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Nervup PG Capsule is used to treat neuropathic pain. It helps rejuvenate and protect damaged nerve cells. Also, it helps in providing a protective effect on the nerve tissues and brain. Therefore, it helps provide relief from neuropathic pain. In some cases, you may experience certain common side effects such as dizziness, sleepiness, tiredness, nausea and vomiting. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

ALPHA LIPOIC ACID-100MG+METHYLCOBALAMIN-750MCG+PREGABALIN-75MG

Manufacturer/Marketer :

Abbott India Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Nervup PG Capsule

Nervup PG Capsule is a medicine primarily used to manage neuropathic pain, which is chronic pain caused by nerve damage. It is commonly prescribed for conditions such as diabetic neuropathy, pain following a shingles infection, and peripheral nerve damage. By calming overactive nerves and supporting nerve repair, this medicine helps reduce persistent, burning, or shooting pain sensations.

To achieve the best results, you must take Nervup PG Capsule regularly and consistently at the same times every day. It can be taken with or without food, but maintaining a set routine helps keep steady levels of the medicine in your body. Combining this treatment with simple lifestyle adjustments, like eating a balanced diet and doing light, regular exercise, can further support your recovery.

Some people may experience mild side effects, such as drowsiness, dizziness, or a dry mouth. While these are usually temporary, you should consult your doctor immediately if you experience serious issues, such as severe swelling in your hands or feet, unexplained muscle pain, or sudden mood changes.

Do not take this if you have a known allergy to any of the ingredients in this medicine. Before starting treatment, tell your doctor if you have kidney problems, heart conditions, or a history of mood disorders, as your dose may need to be adjusted or monitored closely.

This medicine can interact with alcohol, which can significantly increase drowsiness and dizziness. It is important to talk to your doctor or pharmacist if you are pregnant, planning a pregnancy, breastfeeding, or are an elderly individual, as special precautions or adjustments may be needed to ensure your safety.

 

Uses of Nervup PG Capsule

Your doctor may prescribe this medicine to treat several conditions, including:

  • Diabetic Neuropathy: Helps relieve the burning, stabbing, or tingling pain in the hands and feet caused by nerve damage from high blood sugar.
  • Post-Herpetic Neuralgia: Eases the persistent, sharp nerve pain that remains after a shingles infection has healed.
  • Peripheral Neuropathy: Treats ongoing nerve pain caused by physical injury, infections, or metabolic issues affecting the outer nerves.
     

Key Benefits

When taken as prescribed, this medicine offers several important benefits, including:

  • Relief from Nerve Pain and Discomfort: Nervup PG Capsule helps reduce symptoms of nerve-related pain, including burning, tingling, and sharp sensations, improving physical comfort and helping you carry out daily activities more easily.
  • Improved Sleep and Daily Functioning: By reducing the intensity and frequency of nerve pain episodes, Nervup PG Capsule may support better sleep quality and help you return to normal routines with less discomfort.
  • Support for Better Nerve Function: Nervup PG Capsule helps manage symptoms caused by nerve irritation or damage, which may improve sensation, reduce sudden shooting pain episodes, and support more stable movement.
     

Directions for Use

  • Nervup PG Capsule can be taken with or without food, as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Nervup PG Capsule as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Nervup PG Capsule Works

Nervup PG Capsule works through a combination of three active ingredients that target nerve pain and damage in different ways: Pregabalin calms overactive nerves in the body. It does this by binding to specific calcium channels in the brain and spinal cord, which decreases the release of chemical pain signals, thereby reducing the sensation of pain. Methylcobalamin is an active form of Vitamin B12. It helps produce myelin, the protective covering that surrounds and insulates nerve fibres, which is essential for repairing damaged nerves and restoring proper nerve function. Alpha Lipoic Acid is a potent antioxidant. It neutralises harmful chemicals called free radicals that cause oxidative stress and damage to nerves. It also improves blood flow to the nerves, ensuring they receive vital nutrients and oxygen.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Nervup PG Capsule as it may increase dizziness and sleepiness.

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Pregnancy

Caution

Please consult your doctor if you have any concerns about this. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor before taking Nervup PG Capsule ; your doctor will decide whether breastfeeding mothers can take Nervup PG Capsule or not.

