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  3. Pregabid D 50/20 Capsule 10's

Pregabid D 50/20 Capsule 10's, Pack of 10
Pregabid D 50/20 Capsule 10's, Pack of 10
Pregabid D 50/20 Capsule 10's, Pack of 10
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Pregabid D 50/20 Capsule is used in the treatment of diabetic neuropathic pain and fibromyalgia. It contains Pregabalin and Duloxetine. Pregabalin belongs to an anticonvulsant class of drugs, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain. Pregabid D 50/20 Capsule may cause certain side effects such as nausea, constipation, headache, dry mouth, increased sweating, loss of appetite, dizziness, and burning sensation.

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Synonym :

DULOXETINE HYDROCHLORIDE+PREGABALIN

Composition :

DULOXETINE-20MG + PREGABALIN-50MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Pregabid D 50/20 Capsule

Pregabid D 50/20 Capsule belongs to an anticonvulsant class of medicines. It is used in the treatment of diabetic neuropathic pain and fibromyalgia. Neuropathic pain/ peripheral neuropathy is pain that occurs when the nervous system is not working properly or is damaged. Diabetic neuropathic pain/diabetic neuropathy is a condition causing moderate to severe pain due to damage of nerves in the thigh, hip, buttock and leg regions. Symptoms may include tingling, shooting pain, burning, or even an electric shock sensation. Fibromyalgia is a chronic condition with moderate pain and tenderness all over the body resulting in fatigue and trouble sleeping.

Pregabid D 50/20 Capsule is a combination of Pregabalin and Duloxetine. Pregabalin belongs to an anticonvulsant class of drugs, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain.

Pregabid D 50/20 Capsule can be taken with or without food or as prescribed by your doctor. Pregabid D 50/20 Capsule may cause certain side effects such as nausea, constipation, headache, dry mouth, increased sweating, loss of appetite, dizziness, and burning sensation. These side effects do not require medical attention and gradually resolve over time. However, if any of these side effects persist, inform your doctor.

Pregabid D 50/20 Capsule should be avoided if you are allergic to it. Inform your doctor if you have any liver or kidney disease, seizures (fits), mania, bipolar disorder, glaucoma (an eye condition), bleeding disorders, or are at risk of hyponatremia (low sodium levels, especially in patients taking diuretics or water pills). If you are pregnant or breastfeeding, inform your doctor before taking this medicine. It is not recommended for use in children and young adults as it increases the risk of suicidal tendencies. 

Uses of Pregabid D 50/20 Capsule

Pregabid D 50/20 Capsule is used to treat nerve pain. The detailed uses of Pregabid D 50/20 Capsule are as follows:<br/>• Manages diabetic nerve pain: Pregabid D 50/20 Capsule helps reduce pain caused by nerve damage due to diabetes (diabetic neuropathy).<br/>• Relieves fibromyalgia symptoms: Pregabid D 50/20 Capsule is effective in easing widespread muscle pain and tenderness seen in fibromyalgia.<br/>

Directions for Use

• Pregabid D 50/20 Capsule can be taken with or without food as advised by the doctor.• Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.• Swallow Pregabid D 50/20 Capsule as a whole with a glass of water.• Do not chew, crush or break it.

Medicinal Benefits

Pregabid D 50/20 Capsule contains Pregabalin and Duloxetine. Pregabalin belongs to an anticonvulsant class of drugs, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain. Pregabid D 50/20 Capsule effectively treats neuropathic pain, and improves nerve conduction for proper nerve signal functioning in the body. 

How Pregabid D 50/20 Capsule Works

Pregabid D 50/20 Capsule contains Ozenoxacin, a quinolone antibiotic medicine. It works by inhibiting the protein synthesis responsible for bacterial cell growth, thereby killing the bacteria and treating bacterial infections.

Storage

• Store in a cool and dry place away from sunlight.• Keep Pregabid D 50/20 Capsule out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Pregabid D 50/20 Capsule
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.

