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compositionComposition:IMIPRAMINE-25MG
prescription
Prescription Medicine
info
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Antidep Tablet is used to treat depression. It contains Imipramine which increases the activity of certain natural substances (neurotransmitters) which regulate mood. Additionally, it is also used to treat bed-wetting at night in children aged 6 years and older by relaxing the urinary bladder muscles. This medicine may sometimes cause side effects such as dry mouth, nausea, vomiting, increased blood pressure, lack of coordination, swelling of the breast and weakness. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

IMIPRAMINE-25MG

Manufacturer/Marketer :

Torrent Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Antidep Tablet

Antidep Tablet is an oral prescription medication primarily used to treat depression. It helps restore the balance of certain natural chemicals in the brain, which improves mood and emotional well-being. In some cases, it is also prescribed to treat nighttime bedwetting in children.

To achieve the best results, you must take Antidep Tablet consistently every day, often at bedtime, to help minimise daytime sleepiness. You can take this medicine with or without food, but taking it with a meal can help prevent a mild upset stomach. Combining this medication with healthy daily habits, such as regular sleep schedules and stress management, can significantly support your treatment progress.

While taking this medicine, you may experience mild temporary effects like dry mouth, mild sleepiness, or light dizziness. However, you should contact your healthcare provider immediately if you experience any serious side effects, such as a fast or irregular heartbeat, severe mood swings, or difficulty urinating.

Before starting this medication, tell your doctor if you have a history of heart problems, glaucoma, seizures, or difficulty urinating. Do not take this if you have recently had a heart attack or if you are currently taking certain other medications for depression. Your doctor will help determine if this treatment is safe for your specific health history.

This medicine can interact with alcohol, smoking, and medicines such as sleeping pills, which may increase drowsiness or affect how it works. If you are pregnant, breastfeeding, or elderly, consult your doctor before taking this medicine. Antidep Tablet is generally avoided during the first trimester of pregnancy unless the expected benefit clearly outweighs the potential risk to the baby. It may also pass into breast milk, so your doctor will carefully weigh the benefits and risks before recommending its use during breastfeeding.

Uses of Antidep Tablet

Antidep Tablet is used in the treatment of depression and nocturnal enuresis (bed-wetting in children). The detailed uses of Antidep Tablet are as follows:

  • Depression: Antidep Tablet helps raise the levels of mood-regulating chemicals in the brain, relieving feelings of sadness, low energy, and anxiety in adults.
  • Nighttime bedwetting (nocturnal enuresis): It is used as a short-term treatment to help reduce bedwetting in children aged six and older when other non-drug therapies have not been successful.

Key Benefits

Antidep Tablet helps relieve symptoms of depression and manage bedwetting in children, improving daily well-being and confidence.

The following are the benefits of Antidep Tablet :

  • Helps improve mood and reduce symptoms of depression.
  • Increases energy levels and supports better daily functioning.
  • Improves focus and emotional well-being.
  • Reduces nighttime bedwetting episodes in children.
  • Supports better sleep and builds confidence in children with bedwetting.
  • Promotes long-term symptom control when taken as prescribed.
Side effects of Antidep Tablet
  • Do not stand up suddenly. Lie down and get up slowly only when you feel better.
  • Avoid alcohol and large meals.
  • Drink enough water before standing for long periods.
  • Exercise regularly; however, avoid exercising in extreme heat.
  • Eat small, low-carb meals.
  • Wear compression stockings.
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.
  • Avoid triggers like alcohol, caffeine, and energy drinks.
  • Try relaxation techniques such as yoga, meditation, or deep breathing.
  • Exercise regularly as it helps maintain heart health.
  • Follow a nutritious and balanced diet.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • Avoid trigger foods that can cause allergic reactions, such as nuts, shellfish, or dairy products.
  • Keep a food diary to track potential food allergens.
  • Include omega-3 rich foods like salmon and walnuts to reduce inflammation.
  • Wear loose, comfortable clothing made from soft fabrics like cotton.
  • Apply cool compresses or take cool baths to reduce itching.
  • Use gentle soaps and avoid harsh skin products.
  • Reduce stress through relaxation techniques like meditation or deep breathing.