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Driving

Caution

Nervup PG Capsule may cause drowsiness, sleepiness and tiredness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Nervup PG Capsule should not be given to children as the safety and efficacy have not been established.

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Heart

Caution

Nervup PG Capsule should be used with caution in patients with heart problems. Therefore, please inform your doctor before using Nervup PG Capsule .

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Geriatrics

Caution

Nervup PG Capsule should be used with caution in geriatric patients. Therefore, please inform your doctor before using Nervup PG Capsule .

What if I have taken an overdose of Nervup PG Capsule

If you suspect an overdose, seek immediate medical attention or call emergency services right away. Signs of an overdose may include extreme sleepiness, confusion, agitation, or restlessness.

Diet & Lifestyle Advise

  • Monitor your blood sugar levels: If you have diabetes, keeping your blood sugar within your target range is crucial to prevent further nerve damage.
  • Eat a nutrient-dense diet: Focus on foods rich in B-complex vitamins, such as green leafy vegetables, eggs, lean meats, and fortified cereals, to support nerve health.
  • Engage in gentle physical activity: Regular, low-impact exercises like walking, stretching, or swimming can improve blood circulation and help reduce nerve pain.
  • Protect your feet: Check your feet daily for cuts, blisters, or redness, especially if you have reduced sensation from neuropathy.
  • Avoid smoking and limit alcohol: Tobacco and excess alcohol can worsen nerve damage and increase the severity of neuropathic pain.
     

Health Queries

I am taking Nervup PG for a burning sensation on the back of my left thigh, but it has not fully cured the pain; should I continue taking this medicine or do you suggest an alternative medication?

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

Nervup PG (containing Pregabalin) is effective for nerve pain, but it often takes 2 to 4 weeks to show full benefits. Do not stop taking this medicine abruptly, as sudden discontinuation can cause withdrawal symptoms. If your pain has not improved, your doctor may need to increase the dosage or investigate the root cause, such as a pinched nerve in your lower back. While alternative medications like Gabapentin or Duloxetine are available, you should consult your prescribing physician before making any changes to safely evaluate and adjust your treatment plan.
health query

Have a query?

How Soon It Starts Working

The time required for Nervup PG Capsule to start to work: The time required for Nervup PG Capsule to show its action is unknown. The time for which the effects of Nervup PG Capsule last: The duration of action for Nervup PG Capsule is unknown.

What if you forget to take Nervup PG Capsule

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store Nervup PG Capsule at room temperature, ideally between 15°C and 30°C (59°F to 86°F), in a cool, dry place.

Drug Warnings

  • Avoid driving or operating machinery: This medicine can cause significant dizziness and drowsiness. Do not drive or perform activities requiring alertness until you know how this medicine affects you.
  • Do not stop taking this medicine suddenly: Stopping this treatment abruptly can cause withdrawal symptoms, such as sleep disturbances, headaches, nausea, or a return of pain. Your doctor will help you by gradually decreasing the dose.
  • Watch for mood changes: Pay close attention to any sudden shifts in your mood, behaviour, or thoughts of self-harm, and report them to your doctor immediately.
  • Inform your medical team: Let any doctor, dentist, or surgeon know you are taking Nervup PG Capsule before undergoing any medical procedures or tests.
  • Monitor for fluid retention: If you notice sudden weight gain or swelling in your lower limbs, contact your healthcare provider, especially if you have a history of heart issues.
     

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact.

  • Central Nervous System Depressants: Taking this medicine with anxiety medications, sleeping pills, or muscle relaxants can cause extreme drowsiness and slowed breathing.
  • Certain Diabetes Medications: Combining it with thiazolidinedione-class medicines (such as pioglitazone) may increase the risk of weight gain and fluid retention.
  • Narcotic Painkillers: Using this medicine with strong pain relievers (like opioids) may worsen sleepiness and constipation.
     