What if I have taken an overdose of Pregabid D 50/20 Capsule

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Pregabid D 50/20 Capsule may include autonomic instability, blurred vision, coma, confusion, diarrhoea, excessive sleepiness, muscle twitching, numbness, seizures, somnolence, speech disturbances, syncope, tachycardia, and vomiting. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Pregabid D 50/20 Capsule should be avoided if you are allergic to any of the components in it. Do not stop taking Pregabid D 50/20 Capsule suddenly without your doctor’s advice, as it may cause withdrawal symptoms like dizziness, tingling sensation, sleep disturbances, restlessness, nausea or vomiting, headache, or excessive sweating. Inform your doctor if you have any liver or kidney disease, seizures (fits), mania, bipolar disorder, or glaucoma (an eye condition). Pregabid D 50/20 Capsule may increase suicidal thoughts, so it is advised to use caution in patients with mania, bipolar disorder or depression. It is not recommended for use in children below 18 years of age as the safety and efficacy of this medicine are not established. Pregnant or breastfeeding mothers should inform the doctor before using Pregabid D 50/20 Capsule .

Drug-Drug Interactions

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DuloxetineLinezolid
Critical
DuloxetineSafinamide
Critical

Drug-Drug Interactions

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DuloxetineLinezolid
Critical
How does the drug interact with Pregabid D 50/20 Capsule:
Taking Pregabid D 50/20 Capsule with Linezolid can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although taking Pregabid D 50/20 Capsule with Linezolid is not recommended, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, blurred vision, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting a doctor.
DuloxetineSafinamide
Critical
How does the drug interact with Pregabid D 50/20 Capsule:
Coadministration of safinamide with Pregabid D 50/20 Capsule can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Safinamide with Pregabid D 50/20 Capsule is not recommended as it can result in an interaction, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, pain in the muscles, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
DuloxetineTranylcypromine
Critical
How does the drug interact with Pregabid D 50/20 Capsule:
Taking Tranylcypromine with Pregabid D 50/20 Capsule can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Tranylcypromine with Pregabid D 50/20 Capsule is not recommended but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
DuloxetineEliglustat
Critical
How does the drug interact with Pregabid D 50/20 Capsule:
Coadministration of eliglustat and Pregabid D 50/20 Capsule can significantly increase the blood levels of eliglustat. This may increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Pregabid D 50/20 Capsule with Eliglustat is not recommended, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, slow heart rate, or weak pulse. Do not discontinue any medications without consulting your doctor.
DuloxetineProcarbazine
Critical
How does the drug interact with Pregabid D 50/20 Capsule:
Taking Pregabid D 50/20 Capsule with procarbazine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Pregabid D 50/20 Capsule with Procarbazine is not recommended, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering or shaking, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
DuloxetineMetoclopramide
Critical
How does the drug interact with Pregabid D 50/20 Capsule:
Coadministration of metoclopramide with Pregabid D 50/20 Capsule increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Metoclopramide with Pregabid D 50/20 Capsule is not recommended, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
DuloxetineRasagiline
Critical
How does the drug interact with Pregabid D 50/20 Capsule:
Taking Rasagiline with Pregabid D 50/20 Capsule can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Rasagiline and Pregabid D 50/20 Capsule is not recommended as they can possibly result in an interaction, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, pain in the muscles, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
DuloxetineSelegiline
Critical
How does the drug interact with Pregabid D 50/20 Capsule:
Taking Pregabid D 50/20 Capsule with selegiline may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Although there is an interaction between Pregabid D 50/20 Capsule and Selegiline, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, blurred vision, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
DuloxetinePhenelzine
Critical
How does the drug interact with Pregabid D 50/20 Capsule:
Taking phenelzine with Pregabid D 50/20 Capsule can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Pregabid D 50/20 Capsule with Phenelzine is not recommended, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, blurred vision, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
PregabalinFentanyl
Severe
How does the drug interact with Pregabid D 50/20 Capsule:
Using Pregabid D 50/20 Capsule together with Fentanyl can increase the risk of side effects.

How to manage the interaction:
Although taking fentanyl together with Pregabid D 50/20 Capsule can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you have dizziness, sleepiness, difficulty concentrating, or impairment in judgment. Do not stop taking any medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Exercise regularly, which helps in reducing pain.
  • Rest well, and get enough sleep.
  • Always take a warm bath, as it can be soothing.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity, and improve coping skills.

