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  3. Pantocid HP Combipack 6's

Pantocid HP Combipack 6's, Pack of 1
Pantocid HP Combipack 6's, Pack of 1
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Pantocid HP Combipack is used in the treatment of peptic ulcer disease caused by infection with a common type of bacteria called Helicobacter pylori (H. pylori). It kills bacteria or stops the growth of bacteria. Also, it reduces the amount of acid produced in the stomach. It may cause common side effects, such as nausea, diarrhoea, vomiting, stomach pain, taste change, and headache. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

AMOXYCILLIN-750MG + CLARITHROMYCIN-500MG + PANTOPRAZOLE-40MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Pantocid HP Combipack

Pantocid HP Combipack is used in the treatment of peptic ulcer disease caused by infection with a common type of bacteria called Helicobacter pylori (H. pylori). Peptic ulcers are sores (small, shallow wounds) that develop on the intestine and stomach's inner lining.

Pantocid HP Combipack is a combination of three drugs, namely: Pantoprazole, amoxicillin, and clarithromycin. Amoxicillin is bactericidal (kills bacteria) that works by preventing the formation of bacterial cell covering (protective cell wall) necessary for their survival, thereby preventing the growth of bacteria. Clarithromycin is a bacteriostatic antibiotic i.e., it stops the growth of bacteria but necessarily does not kill them. It works by inhibiting the protein synthesis process required for the growth of the bacterial cell. As a result, bacterial cells are not able to reproduce and grow. Pantoprazole is a proton pump inhibitor that works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid in the stomach. Thereby reducing the amount of acid produced in the stomach. Altogether, Pantocid HP Combipack helps in the treatment of peptic ulcer disease.

You are advised to take Pantocid HP Combipack for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as nausea, diarrhoea, vomiting, stomach pain, taste change, and headache. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Inform your doctor before taking Pantocid HP Combipack if you have a history of liver disease, kidney disease, or myasthenia gravis (neuromuscular disease). Do not take Pantocid HP Combipack if you are pregnant or breastfeeding unless prescribed by the doctor. Pantocid HP Combipack causes drowsiness, so drive only if you are alert. Pantocid HP Combipack should not be given to children as safety has not been established. Avoid consuming alcohol along with Pantocid HP Combipack as it could lead to increased drowsiness and can elevate the production of stomach acid. Keep your doctor informed about all the medicines and your health condition to rule out any side effects.

Uses of Pantocid HP Combipack

Treatment of Peptic ulcer disease.

Directions for Use

• Take Pantocid HP Combipack 30-60 minutes before food as advised by your doctor.• It is advised to take Pantocid HP Combipack directed by your doctor, at the same time each day for best results.• Swallow Pantocid HP Combipack as a whole with a glass of water.• Do not crush, chew, or break it.

Medicinal Benefits

Pantocid HP Combipack combines three drugs: Pantoprazole, amoxicillin, and clarithromycin. Amoxicillin is bactericidal (kills bacteria) and prevents the formation of bacterial cell covering (protective cell wall) necessary for their survival, thereby preventing the growth of bacteria. Clarithromycin is a bacteriostatic antibiotic, i.e., it stops the growth of bacteria but does not necessarily kill them. It works by inhibiting the protein synthesis process required for bacterial cell growth. As a result, bacterial cells are not able to reproduce and grow. Pantoprazole is a proton pump inhibitor that works by blocking the action of an enzyme called gastric proton pump, which is responsible for acid production in the stomach. Thereby reducing the amount of acid produced in the stomach. Altogether, Pantocid HP Combipack helps in the treatment of peptic ulcer disease.

How Pantocid HP Combipack Works

Pantocid HP Combipack is a combination of three drugs, namely: Pantoprazole, amoxicillin, and clarithromycin. Amoxicillin is bactericidal (kills bacteria) that works by preventing the formation of bacterial cell covering (protective cell wall) necessary for their survival, thereby preventing the growth of bacteria. Clarithromycin is a bacteriostatic antibiotic i.e., it stops the growth of bacteria but necessarily does not kill them. It works by inhibiting the protein synthesis process required for the growth of the bacterial cell. As a result, bacterial cells are not able to reproduce and grow. Pantoprazole is a proton pump inhibitor that works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid in the stomach. Thereby reducing the amount of acid produced in the stomach. Altogether, Pantocid HP Combipack helps in the treatment of peptic ulcer disease.

Storage

Keep Pantocid HP Combipack out of the sight and reach of children.

What if I have taken an overdose of Pantocid HP Combipack

Do not take more than the prescribed dose of Pantocid HP Combipack as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

  • Eat smaller meals more often.
  • Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid.
  • Avoid foods such as high-fat, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea, and soda.
  • Avoid sitting continuously, as it may trigger acidity. Take a 5-minute break every hour by doing brisk walking or stretching.

