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compositionComposition:HYDROCHLOROTHIAZIDE-12.5MG+S AMLODIPINE-2.5MG
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Prescription Medicine
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Numlo-D Tablet is used for the treatment of hypertension (high blood pressure). It contains S-Amlodipine and Hydrochlorothiazide, which work by relaxing and widening the blood vessels. Also, it helps to remove extra water and certain electrolytes from the body through urine. Thus, it lowers high blood pressure and reduces the chances of future heart attack and stroke. It may cause side effects such as ankle swelling, sleepiness, headache (sense of heat in the face, ears, neck, and trunk), flushing, tiredness, nausea, and decreased potassium level in the blood. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

HYDROCHLOROTHIAZIDE-12.5MG+S AMLODIPINE-2.5MG

Manufacturer/Marketer :

Emcure Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Numlo-D Tablet

Numlo-D Tablet is a prescription tablet used to treat high blood pressure, also known as hypertension. Its medical purpose is to lower elevated blood pressure to help prevent life-threatening complications such as heart attacks and strokes. This medication is typically prescribed when a single active therapy is not enough to control your blood pressure.

For the best results, you must take Numlo-D Tablet consistently once a day, ideally at the same time each day, to maintain steady medicine levels in your body. You can take this tablet with or without food, but it is best to be consistent with your chosen method. Incorporating a low-sodium diet and engaging in regular, moderate exercise will significantly help improve your treatment results.

Some people taking Numlo-D Tablet may experience mild side effects, such as ankle swelling, dizziness, or a mild upset stomach. While these symptoms are often temporary, you must consult your doctor immediately if you experience severe side effects, such as chest pain, a rapid or fluttering heart, or severe muscle weakness.

Before starting Numlo-D Tablet , talk to your doctor if you have kidney problems, liver damage, or gout. Do not take this medicine if you have severe kidney failure, are unable to urinate, or have a known allergy to any of its components.

This medicine can interact with alcohol, causing an unsafe drop in blood pressure, and smoking can reduce its cardiovascular benefits. Always consult your doctor before using this medicine if you are pregnant, planning to become pregnant, breastfeeding, or are an elderly individual, as you may require special monitoring.

Uses of Numlo-D Tablet

Numlo-D Tablet is used in the treatment of Hypertension. The detailed uses of Numlo-D Tablet are as follows:

  • High Blood Pressure (Hypertension): Numlo-D Tablet relaxes the blood vessels and helps your body eliminate excess salt and fluid, bringing your blood pressure back down to a safer range.
  • Reducing Cardiovascular Risks: By maintaining healthy blood pressure levels, Numlo-D Tablet lowers your risk of experiencing serious, life-threatening events like strokes and heart attacks.

Key Benefits

Numlo-D Tablet helps lower and control high blood pressure, making it easier to maintain a healthy and active lifestyle. It also helps protect important organs and lowers the risk of serious complications associated with uncontrolled hypertension.

Benefits may include:

  • Helps lower and maintain healthy blood pressure levels.
  • Reduces the risk of heart attack and stroke.
  • Improves long-term heart and blood vessel health.
  • Supports healthy kidney and brain function by controlling blood pressure.
  • Provides convenient blood pressure management with a single daily medicine.

Directions for Use

  • Swallow the medication whole with a full glass of water.
  • Do not chew, crush, or split the tablet, as this can affect how the medicine is absorbed in your body.
  • Take your dose at the same time each day to build a habit and keep a steady level of the medicine in your bloodstream.
  • You may take this medicine with or without food, but choose one way and stick to it consistently.
  • Please remember to follow your doctor's exact instructions regarding your treatment plan. Do not change how you take this medicine without speaking to your doctor first.