Habit Forming

Yes

Therapeutic Class

ANTICONVULSANT

Pregabid D 50/20 Capsule Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid alcohol consumption during treatment with $nmae as it may increase the risk of serious side effects and worsen your health.

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Pregnancy

Caution

If you are pregnant, especially in the last trimester or planning pregnancy, inform your doctor before taking Pregabid D 50/20 Capsule . It may cause foetal abnormalities if taken in the last trimester of pregnancy. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

If you are breastfeeding, inform your doctor before taking Pregabid D 50/20 Capsule . Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Unsafe

Pregabid D 50/20 Capsule may cause drowsiness. Hence, avoid driving vehicles or operating machines after taking Pregabid D 50/20 Capsule .

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Liver

Caution

If you have liver conditions, inform your doctor before taking Pregabid D 50/20 Capsule . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have kidney conditions, inform your doctor before taking Pregabid D 50/20 Capsule . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Pregabid D 50/20 Capsule is not recommended for children below 18 years as the safety and efficacy of use for this medicine are not established. Please seek medical advice for more information.

Have a query?

FAQs

Pregabid D 50/20 Capsule is used in the treatment of diabetic neuropathic pain and fibromyalgia. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain.

Do not stop using Pregabid D 50/20 Capsule suddenly as it can cause withdrawal symptoms. Your doctor will gradually reduce the dose based on your clinical condition.

Seek medical attention immediately if you notice any depressive thoughts while using Pregabid D 50/20 Capsule . Your doctor may change the dose or medicine to treat your condition.

Neuropathic pain/ peripheral neuropathy is pain that occurs when the nervous system is not working properly or is damaged.

Pregabid D 50/20 Capsule contains Pregabalin and Duloxetine. Pregabalin is an anticonvulsant drug, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. Both medicines mainly work by increasing the chemical messengers in the brain responsible for regulating pain.

To manage weight gain associated with the use of Pregabid D 50/20 Capsule , maintain a balanced diet and engage in regular exercise. Use the lowest effective dose to help reduce the chances of gaining weight. Keep track of your weight and consult your doctor if you notice significant changes. They can help adjust your treatment or suggest ways to manage your weight more effectively.

Pregabid D 50/20 Capsule may cause sleepiness or drowsiness in some individuals as a mild side effect. If you experience these symptoms, it is important to avoid activities that require full alertness, such as driving or operating machinery. If drowsiness persists for a longer period, please consult your doctor.

Pregabid D 50/20 Capsule may take several weeks or longer to show its full effects. While some patients may notice improvements within the first week, it is important to continue taking the medication as prescribed to achieve the full benefits. Your doctor will likely reduce your dose gradually to avoid withdrawal symptoms.

If you forget to take Pregabid D 50/20 Capsule , take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.

No, taking a higher dose of Pregabid D 50/20 Capsule than recommended will not necessarily make it more effective and may increase the risk of side effects. Additionally, it can become habit-forming if misused or taken in larger amounts than prescribed for a prolonged period, leading to dependence. If you feel your current dose is not effective, please consult your doctor for proper adjustments, rather than increasing the dose on your own.

It is not recommended to drink alcohol while taking Pregabid D 50/20 Capsule , as it may increase the risk of side effects such as drowsiness and dizziness. These effects impair your ability to perform tasks that require focus, so avoid driving or operating machinery while taking Pregabid D 50/20 Capsule . Always consult your doctor for personalized advice.

Pregabid D 50/20 Capsule should typically be stored in a cool and dry place, away from direct sunlight and moisture. Keep it out of reach of children.

Pregabid D 50/20 Capsule may cause common side effects such as nausea, constipation, headache, dry mouth, increased sweating, loss of appetite, dizziness, and burning sensation. These side effects do not require medical attention and gradually resolve over time. However, if any of these side effects persist or worsen, please inform your doctor.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - PRE1520

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 7:03 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.larenon.com/wp-content/uploads/2022/11/PBREN-D-LBL.pdf
  2. https://www.sciencedirect.com/science/article/pii/S0304395913002856
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127557/
  4. https://medlineplus.gov/druginfo/meds/a604030.html
  5. https://medlineplus.gov/druginfo/meds/a605045.html

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