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compositionComposition:GRANISETRON-1MG
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Grandem MD Tablet is used to prevent nausea and vomiting caused by chemotherapy or radiation therapy. It contains Granisetron, which works by blocking a natural substance (serotonin) in the body that causes nausea and vomiting. This medicine may sometimes cause side effects such as diarrhoea, constipation, stomach pain, weakness, headache, fever, dizziness, and drowsiness. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

GRANISETRON-1MG

Manufacturer/Marketer :

Aristo Pharmaceuticals Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Grandem MD Tablet

Grandem MD Tablet is a medicine used to prevent nausea and vomiting caused by medical treatments such as chemotherapy and radiation therapy. It belongs to a class of medicines that block natural chemicals in the body that trigger the urge to vomit. By targeting these signals, it helps manage discomfort during intensive medical therapies.

This medicine is typically taken only on the days you receive chemotherapy or radiation, shortly before the treatment begins. You can take it with or without food, depending on your doctor's guidance. Eating small, bland meals and staying hydrated with clear liquids can further support your recovery while using this medicine.

While taking Grandem MD Tablet , some people may experience mild side effects, such as headaches or constipation. However, you should contact your doctor immediately if you experience serious side effects like an irregular heartbeat, severe dizziness, or signs of an allergic reaction.

Talk to your doctor before taking Grandem MD Tablet if you have a history of heart rhythm problems, electrolyte imbalances, or severe constipation. Do not take this if you have had an allergic reaction to this medicine or similar medications in the past.

This medicine can interact with certain antidepressants and heart medications, which may increase the risk of serious side effects. If you are pregnant, breastfeeding, or an older adult, consult your healthcare provider to discuss whether this medicine is safe for you.

Uses of Grandem MD Tablet

Your doctor may prescribe this medicine to treat several conditions, including:

  • Chemotherapy-induced nausea and vomiting: Helps prevent you from feeling sick or throwing up on the days you receive chemotherapy treatments.
  • Radiation-induced nausea and vomiting: Prevents nausea and vomiting associated with radiation treatments, especially whole-body or abdominal radiation.

Key Benefits

Grandem MD Tablet helps prevent and relieve nausea and vomiting caused by medical conditions or treatments, improving comfort and supporting recovery. Key benefits include:

  • Prevents and Relieves Nausea and Vomiting: By blocking the signals that trigger nausea and vomiting, Grandem MD Tablet helps control these symptoms effectively, including those associated with certain medical treatments or conditions.
  • Supports Hydration and Nutrition: By reducing nausea and vomiting, Grandem MD Tablet helps you maintain adequate fluid and food intake, supporting recovery and overall well-being.
  • Improves Comfort and Daily Functioning: By controlling persistent nausea and vomiting, Grandem MD Tablet helps reduce physical exhaustion, preserve energy, and improve your ability to carry out daily activities comfortably.

Directions for Use

  • Grandem MD Tablet can be taken with or without food, or as your doctor advises.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Grandem MD Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Grandem MD Tablet Works

During treatments like chemotherapy or radiation, your body releases a natural chemical called serotonin. Serotonin binds to specific receptors in your gut and brain, sending signals that trigger the vomiting reflex. Grandem MD Tablet contains granisetron, which works by blocking these serotonin receptors, effectively stopping the signals before they can reach the brain's vomiting centre. This action prevents the sensation of nausea and the physical urge to vomit.
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Alcohol

Unsafe

You are recommended to limit or avoid alcohol consumption while taking Grandem MD Tablet . Alcohol intake, along with Grandem MD Tablet , may cause increased dizziness.

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Pregnancy

Consult your doctor

It is not known if Grandem MD Tablet affects pregnancy. Please consult your doctor if you are pregnant or planning to conceive before using Grandem MD Tablet .

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Breast Feeding

Caution

It is not known if this medicine passes into breast milk. Please consult your doctor before taking Grandem MD Tablet if you are a nursing mother.

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Driving

Unsafe

Grandem MD Tablet may make you feel dizzy that affects your mental ability. Do not drive or operate machinery if you experience dizziness.

