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compositionComposition:LITHIUM CARBONATE-400MG
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Prescription Medicine
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Lisr 400Mg Pr Tablet belongs to the class of antipsychotic medicine used in the treatment of bipolar disorder and mania. This medicine suppresses the excess and abnormal activity of nerve cells in the brain by increasing the activity of chemical messengers in the brain. Common side effects include loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination.

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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

LITHIUM CARBONATE-400MG

Manufacturer/Marketer :

Alteus Biogenics Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Lisr 400Mg Pr Tablet

Lisr 400Mg Pr Tablet is a medication primarily prescribed to stabilise mood and treat manic episodes associated with bipolar disorder. It helps prevent and control severe mood swings, bringing emotional balance to those experiencing extreme highs and lows. This medicine plays a crucial role in long-term mental health management.

To get the best results, you must take Lisr 400Mg Pr Tablet consistently at the same times every day as directed by your doctor. You can take this medication with or without food, though taking it with a meal can help prevent a mild upset stomach. Maintaining a highly consistent daily intake of fluids and dietary salt is also vital, as sudden changes can affect how your body handles the medicine.

While taking Lisr 400Mg Pr Tablet , you may experience mild side effects like a slight hand tremor, increased thirst, or urinating more often. However, you must contact your doctor immediately if you experience severe hand shaking, persistent vomiting, severe diarrhoea, or slurred speech, as these can be signs of the medicine reaching unsafe levels in your blood.

Talk to your doctor before taking Lisr 400Mg Pr Tablet if you have kidney disease, heart problems, thyroid issues, or if you are severely dehydrated. Do not take this if you have severe kidney failure, severe cardiovascular disease, untreated underactive thyroid, or severe dehydration, as the medicine can build up to dangerous levels in your body.

This medicine can interact with several other drugs, including common over-the-counter pain relievers, water pills, and certain blood pressure medicines, which can raise the amount of Lisr 400Mg Pr Tablet in your blood and lead to side effects. You should also avoid alcohol, as it can worsen drowsiness and cause dehydration. If you are pregnant, breastfeeding, or an older adult, consult your doctor before starting Lisr 400Mg Pr Tablet to discuss safe options.

Uses of Lisr 400Mg Pr Tablet

Lisr 400Mg Pr Tablet helps stabilise mood and manage certain mental health conditions. Your doctor may prescribe it for the following conditions:

  • Bipolar disorder: It acts as a long-term mood stabiliser to prevent and reduce the frequency and severity of manic (extreme highs) and depressive (extreme lows) episodes.
  • Acute mania: It helps quickly control and calm severe manic symptoms, such as racing thoughts, extreme restlessness, rapid speech, and impulsive behaviours.
  • Recurrent depression: It is sometimes used alongside other medications to treat persistent depression when standard antidepressants have not worked well enough on their own.

Key Benefits

Lisr 400Mg Pr Tablet helps stabilise mood and reduce the symptoms of bipolar disorder. Key benefits include:

  • Stabilises mood: Helps reduce extreme mood swings and maintain a more balanced emotional state.
  • Helps manage manic episodes: Reduces symptoms such as racing thoughts, restlessness, rapid speech, and impulsive behaviour.
  • Supports long-term mental health: Helps lower the risk of future manic and depressive episodes when taken regularly as prescribed.
  • Supports emotional well-being: By improving mood stability, it can help you think more clearly, carry out daily activities, and maintain relationships more effectively.

Directions for Use

  • Take Lisr 400Mg Pr Tablet with food for better absorption, or take it as advised by the doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Swallow it as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Lisr 400Mg Pr Tablet Works

Lisr 400Mg Pr Tablet contains lithium carbonate, which works directly within the central nervous system to balance chemical messengers, known as neurotransmitters, in the brain. It helps reduce overactive brain signals that cause manic behavior while boosting the pathways that calm and stabilise your nervous system. By strengthening these pathways, the medicine protects brain cells from stress and helps regulate the genetic and biological factors that control your daily mood, keeping your emotions on a steady, manageable level.
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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Lisr 400Mg Pr Tablet as it may increase the risk of side effects such as drowsiness, dizziness or difficulty in concentrating.

