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compositionComposition:METFORMIN-500MG+TENELIGLIPTIN-20MG
prescription
Prescription Medicine
info
Zita Met Plus 20/500 Tablet 15's
Zita Met Plus 20/500 Tablet 15's
Zita Met Plus 20/500 Tablet 15's
Zita Met Plus 20/500 Tablet 15's
Zita Met Plus 20/500 Tablet 15's

Zita Met Plus 20/500 Tablet is used to treat type 2 diabetes mellitus. It works by decreasing liver glucose production, lowering intestinal glucose uptake and increasing insulin levels in the body. In some cases, this medicine may cause side effects such as nausea, vomiting, diarrhoea, headache, and stomach ache. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

METFORMIN-500MG+TENELIGLIPTIN-20MG

Manufacturer/Marketer :

Glenmark Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Zita Met Plus 20/500 Tablet

Zita Met Plus 20/500 Tablet belongs to the group of medications called ‘antidiabetic agents’ used to treat type 2 diabetes mellitus. This medication improves glycaemic control in diabetic patients who do not react well to Metformin alone.

Zita Met Plus 20/500 Tablet contains Metformin and Teneligliptin. Metformin acts by decreasing liver glucose production and intestinal glucose uptake. On the other hand, Teneligliptin increases the insulin levels in the body and reduces the glucagon levels. Together, Zita Met Plus 20/500 Tablet helps treat type 2 diabetes.

Zita Met Plus 20/500 Tablet may cause side effects such as nausea, vomiting, diarrhoea, headache, stomach ache, respiratory infection, weight gain, and sweating. Most of these side effects may not require medical attention and will likely resolve over time. However, if the side effects persist or worsen, consult your doctor.

Do not take Zita Met Plus 20/500 Tablet if you are allergic to any of its contents. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Let your doctor know if you are taking any other medicines or have pre-existing medical conditions to prevent any potential interactions.

Uses of Zita Met Plus 20/500 Tablet

Zita Met Plus 20/500 Tablet is used to treat type 2 diabetes. The detailed uses of Zita Met Plus 20/500 Tablet are as follows:

  • Management of Type 2 Diabetes Mellitus: Zita Met Plus 20/500 Tablet improves glycemic control in adults with Type 2 Diabetes Mellitus.
  • Improves Insulin Sensitivity: Zita Met Plus 20/500 Tablet helps the body respond better to insulin.
  • Reduces Glucose Production: Zita Met Plus 20/500 Tablet suppresses the excess sugar made by the liver.
  • Adjunct to lifestyle and therapy: Zita Met Plus 20/500 Tablet is prescribed alongside a healthy diet, regular physical activity to manage type 2 diabetes more effectively.

Key Benefits

  • Zita Met Plus 20/500 Tablet is indicated for the management of type 2 diabetes mellitus in adults. It contains Metformin and Teneligliptin.
  • Metformin is a biguanide, which works by reducing the production of glucose in the liver and decreasing its absorption from the intestines, thereby lowering blood sugar levels.
  • Teneligliptin is a dipeptidyl peptidase 4 (DPP-4) inhibitor that increases insulin secretion and decreases glucagon levels in the blood, especially after meals.
  • It is used when patients are unable to achieve sufficient glycemic control through lifestyle modifications such as diet and physical activity alone.
  • Zita Met Plus 20/500 Tablet is suitable for patients who have not responded adequately to treatment with sulfonylureas (e.g., glimepiride, gliclazide) in combination with dietary control and exercise.
  • It may also be prescribed when treatment with thiazolidinediones (e.g., pioglitazone) along with diet and exercise has failed to achieve satisfactory blood glucose control.
Side effects of Zita Met Plus 20/500 Tablet
  • If you experience low blood sugar levels, inform your doctor. They will assess the severity and make recommendations for the next actions.
  • Your doctor will assess your symptoms, blood sugar levels, and overall health before recommending the best course of action, which may include treatment, lifestyle modifications, or prescription adjustments.
  • Follow your doctor's instructions carefully to manage the episode and adjust your treatment plan.
  • Make medication adjustments as recommended by your doctor to prevent future episodes.
  • Implement diet and lifestyle modifications as your doctor advises to manage low blood sugar levels.
  • Monitor your blood sugar levels closely for patterns and changes.
  • Track your progress by recording your blood sugar levels, food intake, and physical activity.
  • Seek further guidance from your doctor if symptoms persist or worsen so that your treatment plan can be revised.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Directions for Use

  • Zita Met Plus 20/500 Tablet can be taken with or without food. However, taking it with food may help reduce stomach upset.
  • It is recommended to take Zita Met Plus 20/500 Tablet once daily or as advised by your doctor.
  • Swallow Zita Met Plus 20/500 Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Zita Met Plus 20/500 Tablet Works

Zita Met Plus 20/500 Tablet is a combination of two medicines, namely: Metformin and Teneligliptin. Metformin acts by decreasing liver glucose production and intestinal glucose uptake. On the other hand, Teneligliptin works by inhibiting the action of the dipeptidyl Peptidase 4 enzyme, which in turn increases insulin levels in the body and reduces glucagon levels.
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Alcohol

Caution

Alcohol may increase the risk of side effects and worsen the condition.