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Liver

Caution

Grandem MD Tablet should be cautiously used by patients with liver diseases. Please consult your doctor if you have a history of liver impairment before starting Grandem MD Tablet .

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Kidney

Caution

Grandem MD Tablet should be cautiously used by patients with kidney problems. Please consult your doctor if you have a history of kidney impairment/kidney disease.

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Children

Consult your doctor

Safety and efficacy of Grandem MD Tablet are not established in children below 2 years of age.

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Heart

Caution

Grandem MD Tablet should be taken with caution in patients with heart problems. Please inform your doctor about any existing heart problems before using Grandem MD Tablet .

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Geriatrics

Safe if prescribed

Grandem MD Tablet is safe for use in elderly patients if prescribed by the physician.

What if I have taken an overdose of Grandem MD Tablet

If you take more than your prescribed dose, seek emergency medical attention or contact a poison control centre immediately. Watch for symptoms such as a severe headache, dizziness, or a rapid heart rate.

Diet & Lifestyle Advise

  • Eat small, frequent meals: Instead of three large meals, eat five or six small, bland snacks throughout the day to keep your stomach settled.
  • Choose bland foods: Stick to simple options like dry toast, crackers, plain rice, oatmeal, or boiled potatoes. Avoid greasy, spicy, or very sweet foods.
  • Stay hydrated: Sip clear liquids like water, diluted juices, broth, or decaffeinated teas slowly throughout the day. Avoid drinking large amounts of fluids during meals.
  • Avoid strong odours: Stay away from strong cooking smells, perfumes, or smoke, as these can easily trigger nausea. Have someone else prepare food if possible.
  • Rest upright after eating: Sit or recline with your head elevated for at least 30 to 60 minutes after eating to aid digestion and prevent nausea.
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How Soon It Starts Working

The time required for Grandem MD Tablet to start to work: Grandem MD Tablet ideally shows its action within 30 to 60 minutes after administration. The time for which the effects of Grandem MD Tablet last: The effect of Grandem MD Tablet lasts for 24 hours.

What if you forget to take Grandem MD Tablet

This medicine is usually taken shortly before a scheduled medical treatment. If you miss your dose, contact your doctor or healthcare team immediately for instructions. Do not take a double dose to make up for a missed one.

Storage

•Store Grandem MD Tablet tablets at room temperature, ideally between 20°C to 25°C (68°F to 77°F). •Keep the medicine in its original packaging to protect it from direct light and moisture.

Drug Warnings

  • Take it at the prescribed time: Take your dose exactly as directed before your chemotherapy or radiation session so the medicine can work effectively to prevent nausea and vomiting.
  • Use caution when driving: Grandem MD Tablet may cause dizziness, drowsiness, or fatigue. Avoid driving or operating machinery until you know how this medicine affects you.
  • Watch for constipation: Contact your doctor if you develop severe constipation, abdominal pain, or if you do not have a bowel movement for several days.
  • Tell your doctor about all your medicines: Inform your doctor if you are taking medicines for depression, anxiety, migraine, or other conditions, as some can interact with Grandem MD Tablet and increase the risk of serious side effects such as serotonin syndrome or heart rhythm problems.
  • Use only as prescribed: Take Grandem MD Tablet only at the prescribed dose and schedule. Do not take extra doses or continue treatment for longer than recommended unless advised by your doctor.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are using any of the following medicines or skin products, as they may interact with Grandem MD Tablet .

  • Antidepressants (SSRIs, SNRIs, MAOIs): Combining these with Grandem MD Tablet can increase the risk of serotonin syndrome, a rare but serious condition.
  • Heart rhythm medications (QT prolonging drugs): Medicines that affect your heart's electrical activity can increase the risk of irregular heartbeats when taken with Grandem MD Tablet .
GranisetronMesoridazine
Critical

Drug-Drug Interactions

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GranisetronMesoridazine
Critical
How does the drug interact with Grandem MD Tablet:
Taking Grandem MD Tablet with mesoridazine can increase the risk of an irregular heart rhythm. I

