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compositionComposition:DOMPERIDONE-10MG+RANITIDINE-150MG
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Prescription Medicine
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R-Loc D Tablet is used to treat gastro-oesophageal reflux disease (GERD) and peptic ulcers. It contains Ranitidine and Domperidone, which works by reducing gastric acid secretion and increasing the movements and contractions of stomach muscles. Thus, helps in treating acidity. In some cases, you may experience certain common side effects such as dry mouth, stomach pain, constipation, headache, sleepiness, and dizziness. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

DOMPERIDONE-10MG+RANITIDINE-150MG

Manufacturer/Marketer :

Zydus Healthcare Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About R-Loc D Tablet

R-Loc D Tablet belongs to a group of medicines called gastrointestinal agents used to treat gastro-oesophageal reflux disease (GERD) and peptic ulcers. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). Peptic ulcers are sores that develop on the inner lining of the intestine and stomach.

R-Loc D Tablet is a combination of two drugs: Ranitidine and Domperidone. Ranitidine works by blocking histamine H2 receptors located on the stomach lining, thereby reducing gastric acid secretion. Domperidone works by increasing the movements and contractions of stomach muscles. Together, R-Loc D Tablet helps in treating acidity.

You are advised to take R-Loc D Tablet as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as dry mouth, stomach pain, constipation, headache, sleepiness, and dizziness. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Consult your doctor if you are pregnant or breastfeeding. R-Loc D Tablet may cause sleepiness and dizziness, so drive only if you are alert. R-Loc D Tablet should not be given to children as safety has not been established. Avoid consuming alcohol along with R-Loc D Tablet as it could lead to increased drowsiness and can elevate the production of stomach acid. Keep your doctor informed about all the medicines and your health condition to rule out any side effects.

Uses of R-Loc D Tablet

R-Loc D Tablet is used to treat acid-related digestive disorders. The detailed uses of R-Loc D Tablet are as follows:

  • Gastroesophageal reflux disease (GERD): R-Loc D Tablet reduces acid reflux, heartburn, and irritation in the esophagus.
  • Peptic ulcer disease: R-Loc D Tablet aids healing of ulcers in the stomach and upper intestine by lowering acid production.
  • Indigestion: R-Loc D Tablet reduces bloating, discomfort, and pain due to acid and slow digestion.
  • Nausea and vomiting: R-Loc D Tablet helps prevent and control feelings of nausea and vomiting.
  • Prevention of acid-related complications: R-Loc D Tablet protects the oesophagus and stomach lining from damage due to excess acid.

Key Benefits

R-Loc D Tablet belongs to a group of medicines called gastrointestinal agents used to treat gastro-oesophageal reflux disease (GERD) and peptic ulcers. R-Loc D Tablet is a combination of two drugs: Ranitidine and Domperidone. Ranitidine works by blocking histamine H2 receptors located on the stomach lining, thereby reducing gastric acid secretion. Domperidone works by increasing the movements and contractions of stomach muscles. Together, R-Loc D Tablet helps in treating acidity.

Side effects of R-Loc D Tablet
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Regular activity including cardio and weightlifting can help in weight loss and breast tissue reduction.
  • Limit alcohol intake to lower your chances of gynecomastia and hormonal changes.
  • Eat a balanced diet and avoid foods high in estrogen-like compounds.
  • Follow your doctor's instructions take medication consistently to reduce breast enlargement and do not stop taking medication on your own.
  • Eat a balanced diet rich in fruits, vegetables, whole grains, and healthy fats.
  • Engage in regular moderate exercise, avoiding excessive strenuous activity.
  • Practice relaxation techniques like deep breathing, meditation, or yoga to manage stress.
  • Ensure adequate sleep and hydration.
  • Track your menstrual cycle to monitor patterns and symptoms.
  • Increase calorie intake and aim for a healthy energy balance.
  • Prioritize healthy fats annd take omega-3 rich foods like fatty fish, avocado, nuts, and seeds.
  • Eat complex carbohydrates like whole grains like brown rice, quinoa, whole wheat bread, and oats.
  • Ensure adequate protein intake like lean protein sources like chicken, fish, beans, lentils, and tofu.
  • Include calcium-rich foods such as dairy products like milk, yogurt, and fortified plant-based options.
  • Consume vitamin D sources like fortified milk, fatty fish, or consider supplementation.
  • Practice relaxation techniques like yoga, meditation, and deep breathing exercises to manage stress.
  • Do moderate exercise and reduce intensity or duration to prevent hormonal disruption.
  • Aim for 7-8 hours of restful sleep each night to help your body and mind recharge.
  • Stay hydrated by drinking plenty of water.
  • Maintain a healthy body weight through balanced diet and exercise.
  • Consult a healthcare professional before making significant dietary changes, especially if suspecting a medical cause for amenorrhea.