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Pregnancy

Caution

Zita Met Plus 20/500 Tablet is a category C drug. So, it should be used only when the benefits of this medicine outweigh the risks.

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Breast Feeding

Caution

Zita Met Plus 20/500 Tablet should not be used in breastfeeding mothers as it may get secreted in the breast milk and cause unwanted effects in the nursing babies.

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Driving

Caution

Zita Met Plus 20/500 Tablet may cause vision problems. So, do not drive or operate heavy machinery if you have any problems with your vision while using Zita Met Plus 20/500 Tablet .

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Liver

Caution

Zita Met Plus 20/500 Tablet should be taken with caution in patients with liver diseases. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Zita Met Plus 20/500 Tablet should be taken with caution, especially if you have a history of kidney diseases. The dose may have to be adjusted by your doctor.

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Children

Caution

Zita Met Plus 20/500 Tablet is not recommended for use in children below 18 years of age.

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Heart

Caution

Zita Met Plus 20/500 Tablet should be taken with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems before using Zita Met Plus 20/500 Tablet .

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Geriatrics

Caution

Limited information is available regarding the usage of Zita Met Plus 20/500 Tablet in elders, so please consult a doctor if you have any concerns.

What if I have taken an overdose of Zita Met Plus 20/500 Tablet

Take Zita Met Plus 20/500 Tablet only as prescribed by the physician. Avoid exceeding the recommended dose, as doing so could lead to an overdose, which might cause lactic acidosis. Symptoms of lactic acidosis may include nausea, vomiting, and weakness. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Diet & Lifestyle Advise

  • Eat at regular intervals. Do not take a long gap between a meal or snack.
  • Monitor your blood sugar level regularly, especially when there are a lot of fluctuations.
  • Invest at least 150 minutes of moderate-intensity physical activity and 15 minutes of high-intensity exercise every week.
  • Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).
  • Replace refined carbohydrate-containing foods with whole grain foods and increase fruits, veggies, and other fibre-enriched foods.
  • Reduce saturated fat intake (or hidden fats) in food like chips, crisps, pastries, biscuits, and samosas. Choose omega-3 fatty acid-containing oils for daily cooking. You may use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil for frying.
  • Do not take stress as it may elevate your blood sugar level. You may adopt stress management techniques like mindfulness, yoga, or meditation to control stress-related blood sugar changes.
  • Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, and cheese, etc.).
  • Keep your blood pressure as normal (120/80) as possible, as it reduces the risk of heart disease in diabetes patients.

Health Queries

My doctor prescribed Zita Met Plus 20/500 in the morning and Voglimet GM in the evening for my high blood sugar. Since Zeta Met Plus is now discontinued, can I substitute it with another brand containing Teneligliptin 20mg and Metformin 500mg?

G.santoshini Reddy

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

Yes, you can safely substitute your morning medication with another brand, provided it contains the exact same active ingredients in the same strengths: Teneligliptin 20mg and Metformin 500mg. Substituting discontinued brands with equivalent alternatives is a very common and safe practice, and it will keep your blood sugar well-controlled. Please consult your pharmacist or doctor so they can recommend a high-quality alternative brand and update your prescription records. Continue taking your evening medication as scheduled. There is no need to worry, as your treatment remains highly effective.

Have a query?

How Soon It Starts Working

The time required for Zita Met Plus 20/500 Tablet to start to work: Zita Met Plus 20/500 Tablet starts to show its action within 1 to 2 hours of administration. The time for which the effects of Zita Met Plus 20/500 Tablet last: Zita Met Plus 20/500 Tablet effect lasts for 24 hours.

