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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Trinerve Forte Capsule is used in the management of neuropathic pain. It affects the chemicals in the brain that send pain signals to the nervous system thereby relieving nerve pain. It helps in the rejuvenation and protection of damaged nerve cells and also helps in delivering essential nutrients to the nerves. In some cases, you may experience certain common side effects such as dizziness, sleepiness, tiredness, nausea, and vomiting. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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About Trinerve Forte Capsule

Trinerve Forte Capsule is used in the management of neuropathic pain. Neuropathic pain is a chronic progressive nerve disease that causes nerve pain due to nerve damage or a malfunctioning nervous system. Symptoms of neuropathic pain include shooting and burning pain followed by tingling and numbness (loss of sensation). Neuropathic pain can be caused by amputation of limbs, diabetic neuropathy (nerve damage due to excess blood sugar level), excessive alcohol intake (alcoholism) and cancer treatment via chemotherapy.

Trinerve Forte Capsule is a combination of five drugs: Pregabalin, Methylcobalamin, Alpha-lipoic acid, Pyridoxine, and Folic acid. Pregabalin affects the chemicals in the brain that send pain signals to the nervous system, thereby relieving nerve pain. Methylcobalamin and Pyridoxine help in the rejuvenation and protection of damaged nerve cells by producing a substance called myelin. Alpha-lipoic acid helps in providing a protective effect on the nerve tissues and brain. Folic acid helps in delivering essential nutrients to the nerves. Together, Trinerve Forte Capsule provides relief from neuropathic pain.

Take Trinerve Forte Capsule with or without food. Swallow Trinerve Forte Capsule as a whole with a glass of water; do not chew or break it. In some cases, you may experience certain common side effects, such as dizziness, sleepiness, tiredness, nausea, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Consult your doctor if you are pregnant or breastfeeding. Trinerve Forte Capsule may cause drowsiness and dizziness, so drive only if you are alert. Trinerve Forte Capsule should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Trinerve Forte Capsule as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Trinerve Forte Capsule

Trinerve Forte Capsule is used in the treatment of Neuropathic pain. The detailed use of Trinerve Forte Capsule is as follows:<br/>• Neuropathic Pain Management: Trinerve Forte Capsule is used to manage nerve pain, nerve damage, and conditions like diabetic neuropathy, sciatica, and other neuropathic disorders by supporting nerve health, reducing abnormal electrical activity, and providing antioxidant protection, thereby providing relief from pain, numbness, and tingling.<br/>

Directions for Use

• Trinerve Forte Capsule can be taken with or without food as advised by your doctor.• Follow your doctor's instructions on the dosage and timing of this medication.• Swallow Trinerve Forte Capsule as a whole with a glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

Trinerve Forte Capsule is a combination of five drugs: Pregabalin (anti-convulsant or antiepileptic), methylcobalamin (vitamin B12), alpha-lipoic acid (antioxidant), pyridoxine (vitamin B6), and folic acid (vitamin B9). Trinerve Forte Capsule is used to treat neuropathic pain. Pregabalin affects the chemicals in the brain that send pain signals to the nervous system, thereby relieving nerve pain. Methylcobalamin and Pyridoxine help in the rejuvenation and protection of damaged nerve cells by producing a substance called myelin. Alpha-lipoic acid helps in providing a protective effect on the nerve tissues and brain. Folic acid helps in providing essential nutrients to the nerves. Together, Trinerve Forte Capsule helps in providing relief from neuropathic pain.

How Trinerve Forte Capsule Works

Trinerve Forte Capsule is a combination of five drugs: Pregabalin, Methylcobalamin, Alpha-lipoic acid, Pyridoxine, and Folic acid. Pregabalin affects the chemicals in the brain that send pain signals to the nervous system, thereby relieving nerve pain. Methylcobalamin and Pyridoxine help in the rejuvenation and protection of damaged nerve cells by producing a substance called myelin. Alpha-lipoic acid helps in providing a protective effect on the nerve tissues and brain. Folic acid helps in delivering essential nutrients to the nerves. Together, Trinerve Forte Capsule provides relief from neuropathic pain.

