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  3. Epsinil 5mg Tablet

Epsinil 5mg Tablet, Pack of 1 Tablet
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Epsinil 5mg Tablet is used as an adjunct to treat Parkinson's disease and extrapyramidal symptoms (drug-induced movement disorders). It contains Trihexyphenidyl, which works by relaxing the muscles and nerve impulses that control muscle functioning. Besides this, it also balances chemical messengers called neurotransmitters in the brain; thereby improving muscle control and reducing stiffness. In some cases, you may experience common side effects such as nausea, vomiting, dizziness, constipation, weakness, headache, dry mouth, decreased urination, drowsiness, and feeling nervous or restless. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

TRIHEXYPHENIDYL-5MG

Manufacturer/Marketer :

Lifecare Innovations Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Epsinil 5mg Tablet

Epsinil 5mg Tablet is used as an adjunct to treat Parkinson’s disease and extrapyramidal symptoms (drug-induced movement disorders). Parkinson’s disease is a progressive neurological disorder in which the first signs are problems with movement.

Epsinil 5mg Tablet contains ‘Trihexyphenidyl’, which works by relaxing the muscles and nerve impulses that control muscle functioning. Besides this, Epsinil 5mg Tablet also balances chemical messengers called neurotransmitters in the brain, thereby improving muscle control and reducing stiffness, which helps the muscles move naturally.

In some cases, you may experience common side effects such as nausea, vomiting, dizziness, constipation, weakness, headache, dry mouth, decreased urination, drowsiness, and feeling nervous or restless. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if the side effects persist or worsen.

Consult your doctor if you are pregnant or breastfeeding. Epsinil 5mg Tablet may cause drowsiness and dizziness; do not drive unless you are alert. Epsinil 5mg Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Epsinil 5mg Tablet as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your medicines and health conditions to rule out any side effects.

Uses of Epsinil 5mg Tablet

Epsinil 5mg Tablet is used in the management of movement disorders and certain neurological conditions. The detailed uses of Epsinil 5mg Tablet are as follows: <br/>• Treatment of Parkinson’s disease: Epsinil 5mg Tablet reduces muscle stiffness, tremors, and impaired muscle control in patients with Parkinson’s disease.<br/>• Management of drug-induced extrapyramidal symptoms: Controls involuntary movements, restlessness, and muscle spasms caused by antipsychotic medications.<br/>• Relief from dystonia: Used to manage muscle contractions and abnormal postures associated with various types of dystonia.<br/>• Adjunct in combination therapy: Often used in conjunction with other drugs, such as levodopa, to improve Parkinson's symptoms.<br/>• Improves overall motor function: Improves mobility and daily functioning by reducing stiffness and movement issues.<br/>

Directions for Use

  • Epsinil 5mg Tablet can be taken with or without food.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow it as a whole with a glass of water.
  • Do not crush, chew, or open it.

Medicinal Benefits

Epsinil 5mg Tablet belongs to a group of medicines called anti-spasmodic agents. It is used to treat the symptoms of Parkinson’s disease and extrapyramidal symptoms (drug-induced movement disorders). Epsinil 5mg Tablet exerts a direct inhibitory effect upon the parasympathetic nervous system. It works by relaxing the muscles and nerve impulses that control muscle functioning. Epsinil 5mg Tablet enhances muscle control and reduces stiffness, allowing the muscles to move more naturally. Epsinil 5mg Tablet is used as an adjuvant therapy along with levodopa to treat Parkinson's disease. Additionally, Epsinil 5mg Tablet is used to control drug-induced movement disorders caused by CNS drugs such as dibenzoxazepines, thioxanthenes, phenothiazines, and butyrophenones.

How Epsinil 5mg Tablet Works

Epsinil 5mg Tablet contains Trihexyphenidyl, which works by relaxing the muscles and nerve impulses that control muscle functioning. Additionally, Epsinil 5mg Tablet also balances the chemical messengers called neurotransmitters in the brain, thereby improving muscle control and reducing stiffness, which enables the muscles to move naturally.

