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compositionComposition:GANCICLOVIR-250MG
prescription
Prescription Medicine
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Natclovir 250 Capsule is an antiviral drug used to treat viral infections. It plays a vital role in treating Cytomegalovirus infection in immunosuppressed people (having HIV/AIDS) or those who have undergone bone marrow or organ transplantation. It contains Ganciclovir, which prevents the multiplication of the virus in human cells, decreases viral overload and stops the production of new viruses. In some cases, you may experience nausea, headache, dizziness, fever, vomiting, diarrhoea, increased liver enzymes, and stomach pain. Most of these side effects of Natclovir 250 Capsule are temporary, do not require medical attention, and gradually subside over time. However, if the side effects persist, contact your doctor immediately.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

GANCICLOVIR-250MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Natclovir 250 Capsule

Natclovir 250 Capsule is an antiviral prescription medicine used to prevent and treat cytomegalovirus (CMV) infections, particularly in people with weakened immune systems or those who have recently received an organ transplant. CMV is a common virus that can cause severe complications, such as vision loss or organ damage, when the body's natural defences are lowered. By stopping the virus from multiplying, this medication helps protect critical organs and preserves your overall health.

To work effectively, Natclovir 250 Capsule must be taken consistently at the exact times prescribed by your doctor. It is highly recommended to take this medicine with food, as eating a meal significantly increases the amount of medication your body can absorb. Staying well-hydrated by drinking plenty of water throughout the day is a simple lifestyle change that helps support your kidneys while they process this medication.

While taking this medicine, you may experience common mild side effects such as nausea, diarrhoea, or mild headaches. However, because this drug can affect your blood cells, you must contact your doctor immediately if you develop signs of infection like a high fever, severe chills, or unusual bruising and bleeding. Your healthcare team will monitor your blood counts regularly to ensure you stay safe during treatment.

Talk to your doctor before starting Natclovir 250 Capsule if you have a history of kidney disease, low blood cell counts, or are undergoing radiation therapy. Do not take this if you are pregnant, planning a pregnancy, or have had a severe allergic reaction to similar antiviral medicines. Both men and women must use effective birth control while taking this medicine and for some time after stopping.

This medicine can interact with other drugs that strain your kidneys or bone marrow, and alcohol should be avoided as it can increase dizziness and dehydration. If you are pregnant, breastfeeding, or an older adult, consult your doctor or pharmacist to discuss the risks and necessary precautions before starting treatment.

Uses of Natclovir 250 Capsule

Natclovir 250 Capsule is prescribed to help treat and prevent cytomegalovirus (CMV) infections. Common uses include:

  • Prevention of cytomegalovirus (CMV) disease: In patients who have undergone solid organ transplantation, Natclovir 250 Capsule is used to lower the risk of developing a severe CMV infection.
  • Treatment of CMV retinitis: For individuals with compromised immune systems, such as those with advanced HIV, this medicine helps treat CMV infection of the retina to prevent progressive vision loss and blindness.
  • Management of systemic CMV infection: It helps control the spread of CMV in other major organs, protecting the lungs, digestive tract, and liver from viral damage.

Key Benefits

Natclovir 250 Capsule is an antiviral medicine used to treat and prevent infections caused by the cytomegalovirus (CMV), particularly in people with weakened immune systems. It helps control viral replication, reducing the risk of serious complications.

  • Treats CMV Infections: Helps slow the growth and spread of CMV, reducing the severity of the infection.
  • Protects Vision: In patients with CMV retinitis, it helps prevent further damage to the retina and reduces the risk of vision loss.
  • Supports Transplant Success: Helps prevent CMV infection after organ transplantation, protecting the transplanted organ and improving recovery.
  • Reduces CMV-Related Complications: By controlling viral activity, it helps lower the risk of severe CMV-related illness in immunocompromised individuals.
  • Improves Quality of Life: Effective control of CMV infection helps reduce symptoms, prevent disease progression, and supports overall health and recovery.
Side effects of Natclovir 250 Capsule
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Prefer liquid food like juices and soups when you are not likely to eat.
  • Avoid spicy, fatty and fried foods as they cause stomach upset.
  • Eat small and frequent meals, avoiding large meals at a time.
  • Add healthy foods in your diet like fruits and vegetables.
  • Take starchy food like cereals, bread and potatoes etc.

