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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Apinex 5 Tablet 10's is used to treat heavy, painful, or irregular periods, premenstrual syndrome (PMS), and endometriosis. Additionally, it may be used in the treatment of breast cancer. It contains Norethisterone, which works by restoring the hormone levels in the body. In some cases, this medicine may cause side effects such as unusual vaginal bleeding or spotting, dizziness, dry mouth, constipation, nausea, and diarrhoea. Let the doctor know if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Apinex 5 Tablet:
The combined use of Apinex 5 Tablet and phenobarbital can reduce the blood levels and effects of Apinex 5 Tablet.

How to manage the interaction:
Although taking phenobarbital and Apinex 5 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. If you experience any symptoms like abnormal bleeding, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Apinex 5 Tablet:
Taking griseofulvin with Apinex 5 Tablet may reduce blood levels and the effects of Apinex 5 Tablet.

How to manage the interaction:
Although there is a possible interaction between Griseofulvin and Apinex 5 Tablet, you can take these medicines together if prescribed by a doctor. However, if you experience any of these symptoms like unexpected bleeding or abnormal bleeding, it's important to contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Apinex 5 Tablet:
Coadministration of Phenytoin and Apinex 5 Tablet may decrease the blood levels of Apinex 5 Tablet, which may make Apinex 5 Tablet less effective.

How to manage the interaction:
Although taking Phenytoin and Apinex 5 Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. If you experience any symptoms, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
NorethisteroneFosphenytoin
Severe
How does the drug interact with Apinex 5 Tablet:
Coadministration of Apinex 5 Tablet with Fosphenytoin can reduces the blood levels and effects of Apinex 5 Tablet .

How to manage the interaction:
Taking Apinex 5 Tablet with Fosphenytoin together can result in an interaction, but it can be taken if your doctor has advised it. If you experience symptoms of abnormal bleeding while using birth control, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
NorethisteroneBexarotene
Severe
How does the drug interact with Apinex 5 Tablet:
Coadministration of Bexarotene and Apinex 5 Tablet together can decrease the effectiveness of norethindrone and increase the risk of unintended pregnancy.

How to manage the interaction:
Combining Bexarotene with Apinex 5 Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like increased hot flashes, vaginal dryness, or menstrual abnormalities, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Apinex 5 Tablet:
Coadministration of Apinex 5 Tablet with Dabrafenib can reduce the metabolism and decrease the levels of Apinex 5 Tablet in the body.

How to manage the interaction:
Taking Apinex 5 Tablet with Dabrafenib together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of hot flashes, vaginal dryness, or abnormal bleeding, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
NorethisteroneBoceprevir
Severe
How does the drug interact with Apinex 5 Tablet:
Using Boceprevir and Apinex 5 Tablet together can reduce the blood levels and decrease the effectiveness of norethindrone.

How to manage the interaction:
Combining Boceprevir with Apinex 5 Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like increased hot flashes, vaginal dryness, or menstrual abnormalities, abnormal bleeding, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
NorethisteroneRifapentine
Severe
How does the drug interact with Apinex 5 Tablet:
Combining Rifapentine and norethindrone reduces the blood levels and effects of norethindrone and increases the risk of bleeding and unintended pregnancy.

How to manage the interaction:
Although there is a possible interaction between Apinex 5 Tablet and Rifapentine, you can take these medicines together if prescribed by your doctor. If you're having any of these symptoms like unexpected bleeding, abnormal bleeding, it's important to reach out to a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Apinex 5 Tablet:
Coadministration of Apinex 5 Tablet with Tizanidine can cause drowsiness, confusion, slow heart rate, shallow breathing, feeling light-headed, fainting.

How to manage the interaction:
Taking Apinex 5 Tablet with Tizanidine together can result in an interaction, but it can be taken if your doctor has advised it. However, if you notice any symptoms, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
NorethisteroneFosamprenavir
Severe
How does the drug interact with Apinex 5 Tablet:
Using norethindrone together with fosamprenavir may decrease the effects of fosamprenavir.

How to manage the interaction:
Taking Apinex 5 Tablet with Fosamprenavir together can result in an interaction, but it can be taken if your doctor has advised it. If you're taking birth control and experiencing any symptoms, it's important to reach out to a doctor right away. They can recommend other options that won't interfere with your medication. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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NORETHISTERONE-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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NORETHISTERONE-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Consuming Grapefruit juice may increase the blood levels of Apinex 5 Tablet. Avoid or limit the consumption of grapefruit and grapefruit juice while taking the Apinex 5 Tablet dose. Avoid or limit the consumption of grapefruit and grapefruit juice while taking the Apinex 5 Tablet dose.

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