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Trinexovas 40 Tablet is used to treat hypertension (high blood pressure). It effectively lowers elevated blood pressure, improves overall blood circulation, and supports better heart function. By controlling blood pressure, it reduces the risk of serious complications such as heart attack, stroke, and other cardiovascular problems, thereby promoting long-term heart health.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

CHLORTHALIDONE-12.5MG+CILNIDIPINE-10MG+OLMESARTAN-40MG

Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Trinexovas 40 Tablet

Trinexovas 40 Tablet is a prescription medicine used to treat high blood pressure (hypertension). It helps lower blood pressure by relaxing blood vessels and removing excess salt and water from the body. Keeping your blood pressure under control helps reduce the risk of serious complications such as heart attack, stroke, heart failure, and kidney damage.

Take this medicine exactly as prescribed by your doctor, usually once daily. You can take it with or without food, but taking it at the same time each day helps maintain consistent medicine levels in your body. Following a low-salt diet, exercising regularly, maintaining a healthy weight, and managing stress can further improve your blood pressure control.

While taking Trinexovas 40 Tablet , some people may experience mild side effects such as dizziness, headache, ankle swelling, tiredness, or nausea. However, contact your doctor immediately if you experience severe dizziness, fainting, swelling of the face or throat, muscle weakness, irregular heartbeat, or a sudden decrease in urine output.

Talk to your doctor before taking Trinexovas 40 Tablet if you have kidney disease, liver disease, dehydration, low blood pressure, gout, diabetes, or electrolyte imbalances. Do not take this medicine during pregnancy, as it may seriously harm your unborn baby. Your doctor may recommend regular monitoring of your kidney function and electrolyte levels during treatment.

This medicine may interact with certain blood pressure medicines, potassium supplements, lithium, NSAIDs, and other medicines that affect kidney function. If you are breastfeeding, planning pregnancy, or are an older adult, consult your healthcare provider before using this medicine.

Uses of Trinexovas 40 Tablet

Your doctor may prescribe this medicine to treat several conditions, including:

  • High Blood Pressure (Hypertension): Helps lower blood pressure by relaxing blood vessels and reducing excess fluid in the body.
  • Reduction of Cardiovascular Risk: Helps reduce the risk of heart attack, stroke, and other complications associated with uncontrolled high blood pressure.

Key Benefits

Trinexovas 40 Tablet helps lower blood pressure and provides long-term protection against complications of hypertension. Key benefits include:

  • Lowers High Blood Pressure: Works through multiple mechanisms to effectively reduce elevated blood pressure and maintain better blood pressure control.
  • Protects the Heart, Brain, and Kidneys: Helps reduce the risk of heart attack, stroke, heart failure, and kidney damage caused by long-standing high blood pressure.
  • Provides Convenient Combination Therapy: Combines three blood pressure-lowering medicines into a single tablet, making treatment simpler and helping improve medication adherence.

Directions for Use

  • Trinexovas 40 Tablet can preferably be taken with food to avoid stomach upset, or as prescribed by your doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Trinexovas 40 Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Trinexovas 40 Tablet Works

Trinexovas 40 Tablet contains olmesartan, cilnidipine, and chlorthalidone, which work together to lower blood pressure. Olmesartan is an angiotensin II receptor blocker (ARB) that relaxes and widens blood vessels by blocking the action of angiotensin II, a substance that normally causes blood vessels to narrow. Cilnidipine is a calcium channel blocker that relaxes blood vessels by preventing calcium from entering the muscle cells of blood vessels, allowing blood to flow more easily. Chlorthalidone is a thiazide-like diuretic that helps the kidneys remove excess salt and water from the body through urine, reducing blood volume and lowering blood pressure.
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Alcohol

Caution

Alcohol should not be taken while using Trinexovas 40 Tablet . It may worsen the health condition by increasing the risk of side effects.

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Pregnancy

Unsafe

Trinexovas 40 Tablet is a category C medicine and may cause harmful effects to the fetus or unborn baby. So, it is not recommended for use in pregnant women.

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Breast Feeding

Consult your doctor

Trinexovas 40 Tablet should be used with caution in breastfeeding mothers. Please consult your doctor before use.

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Driving

Caution

Trinexovas 40 Tablet may cause dizziness and affect your ability to drive. So, do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Trinexovas 40 Tablet should be used with caution in patients with liver diseases. The dose may have to be adjusted by the doctor as required.

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Kidney

Caution

Trinexovas 40 Tablet should be used with extreme caution in patients with kidney diseases. The dose may have to be adjusted by the doctor as required.

