ISONIAZID+RIFAMPICIN belongs to the group of medicines called anti-tuberculosis drugs primarily used to treat and prevent tuberculosis. Tuberculosis is an infectious disease that mainly affects the lungs, but it can also spread to other body parts such as the kidneys, brain, spine, and bone marrow.
ISONIAZID+RIFAMPICIN is a combination of two anti-tuberculosis drugs, namely: Rifampicin, and Isoniazid. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Together, ISONIAZID+RIFAMPICIN kills Mycobacterium tuberculosis which causes TB (tuberculosis).
In some cases, you may experience certain common side-effects such as drowsiness, dizziness, headache, weakness, muscle pain, heartburn, diarrhoea, gas, and numbness or tingling sensation. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
Consult your doctor before taking ISONIAZID+RIFAMPICIN if you are pregnant or planning for pregnancy. Avoid breastfeeding while taking ISONIAZID+RIFAMPICIN as it passes into breast milk. ISONIAZID+RIFAMPICIN may cause dizziness, and vision problems, so drive only if you are alert. Avoid alcohol consumption while taking ISONIAZID+RIFAMPICIN as it could lead to increased drowsiness, dizziness and liver damage.
Tuberculosis.
ISONIAZID+RIFAMPICIN is a combination of two anti-tuberculosis drugs, namely: Rifampicin, and Isoniazid. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Together, ISONIAZID+RIFAMPICIN kills Mycobacterium tuberculosis which causes TB (tuberculosis).
Do not take ISONIAZID+RIFAMPICIN if you are allergic to any of its contents; if you have jaundice, or if you are taking HIV medicines (saquinavir or ritonavir). Before starting ISONIAZID+RIFAMPICIN, please inform your doctor if you have diabetes, epilepsy, gout, mental health problems, HIV infection, malnutrition, peripheral neuropathy, porphyria, bleeding problems, kidney or liver problems. Consult your doctor before taking ISONIAZID+RIFAMPICIN if you are pregnant or planning for pregnancy. Avoid breastfeeding while taking ISONIAZID+RIFAMPICIN as it passes into breast milk. ISONIAZID+RIFAMPICIN may cause dizziness, and drowsiness, so drive only if you are alert. Avoid alcohol consumption while taking ISONIAZID+RIFAMPICIN as it could lead to increased drowsiness, dizziness and liver damage.
Drug-Drug Interactions: ISONIAZID+RIFAMPICIN may interact with anti-HIV (saquinavir, ritonavir), pain killer (acetaminophen, hydrocodone), anti-depressant (duloxetine, bupropion), calcium channel blocker (diltiazem), anti-TB (ethambutol, pyrazinamide), and vitamins (ergocalciferol, cholecalciferol).
Drug-Food Interactions: Do not consume alcohol while taking ISONIAZID+RIFAMPICIN as it could lead to increased dizziness and liver damage. Avoid foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer while taking ISONIAZID+RIFAMPICIN as they might cause interaction.
Drug-Disease Interactions: Inform your doctor if you have colitis (inflammation in the lining of the colon), peripheral neuropathy (numbness and pain in hands and feet), porphyria, haemodialysis, liver toxicity, kidney and liver dysfunction.
Avoid alcohol consumption while taking ISONIAZID+RIFAMPICIN as it could lead to increased drowsiness, dizziness and liver damage.
Please consult your doctor if you are pregnant, your doctor will prescribe ISONIAZID+RIFAMPICIN only if the benefits outweigh the risks.
ISONIAZID+RIFAMPICIN passes into breast milk. Do not breastfeed while taking ISONIAZID+RIFAMPICIN.
ISONIAZID+RIFAMPICIN may cause dizziness, drowsiness, numbness and tingling sensation in hands and feet. Do not drive or operate machinery if you experience these symptoms.
Dose adjustment may be needed. Please consult your doctor before taking ISONIAZID+RIFAMPICIN if you have liver impairment/liver disease.
Dose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or if you have kidney impairment/kidney disease before taking ISONIAZID+RIFAMPICIN.
Please consult your doctor. Your doctor may suggest suitable dose and dosage form based on your child's age, body weight and medical condition. Kid tablets could be used in children if prescribed by the doctor.
Tuberculosis (TB): Tuberculosis is an infectious disease that affects the lungs, but it could also spread to other body parts such as kidneys, brain, spine, and bone marrow. Tuberculosis is caused by a bacteria named Mycobacterium tuberculosis. It is a contagious disease which can spread to others through small droplets released into the air by a person suffering from tuberculosis. Symptoms include a cough that lasts for a few weeks, pain while coughing or with normal breathing, unexplained fatigue, fever, night sweats, loss of appetite and weight. People who smoke or consume alcohol, people diagnosed with HIV, and immune system problems are more likely at risk of developing active TB.