Hyaluronidase
About Hyaluronidase
Hyaluronidase is a specialised injection used to help your body absorb injected fluids, local anaesthetics, and other medications more quickly and efficiently. It is also commonly used to help absorb fluids given under the skin for hydration, a method called hypodermoclysis. This medicine temporarily helps injected fluids and compatible medicines spread more easily through body tissues.
Because Hyaluronidase is an injection, it is typically given on an as-needed basis by a healthcare professional rather than on a daily, routine schedule. Since it is injected directly into the tissue, it does not matter if you have eaten recently, as food does not affect how this medication works in your body. Drinking plenty of water and resting the treated area after your injection can help support your body's natural recovery process.
Most patients tolerate this treatment well, but it can cause mild, localised side effects such as redness, swelling, or warm feelings at the injection site. If you experience severe reactions like spreading redness, extreme swelling, or hives, you must consult your doctor immediately. These symptoms could indicate an allergic response or an infection that requires prompt medical attention.
Before receiving this medication, you must talk to your doctor if you have any history of severe allergies, active skin infections, or cancer in the area where the injection is planned. Do not receive Hyaluronidase if you have a known allergy to animal proteins (as some formulations are derived from animal sources) or if the target area is actively infected, inflamed, or swollen due to an insect bite.
Certain medications, including antihistamines, corticosteroids, and estrogens, can interact with Hyaluronidase and reduce its overall effectiveness. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly patient, you must consult your healthcare provider to discuss whether this treatment is appropriate for you.
Uses of Hyaluronidase
Medicinal Benefits
Hyaluronidase temporarily makes body tissues easier for injected fluids and compatible medicines to move through, helping them spread and absorb more effectively during selected medical procedures.
- Improves Absorption of Injected Fluids: Helps fluids given under the skin spread through tissues and absorb more efficiently.
- Enhances Dispersion of Certain Medicines: Helps compatible injected medicines, including some local anaesthetics, spread more effectively when used under medical supervision.
- Supports Subcutaneous Fluid Administration: Facilitates fluid absorption when intravenous access is difficult or unsuitable.
- Reduces Localised Fluid Pooling: Improved fluid dispersion may help reduce pressure and discomfort caused by fluid collecting in one area.
- Supports Certain Medical Procedures: Helps injected fluids and compatible medicines move more easily through tissues during selected diagnostic and treatment procedures.
Directions for Use
- Follow your doctor’s instructions on the dosage and timing of this medication.
- Hyaluronidase will be administered by the doctor or nurse in a healthcare setting.
- Do not self-administer.
Storage
Side Effects of Hyaluronidase
Common Side Effects (Usually mild)
- Redness at the injection site
- Mild swelling or puffiness
- Local warmth or itching
- Mild pain or tenderness where the needle entered
Serious Side Effects (Consult your doctor right away)
- Signs of a severe allergic reaction (such as skin rash, hives, itching, difficulty breathing, or swelling of the face, lips, tongue, or throat)
- Spreading redness, heat, or severe pain at the injection site (which may indicate a spreading infection)
- Dizziness, lightheadedness, or a sudden drop in blood pressure
Medicines Containing this Salt
View AllDrug Warnings
- Inspect the Solution Before Use: The solution should be clear and free from visible particles. Do not use it if it appears cloudy, discoloured, or contains particles.
- Avoid Infected or Cancerous Areas: Hyaluronidase should not be injected into or around these areas because it may help infection or cancer cells spread into nearby tissues.
- Report Any History of Allergies: Tell your healthcare provider about previous severe allergic reactions before receiving Hyaluronidase. Appropriate allergy assessment may be considered when clinically indicated.
- Ensure Safe Needle Disposal: Used needles and syringes should be discarded immediately in an approved puncture-resistant sharps container and must never be reused.
Drug Interactions
Certain medicines may interact with Hyaluronidase and alter its effectiveness or affect the absorption and duration of other injected medicines. Important interactions include:
- Local Anaesthetics: When mixed with local anaesthetics, Hyaluronidase can cause the numbing effect to wear off more quickly because the anaesthetic is absorbed faster into your system.
- Antihistamines, Corticosteroids, and Oestrogens: Taking these medications may make your tissues more resistant to Hyaluronidase, meaning a higher dose may be required to achieve the desired fluid-spreading effect.
