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compositionComposition:CALCITRIOL-0.25MCG
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Karol-0.25 Tablet is used to treat low blood calcium levels. It contains Calcitriol, which raises Vitamin D levels and thereby increases calcium levels in the blood. In some cases, this medicine may cause side effects such as stomach upset, nausea, vomiting, loss of appetite, mood changes, weakness, tiredness, and headache. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CALCITRIOL-0.25MCG

Manufacturer/Marketer :

Kairos Healthcare

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Karol-0.25 Tablet

Karol-0.25 Tablet is a prescription medication used to treat and prevent low calcium levels and bone disease in people with kidney failure or parathyroid gland problems. It helps your body absorb calcium from your diet, supporting strong bones and healthy parathyroid gland function. This medicine is typically prescribed for long-term management of these chronic conditions.

It is important to take Karol-0.25 Tablet consistently at the same time each day to maintain a steady level of the medicine in your body. Your doctor will determine your exact schedule based on your blood test results. You can take this medicine with or without food. To get the best results, you may need to follow a specialised low-phosphorus diet and drink plenty of fluids to protect your kidneys.

While taking Karol-0.25 Tablet , some people may experience mild stomach discomfort, headaches, or a metallic taste in the mouth. However, you must contact your doctor immediately if you develop serious side effects such as severe nausea, vomiting, weakness, or unexplained bone pain, which can be signs of too much calcium in your blood.

Do not take this if you already have high calcium levels in your blood or high levels of vitamin D. Before starting this medication, talk to your doctor if you have a history of kidney stones, heart disease, or other kidney conditions. They will help determine if this medication is safe and appropriate for your specific health needs.

Certain medications like water pills or heart drugs can interact with Karol-0.25 Tablet and cause calcium levels to rise dangerously, while smoking and alcohol can further weaken your bones and reduce the drug's effectiveness. You must consult your doctor if you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, as your dose may need extra monitoring.

Uses of Karol-0.25 Tablet

Your doctor may prescribe this medicine to treat several conditions, including:

  • Low blood calcium levels (hypocalcemia): Karol-0.25 Tablet helps restore normal calcium levels in the blood, especially in people undergoing long-term kidney dialysis.
  • Underactive parathyroid glands (hypoparathyroidism): It replaces the active form of vitamin D that your body cannot make when parathyroid hormone levels are too low, raising blood calcium levels.
  • Bone disease from kidney failure (renal osteodystrophy): It helps prevent bone weakness, softening, and pain by regulating calcium and phosphorus levels in patients with chronic kidney disease.

Key Benefits

By keeping your calcium and phosphate levels balanced, Karol-0.25 Tablet provides several key benefits that improve your daily quality of life:

  • Prevents bone pain and weakness: It keeps your bones strong, reducing the risk of bone pain, deformities, and fractures, which helps you maintain your mobility.
  • Reduces muscle cramps and spasms: Proper calcium levels help your muscles contract and relax normally, preventing painful muscle spasms and tingling sensations.
  • Protects bone structure: By keeping parathyroid hormone levels in check, it helps prevent calcium from being stripped from your bones, keeping them structurally sound.
Side effects of Karol-0.25 Tablet
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • Reduce sodium intake to minimize calcium excretion in urine.
  • Limit animal protein consumption to decrease urinary calcium levels.
  • Increase fluid intake by drinking plenty of water to dilute urine.
  • Moderate calcium intake based on individual needs, avoiding drastic restriction.
  • Limit oxalate-rich foods like spinach and chocolate to minimize kidney stone formation.
  • Stay hydrated by drinking plenty of water.
  • Consider reducing vitamin D supplementation if excessive intake is contributing to hypercalciuria.
  • Regularly monitor urine calcium levels through 24-hour urine tests.
  • Always seek guidance from a healthcare expert prior to implementing substantial changes to your diet or lifestyle routine.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Stay hydrated by drinking plenty of water.
  • Avoid dairy product such as cheese, milk, yogurt and ice cream.
  • Maintain healthy weight and exercise daily.
  • Following a low-calcium diet can help reduce hypercalcemia symptoms.

Directions for Use

  • Take Karol-0.25 Tablet with or without food as advised by your doctor.
  • It is advised to take Karol-0.25 Tablet once daily; however, follow your doctor’s recommendation regarding the dosage and duration.
  • Swallow Karol-0.25 Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Karol-0.25 Tablet Works

Karol-0.25 Tablet is the active form of vitamin D3, which plays a vital role in maintaining the body's mineral balance. Unlike regular vitamin D supplements, which must first be processed by the liver and kidneys, this medicine is already in its active state. This means it can start working immediately in your body, which is especially important for people whose kidneys cannot convert standard vitamin D into its active form. Once in your system, Karol-0.25 Tablet binds to specific receptors in your intestines, causing your body to absorb more calcium and phosphorus from the foods you eat. At the same time, it signals your parathyroid glands to slow down the production of parathyroid hormone. High levels of this hormone can cause calcium to be stripped from your bones, so lowering it helps keep your bones strong and intact.
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Alcohol

Caution

Drinking alcohol can affect calcium absorption; hence, it is advised to limit the alcohol intake while using Karol-0.25 Tablet .