Storage

Store in a cool and dry place away from sunlight
Side effects of Epsinil 5mg Tablet
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
Here are the steps to manage medication-triggered Nervousness:
  • Tell your doctor immediately if you experience symptoms of Nervousness, such as anxiety, jitteriness, or an increased heart rate, after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen to alleviate symptoms of Nervousness. This can include switching to a different medication, reducing the dosage, or temporarily stopping the medication. Your doctor may also recommend alternative techniques like relaxation, mindfulness meditation, or journaling. These techniques can help reduce anxiety and Nervousness.
  • Practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling, to help manage Nervousness.
  • Engage in regular physical activity, such as walking or jogging, to help reduce anxiety and improve mood.
  • Your doctor may advise considering cognitive-behavioural therapy (CBT) or other forms of talk therapy to address underlying anxiety or Nervousness.
  • You should maintain regular follow-up appointments with your doctor to monitor nervousness symptoms, adjust treatment plans as needed, and discuss any concerns or questions.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

What if I have taken an overdose of Epsinil 5mg Tablet

Do not take more than the prescribed dose of Epsinil 5mg Tablet as it may cause an overdose. The symptoms of overdose include feeling hot, paleness in face, severe drowsiness, fever, dilated pupils, dry skin and mouth, seizure, hallucinations, paranoia, agitation, or numbness in or around your mouth, nose, or throat. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Epsinil 5mg Tablet if you are allergic to any of its contents or if you have narrow-angle glaucoma. Do not discontinue Epsinil 5mg Tablet on your own. Inform your doctor if you have glaucoma, prostate problems, urination problems, stomach ulcers, acidity, myasthenia gravis (muscle problems), tardive dyskinesia (involuntary facial movements), alcoholism, high blood pressure, heart, liver or kidney problems. Talk to your doctor immediately if you experience hallucinations. Consult your doctor if you are pregnant or breastfeeding. Epsinil 5mg Tablet may cause drowsiness and dizziness, do not drive unless you are alert. Epsinil 5mg Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Epsinil 5mg Tablet as it could lead to increased drowsiness and dizziness.

Drug-Drug Interactions

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TrihexyphenidylPotassium citrate
Critical
TrihexyphenidylPotassium chloride
Critical

Drug-Drug Interactions

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TrihexyphenidylPotassium citrate
Critical
How does the drug interact with Epsinil 5mg Tablet:
Co-administration of Epsinil 5mg Tablet with potassium citrate may increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Epsinil 5mg Tablet with potassium citrate is not recommended as it can possibly result in an interaction, it can be taken if prescribed by a doctor. However, if you experience abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, or black stools contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TrihexyphenidylPotassium chloride
Critical
How does the drug interact with Epsinil 5mg Tablet:
Co-administration of Epsinil 5mg Tablet with potassium chloride can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Epsinil 5mg Tablet with potassium chloride is not recommended as it can possibly result in an interaction, it can be taken if prescribed by a doctor. However, if you experience abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, black stools contact a doctor immediately. Do not discontinue any medications without consulting to a doctor.
TrihexyphenidylAmantadine
Severe
How does the drug interact with Epsinil 5mg Tablet:
Coadministration of Allopurinol with Epsinil 5mg Tablet may increase side effects such as heat intolerance, dry mouth, confusion, constipation, difficulty urinating, and blurred vision especially in the elderly or those with a debilitating (physically weak) condition.

How to manage the interaction:
If you are supposed to take Allopurinol and Epsinil 5mg Tablet together, your doctor may adjust the dose or monitor you more frequently to safely use both medications.
TrihexyphenidylTopiramate
Severe
How does the drug interact with Epsinil 5mg Tablet:
Taking Epsinil 5mg Tablet with topiramate can increase the risk of increase body temperature and reduced sweating.

How to manage the interaction:
Co-administration of Epsinil 5mg Tablet with Topiramate can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience dizziness or lightheaded, increase body temperature contact your doctor right away. Do not discontinue any medications without first consulting your doctor.
TrihexyphenidylEsketamine
Severe
How does the drug interact with Epsinil 5mg Tablet:
Taking Epsinil 5mg Tablet with esketamine can increase the risk of other side effects.

How to manage the interaction:
Although there is a interaction between Epsinil 5mg Tablet and esketamine, but can be taken together if prescribed by your doctor. However, if you experience drowsiness, confusion, difficulty concentrating, and impairment in thinking contact your doctor right away. Do not stop using any medications without talking to your doctor.
TrihexyphenidylZonisamide
Severe
How does the drug interact with Epsinil 5mg Tablet:
Coadministration of Epsinil 5mg Tablet with Zonisamide can increase the risk or severity of Zonisamide side effects like increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Epsinil 5mg Tablet with Zonisamide together is not recommended as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience increased heart rate, fever, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.
TrihexyphenidylKetamine
Severe
How does the drug interact with Epsinil 5mg Tablet:
Taking Epsinil 5mg Tablet with Ketamine can increase the risk of side effects.

