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Mesacol Enema is treating ulcerative colitis and ulcerative proctitis. It contains Mesalamine, which works by preventing the synthesis of chemical messengers such as prostaglandins in the intestines that produce inflammation (swelling). This lowers ulceration, bleeding, and stomach pain while preventing future illness flare-ups. Common side effects of Mesacol Enema are diarrhoea, stomach pain, headache or nausea.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

MESALAMINE-4GM

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

Rectal

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Mesacol Enema

Mesacol Enema is a specialised medication designed to treat inflammatory bowel diseases like ulcerative colitis and proctitis. Its primary medical purpose is to reduce swelling, redness, and irritation directly within the lining of the rectum and lower colon. By calming this inflammation, it helps control painful symptoms and allows the bowel lining to heal.

To achieve the best results, take this medicine consistently and exactly as your doctor prescribes, which is often once daily at bedtime. Because this is a rectal medication, you should insert it after emptying your bowels so it can remain in place to work overnight. Making dietary adjustments, such as avoiding spicy foods and staying well-hydrated, can also support your treatment and improve your digestive health.

While taking Mesacol Enema, some people may experience mild side effects like gas, mild stomach pain, or slight rectal irritation. These effects are usually temporary, but if you notice serious issues like severe abdominal cramps, fever, or bloody diarrhoea, stop taking the medication and consult your doctor immediately. Your health and safety are the top priorities, so monitoring how your body responds is essential.

Before you begin taking Mesacol Enema, you must talk to your doctor if you have certain health conditions, especially kidney disease, liver problems, or active stomach ulcers. Please avoid taking this if you have a known allergy to aspirin or similar salicylate medicines, as this can trigger a severe allergic reaction. Your doctor will help determine if this treatment is safe for your specific medical history.

This medication can interact with other drugs, including common over-the-counter pain relievers, which may increase the risk of kidney damage. If you are pregnant, breastfeeding, or planning a pregnancy, talk to your doctor or pharmacist to discuss the risks and benefits. Elderly individuals should also consult their healthcare provider, as they may require closer monitoring during treatment.

Uses of Mesacol Enema

Mesacol Enema is used in the treatment of Ulcerative colitis and Ulcerative proctitis. The detailed uses of Mesacol Enema are as follows:

  • Ulcerative proctitis: Mesacol Enema helps reduce localised swelling, bleeding, and irritation in the rectum, which is the very end of the large intestine.
  • Distal ulcerative colitis: Mesacol Enema helps by delivering anti-inflammatory medicine directly to the lower parts of the colon to heal the damaged tissue.
  • Maintenance of remission: Mesacol Enema helps keep your symptoms from returning, ensuring the bowel lining remains healthy and quiet over the long term.

Key Benefits

Mesacol Enema works directly at the site of inflammation in the rectum and lower colon, helping control symptoms while limiting medicine exposure to the rest of the body. With regular use as prescribed, it can help reduce inflammation, promote healing of the bowel lining, and support long-term symptom control. 

Benefits may include:

  • Because Mesacol Enema is used rectally, it delivers the medicine directly to the inflamed tissue in the lower bowel, providing targeted treatment where it is needed most.
  • It helps reduce symptoms such as rectal urgency, rectal bleeding, diarrhoea, and discomfort by calming inflammation in the affected area.
  • By reducing inflammation, Mesacol Enema helps the lining of the rectum and lower colon heal over time.
  • Continued use as prescribed can help keep ulcerative colitis or proctitis under control and reduce the likelihood of symptoms returning.
Side effects of Mesacol Enema 60 ml
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Check the label for directions and use it as advised by the doctor.
  • Before using, empty your bowels (if necessary) and wash your hands. Shake the bottle vigorously for at least 30 seconds. Remove the applicator's protective cap and hold the bottle by its top end. Lie on your left side, your left leg extended and your right leg bent. Insert the applicator (lubricant-coated) for easier entry into the rectum. Squeeze the bottle gently while holding it directed towards your navel. When the bottle is empty, remove the applicator from the rectum.
  • Allow the drug to spread throughout the lower section of the large intestine for at least 30 minutes by remaining in this posture.
  • Wash your hands before and after applying the medicament. Make sure that the rectal area is clean and dry before application.
  • For rectal use only.

How Mesacol Enema Works

Mesacol Enema works as a local anti-inflammatory agent inside the rectum and lower colon. It blocks the body's production of specific natural chemicals, such as prostaglandins and leukotrienes (chemicals your body releases that cause pain and swelling), which are responsible for causing pain, redness, and swelling in the tissue. By shutting down these pathways, the medicine stops the inflammatory response in its tracks. Since the medication acts directly on the surface of the inflamed bowel lining rather than being absorbed heavily into the bloodstream, it provides highly concentrated therapy. This targeted action helps the irritated tissues heal safely and efficiently, reducing the risk of side effects in other parts of your body.
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Alcohol

Caution

The interaction of alcohol with Mesacol Enema is unknown. However, avoid consuming alcohol while on treatment with this medicine.

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Pregnancy

Consult your doctor

Mesacol Enema should not be used in pregnancy unless necessary. So, inform your doctor if you are pregnant or suspect pregnancy.

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Breast Feeding

Consult your doctor

Mesacol Enema should not be used while breastfeeding unless necessary. So, inform your doctor if you are a nursing mother.

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Driving

Safe if prescribed

Mesacol Enema usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Inform your doctor before using Mesacol Enema if you have a history of liver disease. It should be used cautiously in patients with mild to moderately impaired liver function. It is not recommended for use in populations with severe liver impairment.

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Kidney

Caution

Inform your doctor before using Mesacol Enema if you have a history of kidney disease. It should be used cautiously in patients with mild to moderately impaired kidney function. It is not recommended for use in populations with severe kidney impairment.