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Pregnancy

Consult your doctor

Use higher doses of Karol-0.25 Tablet during pregnancy than the daily dietary allowance only when the doctor advises. Calcitriol in higher doses may harm the fetus. Your doctor will weigh the potential risks and benefits before prescribing Karol-0.25 Tablet .

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Breast Feeding

Consult your doctor

Consult your doctor before taking Karol-0.25 Tablet if you are breastfeeding. Karol-0.25 Tablet can pass into the breast milk. If Karol-0.25 Tablet is used during breastfeeding, please monitor the mother and the infant's serum calcium levels.

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Driving

Safe if prescribed

Karol-0.25 Tablet may not affect your ability to drive.

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Liver

Caution

Before taking $ name, let your doctor know if you have any history of liver disease. Hepatic impairment/liver disease can alter the metabolic and therapeutic activity of certain Vitamin D forms.

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Kidney

Caution

It is advised to seek a doctor's advice before starting Karol-0.25 Tablet if you have kidney diseases like kidney stones or are undergoing dialysis. Calcitriol in Karol-0.25 Tablet increases inorganic phosphate levels in serum; hence, caution should be taken in patients undergoing dialysis to maintain adequate phosphorus levels and avoid ectopic calcification (calcium deposition).

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Children

Caution

Karol-0.25 Tablet should be used with caution in children and only if prescribed by a doctor.

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Heart

Consult your doctor

Let your physician know if you have any pre-existing heart problems.

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Geriatrics

Consult your doctor

Limited information available for use of Karol-0.25 Tablet in elderly patients. Please consult your doctor.

What if I have taken an overdose of Karol-0.25 Tablet

Taking too much of this medicine can cause dangerously high calcium levels in your blood, which can harm your kidneys and heart. If you suspect an overdose or experience severe weakness, confusion, or extreme vomiting, seek immediate emergency medical attention or contact a poison control centre right away.

Diet & Lifestyle Advise

  • Follow your recommended diet closely: Your doctor or dietitian will likely prescribe a specific diet. Pay close attention to your daily intake of calcium and phosphorus, as both can significantly impact how this medication works.
  • Stay well-hydrated: Drink plenty of fluids, especially water, throughout the day. Proper hydration helps prevent the formation of kidney stones, which can occur when calcium levels rise.
  • Avoid self-treating with supplements: Do not take over-the-counter calcium supplements, vitamin D, or antacids without checking with your doctor first, as these can easily cause your calcium levels to become too high.
  • Get regular blood tests: Attend all scheduled laboratory appointments. Regular blood tests are necessary to monitor your calcium, phosphorus, and kidney function so your doctor can adjust your medication safely.
health query

Have a query?

How Soon It Starts Working

  • The time required for Karol-0.25 Tablet to start to work: Karol-0.25 Tablet starts to show its action within 2 to 6 hours of administration.
  • The time for which the effects of Karol-0.25 Tablet last: Karol-0.25 Tablet effect lasts for 24 hours.

Storage

• Store Karol-0.25 Tablet capsules and tablets at room temperature, ideally between 15°C and 30°C (59°F to 86°F).

What if you forget to take Karol-0.25 Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for the missed one. Talk to your doctor or pharmacist if you are unsure what to do.

Drug Warnings

  • Inspect your medication: Check your capsules or tablets before taking them. Do not use them if the packaging is damaged, if the capsules are leaking, or if the tablets appear discoloured or cracked.
  • Watch for early signs of high calcium: Learn to recognise the early warning signs of too much calcium, such as dry mouth, a metallic taste, headache, and constipation, and report them to your doctor immediately.
  • Inform all healthcare providers: Let your dentist, surgeon, and any other specialists know that you are taking Karol-0.25 Tablet , especially if you are scheduled for any medical procedures, surgery, or tests.
  • Do not share this medicine: Karol-0.25 Tablet is prescribed specifically for your current condition. Sharing it with others can lead to severe health complications.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor about all the medicines you are using before starting Karol-0.25 Tablet , as they may interact with your treatment.

