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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
VALCYTE 450MG TABLET is used to treat cytomegalovirus retinitis (viral infection of the retina). It contains Valganciclovir which works by inhibiting the multiplication of the virus. In some cases, this medicine may cause side effects such as diarrhoea, loss of appetite, cough, headache, stomach pain, nausea, fever, and tiredness. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Manufacturer/Marketer :

Roche Diagnostics India Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About VALCYTE 450MG TABLET

VALCYTE 450MG TABLET is used to treat cytomegalovirus (CMV) infection of the retina of the eye in adult AIDS patients. Also, VALCYTE 450MG TABLET is used to prevent CMV infection in patients who received an organ transplant from a donor infected with CMV. Cytomegalovirus (CMV) retinitis is a viral infection of the retina (light-sensing cells) caused by cytomegalovirus.

VALCYTE 450MG TABLET contains Valganciclovir which works by getting converted to ganciclovir in the body and inhibits the multiplication of the virus. Thereby, it helps to control the infection.  

Take VALCYTE 450MG TABLET as prescribed by your doctor. You are advised to take VALCYTE 450MG TABLET for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience diarrhea, loss of appetite, cough, headache, stomach pain, nausea, fever, tiredness, or sinusitis (sinus infection). Most of these side effects of VALCYTE 450MG TABLET do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to VALCYTE 450MG TABLET or any other medicines, please tell your doctor. Avoid taking VALCYTE 450MG TABLET if you are pregnant, as it may cause birth defects. If you are breastfeeding, do not take VALCYTE 450MG TABLET as it may be excreted in human milk and cause adverse effects in the baby. Women are recommended to use effective contraceptive measures while taking VALCYTE 450MG TABLET and for 30 days after treatment with VALCYTE 450MG TABLET. Drive only if you are alert, as VALCYTE 450MG TABLET may cause dizziness, tiredness, drowsiness, shakiness, or confusion.

Uses of VALCYTE 450MG TABLET

Treatment of Cytomegalovirus (CMV) infection of the retina.

Directions for Use

Take VALCYTE 450MG TABLET with food or as prescribed by your doctor. Swallow it as a whole with a glass of water. Do not break, crush or chew it.

Medicinal Benefits

VALCYTE 450MG TABLET contains Valganciclovir, an antiviral drug used to treat cytomegalovirus (CMV) infection of the retina of the eye in adult AIDS patients. VALCYTE 450MG TABLET gets converted to ganciclovir in the body and inhibits the multiplication of the virus. Thereby, it helps to control the infection.  Additionally, VALCYTE 450MG TABLET is used to prevent CMV infection in patients who received an organ transplant from a donor infected with CMV.

How VALCYTE 450MG TABLET Works

VALCYTE 450MG TABLET contains Valganciclovir which works by getting converted to ganciclovir in the body and inhibits the multiplication of the virus. Thereby, it helps to control the infection.

Storage

Store in a cool and dry place away from sunlight

Side Effects of VALCYTE 450MG TABLET

  • Diarrhoea

  • Loss of appetite

  • Cough

  • Headache

  • Stomach pain

  • Nausea

  • Fever

  • Tiredness

  • Sinusitis (sinus infection)

What if I have taken an overdose of VALCYTE 450MG TABLET

Take VALCYTE 450MG TABLET only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include upset stomach, vomiting, stomach pain, diarrhoea, uncontrolled shaking, seizures, decreased urination, bloody urine, signs of infection (sore throat, fever, chills, cough), excessive tiredness, pale skin, yellowing of skin or eyes, dizziness, fast heartbeat, weakness, and unusual bleeding or bruising. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

If you are allergic to VALCYTE 450MG TABLET or any other medicines, please tell your doctor. If you have a low number of platelets, white blood cells or red blood cells and kidney problems, inform your doctor before taking VALCYTE 450MG TABLET. Avoid taking VALCYTE 450MG TABLET if you are pregnant as it may cause birth defects. If you are breastfeeding, do not take VALCYTE 450MG TABLET as it may be excreted in human milk and cause adverse effects in the baby. Women are recommended to use effective contraceptive measures while taking VALCYTE 450MG TABLET and 30 days after treatment with VALCYTE 450MG TABLET. Men are advised to continue using contraceptive measures for 90 days after treatment with VALCYTE 450MG TABLET. Drive only if you are alert as VALCYTE 450MG TABLET may cause dizziness, tiredness, drowsiness, shakiness or confusion. If you are having blood dialysis or radiotherapy, please inform your doctor before taking VALCYTE 450MG TABLET.