How Numlo-D Tablet Works

Numlo-D Tablet combines two active ingredients that target blood pressure from different angles to achieve a highly effective result. • S Amlodipine: It is a calcium channel blocker that works by stopping calcium from entering the muscle cells of your blood vessels. This action relaxes and widens the blood vessels, allowing blood to flow more freely and reducing the force your heart must use to pump blood throughout your body. • Hydrochlorthiazide: It is a thiazide diuretic, commonly referred to as a water pill. It prompts your kidneys to remove excess water and salt from your bloodstream and release it through your urine. By lowering the overall amount of fluid in your blood vessels, the pressure on the vessel walls decreases.
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Numlo-D Tablet to avoid unpleasant side-effects.

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Pregnancy

Caution

Numlo-D Tablet is not recommended during pregnancy unless your doctor considers it essential. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Breast Feeding

Caution

Numlo-D Tablet should not be used when breastfeeding unless clearly necessary. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

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Driving

Unsafe

It is advised to drive with caution after taking Numlo-D Tablet as it usually causes drowsiness and affects the driving ability.

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Liver

Caution

Numlo-D Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. Your doctor may adjust your dose depending upon your current liver conditions.

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Kidney

Caution

Numlo-D Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. Your doctor may adjust your dose depending upon your current kidney conditions

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Children

Caution

Numlo-D Tablet to be taken with caution, especially if you are children below the age of 12. Your doctor may adjust your dose depending upon your age.

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Heart

Safe if prescribed

Numlo-D Tablet is safe for use in heart patients if recommended by the physician.

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Geriatrics

Caution

Numlo-D Tablet should be used under caution in geriatric patients. Please consult your physician.

What if I have taken an overdose of Numlo-D Tablet

If you accidentally take too much Numlo-D Tablet and experience severe dizziness, confusion, fainting, or a racing heartbeat, seek emergency medical care immediately. You can contact your local hospital or a poison control centre for guidance.

Diet & Lifestyle Advise

  • Reduce Salt Intake: Limit your daily sodium intake. Excess salt causes fluid retention, which directly works against the blood pressure-lowering effects of Numlo-D Tablet .
  • Incorporate Potassium-Rich Foods: Because the diuretic component of this medication can cause your body to lose potassium, discuss with your doctor whether you should eat more potassium-rich foods like bananas, oranges, and leafy greens.
  • Stay Safely Hydrated: This medicine increases urination. Ensure you drink enough water throughout the day to avoid dehydration, but consult your doctor about the ideal amount of fluid for your specific health condition.
  • Avoid Grapefruit Products: Do not eat grapefruit or drink grapefruit juice while taking Numlo-D Tablet . Grapefruit can increase the amount of the amlodipine component of Numlo-D Tablet in your body, which may increase the risk of side effects such as dizziness or low blood pressure.
  • Rise Slowly: To minimise dizziness, take your time when standing up from a lying or sitting position. Let your feet rest on the floor for a few moments before fully standing.
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How Soon It Starts Working

  • The time required for Numlo-D Tablet to start to work: The time required for Numlo-D Tablet to show its action is unknown.
  • The time for which the effects of Numlo-D Tablet last: The duration of action for Numlo-D Tablet is clinically unknown.

What if you forget to take Numlo-D Tablet

If you miss a dose of Numlo-D Tablet , take it as soon as you remember. If your next scheduled dose is only a few hours away, skip the missed dose entirely and resume your regular schedule. Do not take two doses at the same time to make up for a missed tablet.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Monitor Blood Pressure Daily: Use a home blood pressure monitor to track your levels regularly. Keep a written log of your readings to share with your doctor during check-ups.
  • Limit Alcohol Consumption: Avoid drinking alcohol while taking Numlo-D Tablet , as it can severely drop your blood pressure and cause severe dizziness, drowsiness, or fainting.
  • Wear Sunscreen: This medication can make your skin more sensitive to sunlight. Wear protective clothing and apply a broad-spectrum sunscreen when spending time outdoors to prevent sunburns or skin changes.
  • Watch for Signs of Dehydration: If you experience severe vomiting, diarrhoea, or heavy sweating, contact your doctor, as these conditions can lead to severe dehydration and unsafe blood pressure drops.
  • Before Surgery: Tell your surgeon, dentist, or anaesthetist that you are taking Numlo-D Tablet before any planned surgery or medical procedure. Your doctor may advise temporarily stopping or adjusting the medication depending on the type of procedure and your overall health.

