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compositionComposition:ACETAMINOPHEN-325MG+TRAMADOL-37.5MG
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Prescription Medicine
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PT 325 TABLET is used to treat moderate to severe pain. It contains Tramadol and Acetaminophen which work by inhibiting the transmission of pain signals from nerves to the brain and blocking the chemical messengers that cause pain. In some cases, this medicine may cause side effects such as drowsiness, nausea, dizziness, headache, vomiting, dry mouth, constipation, excessive sweating, shaking, confusion or mood changes. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

ACETAMINOPHEN-325MG+TRAMADOL-37.5MG

Manufacturer/Marketer :

Apex Laboratories Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About PT 325 TABLET

PT 325 TABLET is a combination prescription medicine used to manage moderate to moderately severe pain in adults. It is formulated to help relieve acute pain, such as pain following surgical procedures or dental work, when other treatments are not sufficient. This medicine helps restore physical comfort by targeting pain signals in the body.

Your doctor will determine how often you should take PT 325 TABLET , and it is crucial to use it consistently exactly as directed. You can take this medication with or without food, though taking it with a meal can help if you experience stomach upset. To get the best results, incorporate supportive lifestyle adjustments such as staying well-hydrated, resting properly, and eating fibre-rich foods to prevent bowel sluggishness.

While taking PT 325 TABLET , some people may experience common side effects such as mild dizziness, sleepiness, or nausea. However, you must contact your doctor immediately if you experience serious side effects, including severe breathing difficulties, extreme drowsiness, or signs of liver damage such as yellowing of your skin or eyes.

Before you begin taking PT 325 TABLET , tell your doctor about your complete medical history, especially if you have a history of head injuries, seizures, or kidney problems. Do not take this if you have severe lung disease, asthma, severe breathing problems, or a history of drug or alcohol dependency.

This medication can interact with other substances; for instance, taking it with sleeping pills or alcohol can lead to dangerous breathing issues, while taking it with certain antidepressants can cause a rare but serious nervous system reaction. If you are pregnant, breastfeeding, or an older adult, talk to your doctor or pharmacist before starting this medicine to ensure it is safe for you.

Uses of PT 325 TABLET

PT 325 TABLET is used for the short-term management of moderate to moderately severe pain when adequate pain relief is needed. Its uses include:

  • Moderate to moderately severe acute pain: PT 325 TABLET helps reduce severe pain from surgeries, dental procedures, or sudden injuries, allowing you to recover more comfortably.
  • Short-term pain management: This medicine helps control temporary, intense pain flare-ups when non-opioid pain relievers alone do not provide enough relief.
     

Key Benefits

PT 325 TABLET combines two pain-relieving medicines that work in different ways to manage moderate to severe pain. This dual-action approach provides effective pain relief, improving comfort and supporting recovery.

  • Provides Effective Pain Relief: Helps relieve moderate to severe pain associated with injuries, surgical procedures, and other painful conditions.
  • Offers Dual-Action Relief: Combines complementary pain-relieving mechanisms to provide better pain control than either medicine may provide alone in some patients.
  • Improves Daily Comfort: By reducing pain intensity, it can make everyday movements and activities more manageable.
  • Supports Rest and Recovery: Better pain control may improve sleep and rest, which are important during recovery from injury or surgery.
  • Supports Physical Rehabilitation: Reduced pain may help you participate more comfortably in prescribed physiotherapy, rehabilitation exercises, and gentle daily movement.
Side effects of Pt 325 Tablet
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Directions for Use

  • PT 325 TABLET can be taken with or without food as advised by your doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Swallow PT 325 TABLET as a whole with a glass of water.
  • Do not crush, break, or chew it.

How PT 325 TABLET Works

PT 325 TABLET contains tramadol and acetaminophen, which work together to relieve pain. The first ingredient, tramadol, is a central analgesic that acts on specific opioid receptors in the brain to change how your nervous system feels and responds to pain. It also helps keep natural chemical messengers like serotonin and norepinephrine active in the brain, which helps block pain signals from travelling up the spinal cord. The second ingredient, acetaminophen, works centrally to raise your body's overall pain threshold, making you less sensitive to discomfort. It also helps lower fevers. Together, these two ingredients provide a stronger, more comprehensive pain-relief effect than when used individually, allowing for effective pain control.
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Alcohol

Unsafe

Avoid consumption of alcohol with PT 325 TABLET as it may cause drowsiness.