  • Thiazide water pills (diuretics): Taking these with Karol-0.25 Tablet can increase the risk of developing dangerously high calcium levels in your blood.
  • Heart medications (like digoxin): High calcium levels caused by Karol-0.25 Tablet can increase the risk of irregular heartbeats and digitalis toxicity.
  • Magnesium-containing antacids: Combining these can lead to high magnesium levels in the blood, especially in patients on dialysis.
  • Cholestyramine or mineral oil: These substances can reduce how much of this medicine your body absorbs, making your treatment less effective.
CalcitriolFosphenytoin
Severe
CalcitriolCarbamazepine
Severe

Drug-Drug Interactions

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CalcitriolFosphenytoin
Severe
How does the drug interact with Karol-0.25 Tablet:
Taking Karol-0.25 Tablet with Fosphenytoin can reduce the levels and efficacy of Karol-0.25 Tablet.

How to manage the interaction:
Taking Karol-0.25 Tablet with Fosphenytoin together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice any symptoms of sudden dizziness, weakness, chest pain or pressure, abnormal body movements, uncontrollable eye movements, itching, burning, or tingling sensation, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice. Do not discontinue the medication without consulting a doctor.
CalcitriolCarbamazepine
Severe
How does the drug interact with Karol-0.25 Tablet:
Co-administration of Karol-0.25 Tablet with Carbamazepine may decrease the effects of Karol-0.25 Tablet.

How to manage the interaction:
Although there is an interaction, Karol-0.25 Tablet can be taken with Carbamazepine if prescribed by the doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
CalcitriolColecalciferol
Severe
How does the drug interact with Karol-0.25 Tablet:
Co-administration of Cholecalciferol and Karol-0.25 Tablet are forms of vitamin D, and taking too much vitamin D may lead to toxic effects.

How to manage the interaction:
Although there is a possible interaction between colecalciferol and Karol-0.25 Tablet, you can take these medicines together if prescribed by your doctor. If you notice any of these symptoms - irregular heartbeat, seizures, weakness, tiredness, headache, dizziness, ringing in the ears, loss of appetite, feeling sick, dry mouth, strange taste in your mouth, muscle or bone pain, thirst, losing weight, eye infection, sensitivity to light, runny nose or itching - contact a doctor right away. Do not discontinue any medications without consulting a doctor.
CalcitriolBurosumab
Severe
How does the drug interact with Karol-0.25 Tablet:
Co-administration of Karol-0.25 Tablet and Burosumab may cause increases in phosphorus and vitamin D levels in the blood, which may lead to an increased risk of kidney stones.

How to manage the interaction:
There may be a possibility of interaction between Karol-0.25 Tablet and Burosumab, but it can be taken if prescribed by a doctor. If you have any of these symptoms like kidney stones, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice. Do not discontinue the medication without consulting a doctor.
CalcitriolDigitoxin
Severe
How does the drug interact with Karol-0.25 Tablet:
Co-administration of Karol-0.25 Tablet with Digitoxin may increase the risk or severity of digitoxin toxicity and irregular heart rhythm.

How to manage the interaction:
Although there is an interaction, Karol-0.25 Tablet can be taken with Digitoxin if prescribed by the doctor. Consult the prescriber if you experience symptoms that could indicate high blood calcium, such as weakness, fatigue, headache, dizziness, drowsiness, ringing in the ears, loss of appetite, nausea, vomiting, constipation, dry mouth, a metallic taste in the mouth, bone or muscle pain, incoordination, frequent urination, and weight loss. Also, seek medical attention if you experience symptoms of digitoxin toxicity, such as blurred vision, slow pulse, or irregular heartbeats. Do not discontinue the medication without consulting a doctor.
CalcitriolDihydrotachysterol
Severe
How does the drug interact with Karol-0.25 Tablet:
Co-administration of Karol-0.25 Tablet with Dihydrotachysterol can increase the risk of adverse effects.

How to manage the interaction:
Co-administration of Dihydrotachysterol with Karol-0.25 Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms - irregular heartbeat, seizures, weakness, tiredness, headache, dizziness, ringing in the ears, loss of appetite, feeling sick, throwing up, constipation, dry mouth, strange taste in your mouth, muscle or bone pain, trouble coordinating movements, weak muscles, peeing a lot, feeling very thirsty, losing weight, eye infection, sensitivity to light, itching, or a higher body temperature - make sure to call a doctor right away. Do not discontinue any medications without consulting a doctor.
CalcitriolParicalcitol
Severe
How does the drug interact with Karol-0.25 Tablet:
Co-administration of Paricalcitol and Karol-0.25 Tablet are forms of vitamin D, and taking too much vitamin D may lead to toxic effects related to excessive calcium levels in the blood and urine.