- Salicylates (such as aspirin): These medications can also reduce the chemical effectiveness of Hyaluronidase in the body.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionIt is unknown if alcohol interacts with Hyaluronidase. Please consult your doctor before consuming alcohol, along with Hyaluronidase.
Pregnancy
cautionHyaluronidase is pregnancy category C drug. It can only be injected in pregnant women if suggested by the doctor as the safety and effectiveness of Hyaluronidase has not been established.
Breast Feeding
cautionHyaluronidase can only be injected in breastfeeding women when suggested by the doctor as safety and effectiveness of Hyaluronidase has not been established.
Driving
cautionIn some cases, Hyaluronidase may cause dizziness and drowsiness. So if you observe such symptoms, immediately consult your doctor.
Liver
cautionHyaluronidase can only be injected in persons dealing with liver disease if prescribed by a doctor.
Kidney
cautionHyaluronidase can only be injected in persons dealing with kidney disease if prescribed by a doctor.
Children
cautionHyaluronidase can be used in children only when prescribed by a doctor.
Habit Forming
Diet & Lifestyle Advise
- Stay well-hydrated: Drink plenty of water before and after your treatment to support your body's fluid balance and enhance the absorption of the injected fluids.
- Rest the injection site: Avoid heavy lifting, vigorous exercise, or putting excessive pressure on the treated area for at least 24 hours after the injection.
- Do not massage the area: Unless specifically instructed by your healthcare provider, avoid rubbing or massaging the injection site, as this can affect how the medication spreads.
- Monitor your skin: Keep a close eye on the skin around the injection site for any unusual changes, such as worsening redness, warmth, or pus, which could indicate a complication.
Special Advise
Your doctor may perform a skin test to see if you are allergic to Hyaluronidase before you receive]ing the medication.
Patients Concern
Disease/Condition Glossary
Drug absorption is a parameter in which the drug is absorbed from a pharmaceutical formulation into the bloodstream. Many patients with chronic diseases require injections as part of their prolonged medical therapy. Hypodermoclysis is a useful technique for the cure of dehydration in patients and especially for its prevention. Dehydration occurs when more water and fluids leave the body than enter it. Urography is radiography of any part of the urinary tract (kidneys, ureters, or bladder).
FAQs
Hyaluronidase is used together with fluids injected into the body to treat dehydration. It is also used to aid in the absorption of injections and enable excess fluids and blood in the tissues to be more easily re-absorbed. Besides this, it is also used to help contrast dyes in the body show more clearly on certain types of X-rays or scans.
Hyaluronidase contains Hyaluronidase, an enzyme that increases the permeability of connective tissue through the hydrolysis of hyaluronic acid and increases the diffusion of injected fluids or localized transudates exudates, thus facilitating their absorption.
Do not try to take injections on your own. Hyaluronidase has to be given by the registered medical practitioner (RMP) or doctor.
Yes, Hyaluronidase can cause dizziness in some patients. So, drive only if you are alert and omit driving or operating machinery if you feel dizzy or drowsy.
The common side-effects of Hyaluronidase are allergic reaction, hormone imbalance, slow growth in children and teenagers, angioedema (swelling of deeper layers of skin), dizziness, injection site reaction, and oedema (swelling).
A person of age 65 or older should use Hyaluronidase with caution, as directed by the doctor, as the chances of side effects increase in older people.
It is used as an injection to help your body absorb fluids, local anaesthetics, and other injected medications more quickly and efficiently. Talk to your doctor to learn more about why it was prescribed for you.
No, Hyaluronidase is not designed for direct intravenous injection; it is typically injected under the skin or into the muscle to help disperse fluids in those tissues. Talk to your doctor if you have concerns about the administration route.
It should only be used during pregnancy if clearly needed and prescribed by your doctor, as there is limited data on its effects on unborn babies. Talk to your doctor to weigh the benefits and risks.
A skin test may be performed to check if you are allergic to the medication, especially since some formulations are derived from animal sources. Talk to your doctor if you have a history of severe allergies.
While it helps disperse fluids, it is not a direct treatment for general swelling and should never be injected into areas swollen from infections or insect bites. Talk to your doctor about the appropriate treatment for your swelling.
This could be a sign of a localised infection or a severe allergic reaction. You should contact your healthcare provider or seek medical attention immediately. Talk to your doctor if you notice any unusual skin changes.
Yes, it can interact with drugs like antihistamines, corticosteroids, estrogens, and certain pain relievers, which may make Hyaluronidase less effective. Talk to your doctor or pharmacist about all the medications you currently take.
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