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compositionComposition:DICLOFENAC-75MG+TRAMADOL-50MG
prescription
Prescription Medicine
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Durapain Tablet is used to get relief from pain and inflammation (redness and swelling). It contains Diclofenac and Tramadol, which works by blocking the release of chemical messengers responsible for causing pain and inflammation. Also, it blocks the transmission of pain signals to the brain. It may cause common side effects such as nausea, loss of appetite, vomiting, dizziness, indigestion, sleepiness, constipation, heartburn, stomach pain, and dryness in the mouth. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DICLOFENAC-75MG+TRAMADOL-50MG

Manufacturer/Marketer :

Abbott India Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Durapain Tablet

Durapain Tablet is a prescription medicine used to treat moderate to severe pain. It is commonly prescribed to manage sudden, intense pain from physical injuries, surgical procedures, or chronic musculoskeletal conditions. By targeting pain through two distinct pathways in the body, this medicine helps calm severe discomfort and improve your daily physical function.

To get the best results, you must take Durapain Tablet consistently and exactly as your doctor has directed. You should always take this tablet with a meal or a glass of milk to protect your stomach lining from irritation. Making simple lifestyle adjustments, such as drinking plenty of fluids and doing gentle, low-impact stretching, can also support your body’s natural healing process.

While taking Durapain Tablet , you may experience mild, common side effects such as nausea, drowsiness, or lightheadedness. However, you must seek medical attention immediately if you experience serious symptoms like severe stomach pain, black or tarry stools, breathing difficulties, or yellowing of your skin or eyes.

Before you begin taking Durapain Tablet , talk to your doctor if you have a history of stomach ulcers, asthma, high blood pressure, or liver or kidney disorders. Do not take this medicine if you have severe heart failure, active internal bleeding, severe kidney or liver disease, or if you have had an allergic reaction to aspirin or other pain relievers. People with aspirin-sensitive asthma (asthma that worsens after taking aspirin or other NSAID pain medicines) should avoid diclofenac unless specifically advised by their doctor, as it may trigger serious breathing difficulties.

This medicine can interact dangerously with alcohol, sleeping pills, and other prescription pain relievers, potentially causing extreme sleepiness or shallow breathing. Pregnant, breastfeeding, or elderly individuals must always consult their healthcare provider before using this medicine, as they may require special monitoring or dose adjustments.

Uses of Durapain Tablet

Your doctor may prescribe this medicine to treat several conditions, including:

  • Moderate to severe acute pain: Helps relieve intense, sudden pain resulting from dental procedures, physical injuries, or muscle strains.
  • Post-surgical pain management: Helps control pain after surgeries, allowing you to rest comfortably and recover more quickly.
  • Osteoarthritis and joint pain flares: Helps reduce the severe swelling, joint stiffness, and deep pain associated with joint wear-and-tear.
  • Severe back and nerve pain: Helps calm severe, radiating backaches and muscle spasms by blocking pain signals at the source.

Key Benefits

Durapain Tablet provides targeted, dual-action pain relief by combining two pain-relieving ingredients that work together to manage discomfort more effectively. Key benefits include:

  • Comprehensive Pain Management: By addressing pain through two different mechanisms, Durapain Tablet helps provide broader relief and may offer better symptom control than single-ingredient pain medicines.
  • Improves Physical Movement: By reducing moderate to severe pain, Durapain Tablet helps improve mobility, making it easier to participate in physical therapy, complete daily activities, and move with greater comfort.
  • Supports Rest and Recovery: By reducing moderate to severe pain, Durapain Tablet may help patients rest more comfortably during recovery. However, tramadol may affect sleep patterns in some people, and any new or persistent sleep-related changes should be discussed with a doctor. 

Directions for Use

  • Take Durapain Tablet with or without food or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.
  • Swallow the medicine as a whole with glass of water.
  • Do not crush, break, or chew it.

