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  3. Tofza XR 11 mg Tablet 10's

Tofza XR 11 mg Tablet 10's, Pack of 10 TabletS
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Composition :

TOFACITINIB-11MG

Manufacturer/Marketer :

Wallace Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Tofza XR 11 mg Tablet

Tofza XR 11 mg Tablet is used to treat rheumatoid arthritis (an autoimmune disease which leads to joint pain and damage), psoriatic arthritis (an inflammatory condition of the joints), and ulcerative colitis (an inflammatory disease of the large intestine).

Tofza XR 11 mg Tablet contains 'Tofacitinib' which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis. 

Not everyone who is taking Tofza XR 11 mg Tablet will get these side effects. In some cases, you may experience common side effects such as diarrhoea, headache, upper respiratory tract infection, cold, nausea, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

You can take Tofza XR 11 mg Tablet with or without food. It should be swallowed as a whole with a glass of water. Do not chew, bite, crush, or break it. Your doctor will advise you on how often you should take your tablets based on your medical condition. It is always important to complete your treatment course for better results.

Avoid taking Tofza XR 11 mg Tablet if you are allergic to it. Inform your doctor if you have an active infection, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids. Avoid taking Tofza XR 11 mg Tablet if you are pregnant or breastfeeding. Tofza XR 11 mg Tablet is not recommended for use in children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Tofza XR 11 mg Tablet

'Tofza XR 11 mg Tablet is used in the treatment of Rheumatoid arthritis, Psoriatic arthritis, and Ulcerative colitis. The detailed uses of Tofza XR 11 mg Tablet are as follows:
• Treatment of Rheumatoid Arthritis: Tofza XR 11 mg Tablet helps to manage moderate to severe rheumatoid arthritis by reducing joint pain, inflammation, and slowing disease progression.
• Management of Psoriatic Arthritis: Tofza XR 11 mg Tablet treats active psoriatic arthritis by reducing joint pain, swelling, stiffness, and improving overall joint function.
• Treatment of Ulcerative Colitis: Tofza XR 11 mg Tablet helps to induce and maintain remission in moderate to severe ulcerative colitis.
'

Directions for Use

• Tofza XR 11 mg Tablet can be taken with or without food. • It is recommended to take Tofza XR 11 mg Tablet 1-2 times a day, depending on your medical condition, or as prescribed by your doctor. • Swallow Tofza XR 11 mg Tablet as a whole with a glass of water. • Do not crush, chew, or break it.

Medicinal Benefits

Tofza XR 11 mg Tablet belongs to a group of medicines called Janus kinase inhibitors used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. 

Tofza XR 11 mg Tablet is indicated for patients with moderate to severe rheumatic arthritis, and psoriatic arthritis who have had intolerance or inadequate response to methotrexate or DMARDs (Disease-Modifying Anti-Rheumatic Drugs).

How Tofza XR 11 mg Tablet Works

Tofza XR 11 mg Tablet contains 'Tofacitinib' which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis.

Storage

Store in a cool and dry place away from sunlight
Side effects of Tofza XR 11 mg Tablet
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Keep your skin clean by gently washing your face two times daily and after sweating. Choose a mild and non-abrasive cleanser.
  • Use gentle alcohol-free skin care products. Avoid products that might irritate your skin such as exfoliants, astringents and toners.
  • Acne may also occur due to oil in the hair. Thus, if you have oily hair, shampoo more frequently than you do now and keep your hair away from face.
  • Keep your hands off your face as touching face throughout the day might worsen acne. Also, do not pick, squeeze or pop acne as it will prolong the healing process and increase the risk of dark spots and scarring.
  • Avoid tanning by applying a broad spectrum sunscreen and wearing sun-protective clothing when outdoors.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

What if I have taken an overdose of Tofza XR 11 mg Tablet

Take Tofza XR 11 mg Tablet only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Tofza XR 11 mg Tablet if you are allergic to any of its components; if you have a severe infection, bloodstream infection, or if you have severe liver problems such as cirrhosis. Inform your doctor if you have an infection, symptoms of infection, a condition that increases chances of infection, are taking any medicines that affect the immune system; have or had a history of tuberculosis, chronic lung disease, liver problems, hepatitis B/C, cancer, inflammation/ulcers of the large intestine, or kidney problems; are planning to get vaccinated; or have heart problems, high cholesterol, high blood pressure, heart attack, diabetes, or blood clotting problems. If your white blood cell count or red blood cell count is low, avoid taking Tofza XR 11 mg Tablet .