How to manage the interaction:
Concomitant use of Paricalcitol with Karol-0.25 Tablet can lead to an interaction, it can be taken if advised by a doctor. Consult the prescriber if you experience symptoms of vitamin D intoxication such as weakness, fatigue, headache, vertigo, drowsiness, ringing in the ears, loss of appetite, nausea, vomiting, constipation, dry mouth, metallic taste, muscle pain, bone pain, muscle incoordination, and low muscle tone. Do not discontinue the medication without consulting a doctor.
CalcitriolRifapentine
Severe
How does the drug interact with Karol-0.25 Tablet:
Co-administration of Rifapentine with Karol-0.25 Tablet may decrease the effects of Karol-0.25 Tablet.

How to manage the interaction:
Although there is an interaction, Karol-0.25 Tablet can be taken with Rifapentine if prescribed by the doctor. The doctor may recommend dose adjustment or special tests to use both medicines safely. Do not discontinue the medication without consulting a doctor.
CalcitriolMetolazone
Severe
How does the drug interact with Karol-0.25 Tablet:
Co-administration of Metolazone with Karol-0.25 Tablet can cause blood calcium levels to become too high.

How to manage the interaction:
Although there is an interaction, Karol-0.25 Tablet can be taken with metolazone if prescribed by the doctor. Consult the doctor if you experience symptoms such as dizziness, drowsiness, weakness, lethargy, headache, nausea, vomiting, or seizures. Do not discontinue the medication without consulting a doctor.
CalcitriolAmobarbital
Severe
How does the drug interact with Karol-0.25 Tablet:
Co-administration of Amobarbital and Karol-0.25 Tablet may decrease the effects of Karol-0.25 Tablet.

How to manage the interaction:
Co-administration of Karol-0.25 Tablet with Amobarbital can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these symptoms, it's important to contact a doctor right away. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • High-calcium foods: Consuming large amounts of calcium-rich foods (like dairy products) without medical supervision can lead to a sudden spike in blood calcium levels.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[MULTIMINERALS]

FAQs

Karol-0.25 Tablet can increase calcium levels in your blood and urine. If calcium levels become too high, especially with long-term use, it may lead to kidney stones and, in severe or prolonged cases, kidney damage. Your doctor will monitor your calcium and kidney function with regular blood tests and adjust your dose if needed. Contact your doctor if you experience symptoms such as severe back or side pain, blood in the urine, or difficulty passing urine.
Dairy products are very high in calcium. Consuming large amounts while taking Karol-0.25 Tablet can cause your blood calcium levels to rise too quickly. It is best to follow the dietary plan recommended by your doctor or dietitian. Talk to your doctor about your daily intake.
Early signs include a metallic taste in your mouth, dry mouth, headache, loss of appetite, and constipation. More severe signs include vomiting, extreme fatigue, confusion, or increased thirst and urination. If you notice these, contact your doctor right away.
Karol-0.25 Tablet should only be used during pregnancy if the benefits outweigh the risks. High calcium levels in pregnancy can be harmful to the developing baby. If you are pregnant or planning to become pregnant, talk to your doctor.
Yes, regular blood tests are essential. Your doctor will need to check your calcium, phosphorus, and kidney function levels frequently, especially when you first start treatment or when your dose is adjusted. Talk to your doctor to set up your testing schedule.
You should avoid taking any other vitamin D supplements or multivitamins containing vitamin D while using Karol-0.25 Tablet unless specifically advised by your doctor. Doing so can lead to an accidental overdose. Talk to your doctor or pharmacist before starting any new supplement.
Because Karol-0.25 Tablet is already in its active form, it begins working in your digestive tract shortly after you take it. However, it may take several days or weeks of consistent use, alongside dose adjustments, for your blood test results to show stable calcium levels. Talk to your doctor about what to expect.
Mild constipation can sometimes occur, but it can also be an early sign of high calcium levels in your blood. You should let your healthcare provider know if you develop new or worsening constipation while taking this medication. Talk to your doctor for safe ways to manage this.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Clinical Reference Document. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.11802 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Calcitriol [Product Label]. 2019. [Accessed on 20 Jun, 2023]Check here
  4. Office of Dietary Supplements - Vitamin B12 [Internet]. Ods.od.nih.gov. 2022 [Accessed on 19 July 2022]Check here
  5. Lung BE, Mowery ML, Komatsu DEE. Calcitriol November 2021. NIH, National Library of Medicine. National Center for Biotechnology Information. Statpearls. 2023. [Accessed on 10th February 2024]Check here
  6. Calcitriol. Daily Med: National Library of Medicine: National Institute of Health. [Revised in August 2019] [Accessed on 10th February 2024]Check here
  7. Central Drugs Standard Control Organisation (CDSCO). [Accessed on 03 Apr. 2019]Check here

Country of origin

India

Manufacturer/Marketer address

No. 30, Dr MB Velkar Street, Mumbai-400002, Maharashtra, India
Other Info - KAR0220

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