How Durapain Tablet Works

This medicine contains two active pain-relieving ingredients that work together to interrupt pain signals before they can overwhelm your body. The first active ingredient is diclofenac, and it works directly at the site of your injury or joint pain. It blocks specific enzymes in your body from producing natural chemicals that cause pain, heat, and swelling. By lowering the levels of these chemicals, it calms inflammation in your muscles, joints, and tissues. The second active ingredient is tramadol, and it works within your central nervous system. It binds to specific pain receptors in your brain and spinal cord to stop pain signals from being processed by your mind. It also helps keep your body’s natural calming chemicals active in your brain for longer periods. Together, these two actions provide highly coordinated pain relief.
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Durapain Tablet to avoid unpleasant side-effects like gastric bleeding.

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Pregnancy

Unsafe

Durapain Tablet is not recommended for use in pregnant women.

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Breast Feeding

Unsafe

While Durapain Tablet may pass in the lactating mother's breast milk, there is not enough evidence to establish the safety of Durapain Tablet in nursing mothers. So, do it is advisable to take it only if prescribed by your doctor.

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Driving

Caution

In some cases, Durapain Tablet may cause dizziness and drowsiness. So if you observe such symptoms, immediately stop the intake of Durapain Tablet .

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Liver

Caution

Durapain Tablet should be used with caution in patients with liver diseases. Therefore, the doctor may adjust the dose while using it in patients with liver diseases.

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Kidney

Caution

Let your doctor know if you have any history of kidney diseases. Your doctor will weigh the benefits and potential risks before prescribing Durapain Tablet .

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Children

Caution

Durapain Tablet should not be given to children below the age of 18 as it is known to cause breathing problems (like slow breathing or difficulty in breathing)

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Heart

Unsafe

Durapain Tablet should be avoided in patients with cardiac problems due to the increased risk of cardiovascular problems.

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Geriatrics

Caution

Durapain Tablet should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Durapain Tablet .

What if I have taken an overdose of Durapain Tablet

If you suspect an overdose, seek immediate medical attention or call an emergency poison control centre right away. Watch for critical warning signs such as severe breathing difficulties, extreme drowsiness, cold and clammy skin, or loss of consciousness.

Diet & Lifestyle Advise

  • Eat a high-fibre diet: Because this medicine can slow down your digestion and cause constipation, drink plenty of water and eat high-fibre foods like vegetables, fresh fruits, and whole grains.
  • Avoid all alcohol: Do not drink beer, wine, or spirits while taking this medicine, as alcohol dramatically increases the risk of dangerous drowsiness, shallow breathing, and stomach bleeding.
  • Avoid other over-the-counter pain medicines: Do not take aspirin, ibuprofen, or other anti-inflammatory drugs while taking Durapain Tablet , as this combination can damage your stomach and kidneys.
  • Pace your daily activities: Use your pain relief to engage in low-impact movement like short walks, but avoid heavy lifting or intense exercise that could worsen your underlying injury.
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How Soon It Starts Working

The time required for Durapain Tablet to start to work: Durapain Tablet ideally shows its action within 30 to 60 minutes after administration. The time for which the effects of Durapain Tablet last: The effect of Durapain Tablet lasts for 2 to 6 hours.

What if you forget to take Durapain Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and return to your regular timing. Do not take a double dose to make up for a missed tablet.

Storage

•Store Durapain Tablet at room temperature, between 20°C and 25°C (68°F to 77°F). •Keep the tablets in their original packaging to protect them from light and moisture.

Drug Warnings

  • Check the packaging before use: Always inspect the blister pack or bottle before taking a tablet; do not take the medicine if the protective foil is torn, punctured, or damaged.
  • Check the tablet appearance: Ensure the tablet is whole and looks normal; do not take tablets that are discoloured, crumbling, or cracked.
  • Do not drive immediately: Wait to see how this medicine affects you before driving, operating machinery, or doing anything that requires full mental focus, as it can cause sudden drowsiness.
  • Stand up slowly: To prevent dizziness or fainting, take your time when rising from a sitting or lying position.
    Do not share this medicine: Never give this medicine to anyone else, even if they have similar symptoms, as it can cause serious health complications in others.
  • Risk of dependence and withdrawal: Tramadol may cause dependence, and sudden stopping after regular use can lead to withdrawal symptoms; always consult your doctor before discontinuing it.
  • Prescription and controlled medicine warning: Tramadol-containing medicines in India require a valid prescription and should not be shared or used without medical advice due to risks of misuse and serious side effects.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact with Durapain Tablet .