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Pregnancy

Unsafe

Lisr 400Mg Pr Tablet is a Category D pregnancy drug and is not recommended for use during pregnancy as it may cause harm to the unborn baby.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Lisr 400Mg Pr Tablet as it may be excreted in breast milk and cause adverse effects in the baby.

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Driving

Unsafe

Lisr 400Mg Pr Tablet may cause dizziness, drowsiness or other severe adverse effects. Therefore, avoid driving if you feel drowsy or dizzy after taking Lisr 400Mg Pr Tablet .

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Liver

Safe if prescribed

Lisr 400Mg Pr Tablet is safe to use in patients with liver diseases/conditions if prescribed by a doctor.

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Kidney

Caution

Take Lisr 400Mg Pr Tablet with caution, especially if you have a history of kidney diseases/conditions. The dose may be adjusted by your doctor as required. Lisr 400Mg Pr Tablet is not recommended for patients with severe kidney problems.

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Children

Caution

Lisr 400Mg Pr Tablet is generally not recommended for children below 12 years. However, Lisr 400Mg Pr Tablet may be used in children above 7 years for treating bipolar disorder only if prescribed by a doctor.

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Heart

Unsafe

Lisr 400Mg Pr Tablet should not be used in patients with severe heart disease. It should be taken only after seeking advice from your doctor, especially if you have or have had any heart problems.

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Geriatrics

Caution

Lisr 400Mg Pr Tablet should be given with caution in elderly patients due to an increased risk of side effects. Please inform your doctor before use.

What if I have taken an overdose of Lisr 400Mg Pr Tablet

If you take more than the prescribed amount of Lisr 400Mg Pr Tablet , seek immediate medical attention. Symptoms of an overdose may include severe drowsiness, confusion, slurred speech, poor coordination, vomiting, diarrhoea, muscle weakness, tremors, or seizures

Diet & Lifestyle Advise

  • Keep fluid intake steady: Drink a consistent amount of water daily (usually 8 to 12 cups) to prevent dehydration, which can raise medicine levels to dangerous heights.
  • Maintain a stable salt intake: Do not suddenly start a low-salt diet or suddenly increase your salt intake, as changes in dietary sodium directly affect how your kidneys process Lisr 400Mg Pr Tablet .
  • Limit caffeine: Avoid sudden changes in your consumption of coffee, tea, and soda, as caffeine can alter the clearance of this medicine from your system.
  • Avoid overheating: Be cautious during hot weather, heavy exercise, or during illnesses with fever or vomiting, as excessive sweating and dehydration can cause the medicine to build up dangerously.
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How Soon It Starts Working

The time required for Lisr 400Mg Pr Tablet to start to work: The time required for Lisr 400Mg Pr Tablet to show its action is unknown. The time for which the effects of Lisr 400Mg Pr Tablet last: The duration of action for Lisr 400Mg Pr Tablet is unknown.

What if you forget to take Lisr 400Mg Pr Tablet

If you miss a dose, take it as soon as you remember. However, if your next scheduled dose is only a few hours away, skip the missed dose and return to your regular schedule. Do not take a double dose to make up for a missed one. Talk to your doctor or pharmacist if you are unsure.

Storage

•Store Lisr 400Mg Pr Tablet at room temperature between 15°C and 30°C.• Keep the container tightly closed when not in use. Protect from moisture and direct light.

Drug Warnings

  • Keep all blood test appointments: Regular blood draws are absolutely necessary to ensure the drug remains in a safe therapeutic range.
  • Learn the early warning signs: Memorize the signs of toxicity (severe nausea, slurred speech, shakiness) so you can seek help immediately if they occur.
  • Check your pain relievers: Never start taking over-the-counter anti-inflammatory medicines like ibuprofen or naproxen without checking with your pharmacist first, as they can interact poorly.
  • Avoid alcohol: Alcohol can intensify side effects like drowsiness and increase your risk of dehydration.
  • Inform all healthcare providers: Tell all your doctors, dentists, and surgeons that you take Lisr 400Mg Pr Tablet before any medical procedures or new prescriptions.

