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compositionComposition:APREMILAST-20MG
prescription
Prescription Medicine
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Apraize-20 Tablet is used to treat Plaque psoriasis (scaly, itchy, and red patches on the skin), psoriasis arthritis (inflammation in the joints in people with psoriasis), and oral ulcers. It contains Apremilast, which blocks the action of some chemical messengers that are responsible for inflammation related to psoriatic arthritis and psoriasis and thus, lowers the signs and symptoms of these conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

APREMILAST-20MG

Manufacturer/Marketer :

Ipca Laboratories Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Apraize-20 Tablet

Apraize-20 Tablet is a prescription medication used to treat moderate to severe plaque psoriasis and active psoriatic arthritis. It is also prescribed to treat painful mouth ulcers associated with Behçet's disease. By targeting specific pathways involved in inflammation, this medication helps clear skin plaques and reduce joint swelling and stiffness from within.

To get the best results, you should take Apraize-20 Tablet consistently every day, typically twice a day after an initial period of gradually increasing the dose. You can take this tablet with or without food, making it easy to fit into your daily routine. Combining your medical treatment with a balanced diet, regular gentle exercise, and proper skin moisturising can significantly improve your therapeutic results.

While taking Apraize-20 Tablet, you might experience mild side effects like nausea, diarrhea, or tension headaches, especially during the first few weeks of starting the treatment. However, if you experience severe diarrhea, significant unexplained weight loss, or changes in your mood such as depression, you must consult your doctor immediately.

Before starting Apraize-20 Tablet, tell your healthcare provider if you have a history of depression, kidney disease, or severe digestive problems. Do not take this medicine if you have a known allergy to any of its ingredients.

Certain medicines, particularly strong seizure medications or tuberculosis treatments, can make Apraize-20 Tablet less effective, which is why sharing your full medication list with your pharmacist is crucial. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, talk to your doctor to weigh the benefits and risks of this treatment.

Uses of Apraize-20 Tablet

Apraize-20 Tablet is used to treat certain long-term inflammatory conditions by reducing excessive immune activity, including:

  • Plaque Psoriasis: Apraize-20 Tablet helps reduce the overproduction of skin cells, leading to a visible reduction in red, scaly patches and plaques.
  • Psoriatic Arthritis: It targets joint inflammation, which helps decrease pain, swelling, and stiffness in the joints.
  • Behçet's Disease: It aids in healing and preventing painful mouth ulcers associated with this chronic inflammatory condition.

Key Benefits

Apraize-20 Tablet offers several important benefits that help control inflammation, relieve symptoms, and improve quality of life, including:

  • Convenient Oral Relief: Unlike many other advanced treatments for psoriasis or psoriatic arthritis that require injections or infusions, Apraize-20 Tablet offers the convenience of a simple oral tablet.
  • Improved Joint Mobility: By calming chronic inflammation, this medication helps you move more freely and comfortably, making daily physical tasks easier to manage.
  • Clearer Skin: Many patients experience a significant clearing of skin plaques, leading to reduced itching, scaling, and physical discomfort.
  • Targeted Inflammation Control: It works specifically on the inflammatory pathways inside your cells, helping to prevent flare-ups before they start.
Side effects of Apraize-20 Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • You can take your medicine with meals to lower the chances of getting stomach pain.
  • Avoid foods that are acidic, spicy, sugary, or greasy.
  • Eat foods that are easily digestible such as rice, toast, and bananas.
  • Eat your meals in smaller amounts throughout the day to prevent strain on your stomach and digestion.
  • Drink water or fluids to stay hydrated and prevent stomach upset.
  • Use a heating pad or massage your stomach area.
  • Engage in mild physical activities such as yoga and walking.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.