  • Sleeping pills, anti-anxiety medicines, muscle relaxants, or other opioid medications: Taking these medicines together may increase the risk of extreme drowsiness, slowed breathing, loss of consciousness, or coma
  • Blood thinners (such as warfarin) or other anti-inflammatory pain relievers: Combining these medicines may increase the risk of serious stomach bleeding.
  • Certain antidepressants or antipsychotic medicines: These may increase the risk of seizures when used with Durapain Tablet .
  • Blood pressure medicines and water pills (diuretics): Durapain Tablet may reduce the effectiveness of these medicines, affecting blood pressure control or fluid balance.
Tramadol + DiclofenacZiprasidone
Critical
Tramadol + DiclofenacRasagiline
Critical

Drug-Drug Interactions

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Tramadol + DiclofenacZiprasidone
Critical
How does the drug interact with Durapain Tablet:
Co-administration of Ziprasidone with Tramadol and Diclofenac can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Tramadol and Diclofenac with Ziprasidone together can result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
Tramadol + DiclofenacRasagiline
Critical
How does the drug interact with Durapain Tablet:
Taking rasagiline with tramadol and diclofenac can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Tramadol and diclofenac with Rasagiline is not recommended, as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and fainting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
Tramadol + DiclofenacSafinamide
Critical
How does the drug interact with Durapain Tablet:
Taking Safinamide with Tramadol and diclofenac can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Safinamide with Tramadol and diclofenac is not recommended as it can result in an interaction, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fever, excessive sweating, shivering, blurred vision, muscle pain or stiffness, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
Tramadol + DiclofenacMeloxicam
Critical
How does the drug interact with Durapain Tablet:
Co-administration of tramadol and diclofenac with Meloxicam can increase the risk or severity of gastrointestinal side effects.

How to manage the interaction:
Taking Meloxicam with tramadol and diclofenac is not recommended as it can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as dizziness, lightheadedness, black tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop any medication without a doctor's advice.
Tramadol + DiclofenacPhenelzine
Critical
How does the drug interact with Durapain Tablet:
Combining Phenelzine with Tramadol and Diclofenac can increase the risk of serotonin syndrome and seizures.

How to manage the interaction:
Taking Durapain Tablet with Phenelzine results in an interaction, but it can be taken if prescribed by a doctor. However, if you experience confusion, hallucination, fever, shivering, impaired vision, muscle spasms or stiffness, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not stop using any medications without consulting a doctor.
Tramadol + DiclofenacLinezolid
Critical
How does the drug interact with Durapain Tablet:
Co-administration of Linezolid with tramadol and diclofenac can increase the risk of serotonin syndrome and seizures.

How to manage the interaction:
Taking Linezolid with tramadol and diclofenac is not recommended, consult a doctor before taking it. Consult a doctor if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, stomach cramps, nausea, vomiting, and diarrhoea. Do not stop using any medications without talking to a doctor.
Tramadol + DiclofenacTranylcypromine
Critical
How does the drug interact with Durapain Tablet:
Combining Tranylcypromine with Tramadol and diclofenac can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Tranylcypromine with Tramadol and diclofenac is not recommended but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), increased heart rate, fever, excessive sweating, shivering, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
Tramadol + DiclofenacAlvimopan
Critical
How does the drug interact with Durapain Tablet:
Co-administration of Tramadol with Alvimopan can make the side effects worse or more dangerous.

How to manage the interaction:
Taking Alvimopan with Tramadol and diclofenac is not recommended, but it can be taken if prescribed by your doctor. However, contact your doctor if you experience abdominal pain, nausea, vomiting, and diarrhea. Do not stop using any medications without consulting a doctor.
Tramadol + DiclofenacIbuprofen
Severe
How does the drug interact with Durapain Tablet:
Taking Tramadol and diclofenac with ibuprofen can increase the risk of stomach bleeding and ulcers.

How to manage the interaction:
Co-administration of Tramadol and diclofenac with Ibuprofen can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
Tramadol + DiclofenacOxamniquine
Severe
How does the drug interact with Durapain Tablet:
Co-administration of tramadol and diclofenac with oxamniquine can increase the effect of tramadol.