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Children

Unsafe

Trinexovas 40 Tablet is not recommended for use in children below 12 years of age.

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Heart

Caution

Trinexovas 40 Tablet should be taken with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems before using Trinexovas 40 Tablet .

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Geriatrics

Caution

Trinexovas 40 Tablet should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Trinexovas 40 Tablet .

What if I have taken an overdose of Trinexovas 40 Tablet

If you suspect an overdose or have taken too many tablets, seek immediate medical attention or contact your local poison control center right away. Symptoms of an overdose can include severe dizziness, a very slow or fast heartbeat, or fainting.

Diet & Lifestyle Advise

  • Reduce salt intake: Limit your consumption of processed foods, table salt, and salty snacks, as excess sodium raises blood pressure.
  • Eat potassium-rich foods: Incorporate leafy greens, bananas, and sweet potatoes into your meals, but talk to your doctor first as certain blood pressure medicines can alter your potassium levels.
  • Stay physically active: Aim for at least 30 minutes of moderate aerobic exercise, like brisk walking, most days of the week.
  • Limit alcohol and quit smoking: Both alcohol and tobacco can increase your blood pressure and damage your blood vessels, making the medication less effective.
  • Monitor your blood pressure at home: Keep a daily log of your blood pressure readings to share with your healthcare provider during your check-ups.
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How Soon It Starts Working

  • The time required for Trinexovas 40 Tablet to start to work: Trinexovas 40 Tablet ideally shows its action within 2 hours after administration.
  • The time for which the effects of Trinexovas 40 Tablet last: The effect of Trinexovas 40 Tablet lasts for 24 hours.

What if you forget to take Trinexovas 40 Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose entirely and resume your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Trinexovas 40 Tablet tablets at room temperature, ideally between 15°C and 30°C (59°F to 86°F). •Keep the medicine in its original packaging to protect it from direct light, heat, and moisture.

Drug Warnings

  • Stand up slowly: This medicine may cause dizziness or lightheadedness, especially when standing up. Rise slowly from sitting or lying positions to reduce the risk of falls.
  • Use caution when driving: Trinexovas 40 Tablet may cause dizziness or drowsiness. Avoid driving or operating machinery until you know how this medicine affects you.
  • Tell your healthcare providers: Inform your doctor, surgeon, or dentist that you are taking Trinexovas 40 Tablet before any surgery or medical procedure.
  • Attend regular check-ups: Your doctor may monitor your kidney function, blood pressure, and electrolyte levels, including potassium and sodium, during treatment.
  • Avoid potassium supplements unless advised: Do not use potassium supplements or potassium-containing salt substitutes unless recommended by your doctor.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are using any of the following medicines, as they may interact with Trinexovas 40 Tablet .

  • Lithium: May increase lithium levels in the blood, raising the risk of lithium toxicity.
  • NSAIDs (such as ibuprofen or naproxen): May reduce the blood pressure-lowering effect of Trinexovas 40 Tablet and increase the risk of kidney problems.
  • Other blood pressure medicines: May increase the risk of excessive lowering of blood pressure.
  • Potassium supplements or potassium-sparing diuretics: May increase the risk of high blood potassium levels (hyperkalaemia).
Olmesartan medoxomil + Cilnidipine + chlorthalidoneAliskiren
Critical
Olmesartan medoxomil + Cilnidipine + chlorthalidoneCisapride
Critical

Drug-Drug Interactions

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Olmesartan medoxomil + Cilnidipine + chlorthalidoneAliskiren
Critical
How does the drug interact with Trinexovas 40 Tablet:
Using Trinexovas 40 Tablet together with aliskiren may increase the risk of serious side effects (kidney problems, low blood pressure, and high potassium levels in the blood).

How to manage the interaction:
Taking Trinexovas 40 Tablet with Aliskiren is not recommended as it can cause an interaction, they can be taken if advised by a doctor. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat.It is crucial that you continue to consume enough fluids while taking these medications. Do not stop using any medications without consulting a doctor.
Olmesartan medoxomil + Cilnidipine + chlorthalidoneCisapride
Critical
How does the drug interact with Trinexovas 40 Tablet:
Co-administration of Trinexovas 40 Tablet and cisapride may increase the risk or severity of an irregular heart rhythm.

How to manage the interaction:
Taking chlorthalidone with Cisapride is not recommended as it can cause an interaction, they can be taken if advised by a doctor. However, if you experience sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats, consult a doctor. Do not discontinue the medication without consulting a doctor.
Olmesartan medoxomil + Cilnidipine + chlorthalidoneFosinopril
Severe
How does the drug interact with Trinexovas 40 Tablet:
Coadministration of Trinexovas 40 Tablet with fosinopril may cause low blood pressure, kidney problems, and may increase potassium levels in the blood.

