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compositionComposition:ENDOXIFEN-8MG
prescription
Prescription Medicine
info
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ZONALTA 8 TABLETS is an antipsychotic medicine used to treat acute manic episodes in adults associated with bipolar disorder. This medicine inhibits protein kinase C activity, thereby helping to regulate certain brain chemicals that control mood. You may experience side effects like headache, vomiting, Inability to sleep, sleeping more than usual, abdominal discomfort, and diarrhoea. Before starting ZONALTA 8 TABLETS, inform your doctor if you are pregnant, breastfeeding, taking any other medicines or have pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

ENDOXIFEN-8MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About ZONALTA 8 TABLETS

ZONALTA 8 TABLETS is used to treat or reduce the symptoms of manic episodes in bipolar I illness, with or without mixed characteristics (both highs and lows at the same time).

ZONALTA 8 TABLETS contains 'Endoxifen,' which works by managing certain chemicals in the brain that control your moods, such as serotonin, norepinephrine, and dopamine.

ZONALTA 8 TABLETS may cause side effects such as headache, vomiting, abdominal discomfort, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, consult your doctor if the side effects persist or worsen.

Do not stop taking ZONALTA 8 TABLETS without consulting your doctor to avoid worsening your condition. Keep your healthcare professional informed about your medical condition and your medications to rule out any potential negative effects and interactions.

Uses of ZONALTA 8 TABLETS

ZONALTA 8 TABLETS is used in the treatment of Acute manic episodes in adults associated with bipolar disorder. The detailed uses of ZONALTA 8 TABLETS are as follows:

  • Treat manic and mixed episodes in bipolar I disorder: ZONALTA 8 TABLETS is primarily used to manage acute mania and mixed mood states in patients with bipolar I disorder. It helps stabilise mood and reduce symptoms such as elevated energy, impulsivity, and irritability.
  • Modulate brain signalling and neurotransmitter balance: ZONALTA 8 TABLETS works by directly inhibiting protein kinase C (PKC), a key enzyme involved in overactive neuronal signalling. This action helps regulate neurotransmitters like dopamine, serotonin, and norepinephrine that influence mood and behaviour.

Key Benefits

  • ZONALTA 8 TABLETS helps in the management of bipolar disorder, particularly during the manic phase.
  • It inhibits protein kinase C activity, which is elevated in mania, thereby restoring balance in brain activity.
  • It regulates important brain chemicals such as serotonin, norepinephrine, and dopamine to stabilise mood.
  • ZONALTA 8 TABLETS reduces manic symptoms, including irritability, hyperactivity, and elevated mood.
  • It is effective in controlling mixed episodes (both highs and lows occurring simultaneously).
  • ZONALTA 8 TABLETS improves the overall severity of illness, enhancing the quality of life in patients with bipolar disorder.
Side effects of Zonalta 8 mg Tablet
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Prefer liquid food like juices and soups when you are not likely to eat.
  • Avoid spicy, fatty and fried foods as they cause stomach upset.
  • Eat small and frequent meals, avoiding large meals at a time.
  • Add healthy foods in your diet like fruits and vegetables.
  • Take starchy food like cereals, bread and potatoes etc.

Directions for Use

  • ZONALTA 8 TABLETS can be taken with or without food, as food intake does not significantly influence its effectiveness.
  • Adhere to your doctor's guidance regarding the dosage and timing of this medication for optimal effectiveness.
  • Swallow ZONALTA 8 TABLETS as a whole with a glass of water.
  • Do not crush, chew, or break it.

How ZONALTA 8 TABLETS Works

ZONALTA 8 TABLETS contains 'Endoxifen,' which works in the nervous system by inhibiting protein kinase C activity (which is elevated in patients with bipolar I illness during their manic phase) and thus helps to manage certain chemicals in the brain that control your moods, such as serotonin, norepinephrine, and dopamine.
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Alcohol

Caution

Avoid alcohol consumption while taking ZONALTA 8 TABLETS as it may increase dizziness and sleepiness.

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Pregnancy

Unsafe

ZONALTA 8 TABLETS should not be administered to pregnant women as ZONALTA 8 TABLETS falls under pregnancy category D.

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Breast Feeding

Unsafe

Women should be advised not to breastfeed throughout therapy and for three months following the final dosage of ZONALTA 8 TABLETS.

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Driving

Unsafe

ZONALTA 8 TABLETS causes sleepiness and tiredness or restlessness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

If you have a history or evidence of any Liver-related diseases, inform the doctor before taking medicine. Your doctor will measure the benefits and potential risks before prescribing ZONALTA 8 TABLETS.

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Kidney

Caution

If you have a history or evidence of any Kidney-related diseases, inform the doctor before taking medicine. Your doctor will measure the benefits and potential risks before prescribing ZONALTA 8 TABLETS.