Directions for Use

  • Natclovir 250 Capsule can be taken with or without food, as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Natclovir 250 Capsule Works

Natclovir 250 Capsule contains ganciclovir, which belongs to a class of medicines called antivirals. It works by targeting the cytomegalovirus (CMV) inside infected cells and blocking its ability to replicate. Once inside the body, ganciclovir is converted into a form that closely resembles the natural building blocks of viral DNA. The virus mistakenly incorporates this medicine into its growing DNA chain, which stops the virus from multiplying and spreading to healthy cells.
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Alcohol

Caution

Alcohol is not known to cause any unpleasant side effects if taken along with Natclovir 250 Capsule . But intake of alcohol with Natclovir 250 Capsule may damage your liver. So intake of alcohol should be avoided with Natclovir 250 Capsule .

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Pregnancy

Caution

Natclovir 250 Capsule is a pregnancy Category C medicine. It is not known whether Natclovir 250 Capsule will affect pregnant women or fetus or not. Hence, the intake of Natclovir 250 Capsule should be only if prescribed and under medical supervision.

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Breast Feeding

Caution

Natclovir 250 Capsule is a pregnancy Category C medicine. It is not known whether Natclovir 250 Capsule will pass through the milk in breastfeeding women or not. Hence, Natclovir 250 Capsule should only be taken if prescribed by a doctor and under medical supervision.

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Driving

Unsafe

Natclovir 250 Capsule can affect alertness and coordination. So, operating machinery which requires concentration should be avoided.

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Liver

Consult your doctor

Natclovir 250 Capsule to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Consult your doctor

Natclovir 250 Capsule to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Caution

Natclovir 250 Capsule is not recommended for children below 12 years as its safety and efficacy are not established.

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Heart

Consult your doctor

Limited information is available; please consult your doctor.

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Geriatrics

Caution

Because elderly people may have diminished renal function and Natclovir 250 Capsule is known to be largely eliminated by the kidney, the risk of adverse responses to this medicine is higher in patients with impaired renal function.

What if I have taken an overdose of Natclovir 250 Capsule

In case of an accidental overdose, seek emergency medical attention or contact a poison control centre immediately. An overdose can cause serious damage to your blood cells and kidneys.

Diet & Lifestyle Advise

  • Always take with meals: Pair each dose with a meal or snack. High-fat meals can particularly improve how well your body absorbs this medication.
  • Prioritise food safety: Because this medicine is used when the immune system is weak, avoid raw or undercooked meats, unpasteurised dairy, and unwashed produce to prevent foodborne infections.
  • Stay hydrated: Drink plenty of fluids, especially water, throughout the day to help your kidneys flush out the medicine safely and prevent kidney strain.
  • Practice good hand hygiene: Wash your hands frequently with soap and water to protect yourself from opportunistic infections while your immune system is compromised.
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How Soon It Starts Working

The time required for Natclovir 250 Capsule to start to work: The time required for Natclovir 250 Capsule to show its action is clinically not established. The time for which the effects of Natclovir 250 Capsule last: The duration of action for Natclovir 250 Capsule is clinically not established.

What if you forget to take Natclovir 250 Capsule

If you miss a dose, take it as soon as you remember with some food. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Natclovir 250 Capsule capsules at room temperature, ideally between 15°C and 30°C (59°F to 86°F). •Keep the container tightly closed to protect the medication from moisture and light. Avoid storing this medicine in damp areas like bathroom cabinets.

Drug Warnings

  • Never open the capsules: Avoid breaking, crushing, or opening the capsules. If a capsule is damaged and the powder touches your skin, wash the area thoroughly with soap and water.
  • Get regular blood tests: Your doctor will monitor your complete blood count (CBC) and kidney function (serum creatinine) during treatment, especially when you first start the medicine or if your dose is changed. Do not skip these appointments.
  • Use effective birth control: This medicine can cause birth defects and affect fertility. Both men and women using Natclovir 250 Capsule must use highly effective birth control during treatment, and men should continue using barrier methods (like condoms) for at least 90 days after stopping.
  • Avoid contact with sick people: Stay away from individuals who have contagious illnesses like the flu, colds, or chickenpox, as your body's ability to fight infections is reduced.