Drug-Drug Interactions

verifiedApollotooltip
  • NSAID pain relievers (like ibuprofen and naproxen): May increase the risk of toxicity by raising the level of Lisr 400Mg Pr Tablet in your blood.
  • Diuretics (water pills) and ACE inhibitors (blood pressure drugs): Can cause a dangerous buildup of Lisr 400Mg Pr Tablet in your body by reducing how much your kidneys can clear.
  • Certain antidepressants (like SSRIs): May increase the risk of a rare but serious condition called serotonin syndrome, causing confusion, rapid heart rate, and sweating.
LithiumCidofovir
Critical
LithiumCisapride
Critical

Drug-Drug Interactions

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LithiumCidofovir
Critical
How does the drug interact with Lisr 400 mg PR Tablet:
Cidofovir can cause higher levels of Lisr 400 mg PR Tablet carbonate in the blood which increases risk of kidney problems.

How to manage the interaction:
Taking Lisr 400 mg PR Tablet with Cidofovir is not recommended, but can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
LithiumCisapride
Critical
How does the drug interact with Lisr 400 mg PR Tablet:
Taking Cisapride with Lisr 400 mg PR Tablet can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Lisr 400 mg PR Tablet with Cisapride is not recommended as it can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
LithiumDeferasirox
Severe
How does the drug interact with Lisr 400 mg PR Tablet:
Taking deferasirox with Lisr 400 mg PR Tablet may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Lisr 400 mg PR Tablet and Deferasirox, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience nausea, vomiting, loss of hunger, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, palpitations and confusion. Do not discontinue any medications without consulting a doctor.
LithiumEnalapril
Severe
How does the drug interact with Lisr 400 mg PR Tablet:
Taking Enalapril with Lisr 400 mg PR Tablet increases the levels of Lisr 400 mg PR Tablet in your blood, which may cause Lisr 400 mg PR Tablet toxicity. The risk is increased if you are elderly, dehydrated, or have a history of kidney or heart disease.

How to manage the interaction:
Although using Enalapril and Lisr 400 mg PR Tablet together may cause an interaction, they can be taken together if your doctor prescribes it. However, if you experience diarrhoea, vomiting, sleepiness, dizziness, muscular weakness, blurred vision, increased thirst and urination, or ringing in the ears, you should seek medical attention. Do not stop taking any medication without consulting your doctor.
LithiumHydroxychloroquine
Severe
How does the drug interact with Lisr 400 mg PR Tablet:
Taking Lisr 400 mg PR Tablet with Hydroxychloroquine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Lisr 400 mg PR Tablet and Hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
LithiumEnalapril
Severe
How does the drug interact with Lisr 400 mg PR Tablet:
Taking Lisr 400 mg PR Tablet with Enalapril may significantly increase the blood levels of Lisr 400 mg PR Tablet.

How to manage the interaction:
Co-administration of Enalapril with Lisr 400 mg PR Tablet can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience drowsiness, dizziness, loose stools, vomiting, muscle weakness, shaking of hands and legs, excessive thirst, and increased urination. Do not discontinue any medications without consulting a doctor.
LithiumTrichlormethiazide
Severe
How does the drug interact with Lisr 400 mg PR Tablet:
Taking Lisr 400 mg PR Tablet and Trichlormethiazide together can increase the effects of Lisr 400 mg PR Tablet.

How to manage the interaction:
Although taking Trichlormethiazide and Lisr 400 mg PR Tablet together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you have loose stools, vomiting, drowsiness, shaking of hands and legs, thirst, increased urination, lack of coordination, or muscle weakness call your doctor. Do not stop using any medications without a doctor's advice.
LithiumPerindopril
Severe
How does the drug interact with Lisr 400 mg PR Tablet:
Perindopril when taken together with Lisr 400 mg PR Tablet may significantly increase the blood levels of Lisr 400 mg PR Tablet.

