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Adefine-400 Tablet is used to help manage mild to moderate alcoholic liver disease, osteoarthritis, and depression. Adefine-400 Tablet plays a crucial role in supporting cellular functions, regulating key physiological activities, increasing glutathione (a vital antioxidant for liver health), and enhancing overall liver metabolism. Some common side effects may include nausea, diarrhoea, stomach discomfort, and gas (flatulence).

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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Manufacturer/Marketer :

Fine Formulations

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Adefine-400 Tablet

Adefine-400 Tablet is a medication used to support emotional well-being, promote joint comfort, and maintain healthy liver function. It is commonly suggested to help manage symptoms of mood disorders and to ease the physical discomfort associated with wear-and-tear on the joints.

To experience the full benefits of this medicine, you must take it consistently every day as directed by your healthcare provider. For the best absorption, you should take this medicine on an empty stomach, typically 30 to 60 minutes before a meal. Incorporating regular, low-impact exercise and a nutrient-rich diet can also help maximise your results.

While taking this medicine, you may experience mild side effects such as nausea or a slight upset stomach. However, if you develop severe mood swings, intense anxiety, or signs of an allergic reaction like a skin rash, you should contact your doctor immediately.

Talk to your doctor before starting this medicine if you have any pre-existing health conditions, especially nerve-related disorders or a history of mental health challenges. Specifically, individuals diagnosed with bipolar disorder should not take this medicine, as it can cause serious mood shifts.

This medicine can interact with other substances, such as certain suggested antidepressants and over-the-counter cough medicines, potentially causing a dangerous buildup of brain chemicals. If you are pregnant, breastfeeding, or an elderly individual, you should consult your healthcare provider to discuss whether this medicine is safe for you.

Uses of Adefine-400 Tablet

Adefine-400 Tablet is used to support joint health, liver function, and emotional well-being. It helps protect joint tissues, supports healthy bile flow, and promotes balanced brain function. 

  • Osteoarthritis: Helps protect joint tissue, reduces chronic joint pain, and improves overall physical mobility.
  • Depression and Mood Support: Works in the brain to balance essential chemicals, helping to ease symptoms of low mood and emotional distress.
  • Intrahepatic Cholestasis and Liver Health: Supports liver cell function and promotes the healthy flow of bile to prevent liver damage.

Key Benefits

Adefine-400 Tablet supports joint health, emotional well-being, and liver function by targeting the underlying causes of discomfort. It helps improve mobility, supports a balanced mood, and promotes healthy liver function. Key benefits include:

  • Supports joint health: Helps reduce joint stiffness and discomfort, improving mobility and making daily activities easier.
  • Promotes emotional well-being: Helps stabilise mood and supports emotional balance by maintaining healthy brain function.
  • Supports liver health: Helps maintain healthy liver function and promotes the natural flow of bile.
  • Provides antioxidant protection: Helps protect cells from oxidative stress, supporting overall metabolic health and energy levels.

Directions for Use

  • Adefine-400 Tablet can be taken with or without food as advised by the doctor.
  • Follow your doctor's instructions regarding the dosage and timing of this medication for optimal effectiveness.
  • Swallow Adefine-400 Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Adefine-400 Tablet Works

Adefine-400 Tablet contains s-adenosyl l-methionine (SAMe), a naturally occurring compound that delivers essential chemical groups to your cells. This transfer process is fundamental to many important biological functions. In the brain, it helps support the production of key neurotransmitters, such as serotonin and dopamine, which play an important role in regulating mood and emotional well-being. In the joints, SAMe helps maintain and repair cartilage, the protective tissue that cushions your bones, thereby reducing friction and supporting joint comfort. In the liver, it helps support the production of glutathione, a powerful antioxidant that protects liver cells from damage and assists in the body's natural detoxification processes.
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Alcohol

Caution

It is not known whether it is safe to consume alcohol with Adefine-400 Tablet . Please consult your doctor if you have any concerns.

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Pregnancy

Caution

Adefine-400 Tablet should be used with caution in pregnant women. Please consult a doctor if you are pregnant.

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Breast Feeding

Caution

The use of Adefine-400 Tablet should be exercised with caution in nursing mothers. Please consult a doctor.

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Driving

Caution

Adefine-400 Tablet may cause drowsiness and dizziness in rare cases. Exercise caution while driving in case of these side effects.

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Liver

Consult your doctor

Adefine-400 Tablet is possibly safe on the liver. Please consult your doctor if you have any concerns.

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Kidney

Consult your doctor

Adefine-400 Tablet is possibly safe on the kidney. Please consult your doctor in case of any concerns.

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Children

Caution

It is not established if Adefine-400 Tablet is safe to use in children. Please consult the treating doctor in case of any concerns.

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Heart

Safe if suggested

Adefine-400 Tablet is generally considered safe for individuals with heart conditions. However, it is advisable to consult your doctor before using Adefine-400 Tablet .

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Geriatrics

Consult your doctor

Adefine-400 Tablet should be given to elderly patients only when recommended by a doctor. If you have any concerns about using Adefine-400 Tablet for geriatrics, please consult a doctor.

What if I have taken an overdose of Adefine-400 Tablet

If you suspect an accidental overdose or experience severe physical symptoms, seek immediate medical attention or contact your local emergency services right away.

