About S ADENOSYL METHIONINE
S ADENOSYL METHIONINE belongs to the class of medication called Nutritional supplements primarily used to treat S-adenosylmethionine deficiency. Some patients with depression, Alzheimer's disease, dementia, Parkinson's disease treated with levodopa, disorders of folate metabolism, and other illnesses cause S-adenosylmethionine deficiency. S ADENOSYL METHIONINE is a synthetic form of a chemical that occurs naturally in cells, tissue, and body fluids, primarily used to treat depression, reduce pain and swelling in the joints conditions such as osteoarthritis, biliary cholangitis (an autoimmune disease of the liver), excess cholesterol in bile and biliary and liver diseases caused by cystic fibrosis. Additionally, it is also used to treat liver disease during pregnancy, improves symptoms in people with fibromyalgia, and treats nerve problems in people with AIDS or sexual dysfunction in men with depression.
S ADENOSYL METHIONINE contains S-adenosylmethionine, which is a naturally-occurring substance found in cells, tissue, and body fluids. It is produced from methionine (amino acid) and used to treat liver disease, depression, and osteoarthritis. S ADENOSYL METHIONINE ensures sufficient levels of glutathione in the liver are maintained to minimize liver damage. It also prevents the increase of lipids associated with cirrhosis outside the liver. It also affects certain chemical messengers (serotonin) in the brain, which communicate between brain cells, thereby regulating mood and treating depression. It stimulates the production of parts of cartilage, reduces the inflammatory mediator, and has painkilling properties.
Take S ADENOSYL METHIONINE as recommended by your doctor. In some cases, you may experience certain common side-effects such as abdominal discomfort, abdominal pain, diarrhea, nausea, dizziness, insomnia. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Do not discontinue S ADENOSYL METHIONINE without consulting your doctor. Do not take S ADENOSYL METHIONINE if you are pregnant or breastfeeding unless advised. S ADENOSYL METHIONINE can be given to children with extreme caution if recommended by the doctor. Avoid consuming alcohol along with S ADENOSYL METHIONINE as it could lead to increased drowsiness and liver damage. Keep your doctor informed about your health condition and medicines to rule out any side effects.
Uses of S ADENOSYL METHIONINE
Depression, Primary biliary cholangitis, Osteoarthritis
Medicinal Benefits
The S ADENOSYL METHIONINE contains S-adenosylmethionine, a naturally-occurring substance found in cells, tissue, and body fluids. It is produced from methionine (amino acid) and used to treat liver disease, depression, and osteoarthritis. In liver disease, S ADENOSYL METHIONINE ensures sufficient glutathione levels in the liver to minimize liver damage. It also prevents the increase of lipids associated with cirrhosis outside the liver. In depression, it affects certain chemical messengers (serotonin) in the brain, which communicate between brain cells, thereby regulating mood and treating depression. In osteoarthritis, It stimulates the production of cartilage parts, reduces the inflammatory mediator, and has painkilling properties. S ADENOSYL METHIONINE is also effective in treating liver disease during pregnancy, improving symptoms in people with fibromyalgia, treating nerve problems in people with AIDS, or sexual dysfunction in men with depression.
Directions for Use
Storage
Side Effects of S ADENOSYL METHIONINE
- Headache
- Dizziness
- Feeling anxious
- Vomiting
- Stomach upset
- Diarrhea
- Constipation
- Insomnia (sleep problem)
- Increased sweating
In-Depth Precautions and Warning
Drug Warnings
Do not take S ADENOSYL METHIONINE if you are allergic to any of its contents, if you have used an MAO inhibitor in the past 14 days, inflammation of gall bladder and bile ducts, narrowing or blockage bile ducts, biliary colic, calcified gallstones, improper constriction of the gallbladder, gastric or duodenal ulcer. Inform your doctor if you have heart disease, seizure disorders, bone marrow suppression, diabetes, schizophrenia, bipolar disorder, acute alcohol intoxication, glaucoma, thyroid problems, kidney and liver problems. Do not take S ADENOSYL METHIONINE if you are pregnant or breastfeeding unless advised. S ADENOSYL METHIONINE can be given to children with caution if recommended by the doctor. Avoid consuming alcohol along with S ADENOSYL METHIONINE as it could lead to increased drowsiness and liver damage. Keep your doctor informed about your health condition and medicines to rule out any unpleasant side-effects.