Avoid taking Tofza XR 11 mg Tablet if you are pregnant or breastfeeding. Tofza XR 11 mg Tablet is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects. Inform your doctor if you notice painful blisters on the skin or if you experience breathing difficulties. Inform your doctor about your complete medical and medication history before starting treatment with Tofza XR 11 mg Tablet , which helps the physician decide the best treatment plan.

Store Tofza XR 11 mg Tablet at room temperature. You are advised not to chew, crush or break the medicine. Keep the medicine out of reach of children. Please do not take more than the recommended dose of medicine, as it can cause undesirable effects. It is always important to check for the expiry of the medicine. Discard the medicine if it reaches the expiry date.

Drug-Drug Interactions

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TofacitinibIfosfamide
Severe
TofacitinibLinezolid
Severe

Drug-Drug Interactions

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TofacitinibIfosfamide
Severe
How does the drug interact with Tofza XR 11 mg Tablet:
Taking Ifosfamide with Tofza XR 11 mg Tablet may increase the risk of serious infection.

How to manage the interaction:
Taking Tofza XR 11 mg Tablet with Ifosfamide together can possibly result in an interaction, but it can be taken if your doctor has advised it. It is important to keep a close eye on your condition. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
TofacitinibLinezolid
Severe
How does the drug interact with Tofza XR 11 mg Tablet:
When used with linezolid, Tofza XR 11 mg Tablet may raise the risk of serious infections.

How to manage the interaction:
Although taking linezolid and Tofza XR 11 mg Tablet together can result in an interaction, they can be taken if a doctor has prescribed it. However, if you develop a fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in sputum, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, contact a doctor immediately. Do not discontinue any medication without consulting a doctor.
TofacitinibRifampicin
Severe
How does the drug interact with Tofza XR 11 mg Tablet:
Coadministration of rifampicin and Tofza XR 11 mg Tablet reduces the blood levels of Tofza XR 11 mg Tablet.

How to manage the interaction:
Although taking Rifampicin together with Tofza XR 11 mg Tablet can result in an interaction, they can be taken together if prescribed by your doctor. Do not discontinue any medications without consulting a doctor.
TofacitinibAmprenavir
Severe
How does the drug interact with Tofza XR 11 mg Tablet:
Taking Tofza XR 11 mg Tablet with amprenavir may increase the blood levels of Tofza XR 11 mg Tablet and may increase the risk of infections

How to manage the interaction:
There may be a possibility of interaction between Tofza XR 11 mg Tablet and Amprenavir, but it can be taken if prescribed by a doctor. However consult your doctor if you experience fatigue, dizziness, fainting, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
TofacitinibBoceprevir
Severe
How does the drug interact with Tofza XR 11 mg Tablet:
Taking Tofza XR 11 mg Tablet with Boceprevir may increases the blood levels of Tofza XR 11 mg Tablet which increases risk of side effects.

How to manage the interaction:
There may be a possibility of interaction between Tofza XR 11 mg Tablet and Boceprevir, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, fainting, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting your doctor.
TofacitinibEnzalutamide
Severe
How does the drug interact with Tofza XR 11 mg Tablet:
Co-administration of Enzalutamide and Tofza XR 11 mg Tablet may decrease the blood levels of Tofza XR 11 mg Tablet, which may make Tofza XR 11 mg Tablet less effective.

How to manage the interaction:
Although taking Enzalutamide and Tofza XR 11 mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. Do not stop using any medications without consulting a doctor.
TofacitinibMethylprednisolone
Severe
How does the drug interact with Tofza XR 11 mg Tablet:
Using Tofza XR 11 mg Tablet together with methylprednisolone may increase the risk of serious infections.

How to manage the interaction:
Although taking Methylprednisolone and Tofza XR 11 mg Tablet together can cause an interaction, it can be taken if a doctor has suggested it. However, if you have symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, or bleeding, consult the doctor. Do not stop using any medications without a doctor's advice.
TofacitinibCapecitabine
Severe
How does the drug interact with Tofza XR 11 mg Tablet:
Co-administration of Tofza XR 11 mg Tablet with Capecitabine may increase the risk of serious and potential infections.