Directions for Use

  • Take Apraize-20 Tablet with or without food as advised by your doctor.
  • Follow your doctor’s recommendations on the dosage and timing of this medication to achieve optimal results.
  • Swallow Apraize-20 Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Apraize-20 Tablet Works

Apraize-20 Tablet contains apremilast, a phosphodiesterase 4 (PDE4) inhibitor that helps reduce inflammation associated with conditions such as psoriasis and psoriatic arthritis. Apraize-20 Tablet works by blocking the activity of the PDE4 enzyme inside immune cells. This helps restore the balance between inflammatory and anti-inflammatory signals in the body, reducing the production of substances that cause inflammation. As a result, it slows the rapid growth of skin cells and helps calm the overactive immune response that contributes to joint inflammation. Together, these actions help reduce redness, scaling, itching, joint pain, swelling, and stiffness, while improving symptoms of psoriasis and psoriatic arthritis.
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Alcohol

Unsafe

Limit intake of alcohol, as this may increase the risk of serious side effects.

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Pregnancy

Caution

If you are pregnant, inform your doctor before taking Apraize-20 Tablet. Consult your doctor if you become pregnant while taking Apraize-20 Tablet.

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Breast Feeding

Caution

It is not known whether Apraize-20 Tablet may pass into breast milk or not. If you are breastfeeding, inform your doctor before taking Apraize-20 Tablet.

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Driving

Safe if prescribed

Apraize-20 Tablet has no or negligible influence on the ability to drive and use machines.

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Liver

Caution

Apraize-20 Tablet to be taken with caution, especially if you have a history of liver problems. Your doctor may adjust the dose of this medicine based on your condition.

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Kidney

Caution

Apraize-20 Tablet to be taken with caution, especially if you have a history of kidney diseases. Your doctor may adjust the dose of this medicine based on your condition.

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Children

Unsafe

Apraize-20 Tablet is not recommended for use in children and adolescents below 17 years.

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Heart

Consult your doctor

Apraize-20 Tablet can be used in heart patients if prescribed by the physician. Please consult your physician if you have any concerns.

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Geriatrics

Safe if prescribed

Apraize-20 Tablet is safe for use in elderly patients if prescribed by the physician.

What if I have taken an overdose of Apraize-20 Tablet

If you take too much of this medication, seek immediate medical attention or call your local poison control centre. Bring the medication packaging with you to show the emergency medical team.

Diet & Lifestyle Advise

  • Stay Well Hydrated: Because mild diarrhoea or nausea can occur when you start Apraize-20 Tablet, drink plenty of water and electrolyte-rich fluids throughout the day to prevent dehydration.
  • Protect and Moisturise Your Skin: Apply a thick, fragrance-free emollient to your skin within three minutes of bathing to lock in moisture and support the skin barrier.
  • Engage in Low-Impact Exercise: If you have joint pain, engage in gentle activities like swimming, cycling, or yoga to keep your joints flexible without putting excessive stress on them.
  • Eat an Anti-Inflammatory Diet: Focus on foods rich in omega-3 fatty acids (like salmon and flaxseeds) and colorful vegetables, which can help support your body's natural anti-inflammatory processes.
  • Track Your Mood: Keep a daily journal of your mood and emotional well-being to easily notice any changes, and share these observations with your doctor.
health query

Have a query?

How Soon It Starts Working

  • The time required for Apraize-20 Tablet to start to work: The time required for Apraize-20 Tablet to show its action is unknown.
  • The time for which the effects of Apraize-20 Tablet last: The duration of action for Apraize-20 Tablet is unknown.

What if you forget to take Apraize-20 Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular routine. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Apraize-20 Tablet tablets at a controlled room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Monitor Your Weight Regularly: Weigh yourself weekly when starting this treatment and inform your doctor if you experience significant, unexplained weight loss.
  • Prepare for the Starting Phase: Be aware that your doctor will use a starter pack to gradually increase your dose; do not skip this step as it helps prevent severe stomach upset.
  • Report Mood Changes Immediately: Alert a family member or close friend that you are taking this medication so they can help monitor you for signs of depression or mood shifts.
  • Check Your Kidney Health: Ensure your doctor checks your kidney function before starting, as a lower dose may be required if your kidneys do not filter waste efficiently.
  • Review Your Complete Drug List: Tell your doctor about all other medicines you take, as certain liver enzyme-inducing drugs can significantly lower the levels of Apraize-20 Tablet in your blood, making it less effective.