Drug-Drug Interactions

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ClarithromycinDronedarone
Critical
ClarithromycinTerfenadine
Critical

Drug-Drug Interactions

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ClarithromycinDronedarone
Critical
How does the drug interact with Pantocid HP Combipack:
When Dronedarone is taken with Pantocid HP Combipack, can increase the blood levels of dronedarone and cause an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Pantocid HP Combipack with Dronedarone can result in an interaction, it should be taken only if a doctor has advised it. However, if you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitation, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ClarithromycinTerfenadine
Critical
How does the drug interact with Pantocid HP Combipack:
When Terfenadine is taken with Pantocid HP Combipack, the amount of Terfenadine in the blood can go up.

How to manage the interaction:
Co-administration of Pantocid HP Combipack and Terfenadine can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinNimodipine
Critical
How does the drug interact with Pantocid HP Combipack:
When Nimodipine is taken with Pantocid HP Combipack, it can increase the risk of side effects.

How to manage the interaction:
Co-administration of Pantocid HP Combipack and Nimodipine is not recommended as it can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like irregular heart rhythm, swelling, and low blood pressure, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinRifabutin
Critical
How does the drug interact with Pantocid HP Combipack:
Taking Rifabutin and Pantocid HP Combipack together may increase the blood levels of rifabutin.

How to manage the interaction:
Taking Rifabutin with Pantocid HP Combipack is not recommended as it can possibly result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor immediately If you experience unusual symptoms. Do not discontinue any medications without consulting a doctor.
ClarithromycinConivaptan
Critical
How does the drug interact with Pantocid HP Combipack:
When Pantocid HP Combipack is taken with Conivaptan, it can lower the rate at which Conivaptan is broken down in the body.

How to manage the interaction:
Taking Pantocid HP Combipack with Convivaptan can result in an interaction, it should be taken only if a doctor has advised it. However, if you experience swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, or seizures, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ClarithromycinAlprazolam
Critical
How does the drug interact with Pantocid HP Combipack:
The combination of Alprazolam and Pantocid HP Combipack may considerably increase the risk of side effects.

How to manage the interaction:
Despite the fact that there is an interaction between Alprazolam and Pantocid HP Combipack, it can be used if prescribed by a doctor. Consult a doctor if you have excessive drowsiness, problems with movement, memory loss, anxiety, hallucinations (illogical thoughts), or breathing issues (particularly if you have asthma or obstructive sleep apnea). Do not discontinue any medications without consulting a doctor.
ClarithromycinBepridil
Critical
How does the drug interact with Pantocid HP Combipack:
Co-administration of Bepridil with Pantocid HP Combipack may increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Pantocid HP Combipack with Bepridil is not recommended as it can result in an interaction, it should be taken only if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
ClarithromycinNaloxegol
Critical
How does the drug interact with Pantocid HP Combipack:
When Naloxegol is taken with Pantocid HP Combipack, the amount of Naloxegol in the blood can go up.

How to manage the interaction:
Co-administration of Pantocid HP Combipack and Naloxegol can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like sweating, tearing, runny nose, chills, diarrhea, abdominal pain, anxiety, insomnia, irritability, restlessness, and yawning, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinVenetoclax
Critical
How does the drug interact with Pantocid HP Combipack:
When Venetoclax is taken with Pantocid HP Combipack, the body's ability to break down Venetoclax may be reduced.

How to manage the interaction:
Taking Pantocid HP Combipack with Venetoclax is not recommended, please consult your doctor before taking it.
ClarithromycinMesoridazine
Critical
How does the drug interact with Pantocid HP Combipack:
Co-administration of Pantocid HP Combipack and Mesoridazine may increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Pantocid HP Combipack and Mesoridazine can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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AMOXYCILLIN-750MG+CLARITHROMYCIN-500MG+PANTOPRAZOLE-40MGFruit juices
Mild

Drug-Food Interactions

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AMOXYCILLIN-750MG+CLARITHROMYCIN-500MG+PANTOPRAZOLE-40MGFruit juices
Mild
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Consuming Grapefruit juice with Pantocid HP Combipack may delay the gastrointestinal absorption of Pantocid HP Combipack. Avoid Grapefruit juice while being treated with Pantocid HP Combipack.

Diet & Lifestyle Advise

  • Eat smaller meals more often.
  • Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
  • Avoid tight-fitting clothes.
  • Avoid foods such as high-fat, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea, and soda.
  • Avoid sitting continuously, as it may trigger acidity. Take a 5-minute break every hour by doing brisk walking or stretching.