What if you forget to take Zita Met Plus 20/500 Tablet

If you miss a dose of Zita Met Plus 20/500 Tablet , take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

• Store in a cool and dry place away from sunlight.• Keep Zita Met Plus 20/500 Tablet out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Do not take Zita Met Plus 20/500 Tablet if you are allergic to any of its components, or if you have severe ketosis, type 1 diabetes, diabetic coma, or a history of diabetic coma.
  • Inform your doctor if you have liver, kidney or heart problems, severe infection, severe trauma, adrenal insufficiency, bowel obstruction, irregular heartbeat, or are due to undergo surgery.
  • Zita Met Plus 20/500 Tablet may cause ‘lactic acidosis’ (buildup of lactic acid in the blood). Consult your doctor if you experience abdominal pain, muscle cramps, vomiting, severe fatigue, or difficulty breathing. It is a life-threatening condition that requires immediate medical attention.
  • Do not consume excess alcohol, as it increases the risk of lactic acidosis.
  • Zita Met Plus 20/500 Tablet may lower vitamin B12 levels, so it is recommended to take blood tests regularly to identify any vitamin deficiencies.

Drug-Drug Interactions

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Drug-Drug Interactions: Zita Met Plus 20/500 Tablet may have an interaction with medicines used to treat bacterial infections (rifampicin, tetracycline, Clarithromycin), a medicine used to treat fungal infections (fluconazole), other oral antidiabetics, medicines used to treat gout (probenecid).

Drug-Food interactions: Intake of excess alcohol may increase the chance of a life-threatening condition known as lactic acidosis.

Drug-Disease Interactions: Zita Met Plus 20/500 Tablet should be avoided in patients with heart diseases (congestive heart failure and myocardial infarction), vitamin B12 deficiency, alcoholism, type I diabetes, bladder cancer, oedema (fluid retention), liver disease, premenopausal anovulation, obesity (weight gain), anaemia should avoid intake of Zita Met Plus 20/500 Tablet .

Teneligliptin + MetforminMetrizamide
Critical
Teneligliptin + MetforminIodamide
Critical

Drug-Drug Interactions

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Teneligliptin + MetforminMetrizamide
Critical
How does the drug interact with Zita Met Plus 20/500 Tablet:
Co-administration of Zita Met Plus 20/500 Tablet and metrizamide together can cause the risk of lactic acidosis (when the body produces too much lactic acid ).

How to manage the interaction:
Although there is an interaction between Zita Met Plus 20/500 Tablet and metrizamide, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Teneligliptin + MetforminIodamide
Critical
How does the drug interact with Zita Met Plus 20/500 Tablet:
Co-administration of Zita Met Plus 20/500 Tablet with iodamide can increase the risk of kidney problems.

How to manage the interaction:
Although there is an interaction between Zita Met Plus 20/500 Tablet and iodamide, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Teneligliptin + MetforminIomeprol
Critical
How does the drug interact with Zita Met Plus 20/500 Tablet:
Co-administration of iomeprol with Zita Met Plus 20/500 Tablet can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between metformin and Zita Met Plus 20/500 Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Teneligliptin + MetforminGatifloxacin
Critical
How does the drug interact with Zita Met Plus 20/500 Tablet:
Co-administration of Zita Met Plus 20/500 Tablet with gatifloxacin can cause both hypoglycemia (low blood glucose) and, less frequently, hyperglycemia (high blood glucose).

How to manage the interaction:
Although there is an interaction between Zita Met Plus 20/500 Tablet and gatifloxacin, they can be taken together if prescribed by a doctor. However, consult a doctor immediately if you experience headache, dizziness, sleepiness, nervousness, confusion, tremors (shaking of hands and legs), hunger, weakness, sweating, or fast heartbeats. Do not discontinue without consulting a doctor.
Teneligliptin + MetforminIodixanol
Critical
How does the drug interact with Zita Met Plus 20/500 Tablet:
Co-administration of iodixanol with Zita Met Plus 20/500 Tablet can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Zita Met Plus 20/500 Tablet and iodixanol, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Teneligliptin + MetforminIopamidol
Critical
How does the drug interact with Zita Met Plus 20/500 Tablet:
Co-administration of Iopamidol with Metformin can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between metformin and iopamidol, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Teneligliptin + MetforminIopromide
Critical
How does the drug interact with Zita Met Plus 20/500 Tablet:
Co-administration of iopromide with Zita Met Plus 20/500 Tablet can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between iopromide and Zita Met Plus 20/500 Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Teneligliptin + MetforminTopiramate
Severe
How does the drug interact with Zita Met Plus 20/500 Tablet:
Coadministration of Zita Met Plus 20/500 Tablet and topiramate may increase the risk of lactic acidosis (excessive lactic acid production in the blood).

How to manage the interaction:
Although there is an interaction between Zita Met Plus 20/500 Tablet and topiramate, it can be taken if prescribed by a doctor. However, if you experience weakness, muscle pain, fatigue, less desire to eat, slow or irregular heartbeat, breathing difficulty, or chills, consult a doctor immediately. Do not stop using any medication without a doctor's advice.
Teneligliptin + MetforminMethazolamide
Severe
How does the drug interact with Zita Met Plus 20/500 Tablet:
Co-administration of Zita Met Plus 20/500 Tablet with methazolamide may increase the risk of Lactic acidosis (excessive lactic acid production in the blood).