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Children

Not applicable

Mesacol Enema is intended for adults. Not recommended for children.

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Heart

Caution

Inform your doctor before receiving the Mesacol Enema if you have heart disease. Your doctor will prescribe only if the benefits outweigh the risks.

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Geriatrics

Caution

Mesacol Enema should be used in the elderly only if advised by a doctor, as dose adjustment may be required.

What if I have taken an overdose of Mesacol Enema

Although Mesacol Enema is applied rectally, some of the medicine can still be absorbed into the body. If you accidentally use much more than prescribed or someone swallows the medicine, seek immediate medical attention or contact your local poison control centre. Symptoms of overdose may resemble aspirin-like overdose effects and can include ringing in the ears, nausea, vomiting, rapid breathing, dizziness, confusion, or unusual drowsiness.

Diet & Lifestyle Advise

  • Identify trigger foods: Keep a food diary to identify and avoid personal trigger foods, such as spicy, greasy, or high-fiber foods during active flare-ups.
  • Stay hydrated: Drink plenty of water throughout the day to stay hydrated, especially if you are experiencing frequent bowel movements.
  • Eat smaller meals: Eat smaller, more frequent meals rather than large portions to reduce stress on your digestive system.
  • Manage stress: Practice relaxation techniques like deep breathing, meditation, or gentle yoga, as stress can worsen inflammation in the gut.
health query

Have a query?

How Soon It Starts Working

The time required for Mesacol Enema to start to work: The time required for Mesacol Enema to show its action is unknown. 

The time for which the effects of Mesacol Enema last: The duration of Mesacol Enema’s effect is clinically not established.

What if you forget to take Mesacol Enema

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled application, skip the missed dose and resume your regular routine. Do not take a double dose to make up for a missed one.

Storage

• Many rectal formulations are stored at controlled room temperature (20°C to 25°C), while some rectal suspension products have different storage recommendations.

Drug Warnings

  • For rectal use only: This medication is for rectal use only; do not swallow it.
  • Apply at bedtime: Apply the medicine at bedtime to help it stay in your rectum overnight, which gives it the maximum amount of time to soothe the inflamed tissues.
  • Protect clothing and bedding: Protect your clothing and bedding, as this medicine can cause permanent staining on fabrics. Consider using a protective sheet or panty liner.
  • Firm a soft suppository before use: If a suppository feels too soft to insert, hold it under cold running water or place it in the refrigerator for a few minutes before removing the wrapper.
  • Monitor worsening symptoms: Stop using the medication and contact your doctor immediately if your symptoms get worse or if you develop sudden fever and severe stomach pain.

Drug-Drug Interactions

verifiedApollotooltip
  • Pain killers (e.g., ibuprofen or naproxen): May significantly increase the risk of kidney damage.
  • Immune-suppressing drugs (e.g., azathioprine): May increase the risk of bone marrow problems and infections.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Mesacol Enema when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTI- INFLAMMATORY AGENTS]

FAQs

Mesacol Enema is used to treat ulcerative colitis and ulcerative proctitis.
Mesacol Enema contains Mesalamine, which works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. Thus, it helps reduce inflammation (swelling) in the intestines and relieves stomach pain or bleeding symptoms.
Mesacol Enema may cause diarrhoea as a common side effect. However, if the condition persists or worsens with fever, watery stools or consistent stomach pain, please consult a doctor. Also, drink plenty of water while using Mesacol Enema to prevent dehydration.
If you miss a dosage of mesalamine, take it as soon as you remember unless your next dose is approaching. In this situation, skip the missed dose and resume your regular schedule. Do not combine two doses to make up for a missed dosage.
You are recommended not to take Mesacol Enema with other medications without doctor's notice, especially immunosuppressant medications such as Azathioprine.
No, you are not recommended to stop using Mesacol Enema suddenly as it may cause recurring symptoms. Therefore, use Mesacol Enema for as long as your doctor has prescribed it, and if you experience any difficulty while using Mesacol Enema, please consult your doctor.
If you are pregnant or planning to become pregnant, tell your doctor before starting or continuing Mesacol Enema. In many cases, doctors may recommend continuing mesalamine during pregnancy when it is needed to keep ulcerative colitis under control, as active disease can also pose risks to both the mother and the baby. Your doctor will discuss the benefits and any potential risks with you and help you make a treatment decision that is appropriate for your individual situation.
If a suppository slips out within a few minutes, you can gently try to insert it again. If it has been inside for longer or has already dissolved, wait until your next scheduled dose. Talk to your doctor if you frequently have trouble keeping the medicine inside.
Some patients notice an improvement in symptoms like bleeding and urgency within a few days, but it can take several weeks of consistent use to feel the full benefits. Talk to your doctor if you do not see any improvement after a few weeks.
While alcohol does not directly interact with this medicine, it can irritate your stomach and intestines, potentially worsening your colitis symptoms. Talk to your doctor about whether drinking alcohol is safe for you.
Yes, this medicine can cause staining on fabrics, skin, and surfaces. You may want to wear a protective liner or old clothing, and place a towel or protective cover on your bed when applying it.
Most formulations should be stored at room temperature, away from heat and direct light. You can place a soft suppository in the refrigerator briefly to firm it up before use, but do not freeze it. Check your specific product packaging or talk to your pharmacist for details.
It is generally best to take this medicine at bedtime. This allows the medicine to remain in your rectum undisturbed for several hours while you sleep, which makes it much more effective. Talk to your doctor for specific dosing instructions.
You should avoid using other rectal products at the same time unless your doctor specifically advises you to do so, as they may interfere with how well this medicine works. Talk to your doctor or pharmacist before combining treatments.

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Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - MES0002
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