Drug-Drug Interactions

verifiedApollotooltip

Apraize-20 Tablet may interact with certain medicines, which can reduce its effectiveness or require dose adjustments. Inform your doctor about all prescription medicines, over-the-counter products, vitamins, and herbal supplements you are taking, including:

  • Strong CYP3A4 Inducers (such as rifampin, phenytoin, phenobarbital, carbamazepine, or St. John’s wort): These medicines can significantly lower Apraize-20 Tablet levels in the body, reducing its effectiveness.
ApremilastCarbamazepine
Severe
ApremilastRifabutin
Severe

Drug-Drug Interactions

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ApremilastCarbamazepine
Severe
How does the drug interact with Apraize-20 Tablet:
Taking Apraize-20 Tablet with carbamazepine can significantly reduce the blood levels of Apraize-20 Tablet, which may make the medication less effective.

How to manage the interaction:
Taking Apraize-20 Tablet with Carbamazepine together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
ApremilastRifabutin
Severe
How does the drug interact with Apraize-20 Tablet:
Coadministration of Apraize-20 Tablet and Rifabutin may reduce the blood levels of Apraize-20 Tablet.

How to manage the interaction:
Although there is a possible interaction between Apraize-20 Tablet and Rifabutin, you can take these medicines together if prescribed by a doctor. In case you experience any symptoms, consult a doctor. Do not discontinue any medications without consulting a doctor.
ApremilastPhenytoin
Severe
How does the drug interact with Apraize-20 Tablet:
Coadministration of Phenytoin with Apraize-20 Tablet may reduce the blood levels of Apraize-20 Tablet, which may reduce effectiveness in treatment.

How to manage the interaction:
Although taking Phenytoin and Apraize-20 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. Without consulting a doctor, never stop taking any drugs.
ApremilastEnzalutamide
Severe
How does the drug interact with Apraize-20 Tablet:
Coadministration of Enzalutamide with Apraize-20 Tablet may reduce the efficacy of treatment.

How to manage the interaction:
Although taking Apraize-20 Tablet and Enzalutamide together can cause an interaction, it can be taken if a doctor has suggested it. Do not discontinue any medications without consulting a doctor.
ApremilastPrimidone
Severe
How does the drug interact with Apraize-20 Tablet:
Coadministration of Apraize-20 Tablet with primidone may decrease the blood levels of Apraize-20 Tablet, which may make Apraize-20 Tablet less effective in treating.

How to manage the interaction:
Although there is an interaction between Primidone and Apraize-20 Tablet, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ApremilastRifampicin
Severe
How does the drug interact with Apraize-20 Tablet:
Taking Apraize-20 Tablet with rifampicin can decrease the blood levels of Apraize-20 Tablet, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Apraize-20 Tablet and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
ApremilastFosphenytoin
Severe
How does the drug interact with Apraize-20 Tablet:
Coadministration of Fosphenytoin with Apraize-20 Tablet may reduce the effectiveness of treatment.

How to manage the interaction:
Although taking Fosphenytoin and Apraize-20 Tablet together can cause an interaction, it can be taken if a doctor has suggested it. Do not stop using any medications without talking to a doctor.
ApremilastMitotane
Severe
How does the drug interact with Apraize-20 Tablet:
Coadministration of Mitotane with Apraize-20 Tablet may reduce the effectiveness of treatment.

How to manage the interaction:
Although taking Apraize-20 Tablet and Mitotane together can cause an interaction, it can be taken if a doctor has suggested it. Do not discontinue any medications without consulting a doctor.
ApremilastNevirapine
Severe
How does the drug interact with Apraize-20 Tablet:
Coadministration of Nevirapine with Apraize-20 Tablet may decrease the blood levels of Apraize-20 Tablet, which may make the medication less effective.

How to manage the interaction:
Although there is a possible interaction between Apraize-20 Tablet and Nevirapine, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
ApremilastRifapentine
Severe
How does the drug interact with Apraize-20 Tablet:
Rifapentine may decrease the blood levels of Apraize-20 Tablet, which may make Apraize-20 Tablet less effective in treating the condition.

