About TENELIGLIPTIN+METFORMIN HYDROCHLORIDE
METFORMIN HYDROCHLORIDE+TENELIGLIPTIN belongs to the group of medications called 'antidiabetic agents' used to treat type 2 diabetes mellitus. Type-2 diabetes mellitus is also known as non-insulin-dependent diabetes or adult-onset diabetes. It is a medical condition in which blood glucose levels are above normal due to insulin deficiency, insulin resistance, or both.
METFORMIN HYDROCHLORIDE+TENELIGLIPTIN is a combination of two medicines, namely: Teneligliptin and Metformin hydrochloride. Teneligliptin works by stopping the action of the dipeptidyl peptidase-4 enzyme, which in turn increases the insulin levels in the body and reduces the glucagon levels. Metformin hydrochloride acts by decreasing liver glucose production and intestinal glucose uptake. Together, METFORMIN HYDROCHLORIDE+TENELIGLIPTIN helps control blood sugar levels.
Take METFORMIN HYDROCHLORIDE+TENELIGLIPTIN as prescribed. You are advised to take METFORMIN HYDROCHLORIDE+TENELIGLIPTIN for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, METFORMIN HYDROCHLORIDE+TENELIGLIPTIN may cause side effects such as nausea, constipation, abdominal pain, bloating, loss of appetite, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to consult your doctor if you experience these side effects persistently.
Do not take METFORMIN HYDROCHLORIDE+TENELIGLIPTIN if you are allergic to any of its contents. Do not use this medicine if you have heart failure, bladder cancer, or diabetic ketoacidosis (a complication of diabetes). METFORMIN HYDROCHLORIDE+TENELIGLIPTIN may cause 'lactic acidosis' (accumulation of lactic acid in the blood), which requires immediate medical attention. The risk increases if you are previously diagnosed with kidney or liver diseases. Do not consume alcohol or fast for prolonged periods. Also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
Uses of TENELIGLIPTIN+METFORMIN HYDROCHLORIDE
Type 2 Diabetes Mellitus
Medicinal Benefits
METFORMIN HYDROCHLORIDE+TENELIGLIPTIN is suggested for the management of type 2 diabetes to be followed with the right diet and exercise. METFORMIN HYDROCHLORIDE+TENELIGLIPTIN is a combination of two medicines, namely: Teneligliptin and Metformin hydrochloride. Teneligliptin works by stopping the action of the dipeptidyl peptidase-4 enzyme, which in turn increases the insulin levels in the body and reduces the glucagon levels. Metformin hydrochloride acts by decreasing liver glucose production and intestinal glucose uptake. Together, METFORMIN HYDROCHLORIDE+TENELIGLIPTIN helps control blood sugar levels.
Directions for Use
Storage
Side Effects of TENELIGLIPTIN+METFORMIN HYDROCHLORIDE
- Constipation
- Nausea
- Flatulence
- Bloating
- Abdominal discomfort
- Loss of appetite
- Diarrhoea
In-Depth Precautions and Warning
Drug Warnings
METFORMIN HYDROCHLORIDE+TENELIGLIPTIN should be used with caution in patients with heart diseases. METFORMIN HYDROCHLORIDE+TENELIGLIPTIN may cause ‘lactic acidosis’ (buildup of lactic acid in the blood), characterized by abdominal pain, muscle cramps, vomiting, severe fatigue, and difficulty breathing; consult your doctor immediately if you experience these symptoms. Inform your doctor if you have severe liver or kidney problems. Do not consume excess alcohol as it increases the risk of lactic acidosis.
Drug Interactions
Drug-Drug Interactions: METFORMIN HYDROCHLORIDE+TENELIGLIPTIN may have an interaction with antibiotics (rifampicin, tetracycline, clarithromycin), anti-fungal (fluconazole), other oral antidiabetics, medicines used to treat gout (probenecid).
Drug-Food Interactions: Intake of excess alcohol may increase the chance of a life-threatening condition known as lactic acidosis.
Drug-Disease Interactions: Inform your doctor if you have heart diseases (congestive heart failure and myocardial infarction), vitamin B12 deficiency, alcoholism, type I diabetes, bladder cancer, oedema (fluid retention), liver disease, premenopausal anovulation, obesity (weight gain), or anaemia.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionAvoid drinking alcohol with METFORMIN HYDROCHLORIDE+TENELIGLIPTIN as it may increase the risk of hypoglycemia and lactic acidosis.
Pregnancy
cautionPlease consult your doctor if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
cautionMETFORMIN HYDROCHLORIDE+TENELIGLIPTIN should not be used in breastfeeding mothers as it may pass into breast milk. Consult your doctor if you have any concerns.
Driving
cautionIt is not known if METFORMIN HYDROCHLORIDE+TENELIGLIPTIN affects your ability to drive. Drive or operate machinery only if you are alert.
Liver
cautionMETFORMIN HYDROCHLORIDE+TENELIGLIPTIN should be taken with caution in patients with liver diseases. The dose may have to be adjusted by your doctor.
Kidney
cautionMETFORMIN HYDROCHLORIDE+TENELIGLIPTIN should be taken with caution in patients with kidney diseases. The dose may have to be adjusted by your doctor.
Children
unsafeMETFORMIN HYDROCHLORIDE+TENELIGLIPTIN is not recommended for use in children as the safety and effectiveness have not been established.
Habit Forming
Diet & Lifestyle Advise
- Eat at regular intervals. Avoid a long gap between a meal or snack.
- Monitor your blood sugar level regularly, especially when there are a lot of fluctuations.
- Invest at least 150 min of moderate-intensity physical activity and 15 minutes of high-intensity exercise every week.
- Lose weight gradually to achieve a healthy body mass index.
- Replace refined carbohydrates-containing foods with whole grain foods and increase fruits, vegetables, and other fibre-rich foods.
- Reduce saturated fat intake (or hidden fats) in food like chips, crisps, pastries, biscuits, and samosas. Choose omega 3 fatty acid-containing oils for daily cooking.
- Avoid stress as it may elevate your blood sugar level. You may adopt stress management techniques like mindfulness, yoga, or meditation to control stress.
- Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, cheese, etc).
- Try to quit smoking and reduce intake of carbohydrate-rich food like potato, rice, mangoes, bread, sugar, etc.
Special Advise
- Beware of hypoglycemia symptoms such as sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination, etc. Whenever you experience the above-mentioned symptoms, immediately consume 5-6 candies or 3 glucose biscuits or 3 teaspoons of honey/sugar and also get in touch with your physician. Make sure to carry these with you at all times, especially for long travels.
- METFORMIN HYDROCHLORIDE+TENELIGLIPTIN may lower vitamin B12 levels, so it is recommended to take blood tests regularly to check any vitamin deficiencies.
Patients Concern
Disease/Condition Glossary
Type 2 diabetes mellitus: It is a chronic condition in which blood glucose levels are elevated in the body. Insulin is responsible for the utilization of glucose by the cells. In type 2 diabetes, the body cells do not respond to insulin, or in later stages, your body may not produce enough insulin. Symptoms include excessive thirst, excessive hunger, fatigue, increased appetite and dry mouth. This condition may worsen over time and cause toxic effects if not properly treated.