How to manage the interaction:
Taking Mesoridazine with Grandem MD Tablet is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Grandem MD Tablet:
Taking Grandem MD Tablet with Dronedarone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Grandem MD Tablet with Dronedarone is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Grandem MD Tablet:
Taking Grandem MD Tablet with Thioridazine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem MD Tablet with Thioridazine is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Grandem MD Tablet:
Taking Grandem MD Tablet with Pimozide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem MD Tablet with Pimozide is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Grandem MD Tablet:
Taking Grandem MD Tablet with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Grandem MD Tablet with Ziprasidone is not recommended, as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
GranisetronSaquinavir
Critical
How does the drug interact with Grandem MD Tablet:
When Grandem MD Tablet is taken with Saquinavir, can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem MD Tablet with Saquinavir is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Grandem MD Tablet:
Taking Grandem MD Tablet with Sparfloxacin can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Grandem MD Tablet with Sparfloxacin is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Grandem MD Tablet:
Taking Grandem MD Tablet with Cisapride can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem MD Tablet with Cisapride is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Grandem MD Tablet:
When Grandem MD Tablet is taken with rizatriptan, the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in body) increases.

How to manage the interaction:
Although there is a possible interaction between Grandem MD Tablet and Rizatriptan, it can be taken if a doctor has advised it. If you notice any of these symptoms like confusion, hallucination, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, shaking of hands and legs, incoordination, stomach cramps, nausea, vomiting, and loose stools, contact a doctor. Do not discontinue any medications without consulting a doctor.
GranisetronRemifentanil
Severe
How does the drug interact with Grandem MD Tablet:
Combining Grandem MD Tablet with Remifentanil can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in body).

How to manage the interaction:
Co-administration of Grandem MD Tablet with Remifentanil can possibly result in an interaction, but it can be taken if doctor has advised it. However, if you experience confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, blurred vision, muscle spasm, stomach cramp, nausea, vomiting, diarrhea, dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Grandem MD Tablet when used as directed. 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIEMETICS]

FAQs

Grandem MD Tablet is used to treat nausea and vomiting caused by medical treatments.
Grandem MD Tablet contains Granisetron, an anti-emetic drug. It is a serotonin blocker that blocks the activity of serotonin, a chemical messenger that induces nausea and vomiting after treatments like chemotherapy and radiation therapy. Thus, Grandem MD Tablet relieves from post-operative nausea and vomiting symptoms.
Grandem MD Tablet may cause constipation as one of its side effects. You can avoid it by including high fibre food in your diet that improves your digestion. Limit the intake of alcohol to manage your constipation.
Grandem MD Tablet should be used with caution if you have recent stomach/intestinal problems like stomach ache, wind, feeling or being sick or difficulty passing stools, heart problems, electrolyte imbalance (potassium, sodium or calcium), and liver or kidney diseases.
You are advised to complete the course prescribed by your doctor. Please do not stop taking this medicine unless advised by your doctor since it may lead to recurrent episodes of nausea and vomiting.
Take Grandem MD Tablet as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose.
Yes, you can take Grandem MD Tablet with or without food. If you have a sensitive stomach, taking it with a small meal may help. Talk to your doctor for personalised advice.
While drowsiness is not the most common side effect, some people may feel tired, weak, or dizzy while taking this medicine. Avoid driving until you know how it affects you, and talk to your doctor if this concerns you.
There is limited information on the safety of Grandem MD Tablet during pregnancy. You should only use it if your doctor determines the benefits outweigh the risks. Talk to your doctor if you are pregnant or planning to become pregnant.
Do not take an extra dose to replace the one you threw up. Contact your doctor or healthcare team immediately for instructions on what to do next.
No, Grandem MD Tablet is specifically indicated to prevent nausea and vomiting associated with cancer chemotherapy and radiation therapy. It is not recommended for general stomach bugs. Talk to your doctor to find an appropriate treatment.
It is best to avoid alcohol while taking this medicine, as alcohol can increase side effects like dizziness and may worsen nausea. Talk to your doctor or pharmacist about safe drinking habits during your treatment.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Mercantile Chamber, 3rd Floor, 12, J.N. Heredia Marg, Ballard Estate, Mumbai – 400 001, India.
Other Info - GRA0162
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