Storage

Keep Trinerve Forte Capsule out of reach and sight of children.
Side effects of Trinerve Forte Capsule
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.
  • Blood flow to the brain and the rest of the body is increased by physical activity. This could help you maintain your memory.
  • Reading, solving puzzles, and picking up new skills are examples of mental workouts that can keep the brain engaged and enhance memory retention.
  • Maintaining an active social life enhances memory and brain stimulation.
  • Relaxation methods like yoga, meditation, and deep breathing can help because long-term stress can affect memory.
  • Drink plenty of water and stay hydrated.
  • Limit the intake of alcohol and caffeine.
  • Maintain good hygiene habits.
  • Avoid holding on and empty the bladder at regular intervals.
  • Try to quit smoking.
  • Perform balance exercises like heel raises, standing on one leg, and weight shifts with the guidance of a physical therapist.
  • Focus on strengthening leg muscles and core muscles for better stability.
  • Stay hydrated by drinking plenty of water as dehydration may lead to unsteadiness and dizziness.
  • Wear low-heeled shoes with good tread for better grip.
  • Change your surroundings by removing tripping hazards like clutter, loose rugs and poorly lit areas.
  • Avoid sudden position changes; stand up slowly and take your time to move around.
  • Watch out for rapid head movements that might trigger dizziness.
  • Eat fiber-rich foods, fruits, and vegetables, and track your food intake to monitor calorie consumption.
  • Limit takeout and restaurant meals, and weigh yourself weekly to stay motivated.
  • Build balanced meals, allow yourself to enjoy treats in moderation, and prioritize sleep and stress management through exercise and relaxation techniques.

What if I have taken an overdose of Trinerve Forte Capsule

Do not take more than the prescribed dose of Trinerve Forte Capsule as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Do not take Trinerve Forte Capsule if you are allergic to any of its contents. Inform your doctor if you have/had heart problems or bipolar syndrome. Consult your doctor if you are pregnant or breastfeeding. Trinerve Forte Capsule may cause drowsiness and dizziness, so drive only if you are alert. Trinerve Forte Capsule should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Trinerve Forte Capsule as it could lead to increased dizziness and sleepiness. Consult your doctor immediately if you experience suicidal tendencies. Keep your doctor informed about your health condition and medicines to rule out any side-effects.

Drug-Drug Interactions

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PregabalinMethadone
Severe

Drug-Drug Interactions

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PregabalinMethadone
Severe
How does the drug interact with Trinerve Forte Capsule:
Using Trinerve Forte Capsule together with Methadone causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking methadone and Trinerve Forte Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
How does the drug interact with Trinerve Forte Capsule:
When Tramadol is used with Trinerve Forte Capsule, it may possibly lead to side effects such as respiratory difficulties, unconsciousness.

How to manage the interaction:
Although taking tramadol and Trinerve Forte Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
How does the drug interact with Trinerve Forte Capsule:
Using Trinerve Forte Capsule together with Buprenorphine causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Buprenorphine and Trinerve Forte Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience dizziness, drowsiness, difficulty concentrating, and impairment in- judgment, reaction speed and motor coordination, consult the doctor immediately. Avoid driving or operating dangerous machinery. Do not exceed the doses, frequency, or duration of usage advised by the doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Trinerve Forte Capsule:
Using Trinerve Forte Capsule together with Butorphanol causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Butorphanol and Trinerve Forte Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. If you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
PregabalinCodeine
Severe
How does the drug interact with Trinerve Forte Capsule:
Using Trinerve Forte Capsule together with Codeine may cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Codeine and Trinerve Forte Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
PregabalinHydromorphone
Severe
How does the drug interact with Trinerve Forte Capsule:
Using Trinerve Forte Capsule together with Hydromorphone causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Hydromorphone and Trinerve Forte Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
PregabalinSufentanil
Severe
How does the drug interact with Trinerve Forte Capsule:
Using Trinerve Forte Capsule together with Sufentanil causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking sufentanil and Trinerve Forte Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
How does the drug interact with Trinerve Forte Capsule:
Taking Ketamine with Trinerve Forte Capsule may increase the risk of side effects.

How to manage the interaction:
Although taking Trinerve Forte Capsule and ketamine together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience symptoms such as dizziness, drowsiness, confusion, difficulty concentrating, breathing difficulty, consult the doctor. Do not exceed the doses, frequency, or duration of usage advised by a doctor. You should avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
How does the drug interact with Trinerve Forte Capsule:
Using Trinerve Forte Capsule together with Fentanyl can increase the risk of side effects.

How to manage the interaction:
Although taking fentanyl together with Trinerve Forte Capsule can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you have dizziness, sleepiness, difficulty concentrating, or impairment in judgment. Do not stop taking any medication without consulting a doctor.
PregabalinOxycodone
Severe
How does the drug interact with Trinerve Forte Capsule:
Using Trinerve Forte Capsule together with Oxycodone causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking oxycodone and Trinerve Forte Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include food rich in vitamin B and D in your diet.

  • Include cayenne pepper in your diet as it can help in lowering neuropathic pain.