How to manage the interaction:
Taking tramadol and diclofenac with oxamniquine can result in an interaction, but it can be taken if prescribed by a doctor. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

verifiedApollotooltip

Grapefruit or grapefruit juice: A clinically significant interaction between grapefruit and Durapain Tablet has not been clearly established. However, always inform your doctor about your diet and any supplements you regularly consume.
 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

Yes

Therapeutic Class

[ANALGESICS]

FAQs

Durapain Tablet is used to provide relief from pain and inflammation (redness and swelling).
Durapain Tablet contains Diclofenac (non-steroidal anti-inflammatory drug (NSAID)) and Tramadol (an opioid). Diclofenac works by blocking the release of chemical messengers which are responsible to cause pain and inflammation. Tramadol, on the other hand, blocks the transmission of pain signals to the brain, and as a result pain perception is lowered.
Yes, Durapain Tablet contains tramadol, which is known to decrease fertility in both men and women. Before starting Durapain Tablet , inform your doctor if you plan to become pregnant as the salt might be changed.
Durapain Tablet should be avoided in patients with known allergy to NSAIDs, diclofenac, tramadol or any of the ingredients of Durapain Tablet . Durapain Tablet if taken along with sleep medicines or MAO inhibitors (medicines to treat depression or Parkinson’s disease) can cause serious unpleasant side effects. Also, in patients suffering from liver disease or epilepsy, Durapain Tablet should not be used.
Yes, prolonged use of Durapain Tablet can cause kidney damage as pain killers reduce prostaglandin levels (a chemical), which protects the kidneys from damage and helps in its normal functioning. So, Durapain Tablet is mostly prescribed as a short term medication to avoid any kidney damage.
Durapain Tablet may impair mental and/or physical abilities required for the performance of heavy tasks like operating machinery or driving a motor vehicle, especially when used with alcohol or other CNS depressants (sleeping pills or anti-anxiety pills).
Do not take Durapain Tablet for longer durations as it might increase the risk of heart problems, liver problems, breathing problems, and stomach bleeding/ulcer. Please consult a doctor before its use.
Yes, Durapain Tablet contains tramadol, which an opioid and is habit-forming. So, it is recommended not to take Durapain Tablet for prolonged use as it may lead to unpleasant withdrawal symptoms like breathing problems, heart problems, liver/kidney problems.
Yes,the use of Durapain Tablet can cause constipation. Consult a doctor if constipation persists.
You should not stop taking Durapain Tablet abruptly without consulting your doctor, as sudden discontinuation can lead to withdrawal symptoms like breathing problems, heart problems, liver/kidney problems or a return of pain. Consult the doctor before stopping Durapain Tablet as they may suggest gradually reducing the dose to prevent complications. Always follow the doctor's instructions when discontinuing any medication.
Yes, Durapain Tablet may cause mouth dryness as a common side effect. To overcome this, chew sugar-free gum, drink plenty of water throughout the day, or suck on sugar-free lozenges to stimulate saliva production. Using a humidifier at night and avoiding alcohol, tobacco, and caffeine can also help alleviate mouth dryness. If this symptom persists, consult the doctor for further advice.
Durapain Tablet should be stored in a cool and dry place away from sunlight. Keep it out of sight and reach of children.
The side effects of Durapain Tablet include loss of appetite, nausea, vomiting, dizziness, indigestion, sleepiness, constipation, heartburn, stomach pain, and dryness in the mouth. Consult the doctor if any of these side effects persist or worsen.

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Reference

  1. MedlinePlus. A695011 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Product Summary of Product Characteristics (SmPC). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Electronic Medicines Compendium (EMC). Pil.7123 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Drugs.com Clinical Review Team. Diclofenac Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  5. MedlinePlus. A689002 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  6. Diclofenac Diclofenac. 1996. [Accessed on 02 Apr. 2019]Check here
  7. ScienceDirect ScienceDirect. [Accessed on 02 Apr. 2019]Check here

Country of origin

India

Manufacturer/Marketer address

16th Floor, Godrej BKC, Plot – C, “G” Block, Bandra-Kurla Complex, Bandra (East), Mumbai – 400 051, India
Other Info - DUR0175

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