Drug-Drug Interactions

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ValganciclovirCidofovir
Critical
ValganciclovirAdalimumab
Severe

Drug-Drug Interactions

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ValganciclovirCidofovir
Critical
How does the drug interact with Valcyte 450mg Tablet:
Taking cidofovir with Valcyte 450mg Tablet can increase the risk of kidney problems.

How to manage the interaction:
Taking Valcyte 450mg Tablet with Cidofovir is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
ValganciclovirAdalimumab
Severe
How does the drug interact with Valcyte 450mg Tablet:
The combined use of adalimumab and Valcyte 450mg Tablet can increase the risk of serious infections.

How to manage the interaction:
There may be a possibility of interaction between Valcyte 450mg Tablet and Adalimumab, but it can be taken if prescribed by a doctor. If you notice any of the following symptoms - fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain or burning while peeing - reach out to your doctor right away. Do not stop using any medications without talking to your doctor.
ValganciclovirDeferiprone
Severe
How does the drug interact with Valcyte 450mg Tablet:
Taking Valcyte 450mg Tablet and Deferiprone may increase the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between Valcyte 450mg Tablet and Deferiprone, but it can be taken if prescribed by a doctor. If you're having any of these symptoms - like infection, fever, chills, diarrhea, sore throat, trouble breathing, losing weight, or pain while peeing - contact your doctor right away. Do not stop using any medications without a doctor's advice.
ValganciclovirClozapine
Severe
How does the drug interact with Valcyte 450mg Tablet:
Taking Clozapine and Valcyte 450mg Tablet may increase the risk of severe infections.

How to manage the interaction:
Taking Clozapine with Valcyte 450mg Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're having any of these symptoms - like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - contact your doctor right away. Do not stop using any medications without a doctor's advice.
ValganciclovirCertolizumab
Severe
How does the drug interact with Valcyte 450mg Tablet:
Taking Valcyte 450mg Tablet and Certolizumab may increase the risk of serious infection.

How to manage the interaction:
Although there is a possible interaction between Valcyte 450mg Tablet and Certolizumab, you can take these medicines together if prescribed by your doctor. If you notice any of the following symptoms - fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, or burning while urinating - contact your doctor right away. Do not discontinue any medications without consulting your doctor.
ValganciclovirTenofovir alafenamide
Severe
How does the drug interact with Valcyte 450mg Tablet:
When Valcyte 450mg Tablet is taken with Tenofovir alafenamide it may increase the risk of kidney problems.

How to manage the interaction:
Although taking Tenofovir alafenamide and Valcyte 450mg Tablet together can cause an interaction, it can be taken if your doctor has suggested it. However, consult your doctor immediately if you experience symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without talking to your doctor.
ValganciclovirEtanercept
Severe
How does the drug interact with Valcyte 450mg Tablet:
The combined use of etanercept and Valcyte 450mg Tablet can increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction between Valcyte 450mg Tablet and Etanercept, you can take these medicines together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
ValganciclovirGolimumab
Severe
How does the drug interact with Valcyte 450mg Tablet:
The combined use of golimumab and Valcyte 450mg Tablet can increase the risk of infections.

How to manage the interaction:
Although taking Valcyte 450mg Tablet and Golimumab together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any of the following symptoms - fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain or burning while peeing - contact your doctor right away. Do not stop using any medications without talking to your doctor.
ValganciclovirInfliximab
Severe
How does the drug interact with Valcyte 450mg Tablet:
The combined use of infliximumab and Valcyte 450mg Tablet can increase the risk of infections.

How to manage the interaction:
Co-administration of Valcyte 450mg Tablet with Infliximab can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
ValganciclovirZidovudine
Severe
How does the drug interact with Valcyte 450mg Tablet:
Combining Valcyte 450mg Tablet with Zidovudine can increase the risk of side effects.