How to manage the interaction:
Although taking Apraize-20 Tablet and Rifapentine together can cause an interaction, it can be taken if a doctor has suggested it. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip

Apraize-20 Tablet does not have any known significant interactions with food.

  • You can take Apraize-20 Tablet with or without meals.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIPSORIATICS]

FAQs

Apraize-20 Tablet is used to treat plaque psoriasis (scaly, itchy, and red patches on the skin), psoriatic arthritis (inflammation in the joints in people with psoriasis), and oral ulcers caused by Behcet's disease.
Apraize-20 Tablet works by blocking the action of some chemical messengers that are responsible for inflammation.
Yes, Apraize-20 Tablet may cause depression as a side effect. The patient may also have suicidal thoughts. Apraize-20 Tablet should be avoided in people with a history of depression. In case you develop any of these symptoms, Inform your doctor immediately.
Yes, Apraize-20 Tablet may cause a reduction in appetite, which may further lead to weight loss. You should monitor your weight frequently while on treatment with Apraize-20 Tablet. In case of big weight loss, inform your doctor. Your doctor may consider stopping Apraize-20 Tablet.
Rifampicin is an antibiotic. You should not take rifampicin if you are taking Apraize-20 Tablet. Rifampicin interferes with the working of Apraize-20 Tablet by reducing its levels, making it less effective. As a result, you may not see any recovery after taking Apraize-20 Tablet.
As soon as you recall, take the missed dose. If the next dose is approaching, skip the missing dose and resume your regular dosing regimen. Do not duplicate the dose to make up for a missing one.
No, Apraize-20 Tablet is not an immunosuppressant. It belongs to a class of drugs called phosphodiesterase 4 (PDE4) inhibitors which work by blocking the action of PDE4 that is found in inflammatory cells.
Take Apraize-20 Tablet as advised by the doctor. Swallow it as whole with a glass of water. Do not break, crush or chew it.
If you get pregnant during treatment with Apraize-20 Tablet, inform your doctor immediately. You are recommended to avoid pregnancy during treatment with Apraize-20 Tablet as it may harm unborn baby.
Apraize-20 Tablet may cause side effects such as nausea, vomiting, diarrhoea, back pain or weight loss. If these side effects persist or worsen, please consult your doctor.
While there is no direct chemical interaction between alcohol and Apraize-20 Tablet, alcohol can dehydrate you and exacerbate skin inflammation or stomach upset. It is best to limit alcohol intake. Talk to your doctor about what is safe for you.
Hair loss is not a medically recognised or common side effect of Apraize-20 Tablet. If you experience unusual hair thinning or shedding, it may be due to other underlying health factors. Talk to your doctor to determine the cause.
Unlike many biological therapies, Apraize-20 Tablet is a selective oral treatment that targets specific inflammatory pathways rather than suppressing the entire immune system. This means it generally does not carry the same high risk of serious infections. Talk to your doctor for more details.
Unlike some other systemic treatments for psoriasis or arthritis, Apraize-20 Tablet does not typically require routine laboratory monitoring or frequent blood tests. However, your doctor may check your kidney function before starting. Talk to your doctor to plan your monitoring schedule.
There is limited data on the safety of Apraize-20 Tablet during pregnancy. It is generally recommended to discuss family planning with your healthcare provider before starting or while taking this medication. Talk to your doctor about alternative options if you are planning a pregnancy.
Mild nausea and diarrhoea are common when first starting Apraize-20 Tablet but usually improve within a few weeks. If your stomach issues are severe, cause dehydration, or persist beyond the first month, do not stop the medication abruptly. Talk to your doctor for advice on managing these symptoms.
No, you should not crush, chew, or break the Apraize-20 Tablet tablet. The tablets are formulated to release the active medicine safely in your digestive system, and breaking them can interfere with this process. Talk to your doctor or pharmacist if you have difficulty swallowing pills.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

142 Ab, Kandivli Industrial Estate, Kandivli (West), Mumbai - 400 067, Maharashtra
Other Info - APR0144

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