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Pregnancy

Unsafe

PT 325 TABLET is not recommended for pregnant women as it may cause withdrawal symptoms in the newborn baby. However, please consult your doctor if you are pregnant.

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Breast Feeding

Caution

PT 325 TABLET may be excreted in breast milk and cause adverse effects in the baby. However, please consult a doctor if you are breastfeeding.

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Driving

Unsafe

PT 325 TABLET may cause dizziness or drowsiness in some people. It is an offence to drive if PT 325 TABLET affects you. Therefore, avoid driving if you feel drowsy or dizzy after taking PT 325 TABLET .

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Liver

Caution

Take PT 325 TABLET with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required. Avoid taking PT 325 TABLET if you have severe liver insufficiency.

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Kidney

Caution

Take PT 325 TABLET with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required. Avoid taking PT 325 TABLET if you have severe kidney insufficiency.

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Children

Unsafe

PT 325 TABLET is not recommended for children below 12 years of age, as the safety and effectiveness were not established.

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Heart

Caution

PT 325 TABLET can be used in heart patients if prescribed by the physician. Please consult your physician if you have any concerns.

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Geriatrics

Caution

PT 325 TABLET should be used under caution in geriatric patients. Please consult your physician.

What if I have taken an overdose of PT 325 TABLET

If you suspect an overdose, seek immediate emergency medical attention or contact a poison control centre right away. An overdose of this medication can lead to life-threatening breathing difficulties and severe, irreversible liver damage. Look for symptoms such as extreme drowsiness, pinpoint pupils, slow breathing, cold and clammy skin, or severe nausea and vomiting.

Diet & Lifestyle Advise

  • Prevent constipation: Because one of the active ingredients can slow down digestion, drink plenty of fluids throughout the day and eat high-fibre foods such as vegetables, fruits, and whole grains.
  • Avoid alcohol completely: Do not drink beer, wine, or spirits while taking this medicine, as alcohol combined with these active ingredients significantly increases the risk of liver damage and dangerous drowsiness.
  • Stand up slowly: To prevent dizziness or fainting caused by sudden blood pressure changes, rise slowly from a sitting or lying position.
  • Incorporate gentle movement: If recovering from surgery or injury, engage in light stretching or short walks as approved by your doctor to promote blood circulation and muscle recovery.
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How Soon It Starts Working

The time required for PT 325 TABLET to start to work: PT 325 TABLET ideally shows its action within 30 to 60 minutes of administration. The time for which the effects of PT 325 TABLET last: PT 325 TABLET effect lasts for 6 to 8 hours..

What if you forget to take PT 325 TABLET

If you take PT 325 TABLET on a regular schedule and miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular routine. Do not take a double dose to make up for the missed one. Talk to your doctor or pharmacist if you are unsure.

Storage

•Store PT 325 TABLET tablets at a controlled room temperature between 20°C and 25°C (68°F to 77°F). •Keep the medication in its original container, tightly closed, to protect it from light and moisture.

Drug Warnings

  • Check Other Medicine Labels: Avoid taking other medicines containing acetaminophen or paracetamol unless advised by your doctor, as excessive total doses can cause serious liver damage.
  • Use Caution During Activities: Do not drive, operate machinery, or perform tasks requiring full alertness until you know how PT 325 TABLET affects you, as it may cause dizziness, drowsiness, or impaired coordination.
  • Take Only as Prescribed: Tramadol can cause dependence and misuse. Do not take larger doses or use the medicine for longer than prescribed.
  • Do Not Stop Suddenly After Long-Term Use: If you have been taking this medicine regularly for a prolonged period, your doctor may gradually reduce the dose to lower the risk of withdrawal symptoms.
  • Inform Healthcare Providers: Tell your doctor, dentist, surgeon, or other healthcare professional that you are taking PT 325 TABLET before undergoing any procedure or starting new treatment.