How to manage the interaction:
Although there is a interaction between Epsinil 5mg Tablet and ketamine, but it can be taken together if prescribed by your doctor. However, if you experience drowsiness, confusion, difficulty concentrating, and impairment in thinking contact your doctor right away. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly.
  • Include a diet rich in iron, folate and magnesium.
  • Regularly attend therapy sessions.
  • Perform meditation and yoga.
  • Follow a regular sleep pattern.
  • Avoid smoking and alcohol consumption.
  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Habit Forming

No

Therapeutic Class

ANTIPARKINSON AGENTS

Epsinil 5mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Epsinil 5mg Tablet as it may cause increased dizziness and drowsiness.

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Pregnancy

Caution

Epsinil 5mg Tablet belongs to pregnancy category C. Please consult your doctor if you are pregnant or planning to become pregnant. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

It is unknown whether Epsinil 5mg Tablet passes into breastmilk. Consult your doctor if you are breastfeeding.

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Driving

Unsafe

Epsinil 5mg Tablet may cause dizziness, drowsiness and blurred vision. Avoid driving and handling machinery if you experience these symptoms.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Unsafe

Epsinil 5mg Tablet is not recommended for use in children, as safety and effectiveness have not been established.

Have a query?

FAQs

Epsinil 5mg Tablet belongs to a group of medicines called anti-spasmodic agents used as an adjunct to treat Parkinson's disease and extrapyramidal symptoms (drug-induced movement disorders).

Epsinil 5mg Tablet works by relaxing the muscles and nerve impulses that control muscle functioning. It improves muscle control and reduces stiffness, thereby helping the muscles move naturally.

Dry mouth may be a side effect of Epsinil 5mg Tablet. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum or candy may help stimulate saliva and thereby prevent mouth dryness.

Epsinil 5mg Tablet should be used with caution during hot weather as it may increase the chance of having a heat stroke. Inform your doctor if you have heat intolerance or fever.

Antidepressants should be avoided while taking Epsinil 5mg Tablet as it might increase sedative effects. Consult your doctor before taking Epsinil 5mg Tablet if you are using depressants.

Hallucination is a medical condition in which the person may feel, hear or believe things that are not true, see things that are not there, or feel unusually suspicious or confused. Epsinil 5mg Tablet may cause hallucinations in some cases if taken for a prolonged time. So, if you experience hallucinations while taking Epsinil 5mg Tablet, please talk to your doctor immediately.

Constipation may occur as a side-effect of Epsinil 5mg Tablet. Try eating foods that encourage a bowel movement. Consult your doctor if you experience excessive constipation.

Consult your doctor before taking Epsinil 5mg Tablet if you have glaucoma. Epsinil 5mg Tablet is contraindicated in patients with narrow-angle glaucoma. Epsinil 5mg Tablet may cause blindness on long-term use in case of patients with narrow-angle glaucoma.

The dosage and frequency of taking Epsinil 5mg Tablet depend on various factors, including age, weight, medical condition, severity of symptoms, and other medications being taken. So, it's essential to follow the specific instructions provided by your doctor.

Don't stop taking Epsinil 5mg Tablet without consulting your doctor. Stopping suddenly can cause withdrawal symptoms and worsen your condition. If you're doing well, report to your doctor for further guidance. Contact your doctor immediately for appropriate treatment if you experience any difficulties or side effects. Your doctor will help you adjust your medication safely and effectively.

Before starting Epsinil 5mg Tablet, it's crucial to have a thorough consultation with your doctor. Share your comprehensive medical history, including any existing conditions or past illnesses. Also, provide a detailed list of your medications and supplements. Inform your doctor about any medication allergies or sensitivities. Furthermore, discuss your lifestyle habits, such as smoking, alcohol consumption, or recreational drug use. If you're pregnant, breastfeeding, or planning to become pregnant, be sure to disclose this information. This will enable your doctor to determine whether Epsinil 5mg Tablet suits you and provide personalized care.

Swallow it whole with a glass of water. Do not chew or crush the tablet or capsule. It's important to follow your doctor's exact directions, including the recommended dose and duration of treatment.

The common side effects of Epsinil 5mg Tablet include nausea, vomiting, dizziness, constipation, weakness, headache, dry mouth, decreased urination, drowsiness, and feeling nervous or restless. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if the side effects persist or worsen.

Country of origin

India
Other Info - EP47832

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:41 AM IST

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Reference

  1. https://www.lifegenix.in/trihelp-2
  2. https://pmc.ncbi.nlm.nih.gov/articles/PMC6494536/
  3. https://www.medicines.org.uk/emc/files/pil.5271.pdf
  4. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/006773_S036_ARTANE.pdf
  5. https://medlineplus.gov/druginfo/meds/a682160.html
  6. https://www.drugs.com/mtm/trihexyphenidyl.html
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