How to manage the interaction:
Although there is an interaction, Capecitabine can be taken with Tofza XR 11 mg Tablet if prescribed by the doctor. Consult the prescriber if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning sensation during urination. Do not discontinue the medication without consulting a doctor.
TofacitinibPrednisolone
Severe
How does the drug interact with Tofza XR 11 mg Tablet:
Co-administration of Tofza XR 11 mg Tablet and Prednisolone can increase the risk of serious infections, diverticular disease (development of small bulges in the lining of the intestine), or gastrointestinal bleeding or perforation.

How to manage the interaction:
Although taking Tofza XR 11 mg Tablet and Prednisolone together can result in an interaction, it can be taken if a doctor has prescribed it. If you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in the coughing fluid, weight loss, red or inflamed skin, body sores, pain or burning when urinating, severe abdominal pain, fever, nausea, or vomiting, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
TofacitinibMycophenolic acid
Severe
How does the drug interact with Tofza XR 11 mg Tablet:
Coadministration of Mycophenolic acid and Tofza XR 11 mg Tablet can increase the risk or severity of developing serious infections

How to manage the interaction:
Taking Mycophenolic acid and Tofza XR 11 mg Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhoea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination consult a doctor. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS, DISEASE MODIFYING ANTIRHEUMATIC DRUGS (DMARDs)

Tofza XR 11 mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

It is not known if alcohol interacts with Tofza XR 11 mg Tablet , so please consult a doctor.

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Pregnancy

Unsafe

Tofza XR 11 mg Tablet must not be taken during pregnancy. If you are a woman of child-bearing potential, use effective contraception during the treatment with Tofza XR 11 mg Tablet and for 4 weeks after discontinuation.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Tofza XR 11 mg Tablet . Please consult a doctor if you have any concerns.

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Driving

Safe

Tofza XR 11 mg Tablet generally does not affect your ability to drive. However, drive or operate machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this. Tofza XR 11 mg Tablet is not recommended for patients with severe liver problems.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Tofza XR 11 mg Tablet is not recommended for children below 18 years as safety and effectiveness were not established.

Have a query?

FAQs

Tofza XR 11 mg Tablet is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.

Tofza XR 11 mg Tablet works by blocking Janus kinase enzyme, thereby lowers inflammation and symptoms associated with rheumatoid and psoriatic arthritis.

Hypertension/high blood pressure could be a side-effect of Tofza XR 11 mg Tablet . Consult your doctor before taking Tofza XR 11 mg Tablet if you have high blood pressure or if you are taking anti-hypertensive medicines.

Diarrhoea might be a side-effect of Tofza XR 11 mg Tablet . Eat non-spicy meals and drink plenty of fluids to prevent dehydration if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

Tofza XR 11 mg Tablet might impair fertility in females of reproductive potential. It is not known if the effect is reversible. Therefore, talk to a doctor before starting Tofza XR 11 mg Tablet if you are trying to become pregnant or if you have any concerns regarding this.

Tofza XR 11 mg Tablet affects the immune system and might lower the ability of the immune system to fight infections. Inform your doctor if you have an active infection, if you have a condition that increases the chance of having infections, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids.

Tofza XR 11 mg Tablet is not recommended for patients with severe liver impairment. Dose adjustment may be needed in patients with mild to moderate liver impairment. Please consult the doctor if you have liver problems.

Tofza XR 11 mg Tablet may increase the risk of cancer by changing the way the immune system works. Inform the doctor if you ever had any type of cancer.

Tofza XR 11 mg Tablet may begin working within 2-8 weeks after starting the treatment.

Tofza XR 11 mg Tablet should not be taken along with tocilizumab as it might increase the risk of infections. Before starting Tofza XR 11 mg Tablet , inform the doctor if you are taking tocilizumab.

Prior to starting Tofza XR 11 mg Tablet , active or latent tuberculosis test, CBC (complete blood count), LFT (liver function test), and lipid profile tests should be done.

Country of origin

India

Manufacturer/Marketer address

Wallace Pharmaceuticals Pvt. Ltd., 3Rd Floor, Dempo Trade Centre Bldg., Patto Plaza, Edc Complex, Panaji 403001, Goa, India.
Other Info - TOF0078

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 14, 2025 | 12:59 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.2500.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/203214s018lbl.pdf
  3. https://www.drugs.com/mtm/tofacitinib.html
  4. https://www.ema.europa.eu/en/documents/product-information/xeljanz-epar-product-information_en.pdf

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