How to manage the interaction:
Although taking Trinexovas 40 Tablet with fosinopril may lead to an interaction but can be taken if prescribed by the doctor. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. Maintaining an appropriate fluid intake is crucial when taking these medications. Do not stop using any medications without consulting a doctor.
Olmesartan medoxomil + Cilnidipine + chlorthalidonePimozide
Severe
How does the drug interact with Trinexovas 40 Tablet:
Co-administration of Trinexovas 40 Tablet with pimozide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is an interaction, Trinexovas 40 Tablet can be taken with pimozide if prescribed by the doctor. Consult a prescriber if you develop sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats, weakness, drowsiness, confusion, muscle pain, cramps, nausea, or vomiting. Do not discontinue any medications without consulting a doctor.
Olmesartan medoxomil + Cilnidipine + chlorthalidonePotassium citrate
Severe
How does the drug interact with Trinexovas 40 Tablet:
Co-administration of Trinexovas 40 Tablet with potassium citrate may increase potassium levels in the blood, which can lead to kidney failure, muscular paralysis, and abnormal heart rhythm.

How to manage the interaction:
Although taking Trinexovas 40 Tablet together with potassium citrate may result in an interaction, they can be taken together if prescribed by your doctor. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
Olmesartan medoxomil + Cilnidipine + chlorthalidoneEnalapril
Severe
How does the drug interact with Trinexovas 40 Tablet:
Using Trinexovas 40 Tablet together with enalapril may increase the risk of side effects such as low blood pressure, kidney function impairment, and a condition called hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Trinexovas 40 Tablet with enalapril may lead to an interaction but can be taken if prescribed by the doctor. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. Maintaining an appropriate fluid intake is crucial when taking these medications. Do not stop using any medications without consulting a doctor.
Olmesartan medoxomil + Cilnidipine + chlorthalidoneDroperidol
Severe
How does the drug interact with Trinexovas 40 Tablet:
Co-administration of Trinexovas 40 Tablet with droperidol may increase the risk of abnormal heart rhythms.

How to manage the interaction:
Although taking Trinexovas 40 Tablet with droperidol may cause an interaction, it can be taken if a doctor has prescribed it. Consult a doctor, if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or a rapid heartbeat, tiredness, drowsiness, muscle pain, cramps, nausea, or vomiting. Do not stop taking any medications without consulting a doctor.
Olmesartan medoxomil + Cilnidipine + chlorthalidoneLisinopril
Severe
How does the drug interact with Trinexovas 40 Tablet:
Co-administration of Trinexovas 40 Tablet with lisinopril may cause low blood pressure, kidney problems, and may increase potassium levels in the blood.

How to manage the interaction:
Although taking Trinexovas 40 Tablet with lisinopril may lead to an interaction but can be taken if prescribed by the doctor. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. Maintaining an appropriate fluid intake is crucial when taking these medications. Do not stop using any medications without consulting a doctor.
Olmesartan medoxomil + Cilnidipine + chlorthalidoneArsenic trioxide
Severe
How does the drug interact with Trinexovas 40 Tablet:
Co-administration of Trinexovas 40 Tablet with arsenic trioxide may increase the risk of abnormal heart rhythms.

How to manage the interaction:
Although taking Trinexovas 40 Tablet with arsenic trioxide may cause an interaction, it can be taken if a doctor has prescribed it. Consult a doctor, if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or a rapid heartbeat. Do not stop taking any medications without consulting a doctor.
Olmesartan medoxomil + Cilnidipine + chlorthalidoneCaptopril
Severe
How does the drug interact with Trinexovas 40 Tablet:
When Trinexovas 40 Tablet is taken with captopril, it may cause low blood pressure, kidney problems, and may increase potassium levels in the blood.

How to manage the interaction:
Although taking Trinexovas 40 Tablet with captopril may lead to an interaction but can be taken if prescribed by the doctor. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. Maintaining an appropriate fluid intake is crucial when taking these medications. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit or grapefruit juice: May increase the effects of certain components of Trinexovas 40 Tablet , potentially causing excessive lowering of blood pressure.
  • Alcohol: Avoid alcohol, as it may increase dizziness, drowsiness, and the risk of low blood pressure.
CHLORTHALIDONE-12.5MG+CILNIDIPINE-10MG+OLMESARTAN-40MGPotassium rich foods
Moderate