Drug-Drug Interactions

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  • Other Blood Pressure Medications (e.g., enalapril, losartan): Combining Numlo-D Tablet with other drugs that lower blood pressure can cause your pressure to drop too low, resulting in severe dizziness or fainting.
  • Mood stabilisers (e.g., lithium): Numlo-D Tablet can reduce the kidneys' ability to clear lithium from your body, which may increase the risk of lithium toxicity.
  • Nonsteroidal Anti-inflammatory Drugs (e.g., ibuprofen, naproxen): Painkillers such as ibuprofen or naproxen may decrease the blood pressure-lowering effectiveness of Numlo-D Tablet and increase your risk of kidney damage.
  • Potassium Supplements or Potassium-Sparing Medicines (e.g., potassium chloride, spironolactone): Taking these medicines alongside Numlo-D Tablet may affect potassium levels in the blood and may require closer monitoring.
S-Amlodipine + HydrochlorothiazideDofetilide
Critical
S-Amlodipine + HydrochlorothiazideCisapride
Critical

Drug-Drug Interactions

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S-Amlodipine + HydrochlorothiazideDofetilide
Critical
How does the drug interact with Numlo-D Tablet:
Taking Dofetilide with S-Amlodipine and Hydrochlorothiazide can increase the risk of an irregular heart rhythm which can be severe.

How to manage the interaction:
Combining Dofetilide with S-Amlodipine and Hydrochlorothiazide together is not recommended as it can result in an interaction, it can be taken if advised by a doctor. However, if you experience dizziness, shortness of breath, rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
S-Amlodipine + HydrochlorothiazideCisapride
Critical
How does the drug interact with Numlo-D Tablet:
Taking Cisapride with S-Amlodipine and Hydrochlorothiazide can increase the risk of an irregular heart rhythm which can be severe.

How to manage the interaction:
Combining Cisapride and Hydrochlorothiazide together is generally avoided as it can result in an interaction, it can be taken if advised by a doctor. However, if you experience dizziness, or fast or pounding heartbeats, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
S-Amlodipine + HydrochlorothiazidePimozide
Severe
How does the drug interact with Numlo-D Tablet:
The combined use of Pimozide with S-Amlodipine and Hydrochlorothiazide can increase the risk of an irregular heart rhythm which can be severe.

How to manage the interaction:
Taking Pimozide with S-Amlodipine and Hydrochlorothiazide together can result in an interaction, but it can be taken if advised by a doctor. However, consult the doctor immediately if you experience dizziness, fast or pounding heartbeats. Do not stop using any medications without a doctor's advice.
S-Amlodipine + HydrochlorothiazideZiprasidone
Severe
How does the drug interact with Numlo-D Tablet:
Taking Ziprasidone with S-Amlodipine and Hydrochlorothiazide can increase the risk of an irregular heart rhythm which can be severe.

How to manage the interaction:
Taking Ziprasidone with S-Amlodipine and Hydrochlorothiazide is avoided as it can result in an interaction, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, shortness of breath, fast heartbeats. Do not discontinue any medications without consulting a doctor.
S-Amlodipine + HydrochlorothiazideDolasetron
Severe
How does the drug interact with Numlo-D Tablet:
Co-administration of Dolasetron with S-Amlodipine and Hydrochlorothiazide can affect the rhythm of your heart which can be severe.

How to manage the interaction:
Taking Dolasetron with S-Amlodipine and Hydrochlorothiazide together is avoided as it can result in an interaction, it can be taken if advised by a doctor. However, if you experience irregular heartbeat, chest tightness consult the doctor immediately. Do not stop using any medications without a doctor's advice.
S-Amlodipine + HydrochlorothiazideLithium
Severe
How does the drug interact with Numlo-D Tablet:
Coadministration of Lithium with S-Amlodipine and Hydrochlorothiazide can increase the effects of lithium.

