Anaero Gel contains metronidazole and nicotinamide, which help reduce acne-related redness, inflammation, and bumps. Many people start to notice some improvement within 2 to 4 weeks, and clearer skin usually appears by 6 to 8 weeks with regular use. If the skin responds well, it can be safely continued for up to 12 weeks or as advised. Everyone's skin is different, so if you don't see improvement or have any concerns, it's best to consult your doctor for further advice.