How to manage the interaction:
Although there is drug interaction between perindopril and Lisr 400 mg PR Tablet, but can be taken together if advised by a doctor. if experience dizziness, confusion, diarrhea, vomiting, muscle weakness, tremor (shaking of hand & legs) blurred vision, ringing in the ear, excessive thirst, and/or increased urination consult a doctor immediately. Do not discontinue medications without consulting a doctor.
LithiumTelmisartan
Severe
How does the drug interact with Lisr 400 mg PR Tablet:
Co-administration of telmisartan may significantly increase the blood levels of Lisr 400 mg PR Tablet.

How to manage the interaction:
Although there is a possible interaction, telmisartan can be taken with Lisr 400 mg PR Tablet if prescribed by the doctor. Consult the prescriber if you experience symptoms of Lisr 400 mg PR Tablet intoxication such as drowsiness, dizziness, confusion, loose stools, vomiting, muscle weakness, muscle incoordination, shaking of hands and legs, blurred vision, ringing in the ear, excessive thirst, or increased urination. Do not discontinue the medication without consulting a doctor.
LithiumGatifloxacin
Severe
How does the drug interact with Lisr 400 mg PR Tablet:
Taking Gatifloxacin with Lisr 400 mg PR Tablet can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Gatifloxacin with Lisr 400 mg PR Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or unusual memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Caffeine: Sudden changes in coffee, tea, or energy drink intake can lower the effectiveness of Lisr 400Mg Pr Tablet or cause levels to rise if stopped abruptly.
  • Sodium (Salt): Major changes in daily salt intake can directly alter how your kidneys process and eliminate this medicine.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIPSYCHOTICS]