How to manage the interaction:
Taking Lithium with S-Amlodipine and Hydrochlorothiazide together can result in an interaction, but it can be taken if advised by a doctor. However, if you experience diarrhea, shaking of hands and legs, thirst, increased urination consult the doctor immediately. Do not stop using any medications without a doctor's advice.
S-Amlodipine + HydrochlorothiazideArsenic trioxide
Severe
How does the drug interact with Numlo-D Tablet:
Co-administration of Arsenic trioxide with S-Amlodipine and Hydrochlorothiazide can increase the risk of an irregular heart rhythm which can be severe.

How to manage the interaction:
Taking Arsenic trioxide with S-Amlodipine and Hydrochlorothiazide together is avoided as it can result in an interaction, it can be taken if advised by a doctor. However, if you experience dizziness, fast heartbeats, muscle pain. consult the doctor immediately. Do not stop using any medications without a doctor's advice.
S-Amlodipine + HydrochlorothiazideItraconazole
Severe
How does the drug interact with Numlo-D Tablet:
Coadministration of S-Amlodipine and Hydrochlorothiazide with Itraconazole may significantly raise the blood levels and effects of Amlodipine.

How to manage the interaction:
Coadministration of S-Amlodipine and Hydrochlorothiazide with Itraconazole may interact, but if prescribed by a doctor, they can be used together. Consult a doctor if you develop chest discomfort, trouble breathing. Do not discontinue any medications without consulting a doctor.
S-Amlodipine + HydrochlorothiazideTizanidine
Severe
How does the drug interact with Numlo-D Tablet:
The combined use of Tizanidine with S-Amlodipine and Hydrochlorothiazide can have additive effects in lowering your blood pressure.

How to manage the interaction:
Taking Tizanidine with S-Amlodipine and Hydrochlorothiazide together can result in an interaction, but they can be taken if advised by a doctor. However, if you experience headache, changes in pulse or heart rate, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
S-Amlodipine + HydrochlorothiazideAmiodarone
Severe
How does the drug interact with Numlo-D Tablet:
Coadministration of Amiodarone together with S-Amlodipine and Hydrochlorothiazide may raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Even though Amiodarone with S-Amlodipine and Hydrochlorothiazide interact, they can be used if prescribed by a doctor. If you experience dizziness, shortness of breath, or rapid heartbeat get medical attention. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and Grapefruit Juice: Grapefruit may increase the levels of the amlodipine component of Numlo-D Tablet , which can increase the risk of side effects such as dizziness or low blood pressure.
  • Alcohol: Consuming alcohol can dangerously enhance the blood pressure-lowering effect of Numlo-D Tablet , causing extreme lightheadedness or fainting.
HYDROCHLOROTHIAZIDE-12.5MG+S AMLODIPINE-2.5MGPotassium rich foods, Calcium rich foods
Moderate

Drug-Food Interactions

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HYDROCHLOROTHIAZIDE-12.5MG+S AMLODIPINE-2.5MGPotassium rich foods, Calcium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt, Tofu Set With Calcium, Ragi, Seasame Seeds, Kale, Milk, Almonds, Bok Choy, Calcium-Fortified Soy Milk, Cheese

How to manage the interaction:
Consumption of Calcium-containing products with Numlo-D Tablet may decrease the effectiveness of Numlo-D Tablet. Also, grapefruit and its products may slightly increase plasma concentrations of Numlo-D Tablet. Avoid consuming Calcium-containing products, grapefruit and its products while being treated with Numlo-D Tablet.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- HYPERTENSIVES]

