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  3. Zyle-100 Tablet 10's

Zyle-100 Tablet 10's, Pack of 10 TabletS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Zyle-100 Tablet is used to decrease blood uric acid levels in the body. It is used to treat Gout (increased uric acid leading to inflammation), kidney stones, bladder stones. It contains Allopurinol, which stops uric acid formation inside the body without affecting the essential mechanism of cells and the body. It may cause common side effects such as upset stomach, diarrhoea, skin rash, or drowsiness. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

ALLOPURINOL-100MG

Manufacturer/Marketer :

Leeford Healthcare Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About Zyle-100 Tablet

Zyle-100 Tablet belongs to a class of medication called 'enzyme inhibitor', primarily used to decrease blood uric acid levels in the body. It is used to treat Gout (increased uric acid leading to inflammation), kidney stones, bladder stones. Gout is a type of inflammatory reaction (allergic reaction) to uric acid crystals that form and accumulate inside joints, especially  big toe, due to high uric acid levels in the blood resulting in immense pain in joints. 

Zyle-100 Tablet contains allopurinol, which works by inhibiting the enzyme xanthine oxidase, the enzyme responsible for the formation of uric acid. It stops uric acid formation inside the body without affecting the essential mechanism of cells and the body. 

Take Zyle-100 Tablet as prescribed by your doctor. You are advised to take Zyle-100 Tablet for as long as your doctor has prescribed it for you, depending upon your medical condition. The most common side effects of Zyle-100 Tablet are upset stomach, diarrhoea, skin rash, drowsiness. Most of these side effects of Zyle-100 Tablet are temporary, do not require medical attention, and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. 

Do not take Zyle-100 Tablet if you are allergic to any of its ingredients. Zyle-100 Tablet contains monohydrated lactose, if you are intolerant to some sugars, call your doctor before taking this drug. If you are pregnant or planning to get pregnant, are breast-feeding ask your doctor for advice before taking this medicine. Drink at least 2-3 litres of water so that you stay hydrated. For people who have kidney disease or renal dysfunction, dose adjustment is required. If you lose unexplained weight, please visit your doctor immediately.

Uses of Zyle-100 Tablet

Treatment of Gout (increased uric acid in joints), Kidney stones, Bladder stones.

Directions for Use

Take Zyle-100 Tablet with or without food as directed by your physician. Swallow it as a whole with a glass of water. Do not crush, chew, or break it.

Medicinal Benefits

Zyle-100 Tablet contains an 'enzyme inhibitor', medication, primarily used to decrease blood uric acid levels in the body. In addition to this, it is sometimes also used to treat pain caused by pancreas disease, seizures, and improve survival after bypass surgery. It also prevents the rejection of a kidney transplant. Zyle-100 Tablet contains allopurinol, an enzyme inhibitor primarily used to decrease blood uric acid levels in the body. It works by inhibiting the enzyme xanthine oxidase, the enzyme responsible for the formation of uric acid. It stops uric acid formation inside the body without affecting the essential mechanism of cells and the body.

How Zyle-100 Tablet Works

Zyle-100 Tablet contains allopurinol, which works by inhibiting the enzyme xanthine oxidase, the enzyme responsible for the formation of uric acid. It stops uric acid formation inside the body without affecting the essential mechanism of cells and the body.

Storage

Store in a cool and dry place away from sunlight
Side effects of Zyle-100 Tablet
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Limit processed foods and eat more vegetables and fruits.
  • Exercise at least 30 minutes every day.
  • Maintain a healthy weight.
  • Quit smoking as it can worsen kidney damage.
  • Control your blood pressure and blood glucose.
  • Limit salt intake and alcohol consumption.
  • Take cold water baths avoiding soap.
  • Avoid scratching and scrubbing to prevent infections while itching.
  • Use nets to prevent insects and mosquitoes.
  • Stop using lotions and creams that cause irritation.
  • Avoid alcohol and caffeine intake.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

What if I have taken an overdose of Zyle-100 Tablet

Do not take more than the prescribed dose of Zyle-100 Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Do not take Zyle-100 Tablet if you are allergic to any of its ingredients. Zyle-100 Tablet  contains monohydrated lactose; if your doctor mentioned that you are intolerant to some sugars, call your doctor before taking this drug. If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine, you have heart problems or high blood pressure and you take diuretics and/or a medicine called ACE-inhibitors, you have thyroid problems. In rare cases, Zyle-100 Tablet can cause bone marrow depression, especially in patients who are already taking that can cause bone marrow depression. For people who have kidney disease or renal dysfunction, dose adjustment is required. If you lose unexplained weight, please visit your doctor immediately. Zyle-100 Tablet can cause drowsiness so do not operate machinery or car as it can impair judgment.

