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  3. Nefmic Forte 500mg/325mg Tablet

Nefmic Forte 500mg/325mg Tablet, Pack of 1 Tablet
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Nefmic Forte 500mg/325mg Tablet is used for the treatment of pain, inflammation, migraine headache, period pain, heavy bleeding during periods, muscle pain, tooth pain, joint pain, pain after surgery, ear pain, fever, flu, osteoarthritis, and rheumatoid arthritis. It contains Mefenamic acid and Paracetamol which helps reduce mild to moderate pain and inflammation at the injured or damaged site. It may cause common side effects such as nausea, vomiting, indigestion, heartburn, and diarrhoea. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

MEFENAMIC ACID-500MG + PARACETAMOL-325MG

Manufacturer/Marketer :

Solace Biotech Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Nefmic Forte 500mg/325mg Tablet

Nefmic Forte 500mg/325mg Tablet is used for the treatment of pain, inflammation, migraine headache, period pain, heavy bleeding during periods, muscle pain, tooth pain, joint pain, pain after surgery, ear pain, fever, flu, osteoarthritis, and rheumatoid arthritis. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body.

Nefmic Forte 500mg/325mg Tablet contains two drugs, Mefenamic acid and Paracetamol. Nefmic Forte 500mg/325mg Tablet blocks the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes other chemical prostaglandins. By blocking the effect of COX enzymes, fewer prostaglandins are produced. This helps reduce mild to moderate pain and inflammation at the injured or damaged site.

You are advised to take Nefmic Forte 500mg/325mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, Nefmic Forte 500mg/325mg Tablet may cause common side effects such as nausea, vomiting, indigestion, heartburn, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Consult your doctor if you are pregnant or breastfeeding. Nefmic Forte 500mg/325mg Tablet may cause dizziness, so drive only if you are alert. Avoid consuming alcohol with Nefmic Forte 500mg/325mg Tablet as it could lead to increased dizziness and may increase the risk of stomach bleeding. Keep your doctor informed about your health condition and medicines to rule out any side effects/interactions.

Uses of Nefmic Forte 500mg/325mg Tablet

Nefmic Forte 500mg/325mg Tablet is used in the treatment of pain, inflammation, osteoarthritis, and rheumatoid arthritis. The detailed uses of Nefmic Forte 500mg/325mg Tablet are as follows:

  • Pain Relief: Nefmic Forte 500mg/325mg Tablet is commonly used to alleviate moderate to severe pain, including headaches, dental pain, and muscle aches.
  • Menstrual Pain Management: Nefmic Forte 500mg/325mg Tablet is frequently prescribed to relieve dysmenorrhea, which refers to painful menstrual cramps, providing comfort during menstruation.
  • Fever Reduction: Nefmic Forte 500mg/325mg Tablet can be effective in lowering fever, making it suitable for treating febrile conditions associated with various infections.
  • Post-Surgical Pain Relief: Nefmic Forte 500mg/325mg Tablet may be used to manage pain following surgical procedures, helping patients recover more comfortably.
  • Treatment of Inflammatory Conditions: Nefmic Forte 500mg/325mg Tablet can be utilised to reduce inflammation and pain associated with conditions like arthritis or other inflammatory disorders.

Directions for Use

• Recommended to take Nefmic Forte 500mg/325mg Tablet with food to reduce stomach upset or as advised by your doctor. • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety. • Swallow the medicine as a whole with glass of water. • Do not crush, break, or chew it.

Medicinal Benefits

Nefmic Forte 500mg/325mg Tablet contains two Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Mefenamic acid and Paracetamol. Nefmic Forte 500mg/325mg Tablet is used to treat pain, inflammation, migraine headache, period pain, heavy bleeding during periods, muscle pain, tooth pain, joint pain, pain after surgery, ear pain, fever, flu, osteoarthritis, and rheumatoid arthritis. Nefmic Forte 500mg/325mg Tablet blocks the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes another chemical, prostaglandin. Prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, lesser prostaglandins are produced. This helps reduce mild to moderate pain and inflammation at the injured or damaged site.