Pregabalin + Mecobalamin + Thioctic acidRemifentanil
Severe
Pregabalin + Mecobalamin + Thioctic acidTramadol
Severe

Drug-Drug Interactions

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Pregabalin + Mecobalamin + Thioctic acidRemifentanil
Severe
How does the drug interact with Nervup PG Capsule:
Using Nervup PG Capsule together with Remifentanil causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking remifentanil and Nervup PG Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience excessive sleepiness, dizziness, difficulty focusing, impaired-judgment, reaction speed and motor coordination, please consult a doctor immediately. Do not exceed the doses or frequency and duration of use advised by the doctor. Do not discontinue any medications without a doctor's advice.
Pregabalin + Mecobalamin + Thioctic acidTramadol
Severe
How does the drug interact with Nervup PG Capsule:
When Tramadol is used with Nervup PG Capsule, it may cause central nervous system depression(a physiological state that can result in a decreased rate of breathing, decreased heart rate, loss of consciousness).

How to manage the interaction:
Although taking tramadol and Nervup PG Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience excessive sleepiness, dizziness, difficulty focusing, impaired-judgment, reaction speed and motor coordination, please consult a doctor immediately. Do not exceed the doses or frequency and duration of use advised by the doctor. Do not discontinue any medications without a doctor's advice.
Pregabalin + Mecobalamin + Thioctic acidAlfentanil
Severe
How does the drug interact with Nervup PG Capsule:
Using Nervup PG Capsule together with Alfentanil may cause central nervous system depression(a physiological state that can result in a decreased rate of breathing, decreased heart rate, loss of consciousness).

How to manage the interaction:
Although taking Nervup PG Capsule and Alfentanil together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience excessive sleepiness, dizziness, difficulty focusing, impaired-judgment, reaction speed and motor coordination, please consult a doctor immediately. Do not exceed the doses or frequency and duration of use advised by the doctor. Do not discontinue any medications without a doctor's advice.
Pregabalin + Mecobalamin + Thioctic acidSodium oxybate
Severe
How does the drug interact with Nervup PG Capsule:
Using Sodium oxybate together with Nervup PG Capsule may increase the risk of side effects.

How to manage the interaction:
Although taking Nervup PG Capsule with Sodium oxybate together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience excessive sleepiness, confusion, depression, difficulty breathing, and impaired-thinking, judgment, and motor coordination, consult the doctor. Avoid operating machinery or engaging in potentially dangerous activities. Also, be careful when getting up from a sitting or lying down posture. Do not stop using any medications without talking to a doctor.
Pregabalin + Mecobalamin + Thioctic acidCodeine
Severe
How does the drug interact with Nervup PG Capsule:
Using Nervup PG Capsule together with Codeine may cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Codeine and Nervup PG Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience excessive sleepiness, dizziness, difficulty focusing, impaired-judgment, reaction speed and motor coordination, please consult a doctor immediately. Do not exceed the doses or frequency and duration of use advised by the doctor. Do not discontinue any medications without a doctor's advice.
Pregabalin + Mecobalamin + Thioctic acidKetamine
Severe
How does the drug interact with Nervup PG Capsule:
Taking Ketamine with Nervup PG Capsule may increase the risk of side effects.