Drug-Food Interactions

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CHLORTHALIDONE-12.5MG+CILNIDIPINE-10MG+OLMESARTAN-40MGPotassium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
When Trinexovas 40 Tablet is taken along with potassium-containing salt substitutes or over-the-counter potassium supplements it may lead to high potassium levels in blood. Avoid taking potassium-containing salt substitutes or over-the-counter potassium supplements with Trinexovas 40 Tablet as this can lead to high potassium levels in the blood. However, consult a doctor if you experience weakness, irregular heartbeat, confusion, tingling of the extremities, or feelings of heaviness in the legs.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- HYPERTENSIVES]

FAQs

Trinexovas 40 Tablet is used to treat high blood pressure (hypertension).
Trinexovas 40 Tablet reduces elevated blood pressure. It contains Olmesartan, Cilnidipine, and Chlorthalidone. Olmesartan is an angiotensin-II receptor blocker (ARB). Angiotensin narrows the blood vessels increasing the blood pressure, therefore blocking angiotensin can result in widening of the narrowed blood vessels. Cilnidipine is a calcium channel blocker. It acts by relaxing the blood vessels and improving the blood flow. Chlorthalidone is a diuretic or water pill that acts by expelling excess water and salt from the body. It helps in decreasing fluid accumulation and oedema (fluid overload).
Trinexovas 40 Tablet may cause low blood pressure resulting in dizziness or fainting. It may also cause orthostatic hypotension (sudden drop in blood pressure while standing up), so rise slowly while standing up from a sitting or lying position.
You should not discontinue using Trinexovas 40 Tablet without consulting your doctor. The doctor may monitor your blood pressure for at least two weeks before reducing the dose and gradually stopping the medicine.
The common side-effects of Trinexovas 40 Tablet are dizziness, low blood pressure, flushing (reddening of the skin, especially face), headache, palpitations (pounding heartbeat), increased micturition (frequency of urination), and lethargy (feeling weak). These side-effects are usually mild and resolve without requiring any medical attention. However, if any of these side-effects persist or get worse, inform your doctor immediately.
Please inform your doctor before surgery if you are taking Trinexovas 40 Tablet as it needs to be stopped because it might lower the blood pressure further if taken along with general anaesthesia.
Both Trinexovas 40 Tablet and olmesartan medoxomil are used to treat high blood pressure (hypertension). However, Trinexovas 40 Tablet contains three active ingredients: olmesartan medoxomil, cilnidipine, and chlorthalidone, while olmesartan medoxomil contains only one active ingredient.
Trinexovas 40 Tablet can be used with caution in elderly patients. Elderly patients may be more susceptible to hypotensive effects, increasing the risk of falls, dizziness, and orthostatic hypotension. Close monitoring by their healthcare provider is recommended.
Trinexovas 40 Tablet is not recommended for pregnant and breastfeeding women. This combination of medications can harm the fetus or baby, and alternative treatments should be considered. Women of childbearing age should discuss their pregnancy plans with their doctor before starting treatment.
Trinexovas 40 Tablet is not recommended for patients with severe kidney and liver diseases. Patients with mild to moderate kidney or liver disease should use it with caution and under close medical supervision.
Dizziness is common, especially when you first start taking this medicine or when your dose is gradually increased. Sit or lie down until the dizziness passes, and always get up slowly from sitting or lying positions. If the dizziness persists or causes you to faint, talk to your doctor.
It is highly recommended to avoid alcohol while taking this medication. Alcohol can work together with this medicine to drop your blood pressure too low, which can lead to severe dizziness, fainting, or headaches. Talk to your doctor if you have questions about alcohol use.
Yes, Trinexovas 40 Tablet contains a mild diuretic, which helps your body get rid of excess water and salt. This can cause you to urinate more frequently, especially when you first start the medication. To avoid waking up at night, it is usually best to take your dose in the morning. Talk to your doctor if this becomes bothersome.
You should avoid taking pain relievers like ibuprofen or naproxen regularly without medical advice. These medicines can reduce the effectiveness of your blood pressure treatment and increase your risk of kidney damage. Talk to your doctor or pharmacist about safe pain relief alternatives.
It is generally recommended to take Trinexovas 40 Tablet in the morning because it contains a diuretic that increases urination, and taking it late in the day might disrupt your sleep. However, you should follow your doctor's specific advice on when to take your dose. Talk to your doctor to find the best schedule for you.
You should follow a low-sodium, heart-healthy diet to support your treatment. Avoid using potassium-based salt substitutes or potassium supplements unless specifically instructed, as this medication can affect your blood potassium levels. Talk to your doctor or a dietitian for personalised dietary advice.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.
Other Info - TRI1006
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