Diet & Lifestyle Advise

  • Boost your B-vitamins: Ensure your diet includes plenty of foods rich in vitamin B12 and folate, such as leafy greens, eggs, and fortified cereals, as your body needs these nutrients to process Adefine-400 Tablet properly.
  • Keep moving: Engage in low-impact activities like swimming or cycling to support joint lubrication and muscle strength without straining your cartilage.
  • Avoid alcohol: Limit your alcohol intake, as alcohol can compromise liver function and interfere with medications meant to support your mood.
  • Stay hydrated: Drink plenty of water throughout the day to support your body's natural detoxification processes and keep your joints hydrated.
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Have a query?

How Soon It Starts Working

The time required for Adefine-400 Tablet to start to work: The time required for Adefine-400 Tablet to show its action is unknown. The time for which the effects of Adefine-400 Tablet last: The duration of action for Adefine-400 Tablet is clinically unknown.

Storage

• Store this medicine at controlled room temperature (20°C to 25°C / 68°F to 77°F).

What if you forget to take Adefine-400 Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and return to your normal routine. Do not take a double dose to make up for a missed tablet.

Drug Warnings

  • Inspect the blister pack before use: Do not take the tablet if the foil is torn or broken, or if the tablet appears damp or discoloured.
  • Inform your surgeon or dentist: Tell them you are taking Adefine-400 Tablet well before any scheduled surgical or dental procedure.
  • Avoid taking it late in the evening: This may help prevent sleep disturbances or insomnia.
  • Keep an updated medicine list: Share a list of all your current medicines and supplements with your healthcare provider before starting Adefine-400 Tablet .

Drug-Drug Interactions

verifiedApollotooltip
  • Antidepressants (such as SSRIs, SNRIs, or MAOIs): Combining these can cause a dangerous buildup of serotonin in your brain, leading to a serious condition called serotonin syndrome.
  • Cough suppressants containing dextromethorphan: Taking these together may increase the risk of severe neurological side effects.
  • Levodopa: This medicine may reduce the effectiveness of levodopa, which could worsen symptoms of Parkinson's disease.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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  • Food in general: Taking this medicine with a meal significantly lowers how much of it your body can absorb, reducing its therapeutic effect.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[MISCELLANEOUS]

FAQs

Adefine-400 Tablet is used in the treatment of mild to moderate alcoholic liver disease, osteoarthritis‚ and depression.
Please see an orthopaedic doctor if you have had a fracture. Adefine-400 Tablet is used in the case of arthritis and has limited use in the treatment of fractures, as fractures are more often a surgical concern.
Yes, Adefine-400 Tablet finds a lot of benefit in treating depression. However, if you are on any antidepressants, keep your doctor informed to avoid any interactions.
In case you miss a dose of Adefine-400 Tablet , take it as soon as possible. However, if it is too close to the next dose, revert to the original schedule.
Adefine-400 Tablet is probably safe for the kidneys; however, in the case of CKD, it is best to consult your treating doctor before using Adefine-400 Tablet .
Adefine-400 Tablet works by synthesising methionine, an essential amino acid required for cellular energy.
Adefine-400 Tablet may cause side effects such as nausea, diarrhoea, stomach pain, and flatulence. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist.
Adefine-400 Tablet should not be used by people who are allergic to any of its components. It is also not recommended for people with bipolar disorder, HIV, pregnant and nursing women.
Adefine-400 Tablet contains S-Adenosylmethionine, a naturally occurring compound found in almost every tissue and fluid in the body. It is made in the body from methionine, an amino acid found in foods.
It is unknown whether Adefine-400 Tablet is safe for long-term use. Take Adefine-400 Tablet for the duration suggested by the doctor.
Yes, you should take this medicine on an empty stomach, ideally 30 to 60 minutes before a meal. Taking it with food can significantly reduce how much of the medicine your body absorbs. Talk to your doctor or pharmacist if you have a persistent stomach upset.
Weight gain is not a recognised side effect of this medicine. If you notice unexpected changes in your weight, discuss this with your healthcare provider to identify other potential causes. Talk to your doctor for guidance.
It is highly recommended to limit or avoid alcohol while taking this medicine, as alcohol can worsen mood symptoms and stress your liver. Talk to your doctor to see what is safe for you.
The safety of this medicine during pregnancy and breastfeeding has not been fully established. You should avoid taking it during these periods unless your healthcare provider explicitly advises you to do so. Talk to your doctor before starting.
Feeling overly anxious, restless, or hyperactive can happen when starting this medicine. If you experience these feelings, try taking your dose earlier in the day, and talk to your doctor to adjust your care plan.
These tablets are usually manufactured with a special enteric coating that prevents them from dissolving in your stomach acid, ensuring they reach your intestines intact for proper absorption. Chewing or crushing the tablet destroys this coating. Talk to your pharmacist if you have difficulty swallowing pills.
No, you should not take this medicine if you have bipolar disorder, as it can trigger severe manic episodes. Talk to your doctor to explore alternative treatment options.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

#95, 1St Street, Muniappa Nagar,Nerkundram, Chennai-600107, Tamilnadu
Other Info - ADE0115
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