Drug-Drug Interactions

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AllopurinolDidanosine
Critical
AllopurinolLisinopril
Severe

Drug-Drug Interactions

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AllopurinolDidanosine
Critical
How does the drug interact with Zyle-100 Tablet:
When Didanosine is taken with Zyle-100 Tablet, can increase the blood levels of didanosine.

How to manage the interaction:
Taking Zyle-100 Tablet with Didanosine lead to an interaction, please consult a doctor before taking it. Do not discontinue the medication without consulting a doctor.
AllopurinolLisinopril
Severe
How does the drug interact with Zyle-100 Tablet:
Co-administration of Zyle-100 Tablet with Lisinopril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Zyle-100 Tablet and Lisinopril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness chills, sore throat, extreme tiredness, body pains, consult a doctor. Do not discontinue any medications without consulting a doctor.
AllopurinolQuinapril
Severe
How does the drug interact with Zyle-100 Tablet:
Co-administration of Zyle-100 Tablet with Quinapril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Zyle-100 Tablet and Quinapril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also, let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not discontinue any medications without consulting a doctor.
AllopurinolPegloticase
Severe
How does the drug interact with Zyle-100 Tablet:
Co-administration of Zyle-100 Tablet with Pegloticase can increase the chances of side effects.

How to manage the interaction:
Co-administration of Zyle-100 Tablet with Pegloticase can possibly result in an interaction, but it can be taken if your doctor has advised it. This is more common in people who already have high uric acid levels, which may not be obvious if they are taking other uric acid-lowering medications. Do not stop using any medications without first talking to your doctor.
AllopurinolEntecavir
Severe
How does the drug interact with Zyle-100 Tablet:
Coadministration of Zyle-100 Tablet with Entecavir may increase the blood levels of one or both medicines and increase side effects.

How to manage the interaction:
If you are supposed to take Zyle-100 Tablet and Entecavir together, your doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience increased side effects, contact your doctor.
AllopurinolMoexipril
Severe
How does the drug interact with Zyle-100 Tablet:
Co-administration of Zyle-100 Tablet with Moexipril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Zyle-100 Tablet and Moexipril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also, let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not discontinue any medications without consulting a doctor.
AllopurinolEnalapril
Severe
How does the drug interact with Zyle-100 Tablet:
Coadministration of Zyle-100 Tablet with Enalapril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Zyle-100 Tablet and Enalapril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also, let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not stop using any medications without consulting your doctor.
AllopurinolRamipril
Severe
How does the drug interact with Zyle-100 Tablet:
Co-administration of Zyle-100 Tablet with Ramipril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Zyle-100 Tablet and Ramipril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also, let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not discontinue the medication without consulting a doctor.
AllopurinolPerindopril
Severe
How does the drug interact with Zyle-100 Tablet:
Co-administration of Zyle-100 Tablet with Perindopril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Zyle-100 Tablet and Perindopril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms, contact your doctor immediately . Do not discontinue any medications without consulting a doctor.
AllopurinolAzathioprine
Severe
How does the drug interact with Zyle-100 Tablet:
Co-administration of Zyle-100 Tablet with Azathioprine may increase the effects of azathioprine.

How to manage the interaction:
There may be a possibility of interaction between Azathioprine and Zyle-100 Tablet, but it can be taken if prescribed by a doctor. However, if you experience chills, fever, body pains, sore throat, weakness, muscle pain, mouth sores, easy bruising or bleeding, pale stools, darkened urine, or severe nausea, vomiting, and diarrhoea, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Purines are found in certain foods such as alcohol, fish, meat, bacon. People with gout should restrict or avoid them greatly.

  • Losing weight helps lower the levels of uric acid.

  • It is also beneficial to drink plenty of fluids. However, the restricted use of alcohol and tobacco is recommended, raising the levels of uric acid.

  • Maintain a diet that is rich in fruits, vegetables, whole grains, and low-fat dairy products.

