apollo

Online Doctor Consultation & Medicines

Hello,

Select your location

About RIFAMPICIN+ISONIAZID

ISONIAZID+RIFAMPICIN belongs to the group of medicines called anti-tuberculosis drugs primarily used to treat and prevent tuberculosis. Tuberculosis is an infectious disease that mainly affects the lungs, but it can also spread to other body parts such as kidneys, brain, spine, and bone marrow.

ISONIAZID+RIFAMPICIN is a combination of two anti-tuberculosis drugs, namely: Rifampicin, and Isoniazid. Rifampicin works by inactivating a bacterial RNA-polymerase) an enzyme that allows TB bacteria to make and replicate essential proteins. Isoniazid prevents the creation of its own protective coating by these bacteria. Together, they destroy the bacteria named Mycobacterium tuberculosis, which causes TB (tuberculosis)., and the infection is eliminated.

Take ISONIAZID+RIFAMPICIN 30minutes before food or 2hours after food. Swallow ISONIAZID+RIFAMPICIN as a whole; do not crush or chew the tablet. Take ISONIAZID+RIFAMPICIN daily at the same time to ensure better efficacy. The dose and duration of ISONIAZID+RIFAMPICIN can vary depending upon your condition and severity of the infection. In some cases, you may experience certain common side-effects such as drowsiness, dizziness, headache, weakness, muscle pain, heartburn, diarrhoea, gas, and numbness or tingling sensation. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Do not stop taking ISONIAZID+RIFAMPICIN despite symptomatic relief. To treat your condition effectually, continue taking ISONIAZID+RIFAMPICIN for as long as it has been prescribed for you. Avoid foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer while taking ISONIAZID+RIFAMPICIN as they might cause interaction. Maintain a gap of one hour between ISONIAZID+RIFAMPICIN and antacid medicines. Consult your doctor before taking ISONIAZID+RIFAMPICIN if you are pregnant or planning for pregnancy. Avoid breastfeeding while taking ISONIAZID+RIFAMPICIN as it passes into breast milk. ISONIAZID+RIFAMPICIN is not recommended for use in children. ISONIAZID+RIFAMPICIN may cause dizziness, and vision problems, so drive with caution. Avoid alcohol consumption while taking ISONIAZID+RIFAMPICIN as it could lead to increased drowsiness, dizziness and liver damage.

Uses of RIFAMPICIN+ISONIAZID

Tuberculosis.

Medicinal Benefits

ISONIAZID+RIFAMPICIN is a combination of two anti-tuberculosis drugs, namely: Rifampicin, and Isoniazid. Rifampicin works by inactivating a bacterial RNA-polymerase) an enzyme that allows TB bacteria to make and replicate essential proteins. Isoniazid prevents the creation of its own protective coating by these bacteria. Together, they destroy the bacteria named Mycobacterium tuberculosis, which causes TB (tuberculosis)., and the infection is eliminated.

Directions for Use

Take ISONIAZID+RIFAMPICIN 30minutes before food or 2hours after food. Swallow ISONIAZID+RIFAMPICIN as a whole; do not crush or chew the tablet. The dose and duration of ISONIAZID+RIFAMPICIN can vary depending upon your condition and severity of the infection.

Storage

Store in a cool and dry place away from sunlight

Side Effects of RIFAMPICIN+ISONIAZID

Drowsiness

Dizziness

Headache

Weakness

Muscle pain 

Heartburn 

Diarrhoea

Gas

Numbness 

In-Depth Precautions and Warning

Drug Warnings

Do not take ISONIAZID+RIFAMPICIN if you are allergic to any of its contents; if you have jaundice, or if you are taking HIV medicines (saquinavir or ritonavir). Before starting ISONIAZID+RIFAMPICIN, please inform your doctor if you have diabetes, epilepsy, gout, mental health problems, HIV infection, malnutrition, peripheral neuropathy, porphyria, bleeding problems, kidney or liver problems. Avoid foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer while taking ISONIAZID+RIFAMPICIN as they might cause interaction. Maintain a gap of one hour between ISONIAZID+RIFAMPICIN and antacid medicines. Consult your doctor before taking ISONIAZID+RIFAMPICIN if you are pregnant or planning for pregnancy. Avoid breastfeeding while taking ISONIAZID+RIFAMPICIN as it passes into breast milk. ISONIAZID+RIFAMPICIN is not recommended for use in children. ISONIAZID+RIFAMPICIN may cause dizziness, and drowsiness, so drive with caution. Avoid alcohol consumption while taking ISONIAZID+RIFAMPICIN as it could lead to increased drowsiness, dizziness and liver damage.

Drug Interactions

DRUG-DRUG INTERACTIONS: ISONIAZID+RIFAMPICIN may have interaction with anti-HIV (saquinavir, ritonavir), pain killer (acetaminophen, hydrocodone), anti-depressant (duloxetine, bupropion), calcium channel blocker (diltiazem), anti-TB (ethambutol, pyrazinamide), and vitamins (ergocalciferol, cholecalciferol).

FOOD-DRUG INTERACTIONS: Do not consume alcohol while taking ISONIAZID+RIFAMPICIN as it could lead to increased dizziness and liver damage. Avoid foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer while taking ISONIAZID+RIFAMPICIN as they might cause interaction.

DRUG-DISEASE INTERACTION: ISONIAZID+RIFAMPICIN may have interactions with colitis (inflammation in the lining of the colon), peripheral neuropathy (numbness and pain in hands and feet), porphyria, haemodialysis, liver toxicity, kidney and liver dysfunction.