How Nefmic Forte 500mg/325mg Tablet Works

Nefmic Forte 500mg/325mg Tablet contains two drugs, Mefenamic acid and Paracetamol. Nefmic Forte 500mg/325mg Tablet blocks the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes other chemical prostaglandins. By blocking the effect of COX enzymes, fewer prostaglandins are produced. This helps reduce mild to moderate pain and inflammation at the injured or damaged site.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Nefmic Forte 500mg/325mg Tablet
  • Do not consume spicy foods, caffeine, and alcohol.
  • Choose low-acid fruits and vegetables like apples, melons, and carrots.
  • Include whole grains like whole-wheat bread, oatmeal, and brown rice.
  • Limit processed meats like hotdogs and sausages.
  • Avoid fatty, spicy, or acidic salad dressings.
  • Limit tomatoes and tomato-based products.
  • Quit smoking to promote ulcer healing.
  • Adopt a balanced diet and lifestyle to reduce the risk of peptic ulcers.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

What if I have taken an overdose of Nefmic Forte 500mg/325mg Tablet

Do not take more than the prescribed dose of Nefmic Forte 500mg/325mg Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Do not take Nefmic Forte 500mg/325mg Tablet if you are allergic to any of its contents; if you have severe heart, kidney or liver failure; or if you have suffered bleeding problems such as bleeding from the stomach or bowels while taking painkillers or if you have peptic ulcers or inflammatory bowel disease. Inform your doctor if you have high blood pressure, heart problems, high cholesterol, dehydration, asthma, gastrointestinal bleeding, ulceration, perforation of the stomach and intestine, or liver and kidney problems. Consult your doctor if you are pregnant or breastfeeding. Nefmic Forte 500mg/325mg Tablet may cause dizziness, so drive only if you are alert. Stop taking Nefmic Forte 500mg/325mg Tablet and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools. Do not take any other NSAIDs for pain relief along with Nefmic Forte 500mg/325mg Tablet unless prescribed by the doctor.

Drug-Drug Interactions

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Mefenamic acidKetorolac
Critical
Mefenamic acidMeloxicam
Critical

Drug-Drug Interactions

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Mefenamic acidKetorolac
Critical
How does the drug interact with Nefmic Forte 500mg/325mg Tablet:
Coadministration of Nefmic Forte 500mg/325mg Tablet with Ketorolac can increase the risk or severity of gastric bleeding and ulcers.

How to manage the interaction:
Taking Nefmic Forte 500mg/325mg Tablet with Ketorolac together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acidMeloxicam
Critical
How does the drug interact with Nefmic Forte 500mg/325mg Tablet:
Co-administration of Nefmic Forte 500mg/325mg Tablet with Meloxicam together can increase the risk or severity of bleeding.

How to manage the interaction:
Taking Nefmic Forte 500mg/325mg Tablet with Meloxicam together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking a doctor.
Mefenamic acidPiroxicam
Severe
How does the drug interact with Nefmic Forte 500mg/325mg Tablet:
Coadministration of Nefmic Forte 500mg/325mg Tablet with Piroxicam can increase the risk side effects such as inflammation(swelling with redness and pain), bleeding, ulceration, and perforation leading to serious blood loss.

How to manage the interaction:
Taking Nefmic Forte 500mg/325mg Tablet with Piroxicam together can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unusual bleeding or bruising, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acidTenofovir disoproxil
Severe
How does the drug interact with Nefmic Forte 500mg/325mg Tablet:
Coadministration of Nefmic Forte 500mg/325mg Tablet with Tenofovir disoproxil can show additive effect and increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Nefmic Forte 500mg/325mg Tablet with Tenofovir Disoproxil together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, dizziness, red or black tarry stools, vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acidRivaroxaban
Severe
How does the drug interact with Nefmic Forte 500mg/325mg Tablet:
Coadministration of Nefmic Forte 500mg/325mg Tablet with Rivaroxaban can increase the risk or severity of gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Nefmic Forte 500mg/325mg Tablet with Rivaroxaban together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acidLomitapide
Severe
How does the drug interact with Nefmic Forte 500mg/325mg Tablet:
Coadministration of Nefmic Forte 500mg/325mg Tablet with Lomitapide can cause liver damage.

How to manage the interaction:
Co-administration of Nefmic Forte 500mg/325mg Tablet with Lomitapide can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact a doctor right away - fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, bleeding, pain, dark urine, or liver damage. Do not stop using any medications without a doctor's advice.
Mefenamic acidLithium
Severe
How does the drug interact with Nefmic Forte 500mg/325mg Tablet:
Co-administration of Nefmic Forte 500mg/325mg Tablet with Lithium can increase Lithium levels in the body.