Habit Forming

No

Therapeutic Class

ANTIULCERS

Pantocid HP Combipack Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Pantocid HP Combipack. Alcohol intake leads to increased production of stomach acid.

bannner image

Pregnancy

Caution

Consult your doctor before taking Pantocid HP Combipack if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.

bannner image

Breast Feeding

Caution

Consult your doctor before taking Pantocid HP Combipack, your doctor will decide whether Pantocid HP Combipack can be taken by breastfeeding mothers or not.

bannner image

Driving

Caution

Pantocid HP Combipack causes dizziness. Do not drive or operate machinery unless you are alert.

bannner image

Liver

Caution

Dose adjustment may be needed. Consult your doctor before taking Pantocid HP Combipack if you have a liver impairment or any concerns regarding this.

bannner image

Kidney

Caution

Dose adjustment may be needed. Consult your doctor before taking Pantocid HP Combipack if you have kidney impairment or any concerns regarding this.

bannner image

Children

Unsafe

Pantocid HP Combipack should not be given to children as the safety and effectiveness were not established.

Have a query?

FAQs

Pantocid HP Combipack is used in the treatment of peptic ulcer disease caused by infection with a common type of bacteria called Helicobacter pylori (H. pylori). It works by inhibiting the action of gastric proton pump and preventing the growth of micro-organisms.

Speak to your doctor if you do not feel better even after taking Pantocid HP Combipack for 14 days. Do not take Pantocid HP Combipack for longer durations unless prescribed by the doctor.

Pantocid HP Combipack may cause dizziness. Drive only if you are alert and omit driving and operating machinery if you feel dizzy after taking Pantocid HP Combipack.

Avoid or limit the consumption of alcohol while on Pantocid HP Combipack as it may lead to increased dizziness. Alcohol intake may also lead to excess production of stomach acid, thereby increasing acidity and heartburn.

Diarrhoea might be a side-effect of Pantocid HP Combipack. Drink enough fluids and eat fibre rich food if you experience diarrhoea after taking Pantocid HP Combipack. If you find blood in stools (tarry stools) or if you experience excess diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

Pantocid HP Combipack contains pantoprazole, which may increase the risk of bone fracture in the hip, spine, or wrist. Recent clinical studies indicated that pantoprazole may affect the absorption of certain nutrients and minerals required for maintaining good bone health, leading to fractures. This mainly occurs in people taking higher doses of Pantocid HP Combipack for longer durations. Inform your doctor before taking Pantocid HP Combipack if you have osteoporosis or if you are already taking corticosteroids.

Dry mouth could be a side effect of Pantocid HP Combipack. Limiting caffeine intake, avoiding smoking, drinking enough water, and chewing sugar-free gum or candy might help stimulate saliva and thereby prevent dryness of the mouth.

Inform your doctor if you don’t get better after finishing the full course of treatment. Also, let your doctor know if your symptoms are getting worse while using Pantocid HP Combipack. Your doctor may need to reassess your condition, possibly perform additional tests, and prescribe a different treatment if necessary.

A peptic ulcer is a sore that develops on the lining of your stomach, lower esophagus, or small intestine. It's usually caused by an infection with Helicobacter pylori (H. pylori) bacteria or prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs).

Do not use Pantocid HP Combipack if you have a known hypersensitivity to Pantocid HP Combipack. Use Pantocid HP Combipack with caution if you have liver disease, as the antibiotics in Pantocid HP Combipack can affect liver function. Inform your doctor if you have or ever had gastrointestinal bleeding, diabetes, myasthenia gravis (neuromuscular disease), bone fractures, or hypomagnesemia (low levels of magnesium). Also let your doctor know if you are breastfeeding, pregnant or planning pregnancy.

Take Pantocid HP Combipack 30-60 minutes before food or as advised by your doctor. Swallow it as a whole with a glass of water. But try to take it at the same time each day for better efficacy. Do not crush or chew it.

No, do not stop using Pantocid HP Combipack even if you feel better as stopping Pantocid HP Combipack early can result in the infection not being fully treated, which could lead to side effects. Therefore, complete the full course of treatment as prescribed by your doctor.

The common side effects of Pantocid HP Combipack are nausea, diarrhoea, vomiting, stomach pain, taste change, and headache. If any of these side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - PAN0090

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:45 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.484.pdf
  2. https://www.medicines.org.uk/emc/files/pil.526.pdf
  3. https://www.medicines.org.uk/emc/files/pil.7072.pdf
  4. https://www.drugs.com/mtm/amoxicillin-clarithromycin-and-omeprazole.html
  5. https://www.medicalnewstoday.com/articles/9273#treatment
  6. https://www.medicineuses.com/pantop-hp-kit/
  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974811/

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