Drug-Drug Interactions

verifiedApollotooltip

Natclovir 250 Capsule may interact with certain medicines. Inform your doctor if you are taking any of the following:

  • Zidovudine: Taking this alongside Natclovir 250 Capsule can severely lower your white blood cell count, increasing infection risks.
  • Didanosine: Natclovir 250 Capsule can significantly increase the levels of didanosine in your blood, raising the risk of didanosine toxicity.
  • Imipenem-cilastatin: Combining these medications can trigger generalised seizures.
  • Tenofovir or other kidney-cleared drugs: May increase the levels of both medications in your system, elevating the risk of kidney damage.
GanciclovirCidofovir
Critical
GanciclovirTenofovir alafenamide
Severe

Drug-Drug Interactions

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GanciclovirCidofovir
Critical
How does the drug interact with Natclovir 250 Capsule:
Coadministration of cidofovir with Natclovir 250 Capsule can increase the risk of kidney problems.

How to manage the interaction:
Although there is a interaction between Natclovir 250 Capsule and Cidofovir hence it is not recommended to be taken together, but it can be taken only if advised by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
GanciclovirTenofovir alafenamide
Severe
How does the drug interact with Natclovir 250 Capsule:
When Tenofovir alafenamide is taken with Natclovir 250 Capsule, the amount of Tenofovir alafenamide in the blood can go up. This can increase the risk or severity of side effects like kidney damage.

How to manage the interaction:
There may be a possibility of interaction between Tenofovir alafenamide and Natclovir 250 Capsule, but it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
GanciclovirAdalimumab
Severe
How does the drug interact with Natclovir 250 Capsule:
Using Natclovir 250 Capsule together with adalimumab may increase the risk of serious infections.

How to manage the interaction:
Taking Natclovir 250 Capsule with adalimumab together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
GanciclovirZidovudine
Severe
How does the drug interact with Natclovir 250 Capsule:
Using zidovudine together with Natclovir 250 Capsule may increase the risk of side effects affecting the blood leading to decreased levels of blood cells.

How to manage the interaction:
Taking Natclovir 250 Capsule with zidovudine together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of fever, chills, sore throat, rashes, tiredness, headaches, irritation, confusion, edema, fatigue, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
GanciclovirEtanercept
Severe
How does the drug interact with Natclovir 250 Capsule:
Using Natclovir 250 Capsule together with etanercept may increase the risk of serious infections.

How to manage the interaction:
There may be a possibility of interaction between Natclovir 250 Capsule and Etanercept, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor.
GanciclovirInfliximab
Severe
How does the drug interact with Natclovir 250 Capsule:
Combining Infliximab with Natclovir 250 Capsule can increase the risk or severity of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Natclovir 250 Capsule and Infliximab, but it can be taken if prescribed by a doctor. If you have any of these symptom's fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you urinate contact your doctor immediately. Don't hesitate to reach out to a doctor if you experience any of these. Do not stop using any medications without a doctor's advice.
GanciclovirClozapine
Severe
How does the drug interact with Natclovir 250 Capsule:
Clozapine can cause higher levels of Natclovir 250 Capsule in the blood by reducing its excretion rate. This can increase the risk or severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Natclovir 250 Capsule and Clozapine, you can take these medicines together if prescribed by a doctor. If you're having any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, weight loss, or pain, it's important to contact a doctor right away. Do not stop using any medications without talking to a doctor.
GanciclovirDeferiprone
Severe
How does the drug interact with Natclovir 250 Capsule:
Natclovir 250 Capsule can cause higher levels of Deferiprone in the blood by reducing its excretion rate. This can increase the risk or severity of side effects.

How to manage the interaction:
Although taking Natclovir 250 Capsule and Deferiprone together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you're having any of these symptoms - like a sore throat, fever, or muscle aches - it's important to let a doctor know right away. Do not stop using any medications without a doctor's advice.
GanciclovirMaribavir
Severe
How does the drug interact with Natclovir 250 Capsule:
Coadministration of Natclovir 250 Capsule with Maribavir may alter the effectiveness of both these medications. This can lead to low treatment outcomes.

How to manage the interaction:
Taking Maribavir and Natclovir 250 Capsule together can possibly result in an interaction; it can be taken if your doctor has advised it. Do not stop using any medications without talking to your doctor.
GanciclovirTenofovir disoproxil
Severe
How does the drug interact with Natclovir 250 Capsule:
coadministration of Tenofovir disoproxil with Natclovir 250 Capsule can increase the risk or severity of side effects like kidney damage.