Directions for Use

  • Always take Antidep Tablet exactly as your doctor has prescribed.
  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet, as this can affect how the medicine is released into your body.
  • You can take this medicine with or without food. If you experience stomach upset, taking it with a meal or a snack can help.
  • If you are taking it once daily, taking it at bedtime is often recommended to help prevent daytime sleepiness.
  • Always consult your doctor or pharmacist if you are unsure about how to take your dose.
  • Do not stop taking Antidep Tablet suddenly. When it is time to stop treatment, your doctor will gradually reduce your dose over several weeks to help minimise withdrawal symptoms.

How Antidep Tablet Works

Antidep Tablet contains Imipramine, which belongs to a class of medicines known as tricyclic antidepressants. It works by blocking the reabsorption of two natural chemical messengers in the brain: norepinephrine and serotonin. By keeping more of these chemicals active in the brain, it helps improve communication between nerve cells, which lifts your mood and reduces anxiety. To help manage bedwetting, this medicine also blocks a chemical called acetylcholine. This action helps relax the muscle of the bladder wall while tightening the bladder outlet, making it easier to hold urine through the night.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Antidep Tablet as it may cause increased drowsiness.

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Pregnancy

Caution

Antidep Tablet belongs to pregnancy category C. Please consult your doctor if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Antidep Tablet may pass into breastmilk. Consult your doctor before taking Antidep Tablet ; your doctor will decide whether Antidep Tablet can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Antidep Tablet may cause impaired alertness, drowsiness or blurred vision. Do not drive or operate machinery if you experience these symptoms.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Antidep Tablet is not recommended for children below 6 years as its safety and effectiveness have not been established.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Antidep Tablet . Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Caution

Antidep Tablet can be given in elderly patients with extreme caution, if prescribed by the physician.

What if I have taken an overdose of Antidep Tablet

If you suspect an overdose, seek emergency medical care immediately. An overdose of this medication can be life-threatening and requires urgent professional treatment. Common signs of an overdose may include severe sleepiness, rapid heartbeat, confusion, or seizures.

Diet & Lifestyle Advise

  • Manage dry mouth: Chew sugar-free gum, suck on ice chips, or sip water frequently throughout the day to keep your mouth moist.
  • Prevent constipation: Drink plenty of water and gradually increase your intake of dietary fibre, such as whole grains, fresh fruits, and vegetables.
  • Prevent dizziness: Take your time when standing up from a sitting or lying position to allow your blood pressure to adjust.
  • Avoid alcohol: Do not drink alcohol while taking this medicine, as it can dangerously increase sleepiness and affect your coordination.
  • For bedwetting support: Limit your child's fluid intake in the evening, especially caffeinated or sugary beverages, and encourage them to use the bathroom right before bedtime.

Health Queries

I am suffering from benzodiazepine withdrawal symptoms, and although Imipramine tablets have given me some relief, I am still not feeling completely better. What treatment or support may help me recover more comfortably from this condition?

Vikas Singh

Vikas Singh

M Pharmacy

Benzodiazepine withdrawal can last for several weeks or even longer because your nervous system needs time to adjust after regular use. Symptoms like anxiety, fear, trouble sleeping, body aches, restlessness, sweating, heart palpitations, low mood, or trouble focusing may get better slowly instead of all at once. Imipramine might help with some emotional or nerve-related symptoms, but recovery still takes time and may not happen right away. Tapering off the medication gradually with a psychiatrist?s guidance is usually safer than stopping suddenly. Healthy sleep routines, regular meals, staying hydrated, gentle exercise, counselling, breathing exercises, and emotional support can also make recovery more comfortable. Try to avoid alcohol, smoking, or changing your medication on your own, as these can make withdrawal worse or slow down recovery. Everyone recovers at their own pace, depending on how long they used the medication and their overall mental health. If your symptoms are severe, disrupt your daily life, or cause panic attacks, severe depression, confusion, or thoughts of self-harm, please contact your doctor. You may need changes in your treatment and closer monitoring.
health query

Have a query?

How Soon It Starts Working

  • The time required for Antidep Tablet to start to work: Antidep Tablet ideally shows its action within 2 weeks after administration.
  • The time for which the effects of Antidep Tablet last: The effect of Antidep Tablet lasts for 18 to 54 hours.

What if you forget to take Antidep Tablet

If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one. If you take this medicine once daily at bedtime and miss your dose, do not take it the next morning; instead, contact your doctor or pharmacist for guidance. dose to make up for the missed one.