How to manage the interaction:
Although taking Valcyte 450mg Tablet and Zidovudine together can cause an interaction, it can be taken if your doctor has suggested it. If you experience any complications or symptoms, make sure to contact your doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy and balanced diet. Eat vitamin and nutrient-rich food such as dark-green, yellow, orange, and red vegetables and fruits as it helps to boost your immune system. Opt for lean protein and whole grains.

  • Avoid eating raw meat and eggs. Consume properly boiled and cooked meat, poultry or seafood.

  • Eat bland and low-fat foods and avoid spicy or oily foods if you experience nausea or vomiting.

Habit Forming

No

Therapeutic Class

ANTIVIRALS

VALCYTE 450MG TABLET Substitute

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Alcohol

Caution

The interaction of alcohol with VALCYTE 450MG TABLET is unknown. Please consult a doctor before consuming alcohol while using VALCYTE 450MG TABLET.

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Pregnancy

Unsafe

VALCYTE 450MG TABLET is not recommended for pregnant women as it may cause birth defects. Please consult a doctor if you are pregnant.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking VALCYTE 450MG TABLET as it may pass into breast milk. Therefore, please consult a doctor if you are breastfeeding.

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Driving

Caution

VALCYTE 450MG TABLET may cause dizziness, tiredness, drowsiness, shakiness or confusion in some people. Therefore, avoid driving or operating heavy machinery if you experience any of these symptoms after taking VALCYTE 450MG TABLET.

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Liver

Caution

Take VALCYTE 450MG TABLET with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take VALCYTE 450MG TABLET with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

VALCYTE 450MG TABLET should be used in children only if recommended by a doctor.

FAQs

VALCYTE 450MG TABLET is used to treat cytomegalovirus (CMV) infection of the retina of the eye in adult AIDS patients. Also, it is used to prevent CMV infection in patients who received an organ transplant from a donor infected with CMV.

VALCYTE 450MG TABLET contains Valganciclovir that works by getting converted to ganciclovir in the body and inhibits the multiplication of the virus. Thereby, it helps to control the infection.

VALCYTE 450MG TABLET may be used to prevent cytomegalovirus infection in patients who received an organ transplant from a donor infected with CMV.

VALCYTE 450MG TABLET may cause diarrhoea as a temporary side effect. However, if the condition persists or worsens, please consult a doctor.

VALCYTE 450MG TABLET should be used with caution in patients with kidney problems and only in doses as prescribed by a doctor. However, regular blood tests are recommended while taking VALCYTE 450MG TABLET to monitor kidney functioning.

You are not recommended to take VALCYTE 450MG TABLET with tacrolimus (immunosuppressant) as it may increase the risk of kidney or nerve damage, cause side effects affecting bone marrow function leading to a low number of blood cells. Therefore, please consult a doctor before taking VALCYTE 450MG TABLET with other medicines.

VALCYTE 450MG TABLET is classed as a cytotoxic medicine and will therefore require special handling.

Common side effects of VALCYTE 450MG TABLET may include diarrhea, loss of appetite, cough, headache, stomach pain, nausea, fever, tiredness, or sinusitis (sinus infection). Most of these side effects of VALCYTE 450MG TABLET do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Yes, it also have activity against the alpha herpesviruses. But it should be taken only if recommended by the healthcare professional.

VALCYTE 450MG TABLET contains Valganciclovir as an active ingredient.

It is a viral infection of the retina (light-sensing cells) caused by cytomegalovirus. In serious cases, it may lead to blindness. CMV retinitis is more likely to affect people with a weakened immune system from HIV/AIDS. The symptoms include blurred vision, a blind spot in vision, floaters in the eye, loss of peripheral vision or flashes in the eye.

VALCYTE 450MG TABLET is not recommended for pregnant women as it may cause birth defects. Please consult a doctor if you are pregnant or have any concerns.

If you are breastfeeding, do not take VALCYTE 450MG TABLET as it may be excreted in human milk and cause adverse effects in the baby.

VALCYTE 450MG TABLET may cause dizziness, tiredness, drowsiness, shakiness or confusion in some people. Therefore, avoid driving or operating heavy machinery if you experience these symptoms after taking VALCYTE 450MG TABLET.

Country of origin

INDIA

Manufacturer/Marketer address

1503, 15th Floor, ‘The Capital’, Plot no. C-70, Behind ICICI Bank, BKC, Bandra (E) , Mumbai 400051
Other Info - VAL0072

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