How to manage the interaction:
Although taking Natclovir 250 Capsule and Tenofovir disoproxil together can cause an interaction, it can be taken if your doctor has suggested it. If you have symptoms like feeling sick, not wanting to eat, gaining or losing weight suddenly, holding onto fluids, swelling, trouble breathing, bone or muscle pain, feeling weak or dizzy, feeling confused, or having an irregular heartbeat -contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

Certain foods may affect how Natclovir 250 Capsule works. Inform your doctor about your eating habits and follow these recommendations during treatment:

  • Taking with food: Taking this medicine on an empty stomach reduces its absorption, making it less effective. Always take it with food.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIVIRALS]

FAQs

Natclovir 250 Capsule is used to treat viral infections. It plays a vital role in treating Cytomegalovirus infection in immunosuppressed people (having HIV/AIDS) or those who have undergone bone marrow or organ transplantation.
It contains Ganciclovir, an antiviral agent that is specifically effective against certain viral infections such as cytomegalovirus (CMV). Ganciclovir works by entering virus-infected cells and interfering with the replication of viral DNA, which is essential for the virus to multiply. By inhibiting DNA synthesis, it prevents the virus from spreading further in the body. As a result, it helps control the infection, reduce viral load, and support recovery.
The most common side effects of Natclovir 250 Capsule are headaches, dizziness, nausea, fever, vomiting, diarrhoea, and stomach pain. Most of these side effects of Natclovir 250 Capsule are temporary, do not require medical attention, and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.
No, you should not stop taking Natclovir 250 Capsule without consulting the doctor, even if you feel better. The symptoms may improve, but the infection may not be completely cured. Therefore, it is advisable to continue the treatment at the prescribed dose and duration for optimal results.
Natclovir 250 Capsule may affect fertility. It may temporarily or permanently stop men from producing sperm and reduce fertility in women. So, if you are planning a baby, inform your doctor before taking Natclovir 250 Capsule . Also, wear a condom during sexual intercourse to avoid the transfer of infection to the female counterpart.
No, Natclovir 250 Capsule should be taken as advised by the doctor in terms of dose and duration. If you take it in a dose greater than the recommended amount, it may cause unpleasant side effects. If you think your symptoms are not improving, please consult your doctor.
No, you must not open, crush, or chew Natclovir 250 Capsule capsules. The active ingredient is highly potent and can be dangerous if the powder contacts your skin or eyes, or is inhaled. If you struggle to swallow capsules, talk to your doctor or pharmacist for alternative options.
Taking Natclovir 250 Capsule with a meal or snack significantly increases the amount of medicine your body can absorb. If you take it on an empty stomach, the treatment may not work effectively to control the virus. Talk to your doctor or pharmacist if you struggle to eat with your doses.
No, Natclovir 250 Capsule does not cure CMV. It works by slowing the virus from multiplying, helping manage active infections or prevent the virus from becoming active. The virus remains in your body in an inactive state. If your symptoms do not improve, worsen, or return despite treatment, contact your doctor promptly, as further evaluation may be needed, including checking for viral resistance or reviewing your treatment plan.
It is best to avoid alcohol while taking Natclovir 250 Capsule . Alcohol can worsen side effects like dizziness, stomach upset, and dehydration, which can put additional strain on your kidneys. Talk to your doctor or pharmacist before consuming alcohol.
You must avoid pregnancy during treatment because Natclovir 250 Capsule can cause birth defects and affect fertility. Both male and female patients should use effective birth control during treatment. Men must continue using barrier protection for at least 90 days after their last dose. Talk to your doctor immediately if you or your partner are planning a pregnancy.
This medicine can temporarily lower your blood cell counts, including white blood cells that fight infection and platelets that help your blood clot. Regular blood tests allow your doctor to monitor these levels and adjust your treatment safely. Talk to your doctor about your blood test schedule.
You should consult your doctor before receiving any vaccinations. Since Natclovir 250 Capsule is often prescribed to patients with weakened immune systems, certain live vaccines may not be safe or effective for you. Talk to your doctor before scheduling any vaccines.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. MedlinePlus. A605011 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.10242 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. U.S. Food and Drug Administration (FDA). 209347Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  4. Drugs.com Clinical Review Team. Ganciclovir Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  5. Ganciclovir Ganciclovir. 2000. [Accessed on 01 Apr. 2019]Check here
  6. Ema.Ganciclovir [[Accessed on 27 Aug]. 2019]Check here
  7. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Ganciclovir. [Updated 2018 Dec 3]Check here

Country of origin

INDIA

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - NAT0052
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