Drug-Drug Interactions

verifiedApollotooltip

Certain medicines may interact with PT 325 TABLET and increase the risk of serious side effects, including excessive sedation, breathing problems, serotonin syndrome, or liver damage. Important interactions include:

  • Other acetaminophen-containing products: Taking these together increases the risk of severe liver damage.
  • MAO Inhibitors (MAOIs): Do not take this medicine within 14 days of using an MAO inhibitor, as this can cause a dangerous, life-threatening reaction.
  • Antidepressants (SSRIs, SNRIs, tricyclics): Combining these can increase the risk of a serious, high-fever condition called serotonin syndrome.
  • Sedatives, sleeping pills, or muscle relaxants: Taking these with PT 325 TABLET can cause extreme drowsiness, shallow breathing, coma, or death.
     
Paracetamol + TramadolZiprasidone
Critical
Paracetamol + TramadolSafinamide
Critical

Drug-Drug Interactions

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Paracetamol + TramadolZiprasidone
Critical
How does the drug interact with Pt 325 Tablet:
Co-administration of Ziprasidone with Pt 325 Tablet can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Pt 325 Tablet with Ziprasidone together can result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
Paracetamol + TramadolSafinamide
Critical
How does the drug interact with Pt 325 Tablet:
Taking Safinamide with Pt 325 Tablet can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Safinamide with Pt 325 Tablet is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting s doctor.
Paracetamol + TramadolPhenelzine
Critical
How does the drug interact with Pt 325 Tablet:
Combining Phenelzine with Pt 325 Tablet can increase the risk of serotonin syndrome and seizures.

How to manage the interaction:
Taking Pt 325 Tablet with Phenelzine is not recommended, please consult a doctor before taking it.
Paracetamol + TramadolTranylcypromine
Critical
How does the drug interact with Pt 325 Tablet:
Combining Tranylcypromine with Pt 325 Tablet can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Tranylcypromine with Pt 325 Tablet is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fit blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
Paracetamol + TramadolRasagiline
Critical
How does the drug interact with Pt 325 Tablet:
Taking Rasagiline with Pt 325 Tablet can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Pt 325 Tablet with Rasagiline is not recommended, as it can lead to an interaction, but can be taken if advised by a doctor. However, if you experience any symptoms like severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and fainting, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Paracetamol + TramadolLinezolid
Critical
How does the drug interact with Pt 325 Tablet:
Co-administration of Linezolid with Pt 325 Tablet can increase the risk of serotonin syndrome.

How to manage the interaction:
Taking Linezolid with Pt 325 Tablet is not recommended, consult a doctor before taking it. Consult a doctor if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not stop using any medications without talking to a doctor.
Paracetamol + TramadolAlvimopan
Critical
How does the drug interact with Pt 325 Tablet:
Co-administration of Pt 325 Tablet with Alvimopan can make the side effects worse or more dangerous.

How to manage the interaction:
Taking Alvimopan with Pt 325 Tablet is not recommended, please consult a doctor before taking it.
Paracetamol + TramadolPhysostigmine
Severe
How does the drug interact with Pt 325 Tablet:
Co-administration of Pt 325 Tablet with Physostigmine can increase the effect of Pt 325 Tablet.

How to manage the interaction:
Taking Physostigmine with Paracetamol and tramadol together can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
Paracetamol + TramadolBaclofen
Severe
How does the drug interact with Pt 325 Tablet:
Co-administration of Baclofen with Pt 325 Tablet may significantly lead to adverse effects such as respiratory distress (a condition in which fluid builds up in the lungs).

How to manage the interaction:
Although taking Baclofen and Pt 325 Tablet together can result in an interaction, it can be taken on a doctor's advice. If you experience any symptoms such as dizziness, drowsiness, difficulty concentrating, numbness and tingling of extremities, or hypersensitivity to light and noise, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
Paracetamol + TramadolLomitapide
Severe
How does the drug interact with Pt 325 Tablet:
Co-administration of Lomitapide and Pt 325 Tablet may increase the risk of severity of liver injury.