Directions for Use

  • R-Loc D Tablet should be taken 30-60 minutes before meals to prevent gastrointestinal side effects.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow R-Loc D Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How R-Loc D Tablet Works

R-Loc D Tablet is a combination of two drugs: Ranitidine and Domperidone. Ranitidine works by blocking histamine H2 receptors located on the stomach lining, thereby reducing gastric acid secretion. Domperidone works by increasing the movements and contractions of stomach muscles. Together, R-Loc D Tablet helps in treating acidity.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking R-Loc D Tablet . Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.

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Pregnancy

Caution

Consult your doctor before taking R-Loc D Tablet if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor before taking R-Loc D Tablet ; your doctor will decide whether R-Loc D Tablet can be taken by breastfeeding mothers or not.

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Driving

Caution

R-Loc D Tablet may cause dizziness and sleepiness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed. Consult your doctor before taking R-Loc D Tablet if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed. Consult your doctor before taking R-Loc D Tablet if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

R-Loc D Tablet should not be given to children as the safety and effectiveness were not established.

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Heart

Unsafe

R-Loc D Tablet is not recommended for use in heart patients as it can lead to cardiovascular effects.

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Geriatrics

Unsafe

R-Loc D Tablet is not recommended for use in elderly patients as it can lead to side effects like confusion, stroke, etc.

What if I have taken an overdose of R-Loc D Tablet

Do not take more than the prescribed dose of R-Loc D Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Eat smaller meals more often.
  • Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.
  • Maintain a healthy weight by regular exercising.
  • Avoid lying down after eating.
  • Avoid tight-fitting clothes.
  • Maintain a healthy weight by regular exercising.
  • Practise relaxation techniques and avoid stress by doing yoga or meditation.
  • Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda. 
  • Avoid sitting continuously as it may trigger acidity. Take a break of 5 minutes every hour by doing brisk walking or stretching.
health query

Have a query?

How Soon It Starts Working

The time required for R-Loc D Tablet to start to work: R-Loc D Tablet ideally shows its action within 30 to 60 minutes after administration. The time for which the effects of R-Loc D Tablet last: The effect of R-Loc D Tablet lasts for 12 hours.

What if you forget to take R-Loc D Tablet

Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and follow your regular dosing schedule. Do not take a double dose to make up for your missed dose.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

Do not take R-Loc D Tablet if you are allergic to any of its contents. Inform your doctor before taking R-Loc D Tablet if you have a history of gastrointestinal bleeding, porphyria, or intestinal obstruction. R-Loc D Tablet may cause B12 deficiency in long-term treatment. Consult your doctor if you are pregnant or breastfeeding. R-Loc D Tablet may cause sleepiness and dizziness, so drive only if you are alert. R-Loc D Tablet should not be given to children as safety has not been established. Avoid consuming alcohol along with R-Loc D Tablet as it could lead to increased drowsiness and can elevate the production of stomach acid.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions: R-Loc D Tablet may have interaction with pain killers (acetaminophen, ibuprofen, aspirin, naproxen, methadone), an antidepressant (duloxetine, citalopram, escitalopram), vitamin (vitamin b12), anti-fungal (ketoconazole, fluconazole, voriconazole), antibiotics (erythromycin, clarithromycin, telithromycin, moxifloxacin, pentamidine), heart-related medicines (propranolol, procainamide, amiodarone, dronedarone, quinidine, disopyramide, dofetilide, sotalol, diltiazem, verapamil), antipsychotics (haloperidol, pimozide, sertindole), gastrointestinal drugs (cisapride, dolasetron), antihistamine  (mequitazine, mizolastine), anti-malarial (halofantrine), a protease inhibitor (telaprevir), anti-cancer (toremifene, vandetanib, vincamine), anti-muscarinic (diphemanil), anti-anxiety (diazepam), anticonvulsant (phenytoin), anti-asthma (theophylline), blood thinner (warfarin), antidiabetic (glipizide).