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Children

Unsafe

The ZONALTA 8 TABLETS is not recommended for use on children under 18 because of insufficient data on efficacy and safety.

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Heart

Caution

ZONALTA 8 TABLETS should be taken with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems before using ZONALTA 8 TABLETS.

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Geriatrics

Caution

The use of ZONALTA 8 TABLETS is not recommended in elderly patients due to insufficient data on its safety and efficacy.

What if I have taken an overdose of ZONALTA 8 TABLETS

An overdose of ZONALTA 8 TABLETS may cause unpleasant side effects. If you suspect you have taken an overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Lifestyle adjustments and mood-management techniques can be beneficial.
  • Always maintain a healthy diet and exercise regularly.
  • Attend counselling regularly.
  • Practice meditation and yoga.
  • Maintain a consistent sleep schedule.
  • Avoid smoking and drinking alcohol.
health query

Have a query?

How Soon It Starts Working

The time required for ZONALTA 8 TABLETS to start to work: The time required for ZONALTA 8 TABLETS to show its action is unknown.

The time for which the effects of ZONALTA 8 TABLETS last: The duration of action for ZONALTA 8 TABLETS is clinically unknown.

What if you forget to take ZONALTA 8 TABLETS

Take the missed dose of ZONALTA 8 TABLETS as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not take two doses at the same time to make up for the missed one.

Storage

• Store in a cool and dry place away from sunlight.• Keep ZONALTA 8 TABLETS out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Avoid taking ZONALTA 8 TABLETS if you are allergic to any of its components.
  • Do not stop taking ZONALTA 8 TABLETS without consulting your doctor to avoid worsening your condition.
  • To treat your condition effectually, continue taking ZONALTA 8 TABLETS for as long as your doctor has suggested, even if you feel better.
  • Do not take ZONALTA 8 TABLETS if you are pregnant or breastfeeding.
  • It is recommended to use effective contraceptive methods while using ZONALTA 8 TABLETS.
  • ZONALTA 8 TABLETS causes sleepiness and restlessness; do not drive unless alert.
  • ZONALTA 8 TABLETS should not be given to children as safety and effectiveness have not been established.
  • Avoid consuming alcohol with ZONALTA 8 TABLETS as it could lead to undesirable effects.
  • Keep your doctor updated on your medical condition and medications to rule out any potential side effects.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions: ZONALTA 8 TABLETS may interact with coumarin derivative medications (phenprocoumon, warfarin, acenocoumarol) and cytochrome P450 inducer medications (omeprazole, Lansoprazole).

Food-Drug Interactions: Limit or avoid the consumption of alcohol.

Drug-Disease Interactions: ZONALTA 8 TABLETS may have interactions with hepatic or renal dysfunction, ocular disturbances, and blood clotting disorders.

No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

Not enough scientific literature available around this hence it is best to consult your physician

Therapeutic Class

[PSYCHOTHERAPEUTICS]

FAQs

ZONALTA 8 TABLETS is used to treat or reduce the symptoms of manic episodes in bipolar I illness, with or without mixed characteristics (both highs and lows at the same time).
ZONALTA 8 TABLETS contains Endoxifen, which acts in the neurological system by suppressing protein kinase C activity and so aids in the management of various brain chemicals that affect your moods, such as serotonin, norepinephrine, and dopamine.
ZONALTA 8 TABLETS is indicated in adults for the acute treatment of manic episodes with or without mixed features (both highs and lows simultaneously) that happen with bipolar disorder.
You are not recommended to stop taking ZONALTA 8 TABLETS even if you begin to feel better as it may cause recurring symptoms. Therefore, continue taking ZONALTA 8 TABLETS for as long as it is suggested by a doctor.
ZONALTA 8 TABLETS may cause stomach upset or diarrhoea. Do not take any medication to treat this condition without a doctor's notice. It does not require medical attention and will resolve gradually over time in most cases. However, you are advised to talk to your doctor if you experience these side effects persistently.
The side effects of ZONALTA 8 TABLETS include headache, vomiting, insomnia (inability to sleep), diarrhoea, restlessness, or stomach upset. If these side effects persist or worsen, please consult your doctor.
Bipolar disorder also called as manic depression is a mental illness that causes unusual shifts in a person's mood, energy, concentration, and activity levels. It is marked by episodes of mood swings ranging from depressive lows to manic highs.
ZONALTA 8 TABLETS is not recommended for use during pregnancy and breastfeeding. Therefore, if you are pregnant, planning pregnancy or are breastfeeding, inform your doctor before taking ZONALTA 8 TABLETS.
Yes, ZONALTA 8 TABLETS may cause eye problems, including visual disturbances or more serious retinopathy (damage to the retina of the eyes). If you experience such problems, consult your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - ZON0106

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