FAQs

Lisr 400Mg Pr Tablet belongs to a psychological class of drugs called 'anti-manic agents' or 'mood stabilizers' primarily used to prevent and treat mood disorders like mania and bipolar disorder.
Lisr 400Mg Pr Tablet helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.
Lisr 400Mg Pr Tablet is not recommended for hypothyroid (underactive thyroid gland) patients as it may increase the risk of low levels of thyroid hormone. Therefore, if you have hypothyroidism, please inform your doctor before taking Lisr 400Mg Pr Tablet .
Lisr 400Mg Pr Tablet may cause weight gain but it is not necessary for everyone taking Lisr 400Mg Pr Tablet to experience this side effect. However, in order to avoid gaining weight while taking Lisr 400Mg Pr Tablet , you are advised to do regular exercise and avoid high-calorie drinks. Instead take non-alcoholic drinks, herbal tea and lemon water.
It is advised to inform your doctor if you are planning or had weight loss surgery as the dose may be adjusted accordingly based on lithium levels in blood.
Lisr 400Mg Pr Tablet may cause dehydration especially if you have low sodium levels in the body or consume too much alcohol. However, if you notice dark, strong-smelling urine or a decrease in urination, it indicates that you are dehydrated, and this may affect lithium levels in the blood. Therefore, you are recommended to drink plenty of fluids while taking Lisr 400Mg Pr Tablet to avoid dehydration.
You are not recommended to stop taking Lisr 400Mg Pr Tablet without consulting your doctor as it may worsen the condition or cause recurring symptoms. Therefore, take Lisr 400Mg Pr Tablet for as long as your doctor has prescribed it and if you experience any difficulty while taking Lisr 400Mg Pr Tablet , please consult your doctor so that the dose may be gradually reduced.
You are not recommended to take Lisr 400Mg Pr Tablet with fluoxetine or other antidepressants such as paroxetine and sertraline as co-administration of these medicines may increase the risk of a rare and serious condition known as serotonin syndrome. If you experience blurred vision, increased heart rate, hallucination, fits, confusion, muscle stiffness or spasm, vomiting, nausea, diarrhoea, excessive sweating, stomach cramps, fever, shaking, or shivering, please consult a doctor immediately. However, before using Lisr 400Mg Pr Tablet with any other medicines, you are advised to contact your doctor.
It's important to inform your doctor about your hypertension and the medications you're taking for it as Lisr 400Mg Pr Tablet can interact with certain blood pressure medications, and your doctor may need to adjust your treatment plan to ensure your safety.
No, you should not increase the dose of Lisr 400Mg Pr Tablet on your own. It can take 1-3 weeks to feel the full effects, and increasing the dose without medical advice can be dangerous and may lead to adverse effects. However consult your doctor if you have any concerns.
Yes, Lisr 400Mg Pr Tablet can cause sleepiness as a side effect. It's important to be cautious when performing activities that require alertness, such as driving or operating heavy machinery, until you know how the medication affects you.
Yes, Lisr 400Mg Pr Tablet can affect the kidneys. Long-term use of lithium can lead to kidney problems, and regular monitoring of kidney function is necessary during treatment. It's important to inform your doctor if you have any pre-existing kidney conditions or if you experience any symptoms of kidney problems while taking Lisr 400Mg Pr Tablet .
Lisr 400Mg Pr Tablet should only be started if adequate facilities for assessing Lisr 400Mg Pr Tablet levels are available. Because elevated levels of Lisr 400Mg Pr Tablet are linked to Lisr 400Mg Pr Tablet toxicity. Lisr 400Mg Pr Tablet toxicity can even occur at dose which is effective for treatment. Therefore, your doctor may closely monitor your Lisr 400Mg Pr Tablet levels weekly until stabilization is achieved, then weekly for one month and then at monthly intervals thereafter.
Lisr 400Mg Pr Tablet should be taken as prescribed by your doctor. It is recommended to take with food to reduce nausea. Lisr 400Mg Pr Tablet may be taken before or after meals. Swallow it as a whole with a glass of water. Do not crush, chew or break it.
Certain medications which decrease the levels of Lisr 400Mg Pr Tablet in blood include carbonic anhydrase inhibitors, chlorpromazine, sodium-containing preparations, theophylline, urea and herbal medicines. Therefore, before starting Lisr 400Mg Pr Tablet , inform your doctor about all the medicines you are taking.
The common side effects of Lisr 400Mg Pr Tablet are loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination. If any of these side effects persist or worsen, please consult your doctor.
Yes, regular blood tests are essential to ensure the medication level in your blood is effective but not toxic. Your doctor will also use these tests to monitor your kidney and thyroid function over time. Talk to your doctor to understand your testing schedule.
It is highly recommended to avoid alcohol while taking this medicine. Alcohol can worsen side effects like drowsiness and dizziness, and it can cause dehydration, which increases the risk of drug toxicity. Talk to your doctor or pharmacist if you have questions.
Early warning signs of high levels include severe vomiting, persistent diarrhea, severe hand tremors, lack of coordination, and slurred speech. If you notice any of these symptoms, seek emergency medical care immediately. Talk to your doctor for more details.
You should avoid common anti-inflammatory drugs like ibuprofen or naproxen, as they can raise the levels of Lisr 400Mg Pr Tablet in your body to unsafe levels. Acetaminophen is generally a safer option, but you should always talk to your doctor or pharmacist before taking any new medicine.
Some individuals may experience mild weight gain while taking this medication due to water retention or changes in metabolism. Maintaining a balanced diet and regular exercise routine can help manage this. Talk to your doctor if weight changes become a concern.
Taking Lisr 400Mg Pr Tablet during pregnancy can carry risks for the developing baby, particularly during the first trimester. If you are pregnant, planning to become pregnant, or breastfeeding, you must discuss the risks and benefits with your physician. Talk to your doctor to weigh your options.
No, you must not stop taking Lisr 400Mg Pr Tablet suddenly, even if you feel completely healthy. Stopping the medicine abruptly can cause your mood symptoms to return or worsen. Talk to your doctor to discuss any changes to your treatment plan.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.10828 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 017812S033,018421S032,018558S027Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Lithium Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. National Health Service (NHS). Lithium - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  5. Drugs and Lactation Database (LactMed) [Internet]. 2006. [Accessed on 20 Feb. 2020]Check here
  6. Krutika Chokhawala, Sarah Lee, Abdolreza Saadabadi. Lithium. National Library of Medicine. National Center for Biotechnology Information. PubMed Central. May 2022. [Accessed on 13th February 2024]Check here

Country of origin

India

Manufacturer/Marketer address

Alteus Biogenics Pvt. Ltd., 14-B Dover Lane, Kolkata - 700029, WB, India.
Other Info - LIS0084

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