Safety Advice

  • Safety Warning

    Alcohol

    Consult Your Doctor

    Avoid alcohol consumption while taking ISONIAZID+RIFAMPICIN as it could lead to increased drowsiness, dizziness and liver damage.

  • Safety Warning

    Pregnancy

    Please consult your doctor if you are pregnant, your doctor will prescribe ISONIAZID+RIFAMPICIN only if the benefits outweigh the risks.

  • Safety Warning

    Breast Feeding

    Consult Your Doctor

    ISONIAZID+RIFAMPICIN passes into breast milk. Do not breastfeed while taking ISONIAZID+RIFAMPICIN.

  • Safety Warning

    Driving

    ISONIAZID+RIFAMPICIN may cause dizziness, drowsiness, numbness and tingling sensation in hands and feet. Do not drive or operate machinery if you experience these symptoms.

  • Safety Warning

    Liver

    Dose adjustment may be needed. Please consult your doctor before taking ISONIAZID+RIFAMPICIN if you have liver impairment/liver disease.

  • Safety Warning

    Kidney

    Dose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or if you have kidney impairment/kidney disease before taking ISONIAZID+RIFAMPICIN.

Habit Forming

No

Diet & Lifestyle Advise

  • Pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.
  • Foods rich in vitamin C such as kiwi, broccoli, and bell pepper helps in improving the immune system. 
  • Avoid processed and fried foods.
  • Warm ginger tea or warm soup can help in providing relief from cough.
  • Avoid foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer.
  • Quit smoking and avoid alcohol consumption.

Special Advise

  • ISONIAZID+RIFAMPICIN may affect test results of some blood tests such as tests for folate, vitamin B12, and liver function. Inform the person doing the tests that you are taking ISONIAZID+RIFAMPICIN.
  • Your doctor may advise you to get regular liver tests while taking ISONIAZID+RIFAMPICIN to check how your liver is functioning.

Patients Concern

Disease/Condition Glossary

Tuberculosis (TB): Tuberculosis is an infectious disease that affects the lungs, but it could also spread to other body parts such as kidneys, brain, spine, and bone marrow. Tuberculosis is caused by a bacteria named Mycobacterium tuberculosis. It is a contagious disease which can spread to others through small droplets released into the air by a person suffering from tuberculosis. Symptoms include a cough that lasts for a few weeks, pain while coughing or with normal breathing, unexplained fatigue, fever, night sweats, loss of appetite and weight. People who smoke or consume alcohol, people diagnosed with HIV, and immune system problems are more likely at risk of developing active TB.

FAQs

ISONIAZID+RIFAMPICIN is a combination of two anti-tuberculosis drugs, namely: Rifampicin, and Isoniazid. Rifampicin works by inactivating a bacterial RNA-polymerase) an enzyme that allows TB bacteria to make and replicate essential proteins. Isoniazid prevents the creation of its own protective coating by these bacteria. Together, they destroy the bacteria named Mycobacterium tuberculosis, which causes TB (tuberculosis)., and the infection is eliminated.

Do not stop taking ISONIAZID+RIFAMPICIN despite symptomatic relief. To treat your condition effectually, continue taking ISONIAZID+RIFAMPICIN for as long as it has been prescribed for you.

Do not take ISONIAZID+RIFAMPICIN along with antacids as it might decrease the effectiveness of ISONIAZID+RIFAMPICIN. Maintain a minimum gap of 1hour between both.

Consult your doctor before taking ISONIAZID+RIFAMPICIN with other medicines. Medicines used to treat TB such as PAS (P-amino salicylic acid) and cycloserine should be taken 8hours apart from ISONIAZID+RIFAMPICIN.

ISONIAZID+RIFAMPICIN contains isoniazid which might interact with foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer. Avoid these foods while taking ISONIAZID+RIFAMPICIN.

ISONIAZID+RIFAMPICIN might decrease the effectiveness of oral contraceptives (birth control pills). This could lead to an unplanned pregnancy. Instead, use a reliable barrier method of contraception such as condoms or the coil while taking ISONIAZID+RIFAMPICIN. Consult your doctor if you have any concerns regarding this; your doctor may suggest an alternate method of contraception.

ISONIAZID+RIFAMPICIN may cause discolouration of teeth, sweat, urine, sputum (phlegm), saliva, or tears. The colour in tears may last for some time even after you stop taking ISONIAZID+RIFAMPICIN. Do not worry as it is a common side-effect of ISONIAZID+RIFAMPICIN.

Yes, ISONIAZID+RIFAMPICIN might permanently stain soft contact lenses. Use spectacles and avoid wearing contact lens while taking ISONIAZID+RIFAMPICIN.

ISONIAZID+RIFAMPICIN may affect test results of some blood tests such as tests for folate, vitamin B12, and liver function. Inform the person doing the tests that you are taking ISONIAZID+RIFAMPICIN.

Yes, ISONIAZID+RIFAMPICIN may cause liver problems, especially in people who are 35 and older. Consult your doctor if you notice symptoms such as yellowing of eyes or skin, dark urine, pale stools, weakness, loss of appetite, nausea or vomiting. Your doctor may advise you to get regular liver tests while taking ISONIAZID+RIFAMPICIN to check how your liver is functioning.

Available Medicines for

ISONIAZID+RIFAMPICIN