recurrence of symptoms and worsening of the disease.

VOLIBRIS 5MG TABLET should be used with caution in cases of any allergic reactions, heart failure, liver, kidney diseases, lung conditions (pulmonary fibrosis), anaemia, oedema (fluid retention) and hypotension (low blood pressure).

Store VOLIBRIS 5MG TABLET away from direct sunlight and at a temperature not exceeding 30°C. Keep this medicine out of the sight and reach of children.

VOLIBRIS 5MG TABLET may rarely cause liver problems. Your doctor will monitor your liver function while you're taking VOLIBRIS 5MG TABLET. If you experience symptoms like yellowing skin, dark urine, or abdominal pain, seek medical attention. Discuss any concerns with your doctor.

Take VOLIBRIS 5MG TABLET exactly as your doctor tells you to. Typically, it's one tablet once a day. Swallow the tablet whole with water, and take it at the same time each day. Don't crush, chew, or break it.

Don't stop taking VOLIBRIS 5MG TABLET without talking to your doctor first. Stopping suddenly can worsen your condition and increase the risk of heart problems. Your doctor will advise you on how to safely stop taking VOLIBRIS 5MG TABLET if needed. Follow their instructions carefully.

VOLIBRIS 5MG TABLET is used to treat high blood pressure in the lungs, but have risks and limitations. They can cause serious side effects and may not be suitable for everyone, including pregnant women and those with certain medical conditions. Always follow your doctor's instructions and ask questions if needed.

VOLIBRIS 5MG TABLET can be effective in treating certain conditions, but in some cases, it can cause serious side effects. Watch out for severe swelling, difficulty breathing or swallowing, and sudden weight gain. Additionally, be aware of extreme tiredness, yellowing of the skin or eyes, dark urine, and severe itching. If you experience any of these symptoms, call your doctor right away or seek emergency medical help. Don't delay; these side effects can be serious and require prompt attention. Discussing the potential risks and benefits with your doctor before starting treatment is essential.

You have been prescribed VOLIBRIS 5MG TABLET to treat pulmonary arterial hypertension (PAH), which is high blood pressure in the lungs.

Avoid exceeding the recommended dose, as it could lead to an overdose. Symptoms of overdose may include sweating, confusion, blurred vision, dizziness, light-headedness when getting up suddenly from a sitting/lying position, or faintness. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Common side effects of VOLIBRIS 5MG TABLET may include headache, dizziness, palpitations, breathlessness, runny nose, feeling sick, diarrhoea, and fatigue. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

No, you should not take VOLIBRIS 5MG TABLET on your own without consulting a doctor. This medication is prescribed for specific medical conditions and requires a doctor's supervision to ensure safe and effective use.

Safety and effectiveness of VOLIBRIS 5MG TABLET have not been established in patients below 18 years of age.

Country of origin

India

Manufacturer/Marketer address

24-25 Floor, One Horizon Center Golf Course Road, DLF Phase 5 Gurgaon 122002, India.
Other Info - VOL0182

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 22, 2025 | 11:06 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.11697.pdf
  2. https://www.webmd.com/drugs/2/drug-148530/ambrisentan-oral/details
  3. https://www.drugs.com/dosage/ambrisentan.html

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