Storage

• Store in a cool and dry place away from sunlight.• Keep Antidep Tablet out of reach and sight of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Do not stop suddenly: Do not stop taking this medicine all of a sudden. Stopping quickly can cause withdrawal symptoms like nausea, headache, irritability, sleep problems, or flu-like symptoms. Your doctor will reduce the dose slowly if needed.
  • Be careful with driving: Avoid driving, cycling, or using heavy machinery until you know how this medicine affects your alertness. It may cause drowsiness or slow your reaction time.
  • Watch for mood changes: Pay close attention to any worsening depression, sudden mood changes, or suicidal thoughts, especially in the first few weeks or after dose changes. Contact your doctor immediately if these occur.
  • Protect your skin from the sun: Use sunscreen, wear sunglasses, and cover your skin when outdoors. This medicine can make your skin more sensitive to sunlight and increase the risk of sunburn.
  • Inform healthcare providers: Tell your dentist, surgeon, or any healthcare professional that you are taking this medicine before any procedure. It may interact with certain anaesthetics.

Drug-Drug Interactions

verifiedApollotooltip
  • Monoamine oxidase inhibitors (MAOIs) (e.g., phenelzine, tranylcypromine): Do not take Antidep Tablet with MAOIs, as this can cause extremely high blood pressure, high body temperature, and seizures. You must wait at least 14 days after stopping an MAOI before starting this medicine.
  • Central nervous system depressants (e.g., diazepam, zolpidem): Taking this medicine with sleeping pills, prescription pain relievers, or muscle relaxants can cause extreme drowsiness and dangerous breathing difficulties.
  • Heart medications (e.g., amiodarone, quinidine): Certain medicines used to treat abnormal heart rhythms can interact with Antidep Tablet , increasing the risk of serious heart rhythm problems.
ImipramineSafinamide
Critical
ImipramineThioridazine
Critical

Drug-Drug Interactions

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ImipramineSafinamide
Critical
How does the drug interact with Antidep Tablet:
Coadministration of Safinamide with Antidep Tablet can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking safinamide and Antidep Tablet together is not recommended as it can result in an interaction, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
ImipramineThioridazine
Critical
How does the drug interact with Antidep Tablet:
When Thioridazine and Antidep Tablet are taken together, the body's ability to break down Thioridazine may be reduced. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Antidep Tablet with Thioridazine is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience extreme drowsiness, confusion, agitation, vomiting, blurred vision, feeling hot or cold, sweating, muscle stiffness, fainting, or seizure, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
ImipramineZiprasidone
Critical
How does the drug interact with Antidep Tablet:
Using ziprasidone together with Antidep Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Ziprasidone with Antidep Tablet is not recommended, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
ImipramineSparfloxacin
Critical
How does the drug interact with Antidep Tablet:
Taking Sparfloxacin with Antidep Tablet can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Sparfloxacin and Antidep Tablet together is not recommended as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ImipramineDronedarone
Critical
How does the drug interact with Antidep Tablet:
Taking Antidep Tablet with Dronedarone can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Antidep Tablet with Dronedarone together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ImipramineSelegiline
Critical
How does the drug interact with Antidep Tablet:
Co-administration of Antidep Tablet with Selegiline might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to side effects.

How to manage the interaction:
Taking Antidep Tablet and Selegiline together is not recommended as it can result in an interaction. It can be taken if a doctor has advised it. However, if you experience confusion, hallucinations, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, shaking, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ImipraminePhenelzine
Critical
How does the drug interact with Antidep Tablet:
Coadministration of Antidep Tablet with Phenelzine might raise serotonin hormone levels in the body, affecting the brain and nerve cells.

How to manage the interaction:
Taking Antidep Tablet and Phenelzine together is not recommended as it can result in an interaction. It can be taken if your doctor has advised it. However, if you experience confusion, hallucinations, seizures, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ImipramineTranylcypromine
Critical
How does the drug interact with Antidep Tablet:
Taking Tranylcypromine can increase the risk of Antidep Tablet on serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Tranylcypromine with Antidep Tablet is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
ImipramineLinezolid
Critical
How does the drug interact with Antidep Tablet:
Coadministration of Linezolid with Antidep Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells.