FAQs

Numlo-D Tablet is used to treat high blood pressure. It works by relaxing the blood vessels, improving blood flow and lowering fluid retention.
No, you are advised to inform your doctor and monitor your blood pressure for at least two weeks before stopping the medicine. Depending upon your current blood pressure readings, there is a possibility your doctor may lower your medicine dosage and not recommend discontinuing it.
In case, If you forget to take Numlo-D Tablet at any time, take it as soon as you remember, then continue to take it at the usual times. Do not take a double dose to make up for a forgotten dose.
Numlo-D Tablet can be safely taken as long as your doctor has prescribed it to you. Conditions such as high blood pressure are life-long conditions, and one should not abruptly discontinue it without discussing it with a doctor.
No, it is a prescribed drug, given by a physician for preventing specific medical conditions. Taking it on your own can cause unwanted side-effects.
Yes, Numlo-D Tablet may cause swelling of ankle and feet, it is advised to not sit for a long time, and keep the feet up when sitting or lying down.
Numlo-D Tablet should be taken in the morning with or without food as prescribed by the doctor, as it contains chlorothiazide, a diuretic that increases urination. So, morning doses help to prevent frequent urination at night, which could disturb your sleep.
You can take other supplements for controlling blood pressure along with Numlo-D Tablet only if prescribed by the doctor. Consult the doctor before taking Numlo-D Tablet with supplements.
Nausea is a common side effect caused by Numlo-D Tablet . If you experience nausea drink ginger or peppermint tea, stay hydrated, eat small, frequent meals and get fresh air.
Regular monitoring of heart rate, blood pressure, breathing and oxygen levels and electrolytes are advised in order to ensure Numlo-D Tablet is working effectively and to detect any potential side effects early while taking Numlo-D Tablet .
If you are having trouble remembering to take Numlo-D Tablet , link your medication doses with daily activity, use alarms to notify the time, use a pill organiser and create a routine by taking your medication at the same time every day.
The side effects of Numlo-D Tablet include ankle swelling, oedema, tiredness, fatigue nausea, sleepiness, headache (sense of heat in the face, ears, neck, and trunk), flushing, and decreased potassium levels in the blood. Consult the doctor if any of these side effects persist or worsen.
Numlo-D Tablet is generally not recommended during pregnancy unless your doctor determines it is clearly needed. The hydrochlorothiazide component may increase the risk of problems such as neonatal jaundice, low platelet counts, or electrolyte disturbances, while there is limited safety information for amlodipine during pregnancy. If you become pregnant while taking this medication, contact your doctor promptly to discuss the safest treatment option.
One of the active ingredients in Numlo-D Tablet is a mild diuretic, or water pill, which prompts your kidneys to filter out excess water and salt. This naturally increases the frequency of urination, especially when you first start the medication. To avoid waking up at night, try taking your dose in the morning. Talk to your doctor if this becomes problematic.
You should avoid or strictly limit alcohol consumption while taking Numlo-D Tablet . Alcohol can combine with the medication to cause a sharp, unsafe drop in your blood pressure, leading to extreme dizziness, drowsiness, or fainting. Talk to your doctor if you have questions about alcohol use.
Numlo-D Tablet can cause dizziness or fatigue, particularly when you first start taking it or after a dose adjustment. Do not drive, ride a bicycle, or operate machinery until you are certain how this medication affects your alertness. Talk to your doctor if you experience persistent dizziness.
Mild swelling in the ankles and feet is a known side effect of this medication. Elevating your legs when sitting can help alleviate this symptom. However, if the swelling is sudden, painful, or accompanied by breathing difficulties, you should talk to your doctor immediately.
Yes, the diuretic component in Numlo-D Tablet can cause your body to lose potassium through your urine. Your doctor may perform routine blood tests to check your potassium levels and might suggest specific dietary changes or supplements if your levels drop too low. Talk to your doctor if you experience severe muscle cramps or unexplained weakness.
Yes. Your doctor may recommend periodic blood tests while you are taking Numlo-D Tablet to monitor your potassium and other electrolyte levels, kidney function (such as creatinine and eGFR), and, if needed, uric acid or blood sugar levels. These tests help ensure the medicine is working safely and allow your doctor to adjust your treatment if necessary.

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Country of origin

India

Manufacturer/Marketer address

255/2, Hinjawadi, Pune - 411057, India
Other Info - NUM0002
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