How to manage the interaction:
Taking Nefmic Forte 500mg/325mg Tablet with Lithium together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any drowsiness, dizziness, confusion, loose stools, vomiting, muscle weakness, muscle incoordination, shaking of hands and legs, blurred vision, ringing in the ear, excessive thirst, and/or increased urination, contact a doctor. Do not stop using any medications without talking to a doctor.
Mefenamic acidNaproxen
Severe
How does the drug interact with Nefmic Forte 500mg/325mg Tablet:
Coadministration of Nefmic Forte 500mg/325mg Tablet with Naproxen can increase the risk or severity of stomach bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Nefmic Forte 500mg/325mg Tablet with Naproxen together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acidDalteparin
Severe
How does the drug interact with Nefmic Forte 500mg/325mg Tablet:
Combining Nefmic Forte 500mg/325mg Tablet with Dalteparin can increase the risk of bleeding and hemorrhage.

How to manage the interaction:
Although taking Dalteparin and Nefmic Forte 500mg/325mg Tablet together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any signs like bleeding, bruising, swelling, vomiting, headache, dizziness, weakness, or blood in your urine or stool, make sure to contact your doctor right away. Do not stop using any medications without talking to a doctor.
Mefenamic acidEverolimus
Severe
How does the drug interact with Nefmic Forte 500mg/325mg Tablet:
Coadministration of Nefmic Forte 500mg/325mg Tablet with Everolimus can increase the risk or severity of kidney disease.

How to manage the interaction:
Taking Nefmic Forte 500mg/325mg Tablet with Everolimus together can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any symptoms of nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles and relieves joint stiffness. Gentle activities like 20-30 minutes of walking or swimming would be helpful.

  • Performing yoga may also help in improving joint flexibility and pain management.

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

  • Get adequate sleep, as resting the muscles can help reduce inflammation and swelling.

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.

  • Acupuncture, massage and physical therapy may also be helpful.

  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.

  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANALGESICS

Nefmic Forte 500mg/325mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Nefmic Forte 500mg/325mg Tablet as it may cause increased dizziness. It can also increase the risk of stomach bleeding.

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Pregnancy

Caution

Please consult your doctor if you are pregnant or if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Please consult your doctor before taking Nefmic Forte 500mg/325mg Tablet; your doctor will decide whether Nefmic Forte 500mg/325mg Tablet can be taken by breastfeeding mothers or not.

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Driving

Caution

Nefmic Forte 500mg/325mg Tablet may cause dizziness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have liver problems or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney problems or any concerns regarding this.

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Children

Caution

Please consult your doctor. Your doctor will prescribe the dose and duration based on your child's condition.

Have a query?

FAQs

Nefmic Forte 500mg/325mg Tablet is used for the treatment of pain, inflammation, migraine headache, period pain, muscle pain, tooth pain, joint pain, pain after surgery, ear pain, fever, flu, osteoarthritis, and rheumatoid arthritis.

Nefmic Forte 500mg/325mg Tablet blocks the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes another chemical, prostaglandins. This helps reduce mild to moderate pain and inflammation at the injured or damaged site.

Nefmic Forte 500mg/325mg Tablet is used to reduce and relieve pain and inflammation associated with osteoarthritis and rheumatoid arthritis. Arthritis is tenderness and swelling in the joints.

Avoid taking Nefmic Forte 500mg/325mg Tablet if you have stomach ulcers, bleeding problems, or heart problems. Talk to your doctor regarding your concerns; he/she may prescribe alternate medicine.

Diarrhoea might be a side-effect of Nefmic Forte 500mg/325mg Tablet. Drink enough fluids and eat non-spicy food if you experience diarrhoea. If you find blood in your stools (tarry stools) or experience severe diarrhea, consult your doctor. Do not take anti-diarrheal medicine on your own.

Nefmic Forte 500mg/325mg Tablet is used to relieve menstrual (period) pain and management of excessively heavy periods. Take Nefmic Forte 500mg/325mg Tablet only as prescribed by the doctor.

Nefmic Forte 500mg/325mg Tablet is generally prescribed for short-term use. Do not take Nefmic Forte 500mg/325mg Tablet for longer durations as it might increase the risk of kidney problems and stomach bleeding.

Country of origin

India
Other Info - NE10977

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Aug 6, 2025 | 12:31 PM IST

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Reference

  1. https://http://www.salvavidaspharma.com/product/mefenamic-acid-paracetamol-suspension/
  2. https://vibcare.co.in/mefenamic-acid-paracetamol/
  3. https://www.medicines.org.uk/emc/files/pil.5916.pdf
  4. https://medlineplus.gov/druginfo/meds/a681028.html
  5. https://www.drugs.com/paracetamol.html
  6. https://www.drugs.com/cdi/mefenamic-acid.html
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