How to manage the interaction:
Taking Linezolid and Antidep Tablet together is not recommended as it can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience confusion, hallucinations, seizures, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ImipraminePotassium citrate
Critical
How does the drug interact with Antidep Tablet:
Taking Antidep Tablet and Potassium citrate (in tablet or capsule form) together can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Potassium citrate and Antidep Tablet is not recommended, as it may lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Avoid drinking alcohol, as it can drastically worsen drowsiness, dizziness, and impair your motor skills while taking this medication.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

Antidep Tablet is used to treat depression. Additionally, it is also used to treat bed-wetting at night in children aged 6 years and older.
Antidep Tablet works by increasing mood-enhancing chemical messengers (neurotransmitters) such as serotonin and norepinephrine in the brain that communicate between brain cells, thereby regulating mood and treating depression.
Do not discontinue Antidep Tablet without consulting your doctor as it could lead to withdrawal symptoms. To treat your condition effectually, continue taking Antidep Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Antidep Tablet . The doctor may reduce the dose gradually to prevent withdrawal symptoms.
Dry mouth could be a side-effect of Antidep Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
Orthostatic hypotension could be a side-effect of Antidep Tablet . Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking, instead, lie down and get up slowly only when you feel better.
Antidep Tablet may cause photosensitivity or increased sensitivity to sunlight. Therefore, people taking Antidep Tablet should avoid excessive exposure to sunlight or tanning beds. Use effective sunscreen and wear protective clothing while going outside.
Consult your doctor before taking Antidep Tablet if you are diabetic, as Antidep Tablet may cause elevation or lower blood glucose levels. Regularly monitor blood sugar levels while taking Antidep Tablet .
Antidep Tablet may make your open-angle glaucoma worse. Your doctor may monitor your vision while you are taking this medication.
Antidep Tablet may affect blood sugar levels, especially in people with diabetes. It can cause fluctuations in blood sugar, so it's important to monitor your levels closely and consult your doctor for personalized advice.
Antidep Tablet may cause weight gain in some people as it is an antidepressant that works by blocking certain neurotransmitters. This can lead to increased appetite and changes in metabolism, resulting in weight gain. Monitor your weight and discuss any changes with your doctor. They can adjust your medication or suggest lifestyle changes to manage this side effect.
Antidep Tablet is not an addictive or habit-forming medication.
The common side effects of Antidep Tablet you may experience are dry mouth, nausea, vomiting, increased blood pressure, lack of coordination, swelling of the breast, and weakness. However, these symptoms vanish as your body adjusts to the medication. If these symptoms become worse, please consult a doctor for relief.
No, you should not stop taking Antidep Tablet suddenly without consulting your doctor. Stopping abruptly can lead to withdrawal symptoms like nervousness, anxiety, and irritability.
Antidep Tablet belongs to pregnancy category C medication, meaning it may be harmful to a fetus. Please consult your doctor before taking Antidep Tablet if you plan to become pregnant or are already pregnant. Your doctor will weigh the potential risks and benefits before prescribing Antidep Tablet .
Store Antidep Tablet in a cool, dry place away from sunlight. Keep it out of reach of children.
Antidep Tablet may cause drowsiness or sleepiness, especially when first starting the medication or increasing the dosage. This sedative effect may decrease as your body adjusts to the medication. If it is not, consult the doctor.
If you forget a dose of Antidep Tablet , take it immediately when you remember. However, if your next dose is near, skip the missed dose and continue with your regular schedule. Never double dose to make up for a missed dose, as this may increase side effects.
Taking more than the recommended dosage does not provide additional relief and can increase the risk of adverse effects.
No, you should avoid alcohol while taking Antidep Tablet . Alcohol can severely increase drowsiness and dizziness, and it can also interfere with how well the medicine treats your symptoms. Talk to your doctor.
Yes, Antidep Tablet can be prescribed to children aged 6 and older for the short-term treatment of nighttime bedwetting when other treatments have not worked. Your child's doctor will determine the safest dose and monitor their progress closely. Talk to your doctor.
For most people, taking Antidep Tablet at bedtime is recommended because it can cause drowsiness. However, your doctor will give you the best schedule based on why you are taking it and how it affects you. Talk to your doctor or pharmacist.

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Reference

  1. U.S. Food and Drug Administration (FDA). 040903Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.5789 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. MedlinePlus. A682389 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  4. Drugs.com Clinical Review Team. Imipramine Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  5. Imipramine. NIH National Library of Medicine, National Centre for biotechnology information. PubChem. September 2022. [Accessed on 7th September 2022]Check here
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed on 25 Mar. 2019]Check here

Country of origin

India

Manufacturer/Marketer address

Off. Ashram Road, Ahmedabad - 380 009., Gujarat, India
Other Info - ANT0007

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