Drug Interactions
Drug-Drug Interactions: S ADENOSYL METHIONINE may have interaction with monoamine oxidase inhibitors (medicines used to treat depression) (moclobemide, phenelzine, iproniazid, isocarboxazid, nialamide, tranylcypromine, selegiline), an antidepressant (bupropion, duloxetine, fluoxetine, sertraline), antiparkinsons (levodopa), pain killers (tramadol, trazodone, hydrocodone, oxycodone, acetaminophen).
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: S ADENOSYL METHIONINE may have interactions with bipolar depression, Parkinson's disease, biliary obstruction and liver impairment, variceal bleeding (high blood pressure in portal veins), ascites (excess abdominal fluid), liver encephalopathy.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionAvoid consumption of alcohol while taking S ADENOSYL METHIONINE as it may cause increased dizziness and liver damage.
Pregnancy
cautionAvoid taking S ADENOSYL METHIONINE if you are pregnant unless advised by a doctor. Please consult your doctor if you have any concerns regarding this, your doctor will recommend only if the benefits outweigh the risks.
Breast Feeding
cautionConsult your doctor before taking S ADENOSYL METHIONINE, your doctor will decide whether S ADENOSYL METHIONINE can be taken by breastfeeding mothers or not.
Driving
cautionS ADENOSYL METHIONINE does not affect your ability to drive. However, you are advised to be cautious while driving if you experience dizziness.
Liver
cautionDose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.
Kidney
cautionDose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.
Children
cautionS ADENOSYL METHIONINE can be given to children with caution only if recommended by the doctor.
Habit Forming
Diet & Lifestyle Advise
Liver disease:
- Include foods such as bell peppers, citrus fruits, leafy vegetables, tomatoes, milk, fish, low-fat dairy, beans, nuts, lentils, tofu, and tempeh in your diet.
- Foods rich in Vitamin B, C, and calcium, are good for the gallbladder.
- Plant-based protein foods such as beans, nuts, lentils, tofu, and tempeh help prevent gallbladder disease.
- Avoid high-fat, trans-fat, and processed foods, white bread, white pasta, and sugars.
- Avoid tobacco and alcohol consumption.
Depression:
- Maintain a healthy diet and exercise regularly helps in improving overall health and boosts self-esteem.
- Perform meditation and yoga. This helps in relieving stress and provides relaxation.
- Follow a regular sleep pattern to improve the amount and quality of sleep you get.
- Include foods rich in omega fatty acids such as fish, nuts, fresh fruits, vegetables, and olive oils.
- Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help in the proper maintenance of neurotransmitters.
- Avoid smoking and alcohol consumption.
Osteoarthritis:
- Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
- Performing yoga may also help in improving joint flexibility and pain management.
- Follow heat or cold therapy, apply a cold or hot compress on the joints for 15-20minutes regularly.
Special Advise
- Your doctor may advise a regular liver function test to monitor the liver's function and the progress of the treatment.
- Do not use S ADENOSYL METHIONINE if you have used an MAO inhibitor (antidepressant) in the past 14 days, as a dangerous drug interaction could occur.
Patients Concern
Disease/Condition Glossary
Primary biliary cholangitis: Primary biliary cholangitis, formerly known as primary biliary cirrhosis, is an autoimmune disease caused by bile duct damage in the liver. Bile ducts are the small channels that carry the bile (digestive fluid) from the liver to the small intestine, where it breaks down fats and aids in its absorption. Biliary cirrhosis causes a build-up of bile in the liver, which leads to liver damage.
Depression: It is a mood disorder characterized by the feeling of sadness, unhappiness, anger, hopelessness, or loss that interferes with a person’s daily activities. Depression can also influence some chronic health conditions and relationships. The exact cause of depression is unknown, but it may be associated with mental problems, trauma, family history, drug use, and medical conditions.
Osteoarthritis: It is a degenerative joint disease in which the two ends of the joints come together due to the breakdown of a protective covering of cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms of osteoarthritis include pain, stiffness, inflammation, and tenderness. The main reason for osteoarthritis is age, the older you are, the more likely you could get osteoarthritis, thus known as degenerative disease, meaning that the joints wear-out as a person ages. Other reasons include a past injury such as torn cartilage, dislocated joints, and ligament injuries.