How to manage the interaction:
Although there is an interaction between Zita Met Plus 20/500 Tablet and methazolamide, they can be taken together if prescribed by a doctor. However, if you experience weakness, muscle pain, fatigue, less desire to eat, slow or irregular heartbeat, breathing difficulty, or chills, contact a doctor immediately. Do not stop using any medications without a doctor’s advice.
Teneligliptin + MetforminZonisamide
Severe
How does the drug interact with Zita Met Plus 20/500 Tablet:
Coadministration of Zita Met Plus 20/500 Tablet and zonisamide may increase the risk of lactic acidosis (excessive lactic acid production in the blood).

How to manage the interaction:
Although there is an interaction between Zita Met Plus 20/500 Tablet and zonisamide, it can be taken if prescribed by a doctor. However, if you experience weakness, muscle pain, fatigue, less desire to eat, slow or irregular heartbeat, breathing difficulty, or chills, consult a doctor immediately. Do not stop using any medication without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

Zita Met Plus 20/500 Tablet is used to treat Type 2 diabetes mellitus. It improves glycaemic control in diabetic patients who do not react well to Metformin alone.
Zita Met Plus 20/500 Tablet is a combination of two antidiabetic medicines, Metformin and Teneligliptin. It works by increasing insulin production, helping to restore your body's appropriate response to insulin, especially in muscle and fatty tissues, thereby lowering your elevated blood sugar levels.
Hypoglycemia refers to low blood glucose levels. Zita Met Plus 20/500 Tablet may cause hypoglycemia. Hypoglycemia can occur if you miss or delay your food, drink alcohol, engage in intense exercise, or take other antidiabetic medicine along with this medicine. So, take your medicine as advised by your doctor to avoid any unwanted effects of this medicine.
If you feel that your blood sugar levels are dropping, eat glucose tablets or chocolate immediately. This will help to increase your sugar levels instantly. So, it is always advised to carry glucose tablets or sugar candies with you.
Yes, Zita Met Plus 20/500 Tablet is safe to use if taken in the dose and duration prescribed by the doctor.
Zita Met Plus 20/500 Tablet may cause nausea and vomiting as side effects. Consume bland food and water, avoid foods with strong smells, spicy food, caffeine, alcohol and carbonated drinks.
Zita Met Plus 20/500 Tablet is contraindicated in people who are allergic to any of its components, patients having severe ketoacidosis, diabetic coma or pre-coma, type 1 diabetes, severe infection, severe trauma and severe external injury and in patients with a history of lactic acidosis.
Zita Met Plus 20/500 Tablet can cause lactic acidosis, a rare but serious metabolic complication. Consult the doctor if you notice symptoms of lactic acidosis like abdominal pain, vomiting, muscle cramps, difficulty breathing, reduced body temperature and heartbeat, and severe tiredness.
Long-term use of Zita Met Plus 20/500 Tablet may lead to vitamin B12 deficiency as Zita Met Plus 20/500 Tablet might interfere with the absorption of vitamin B12. Consult the doctor if you experience symptoms of vitamin B12 deficiency like tingling sensations and numbness in hands and feet, urinary problems, weakness, change in mental status and difficulty in maintaining balance.
Store Zita Met Plus 20/500 Tablet at room temperature, in a dry place. Keep it out of sight and reach of children.
Zita Met Plus 20/500 Tablet is not recommended during pregnancy as its safety in pregnant women is unknown. Contact the doctor if you are pregnant, planning for pregnancy or think you may be pregnant.
Zita Met Plus 20/500 Tablet is not recommended for nursing mothers as this medicine may get secreted in the breast milk and cause unwanted effects in the nursing babies. Contact the doctor if you are breastfeeding.
Zita Met Plus 20/500 Tablet is not recommended for use in children below 18 years of age.
Overdose of Zita Met Plus 20/500 Tablet might cause lactic acidosis. Symptoms of lactic acidosis may include nausea, vomiting, and weakness. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.
Side effects of Zita Met Plus 20/500 Tablet include nausea, vomiting, diarrhoea, headache, stomach ache, respiratory infection, weight gain, sweating, palpitations, and vision problems. Consult the doctor if any of the side effects persist or worsen.
Consult the doctor if you have severe joint pain after taking Zita Met Plus 20/500 Tablet . The doctor might ask you to discontinue the medicine if appropriate.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai – 400 026.
Other Info - ZIT0131

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