Drug-Food Interactions: Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.

Drug-Disease Interactions: Inform your doctor if you have gastrointestinal bleeding, porphyria, haemodialysis, phenylketonuria, liver and kidney dysfunction.

Domperidone + RanitidineLoperamide
Severe
Domperidone + RanitidineDasatinib
Severe

Drug-Drug Interactions

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Domperidone + RanitidineLoperamide
Severe
How does the drug interact with R-Loc D Tablet:
Coadministration of loperamide with ranitidine and Domperidone may significantly increase the blood levels of loperamide. This can increase the risk of serious side effect like irregular heart rhythm.

How to manage the interaction:
Although taking loperamide with ranitidine and Domperidone together can result in an interaction, they can be taken if a doctor has prescribed it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
Domperidone + RanitidineDasatinib
Severe
How does the drug interact with R-Loc D Tablet:
Taking Domperidone and Ranitidine with Dasatinib together reduces the effectiveness of Dasatinib.

How to manage the interaction:
Although taking Domperidone and Ranitidine together with Dasatinib can result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor if you experience any unusual symptoms. Do not discontinue any medicine without consulting a doctor.
Domperidone + RanitidineMizolastine
Severe
How does the drug interact with R-Loc D Tablet:
Taking Mizolastine with Domperidone and Ranitidine can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Although taking Domperidone and Ranitidine with Mizolastine together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Domperidone + RanitidineMesalazine
Severe
How does the drug interact with R-Loc D Tablet:
Co-administration of ranitidine and domperidone with mesalazine can decrease the levels of mesalazine, which may be less effective in treating your condition.

How to manage the interaction:
There may be a possible interaction between Mesalazine with domperidone and Ranitidine, but they can be taken together if your doctor has prescribed them. Do not discontinue any medications without consulting a doctor.
Domperidone + RanitidineToremifene
Severe
How does the drug interact with R-Loc D Tablet:
Coadministration of Domperidone and Rantidine with Toremifene can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Domperidone and Rantidine with Toremifene together can cause an interaction, it can be taken if your doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
Domperidone + RanitidinePazopanib
Severe
How does the drug interact with R-Loc D Tablet:
Using Pazopanib with Ranitidine and Domperidone can reduce the effectiveness of pazopanib

How to manage the interaction:
Although taking Ranitidine and Domperidone together with Pazopanib can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
Domperidone + RanitidineMethadone
Severe
How does the drug interact with R-Loc D Tablet:
Coadministration of Domperidone and Ranitidine with Methadone can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Domperidone and Ranitidine with Methadone together can cause an interaction, it can be taken if your doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
Domperidone + RanitidineNefazodone
Severe
How does the drug interact with R-Loc D Tablet:
Coadministration of Domperidone and Ranitidine with Nefazodone can increase the blood levels of Domperidone.

How to manage the interaction:
There may be a possibility of interaction between Domperidone and Ranitidine with Nefazodone, but it can be taken if prescribed by a doctor. In case you experience any side effects like swelling of the ankles or feet, unusual tiredness, redness, changes in menstrual ability, contact a doctor. It is recommended to do this to ensure your heart stays healthy. Do not stop using any medications without talking to a doctor.
Domperidone + RanitidineCitalopram
Severe
How does the drug interact with R-Loc D Tablet:
Coadministration of Domperidone and Ranitidine with Citalopram can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Domperidone and Ranitidine with Citalopram together can cause an interaction, it can be taken if your doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
Domperidone + RanitidineRilpivirine
Severe
How does the drug interact with R-Loc D Tablet:
Coadministration of Rilpivirine with Domperidone and Ranitidine can reduce the acidity levels in the stomach and also decrease the effectiveness of Rilpivirine.

