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  3. Tofakin ER 11 mg Tablet 10's

Tofakin ER 11 mg Tablet 10's, Pack of 10 TABLETS
Tofakin ER 11 mg Tablet 10's, Pack of 10 TABLETS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Tofakin ER 11 mg Tablet is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. It contains Tofacitinib which works by lowering inflammation and symptoms associated with arthritis. In some cases, this medicine may cause side effects such as diarrhoea, headache, upper respiratory tract infection, nausea, and vomiting. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition :

TOFACITINIB-11MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Tofakin ER 11 mg Tablet

Tofakin ER 11 mg Tablet belongs to a group of medicines called Janus kinase inhibitors used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is an inflammatory condition of the joints, often associated with psoriasis. Ulcerative colitis is an inflammatory disease of the large intestine.
 
Tofakin ER 11 mg Tablet contains 'Tofacitinib' which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis. 
 
In some cases, you may experience common side-effects such as diarrhoea, headache, upper respiratory tract infection, cold, nausea, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Inform your doctor if you have an active infection, if you have a condition that increases the chance of having infections, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids. Avoid taking Tofakin ER 11 mg Tablet if you are pregnant or breastfeeding. Tofakin ER 11 mg Tablet is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Tofakin ER 11 mg Tablet

Treatment of Rheumatoid arthritis, Psoriatic arthritis, Ulcerative colitis.

Directions for Use

Swallow Tofakin ER 11 mg Tablet as a whole with a glass of water; do not chew or break it.

Medicinal Benefits

Tofakin ER 11 mg Tablet belongs to a group of medicines called Janus kinase inhibitors used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. Tofakin ER 11 mg Tablet works by blocking Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis. Tofakin ER 11 mg Tablet is indicated for patients with moderate to severe rheumatic arthritis, and psoriatic arthritis who have had intolerance or inadequate response to methotrexate or DMARDs (Disease-Modifying Anti-Rheumatic Drugs).

How Tofakin ER 11 mg Tablet Works

Tofakin ER 11 mg Tablet contains 'Tofacitinib' which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis.

Storage

Store in a cool and dry place away from sunlight
Side effects of Tofakin ER 11 mg Tablet
  • Practice good hygiene by washing hands frequently when touching any wounds.
  • Apply creams or lotions to the dry skin and moisturize it.
  • Wear the proper clothing and footwear when working outside.
  • Cover the wounds with bandage and change it daily.
  • Avoid baths at swimming pools, lakes and rivers.
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.
  • Drink a lot of water to control diarrhoea and prevent dehydration.
  • Avoid spicy, fatty, or high-fiber foods that may irritate the colon.
  • Reduce stress through methods such as deep breathing or meditation.
  • Include probiotics or supplements containing live bacteria to maintain the health of the gut.
  • Quit smoking since smoking makes colitis symptoms worse.
  • See your doctor right away if you experience extreme inflammation, bleeding stools, or abdominal pain.
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • To promote overall health, drink plenty of water and consume hydrating foods like watermelon and leafy greens.
  • Support gut health with probiotic-rich foods such as yoghurt and sauerkraut.
  • Eat antioxidant-rich foods like berries and green tea, while limiting sugary drinks, alcohol, and processed foods.
  • Additionally, reduce stress through relaxation techniques like deep breathing and meditation.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.

What if I have taken an overdose of Tofakin ER 11 mg Tablet

Take Tofakin ER 11 mg Tablet only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Tofakin ER 11 mg Tablet if you are allergic to any of its components; if you have a severe infection, bloodstream infection, active tuberculosis, or if you have severe liver problems such as cirrhosis. Avoid taking Tofakin ER 11 mg Tablet if you are pregnant or breastfeeding. Inform your doctor if you have an infection, symptoms of infection, a condition that increases chances of infection, are taking any medicines that affect the immune system; have or had a history of tuberculosis, or were in close contact with someone who has/had tuberculosis; chronic lung disease, liver problems, hepatitis B/C, cancer, are at a high risk of developing skin cancer, inflammation/ulcers of the large intestine, kidney problems, planning to get vaccinated, heart problems, high cholesterol, high blood pressure, heart attack, diabetes, or blood clotting problems. If your white blood cell count or red blood cell count is low, avoid taking Tofakin ER 11 mg Tablet . Tofakin ER 11 mg Tablet is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Drug-Drug Interactions

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TofacitinibIrinotecan
Severe
TofacitinibCarbamazepine
Severe

Drug-Drug Interactions

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TofacitinibIrinotecan
Severe
How does the drug interact with Tofakin ER 11 mg Tablet:
Taking Tofakin ER 11 mg Tablet with Irinotecan may increase the risk of serious infection.

How to manage the interaction:
Co-administration of Tofakin ER 11 mg Tablet with Irinotecan can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
TofacitinibCarbamazepine
Severe
How does the drug interact with Tofakin ER 11 mg Tablet:
Taking carbamazepine and Tofakin ER 11 mg Tablet together may possibly reduce the blood levels of Tofakin ER 11 mg Tablet.

How to manage the interaction:
Although taking carbamazepine and Tofakin ER 11 mg Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. If your symptoms worsen or your condition changes while taking these medications, consult your doctor without delay.
TofacitinibHydroxycarbamide
Severe
How does the drug interact with Tofakin ER 11 mg Tablet:
Hydroxycarbamide when used with Tofakin ER 11 mg Tablet may raise the risk of severe infections, cancers.

How to manage the interaction:
There may be a possibility of interaction between hydroxycarbamide with Tofakin ER 11 mg Tablet, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
TofacitinibNilotinib
Severe
How does the drug interact with Tofakin ER 11 mg Tablet:
Taking Tofakin ER 11 mg Tablet with Nilotinib may increase the risk of infections.