How to manage the interaction:
Although taking Nervup PG Capsule and ketamine together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience symptoms such as dizziness, drowsiness, confusion, difficulty focusing, breathing difficulty, consult the doctor. Do not exceed the doses, frequency, or duration of usage advised by a doctor. You should avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
Pregabalin + Mecobalamin + Thioctic acidPethidine
Severe
How does the drug interact with Nervup PG Capsule:
Using Nervup PG Capsule together with Pethidine causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking pethidine and Nervup PG Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience excessive sleepiness, dizziness, difficulty focusing, impaired-judgment, reaction speed and motor coordination, please consult a doctor immediately. Do not exceed the doses or frequency and duration of use advised by the doctor. Do not discontinue any medications without a doctor's advice.
Pregabalin + Mecobalamin + Thioctic acidTapentadol
Severe
How does the drug interact with Nervup PG Capsule:
Using Tapentadol together with Nervup PG Capsule may cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Taking Nervup PG Capsule with Tapentadol can result in an interaction, it can be taken if a doctor has advised it. However, if you experience excessive sleepiness, dizziness, difficulty focusing, impaired-judgment, reaction speed and motor coordination, please consult a doctor immediately. Do not exceed the doses or frequency and duration of use advised by the doctor. Do not discontinue any medications without a doctor's advice.
Pregabalin + Mecobalamin + Thioctic acidDezocine
Severe
How does the drug interact with Nervup PG Capsule:
Using Nervup PG Capsule together with Dezocine causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking Dezocine and Nervup PG Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience excessive sleepiness, dizziness, difficulty focusing, impaired-judgment, reaction speed and motor coordination, please consult a doctor immediately. Do not exceed the doses or frequency and duration of use advised by the doctor. Do not discontinue any medications without a doctor's advice.
Pregabalin + Mecobalamin + Thioctic acidHydromorphone
Severe
How does the drug interact with Nervup PG Capsule:
Using Nervup PG Capsule together with Hydromorphone causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Hydromorphone and Nervup PG Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience excessive sleepiness, dizziness, difficulty focusing, impaired-judgment, reaction speed and motor coordination, please consult a doctor immediately. Do not exceed the doses or frequency and duration of use advised by the doctor. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Avoid drinking alcohol while taking this medicine, as it can severely multiply side effects like dizziness, drowsiness, and lack of coordination.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

FAQs

Nervup PG Capsule is used to treat neuropathic pain, a chronic progressive nerve disease which causes nerve pain due to nerve damage.
Nervup PG Capsule contains Pregabalin, methylcobalamin and alpha-lipoic acid. Pregabalin affects the chemicals in the brain that send pain signals across the nervous system. It works by binding to the specific site on voltage-gated calcium channels; this helps in relieving nerve pain. Methylcobalamin helps in the rejuvenation and protection of damaged nerve cells by producing a substance called myelin. Alpha-lipoic acid helps in providing a protective effect on the nerve tissues and brain.
Nervup PG Capsule is a combination of Alpha lipoic acid, Methylcobalamin and Pregabalin as its active substances.
No, you should avoid alcohol while taking this medicine. Alcohol can significantly increase side effects like dizziness, drowsiness, and confusion, making activities like driving unsafe. Talk to your doctor if you have concerns.
Yes, weight gain is a recognized side effect for some individuals taking this medicine, often due to an increased appetite or fluid retention. Regular physical activity and a balanced diet can help manage this. Talk to your doctor if you experience sudden or excessive weight gain.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed one and continue with your regular schedule. Never take a double dose to make up for a missed one. Talk to your doctor or pharmacist if you have questions.
No, you should not stop taking this medicine suddenly, even if you feel better. Stopping abruptly can lead to withdrawal symptoms like anxiety, nausea, or a return of your pain. Your doctor will help you stop safely by gradually decreasing your dose.
This medicine is generally not recommended during pregnancy unless your doctor decides the benefits clearly outweigh the risks. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor before starting this medicine.
Yes, drowsiness and dizziness are among the most common side effects of this medicine. These effects are usually strongest when you first start the treatment or when your dose is increased. Avoid driving or operating machinery until you know how it affects you, and talk to your doctor if these feelings persist.
While Nervup PG Capsule helps repair nerve fibres and manage the pain associated with nerve damage, it may not completely cure the underlying medical condition causing the damage. It is designed to relieve pain and support nerve recovery over time. Talk to your doctor to understand your long-term treatment plan.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 021446S026,022488S005Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). Download [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Pregabalin Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Pregabalin Pregabalin. 2009. [Accessed on 22 Apr. 2019]Check here
  5. MedlinePlus MedlinePlus. [Accessed on 22 Apr. 2019]Check here
  6. Mecobalamin Template Oral Website. [Accessed on 02 Jun. 2026]Check here
  7. Pregabalin, Methylcobalamin, Alpha Lipoic Acid, Pyridoxine Hydrochloride and Folic Acid [Patient Information Sheet]. 2021. [Accessed on 21 Aug. 2024]Check here

Country of origin

India

Manufacturer/Marketer address

401, LSC, C-Block, Mohan Place Saraswati Vihar Delhi DL 110034 In
Other Info - NER0026

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