How to manage the interaction:
Although taking Ranitidine and Domperidone together with Rilpivirine can possibly result in an interaction, they can be taken together if prescribed by your doctor. To reduce the chance of interaction, take ranitidine at least 12 hours before or 4 hours after taking rilpivirine. Do not discontinue any medicine without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[GASTROINTESTINAL AGENTS]

FAQs

R-Loc D Tablet belongs to a group of medicines called gastrointestinal agents used to treat gastro-oesophageal reflux disease (GERD) and peptic ulcers.
R-Loc D Tablet is a combination of two drugs, namely: Ranitidine (H2 receptor antagonist) and Domperidone (a dopamine antagonist). Ranitidine works by blocking histamine H2 receptors located on the stomach lining, thereby reduces gastric acid secretion. Domperidone works by increasing the movements and contractions of stomach muscle. Together, R-Loc D Tablet helps in treating acidity.
Talk to your doctor if you do not feel better even after taking R-Loc D Tablet for 7 days. Do not take R-Loc D Tablet for longer durations unless prescribed by the doctor.
Constipation might be a side-effect of R-Loc D Tablet . Drink enough fluids and eat fibre rich food if you experience constipation.
Avoid lying down immediately after meals to prevent acid reflux. Raise the head of the bed 10-20cm by putting a pillow so that the head and chest are above the waist. This helps in preventing acid reflux.
Dry mouth could be a side-effect of R-Loc D Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.
R-Loc D Tablet contains domperidone which helps in treating nausea and vomiting. However, R-Loc D Tablet is used to treat acidity. Please consult your doctor, he/she may prescribe you an alternate medicine for treating nausea and vomiting.
Store R-Loc D Tablet in a cool, dry place, away from direct sunlight and moisture. Keep this medication out of reach of children.
The best time to take R-Loc D Tablet is at the dosage and timing your doctor prescribes. Typically, it's taken 30 minutes to 1 hour before a meal to prevent indigestion and heartburn. If you're unsure, consult your doctor for personalized advice.
An overdose of R-Loc D Tablet can lead to serious side effects such as extreme drowsiness, confusion, uncontrollable movements (like unusual eye or tongue movements or abnormal posture), and difficulty breathing. If you suspect an overdose, seek medical help immediately. Your doctor will focus on managing symptoms and may monitor your heart with an ECG (electrocardiogram) due to the risk of irregular heart rhythms (prolonged QT interval).
If you are pregnant, it is essential to consult your doctor. Your doctor will only evaluate and prescribe your condition if the benefits outweigh the risks.
It is generally not recommended to drink alcohol while taking R-Loc D Tablet . Alcohol can increase the risk of side effects such as drowsiness, dizziness, and stomach irritation. Additionally, it may reduce the effectiveness of the medication by increasing stomach acid production. For your safety and to ensure the best results from your treatment, always consult your doctor before consuming alcohol.
The common side effects of R-Loc D Tablet include dry mouth, stomach pain, constipation, headache, sleepiness, and dizziness. These side effects usually resolve on their own, but if they persist or worsen, consult your doctor.

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.6040 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.556 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Ranitidine Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Drugs.com Clinical Review Team. Domperidone Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  5. Zeelab Pharmacy: Ranitidine + Domperidone. [Accessed on 16 Mar. 2025]Check here
  6. F P Ryan, R Jorde, R S B Ehsanullah, K Summers, And J R Wood. A single night-time dose of ranitidine in the acute treatment of gastric ulcer: a European multicentre trial. BMJ. July 1986. [Accessed on 26th December 2022]Check here

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads,Ahmedabad 380015 Gujarat, India.
Other Info - RLO0007

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