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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Spazio Kit Tablet 5's is used for the medical termination of the pregnancy before 63 days after the first day of the last menses period. It also works in the second trimester of pregnancy. It contains Mifepristone and Misoprostol, which blocks the effects of the progesterone hormone required in women to continue the pregnancy. Also, it increases the womb's (uterus) contraction and dilates the cervix, thereby expelling the pregnancy. In some cases, you may experience side effects such as nausea, uterine cramps, vomiting, diarrhoea, infection following abortion, dizziness, and uterine bleeding. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Spazio Kit Tablet:
Co-administration of Spazio Kit Tablet with Ticagrelor can increase the risk of vaginal bleeding in women.

How to manage the interaction:
Taking Ticagrelor with Spazio Kit Tablet is not recommended, but can be taken together if prescribed by a doctor. However, consult your doctor if you experience any symptoms like heavy period bleed for more than 7 days, weakness, tiredness, shortness of breath or paleness. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Spazio Kit Tablet:
Using Spazio Kit Tablet together with fondaparinux may increase the risk and/or severity of vaginal bleeding in women

How to manage the interaction:
Taking Fondaparinux with Spazio Kit Tablet together is not recommended as it can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Spazio Kit Tablet:
Co-administration of Fluticasone with Spazio Kit Tablet may make Fluticasone less effective as a therapy.

How to manage the interaction:
Taking Fluticasone with Spazio Kit Tablet is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
MifepristoneMesoridazine
Critical
How does the drug interact with Spazio Kit Tablet:
Co-administration of Mesoridazine with Mefipristone can increase the risk of an abnormal heart rhythm, low potassium levels in the body.

How to manage the interaction:
Taking Mesoridazine with Spazio Kit Tablet is not recommended, but it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, weakness, tiredness, drowsiness, confusion, painful muscle cramping, nausea, or vomiting, constipation, abdominal cramping, chest pain, and/or swelling in the legs or feet, get medical attention. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Spazio Kit Tablet:
Taking fentanyl and Spazio Kit Tablet may significantly increase the blood levels of fentanyl, which may increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Spazio Kit Tablet and fentanyl, they can be taken together if advised by a doctor. Do not stop using any medications without talking to your doctor.
How does the drug interact with Spazio Kit Tablet:
Co-administration of Spazio Kit Tablet and Midazolam may significantly increase Midazolam blood levels and effects, which increases the risk of side effects.

How to manage the interaction:
Although taking Spazio Kit Tablet and Midazolam together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Spazio Kit Tablet:
Using Fluticasone furoate with Spazio Kit Tablet can reduce the effect of fluticasone furoate.

How to manage the interaction:
Taking Fluticasone furoate with Spazio Kit Tablet is not recommended, but it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Spazio Kit Tablet:
Co-administration of Spazio Kit Tablet with Bivalirudin can increase the risk of negative side effects.

How to manage the interaction:
Taking Bivalirudin with Spazio Kit Tablet together is not generally recommended as it may lead to an interaction, but it can be taken if prescribed by a doctor. However, if you experience persistent, excessive bleeding, consult the doctor. Without consulting a doctor, never stop taking any medication.
How does the drug interact with Spazio Kit Tablet:
When Fludrocortisone is taken with Spazio Kit Tablet, it can increase the risk of side effects.

How to manage the interaction:
Taking Spazio Kit Tablet with Fludrocortisone is not recommended, but it can be taken if prescribed by the doctor. Do not stop using any medication without consulting a doctor.
How does the drug interact with Spazio Kit Tablet:
Combining Spazio Kit Tablet with Enoxaparin can increase the risk or severity of side effects of vaginal bleeding.

How to manage the interaction:
Taking Enoxaparin with Spazio Kit Tablet is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience prolonged, excessive bleeding, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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MIFEPRISTONE-200MG+MISOPROSTOL-200MCGFruit juices, Fruits
Moderate

Drug-Food Interactions

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MIFEPRISTONE-200MG+MISOPROSTOL-200MCGFruit juices, Fruits
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consumption of grapefruit or grapefruit juice along with Spazio Kit Tablet may cause the medication's blood levels to rise to unwanted levels and raise the chance of adverse effects. Avoid taking grapefruit or grapefruit juice along with Spazio Kit Tablet as this can raise the chance of adverse effects. However, consult a doctor if you experience headache, dizziness, fatigue, nausea, vomiting, cramping, diarrhea, hypokalemia (low blood potassium), fluid retention, swelling, and high blood pressure.

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