  • Exercising regularly helps in improving overall health and combating pain. 

  • Rest well, get plenty of sleep.

  • Try taking a warm bath as it can be soothing.

  • Avoid smoking and alcohol consumption.

  • Meditation and yoga can help lower stress, decrease pain sensitivity and improves coping skills.

  • Acupuncture can be helpful by stimulating pressure points.

  • Using essential oils for massages can help increase circulation.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Trinerve Forte Capsule as it may increase dizziness and sleepiness.

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Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor before taking Trinerve Forte Capsule ; your doctor will decide whether Trinerve Forte Capsule can be taken by breastfeeding mothers or not.

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Driving

Caution

Trinerve Forte Capsule may cause drowsiness, sleepiness and tiredness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Trinerve Forte Capsule should not be given to children as the safety and efficacy have not been established.

Have a query?

FAQs

Trinerve Forte Capsule is used in the management of neuropathic pain.

Trinerve Forte Capsule may cause weight gain due to an increase in appetite. Maintain a healthy weight by regular exercise and following a proper diet.

To treat your condition effectually, continue taking Trinerve Forte Capsule for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Trinerve Forte Capsule ; your doctor will reduce the dose gradually.

Trinerve Forte Capsule can cause life-threatening breathing problems in patients with COPD and asthma. So a person with long paused breathing, blue coloured lips, or sleeping disorder should inform the doctor before use of Trinerve Forte Capsule .

Trinerve Forte Capsule can decrease the sperm count and may affect men&amp;#039;s fertility. However, it is unclear whether these effects would occur. So it is advisable to ask your doctor about your risk.

No, Trinerve Forte Capsule is not a usual painkiller but is used in the management of neuropathic pain by providing essential nutrients to the nerves.

Trinerve Forte Capsule contains Pregabalin, Methylcobalamin, Alpha-lipoic acid, Pyridoxine, and Folic acid. Pregabalin affects the chemicals in the brain that send pain signals to the nervous system, thereby relieving nerve pain. Methylcobalamin and Pyridoxine help in the rejuvenation and protection of damaged nerve cells by producing a substance called myelin. Alpha-lipoic acid helps in providing a protective effect on the nerve tissues and brain. Folic acid helps in delivering essential nutrients to the nerves. Together, Trinerve Forte Capsule provides relief from neuropathic pain.

Yes, Trinerve Forte Capsule may make you feel drowsy or you cause you to fall asleep suddenly during your daily activities. Sometimes, you might not even feel sleepy or have any other warning signs before you fall asleep suddenly. Thus, avoid driving or operating machinery, working at heights or participating in potentially dangerous activities until you know how Trinerve Forte Capsule affects you. If you experience such episodes while taking Trinerve Forte Capsule , inform your doctor.

Trinerve Forte Capsule may rarely cause serious side effects such as allergic reaction, suicidal thoughts or swelling of limbs (legs, hands, or feet). If you experience any signs of these side effects, discontinue Trinerve Forte Capsule and consult your doctor. Signs of an allergic reaction include swelling of your face, lips, mouth, tongue, gums, and neck. Allergic reactions can also lead to skin rash, difficulty breathing, hives (raised bumps) or blisters. Watch out for any changes, especially sudden changes in behaviors, mood, thoughts or feelings, or if you have suicidal thoughts.

It may take about 2 weeks to experience the first benefit with Trinerve Forte Capsule . However, to see full effect, it may take around 2-3 months or it may take longer in some patients.

If you forget to take a dose of Trinerve Forte Capsule , take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue your regular dose. Do not double the dose to make up for the missed one as this may increase the risk of side effects.

If you suspect you have taken too much of Trinerve Forte Capsule , please contact your doctor immediately. Do this even if you have no signs of discomfort or poisoning.

No, taking a higher than the recommended dose may not be more effective, rather it may increase the risk of toxicity and serious side effects. If your symptoms are not relieved or there is an increased severity of your symptoms after using the recommended doses, please consult your doctor.

You are advised to avoid alcohol consumption while taking Trinerve Forte Capsule as it may increase the severity of dizziness and sleepiness. However, if you have any concerns, please discuss with your doctor.

If you have started taking Trinerve Forte Capsule , you may need to see your doctor regularly. However, if the recommended doses does not improve your symptoms or if the side effects persist or worsen which affect your routine activities, consult your doctor.

Store Trinerve Forte Capsule at room temperature in a cool and dry place. Protect from light and moisture. Keep it out of reach of children.

The side effects of Trinerve Forte Capsule include sleepiness, dizziness, drowsiness, tiredness, nausea and vomiting. If these side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - TRI0288

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