How to manage the interaction:
Although there is a possible interaction between Tofakin ER 11 mg Tablet and Nilotinib, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
TofacitinibLevamisole
Severe
How does the drug interact with Tofakin ER 11 mg Tablet:
When Tofakin ER 11 mg Tablet and levamisole are used together, there is a higher chance of getting serious infections.

How to manage the interaction:
Although taking Levamisole and Tofakin ER 11 mg Tablet together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you notice any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - contact your doctor right away. Do not stop using any medications without first talking to your doctor.
TofacitinibAtazanavir
Severe
How does the drug interact with Tofakin ER 11 mg Tablet:
Taking Tofakin ER 11 mg Tablet with atazanavir may increase the blood levels of Tofakin ER 11 mg Tablet. This may lead to cause severe infections.

How to manage the interaction:
Co-administration of Tofakin ER 11 mg Tablet with Atazanavir can possibly result in an interaction, but it can be taken if your doctor has advised it. However consult your doctor if you experience fatigue, dizziness, fainting, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without talking to your doctor.
TofacitinibIdarubicin
Severe
How does the drug interact with Tofakin ER 11 mg Tablet:
Taking Idarubicin and Tofakin ER 11 mg Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Idarubicin can be taken with Tofakin ER 11 mg Tablet, if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.
TofacitinibCytarabine
Severe
How does the drug interact with Tofakin ER 11 mg Tablet:
Taking Tofakin ER 11 mg Tablet with Cytarabine may increase the risk of serious infection.

How to manage the interaction:
Taking Tofakin ER 11 mg Tablet with Cytarabine together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
TofacitinibAbemaciclib
Severe
How does the drug interact with Tofakin ER 11 mg Tablet:
Taking Abemaciclib with Tofakin ER 11 mg Tablet can lead to or increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Abemaciclib with Tofakin ER 11 mg Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TofacitinibTelaprevir
Severe
How does the drug interact with Tofakin ER 11 mg Tablet:
Using Tofakin ER 11 mg Tablet together with telaprevir can increase the risk of side effects.

How to manage the interaction:
Although taking Tofakin ER 11 mg Tablet and Telaprevir together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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TOFACITINIB-11MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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TOFACITINIB-11MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit, Grapefruit Juice

How to manage the interaction:
Consuming grapefruit products while taking Tofakin ER 11 mg Tablet can increase the risk of side effects. Avoid consuming grapefruit products while being treated with Tofakin ER 11 mg Tablet, as it can lead to an interaction.

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.

  • Performing yoga may also help in improving joint flexibility and pain management.

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.

  • Acupuncture, massage and physical therapy may also be helpful.

  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.

  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS, DISEASE MODIFYING ANTIRHEUMATIC DRUGS (DMARDs)

Product Substitutes

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Alcohol

Caution

It is not known if alcohol interacts with Tofakin ER 11 mg Tablet , so please consult a doctor.

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Pregnancy

Unsafe

Tofakin ER 11 mg Tablet must not be taken during pregnancy. If you are a woman of child-bearing potential, use effective contraception during the treatment with Tofakin ER 11 mg Tablet and for 4 weeks after discontinuation.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Tofakin ER 11 mg Tablet . Please consult a doctor if you have any concerns.

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Driving

Safe

Tofakin ER 11 mg Tablet generally does not affect your ability to drive. However, drive or operate machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this. Tofakin ER 11 mg Tablet is not recommended for patients with severe liver problems.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Tofakin ER 11 mg Tablet is not recommended for children below 18 years as safety and effectiveness were not established.

Have a query?

FAQs

Tofakin ER 11 mg Tablet is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.

Tofakin ER 11 mg Tablet works by blocking Janus kinase enzyme, thereby lowers inflammation and symptoms associated with rheumatoid and psoriatic arthritis.

Hypertension/high blood pressure could be a side-effect of Tofakin ER 11 mg Tablet . Consult your doctor before taking Tofakin ER 11 mg Tablet if you have high blood pressure or if you are taking anti-hypertensive medicines.

Diarrhoea might be a side-effect of Tofakin ER 11 mg Tablet . Eat non-spicy meals and drink plenty of fluids to prevent dehydration if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

Tofakin ER 11 mg Tablet might impair fertility in females of reproductive potential. It is not known if the effect is reversible. Therefore, talk to a doctor before starting Tofakin ER 11 mg Tablet if you are trying to become pregnant or if you have any concerns regarding this.

Tofakin ER 11 mg Tablet affects the immune system and might lower the ability of the immune system to fight infections. Inform your doctor if you have an active infection, if you have a condition that increases the chance of having infections, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids.

Tofakin ER 11 mg Tablet is not recommended for patients with severe liver impairment. Dose adjustment may be needed in patients with mild to moderate liver impairment. Please consult the doctor if you have liver problems.

Tofakin ER 11 mg Tablet may increase the risk of cancer by changing the way the immune system works. Inform the doctor if you ever had any type of cancer.

Tofakin ER 11 mg Tablet may begin working within 2-8 weeks after starting the treatment.

Tofakin ER 11 mg Tablet should not be taken along with tocilizumab as it might increase the risk of infections. Before starting Tofakin ER 11 mg Tablet , inform the doctor if you are taking tocilizumab.

Prior to starting Tofakin ER 11 mg Tablet , active or latent tuberculosis test, CBC (complete blood count), LFT (liver function test), and lipid profile tests should be done.

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3Rd Floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India Country Of Origin: India
Other Info - TOF0068

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:47 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.2500.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/203214s018lbl.pdf
  3. https://www.drugs.com/mtm/tofacitinib.html
  4. https://www.ema.europa.eu/en/documents/product-information/xeljanz-epar-product-information_en.pdf
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