How to manage the interaction:
Although there is a possible interaction between Pt 325 Tablet and Lomitapide, you can take these medicines together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip

Certain foods and drinks may interact with PT 325 TABLET or increase the risk of adverse effects. Important interactions include:

  • Alcohol: Significantly increases the risk of liver damage, extreme sleepiness, and dangerously slow breathing.
  • Grapefruit or grapefruit juice: May interfere with how your body processes tramadol, increasing the risk of adverse side effects.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

Yes

Therapeutic Class

[ANALGESICS]

FAQs

PT 325 TABLET is used to treat moderate to severe pain.
PT 325 TABLET contains Tramadol and Acetaminophen. Tramadol is an opioid analgesic that works by mimicking the action of endorphins (pain-reducing chemicals) in the brain and spinal cord. Thereby, inhibits the transmission of pain signals from nerves to the brain. Also, it improves the effect of serotonin and noradrenaline (chemical messengers in the brain and spinal cord) and helps in relieving pain. Acetaminophen is an analgesic (relieves pain) and antipyretic (reduces fever) that works by inhibiting the production of certain chemical messengers in the brain known as prostaglandins that are responsible for pain and fever.
PT 325 TABLET may cause dry mouth as a common side effect. It is not necessary for everyone taking PT 325 TABLET to experience this side effect. However, drink plenty of water, suck on sugar candy or chew sugar-free gum to prevent such side effects while taking PT 325 TABLET . If the condition worsens or persist, please consult a doctor.
PT 325 TABLET should be used with caution in patients suffering from fits as it may worsen the condition. Therefore, it is recommended to inform your doctor if you ever had fits before taking PT 325 TABLET .
No, you are not recommended to take PT 325 TABLET with antidepressants (medicines used to treat depression), and antipsychotics (medicines used to treat bipolar disorder and psychosis) as co-administration of these medicines with PT 325 TABLET may increase the risk of fits. However, please consult a doctor before taking PT 325 TABLET with other medicines.
PT 325 TABLET may cause addiction, especially if taken for a prolonged time. Therefore, PT 325 TABLET should be given only for a short duration under strict medical supervision, particularly to patients who are susceptible to drug abuse. Take PT 325 TABLET only as a doctor advised as overuse or misuse of PT 325 TABLET can lead to overdose and cause severe adverse effects.
You are not recommended to take PT 325 TABLET with warfarin as co-administration of these two medicines may increase bleeding risk more easily. However, if you are supposed to use these medicines together, you are advised to contact your doctor so that the dose may be adjusted appropriately to use safely.
PT 325 TABLET may cause withdrawal symptoms such as difficulty sleeping, anxiety, nervousness, shaking, stomach or bowel disorders, or making you overactive when you stop taking PT 325 TABLET suddenly. Therefore, if you experience any difficulty while taking PT 325 TABLET , do not stop taking suddenly and consult your doctor so that the dose may be reduced gradually to avoid withdrawal symptoms.
Yes, you can take PT 325 TABLET with or without food. If you experience mild nausea, taking the tablet with food may help settle your stomach. Talk to your doctor or pharmacist if nausea persists.
Taking PT 325 TABLET during pregnancy is generally not recommended, as the active ingredients can pass to the unborn baby and cause severe breathing problems or withdrawal symptoms after birth. Talk to your doctor or pharmacist about safer pain-relief options.
You must check the labels of all over-the-counter products carefully. Many contain acetaminophen, which can cause severe liver damage if combined with PT 325 TABLET . Talk to your doctor or pharmacist before taking any additional medicines.
If you are taking it on a regular schedule, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed one and continue your regular routine. Do not double the dose. Talk to your doctor or pharmacist for guidance.
Alcohol significantly increases the risk of severe liver damage, extreme drowsiness, and life-threatening breathing difficulties when combined with PT 325 TABLET . Talk to your doctor or pharmacist if you have concerns about avoiding alcohol.

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Country of origin

India

Manufacturer/Marketer address

III Floor SIDCO Garment Complex, Guindy, Chennai 600 032, India
Other Info - PT30001

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