Habit Forming

No

Therapeutic Class

GOUT THERAPY

Zyle-100 Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Zyle-100 Tablet should not be taken along with alcohol as it increases uric acid levels.

bannner image

Pregnancy

Caution

Zyle-100 Tablet is a Category C pregnancy drug. If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.

bannner image

Breast Feeding

Unsafe

Zyle-100 Tablet is excreted in human breast milk, so it is not recommended during breastfeeding.

bannner image

Driving

Unsafe

Zyle-100 Tablet may make some people feel drowsy or sleepy. Do not drive or operate dangerous machinery if you are affected.

bannner image

Liver

Caution

Zyle-100 Tablet to be taken with caution, especially if you have a history of Liver diseases/conditions. The dose may have to be adjusted by your doctor.

bannner image

Kidney

Caution

Zyle-100 Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.

bannner image

Children

Unsafe

Zyle-100 Tablet hasn’t been studied and shouldn’t be used in people younger than 18 years to treat gout or kidney stones.

Have a query?

FAQs

Zyle-100 Tablet is used to treat Gout (increased uric acid leading to inflammation), kidney stones, and bladder stones. It decreases blood uric acid levels in the body.

Zyle-100 Tablet contains allopurinol, an enzyme inhibitor that works by inhibiting the enzyme xanthine oxidase, the enzyme responsible for uric acid formation. It stops uric acid formation inside the body without affecting the essential mechanism of cells and the body.Â

If you are taking Zyle-100 Tablet and it makes you vomit, then your contraceptive pill would not be effective, and it could lead to unwanted pregnancy. If you are of childbearing age, inform your doctor before starting Zyle-100 Tablet and use another form of contraceptive like condoms.

Initially, when you start Zyle-100 Tablet , it can increase the number of gout attacks. Please do not stop taking Zyle-100 Tablet on having an acute attack (sudden attack) of gout as it can make the attack even worse. Co-administration with an anti-inflammatory agent (colchicine) is recommended and slowly increasing the dose of Zyle-100 Tablet .

Generally, when Zyle-100 Tablet is given to elderly patients (above 65 years), the dose is lowered depending upon the patient's condition. Also, if mention all underlining disease you suffer from which could affect Zyle-100 Tablet , the dose will be adjusted accordingly by your doctor

Yes, Zyle-100 Tablet can cause drowsiness in some people. It can even make you feel dizzy or have a problem with coordination. It is advisable to avoid driving or operate machinery to avoid any unpleasant side effects.

No, Zyle-100 Tablet is not an anti-inflammatory medicine. It works by inhibiting the enzyme xanthine oxidase, the enzyme responsible for the formation of uric acid. It stops uric acid formation inside the body without affecting the essential mechanism of cells and the body.Â

It may take several weeks to lower the uric acid levels, before you start feeling better or notice any significant reduction in attacks of gout.

Zyle-100 Tablet may cause side effects such as nausea, vomiting, diarrhoea, stomach upset, or drowsiness. If these side effects persist or worsen, please consult your doctor.

It is preferable to take Zyle-100 Tablet after a meal to prevent stomach upset. But take it at the same time every day to help you remember to take it. However, follow your doctor’s instructions carefully.

You may experience an increase in gout attacks after you have started taking Zyle-100 Tablet . However, with several months of therapy, these attacks typically become less severe and shorter. This increase in attacks could be due to slow breakdown of uric acid crystals, causing fluctuations in blood uric acid levels. If you still have any concerns, please discuss with your doctor.

If you consume alcohol while taking Zyle-100 Tablet , it increases uric acid levels and worsen your condition. Therefore, avoid alcohol consumption while taking Zyle-100 Tablet .

If you forget to take a dose of Zyle-100 Tablet , take it as soon as you remember. But, if it is time for your next dose, skip the missed dose and take your regular dose. Do not take a double dose to make up for a forgotten dose.

Store Zyle-100 Tablet in a cool, dry and dark place. Protect from direct sunlight and moisture. Keep it out of sight and reach of children.

Country of origin

India

Manufacturer/Marketer address

Leeford Healthcare Limited , Leo House, Shaheed Bhagat Singh Nagar, Dugri-Dhandra Road, Near Joseph School , Ludhiana-141116.
Other Info - ZYL0041

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:49 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.6006.pdf
  2. https://medlineplus.gov/druginfo/meds/a682673.html
  3. https://www.drugs.com/allopurinol.html
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