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About TENELIGLIPTIN

TENELIGLIPTIN belongs to the category of medicines called “anti-diabetic” primarily used to treat type 2 diabetes, especially in persons whose sugar levels are too high and cannot be controlled by dieting and exercising. It is used alone or in combination with other drugs to lower blood sugar levels. People with type 2 diabetes either do not produce enough insulin, or the insulin produced cannot perform its function in the body (insulin resistance). Middle-aged or older individuals are most likely to suffer from type 2 diabetes, also known as adult-onset diabetes.

TENELIGLIPTIN contains Teneligliptin, which belongs to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors used TENELIGLIPTIN is prescribed for the condition of type 2 diabetes when diet and exercise alone cannot control their blood sugar levels. It works by blocking the action of DPP-4 (an enzyme that destroys the hormone 'Incretin'). The enzyme 'Incretins' helps produce more insulin only when required and reduces the liver's blood sugar level when not needed.

Take TENELIGLIPTIN as prescribed by your doctor. Your doctor will decide what dose should be taken for better advice, and it can change timely depending upon your medical condition. In some cases, you may experience certain common side effects such as headache, hypoglycaemia (low blood glucose levels), upper respiratory tract infection, and nasopharyngitis (infection of nose and throat with common cold). Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

TENELIGLIPTIN should not be stopped even if you feel better, without consulting your doctor as sugar level keeps changing. If you stop taking TENELIGLIPTIN abruptly, it may increase your sugar levels, which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy), and nerve damage (neuropathy). Please inform your doctor if you have any heart disease is or planning to get pregnant or breastfeeding. Safety and efficacy of TENELIGLIPTIN in children have not been established, so it should not be given to them. TENELIGLIPTIN works best when coupled with a healthy lifestyle like losing weight if you are overweight (BMI>25), eating fewer calories (low fat and sugary food), and being more physically active (at least 150 min of activity every week). 

Uses of TENELIGLIPTIN

Type 2 Diabetes Mellitus

Medicinal Benefits

TENELIGLIPTIN contains ‘Teneligliptin’ which belongs to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors used to treat type 2 diabetes when diet and exercise alone cannot control their blood sugar levels. It works by blocking the action of DPP-4 (an enzyme that destroys the hormone ‘Incretin’). The enzyme ‘Incretins’ helps produce more insulin only when required and reduces the liver's blood sugar level when not needed. TENELIGLIPTIN should not be used in patients with type 1 diabetes and for the treatment of diabetic ketoacidosis. Thus, TENELIGLIPTIN plays a vital role in controlling blood sugar levels and prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), nerve damage (neuropathy), diabetic foot ulcer, and delayed wound healing.

Directions for Use

Take TENELIGLIPTIN as advised by your doctor. Preferably take it with a meal to minimize stomach upset. Swallow it as a whole with a glass of water. Do not chew, crush, or break it. In case you missed taking TENELIGLIPTIN do not double the dose as it may decrease your blood sugar level (hypoglycemia) which can be fatal.

Storage

Store in a cool and dry place away from sunlight

Side Effects of TENELIGLIPTIN

Every medicine has some side effects. In the beginning days of the treatment with TENELIGLIPTIN, you may suffer from headache, hypoglycemia (low blood glucose levels), upper respiratory tract infection, and nasopharyngitis (infection of nose and throat with common cold). But these would be temporary and may be relieved after some time. However, if you still have discomfort speak with the doctor.

In-Depth Precautions and Warning

Drug Warnings

TENELIGLIPTIN should not be taken if you are allergic to TENELIGLIPTIN or any of its ingredients. Please inform your doctor if you are pregnant or breastfeeding before starting TENELIGLIPTIN. Safety and efficacy of TENELIGLIPTIN in children have not been established, so it should not be given to them. Prolonged intake of TENELIGLIPTIN may cause acute pancreatitis (swollen pancreas). Increased risk of hypoglycemia (low blood sugar level) can occur when TENELIGLIPTIN is added to other anti-diabetic agents or insulin therapy. In this case, your doctor may adjust the dose of TENELIGLIPTIN. Severe allergic reactions might occur in some patients taking TENELIGLIPTIN like anaphylaxis, angioedema (swelling under the skin), and exfoliative skin conditions. TENELIGLIPTIN should not be used in patients with type 1 diabetes and for the treatment of diabetic ketoacidosis.

Drug Interactions

Drug-Drug Interaction: TENELIGLIPTIN interacts with medicines used to treat diabetes (glipizide, gliclazide, glimepiride) medicines used to treat high blood pressure (atenolol, bisoprolol, metoprolol, nadolol, propranolol), anti-depressant (bupropion, selegiline, isocarboxazid, phenelzine), painkillers (aspirin).

Drug-Food Interaction: Intake of excessive alcoholic beverages may increase the chance of a life-threatening condition known as Lactic Acidosis. So, avoid intake of alcoholic beverages with TENELIGLIPTIN.

Drug-Disease Interaction: TENELIGLIPTIN should be used with caution in patients with a history of pancreatitis/pancreatic disease, heart disease, severe ketosis, diabetic coma or history of diabetic coma, severe infection, surgery, and severe trauma.

Safety Advice

  • Safety Warning

    Alcohol

    It is best to avoid alcohol while taking medication.

  • Safety Warning

    Pregnancy

    TENELIGLIPTIN, safety in pregnant women is not established. So, it should be taken only if prescribed by a doctor.

  • Safety Warning

    Breast Feeding

    Please consult your doctor for advice before taking TENELIGLIPTIN.

  • Safety Warning

    Driving

    There is no sufficient data on the effects on the ability to drive and use machines have been performed. However, do not drive or operate machinery if you experience dizziness.

  • Safety Warning

    Liver

    If u have or had a history or evidence of any liver-related diseases, please consult the doctor before taking medicine.

  • Safety Warning

    Kidney

    If u have or had a history or evidence of any kidney-related diseases, please consult the doctor before taking medicine.

Habit Forming

No

Diet & Lifestyle Advise

  • Fill your half plate with starchy veggies, a quarter with proteins, and a quarter with whole grain.

  • Eat at regular intervals. Do not take a long gap between a meal or snack.

  • Monitor your blood sugar level regularly, especially when there are lots of fluctuations.

  • Invest at least 150 min of moderate-intensity physical activity or one hour and 15 minutes of high-intensity exercise every week.

  • Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).

  • Replace refined carbohydrates containing whole-grain foods and increase the intake of fruits and veggies and other fibre-enriched foods.

  • Reduce intake of saturated fat (or hidden fats) in food like chips, crisps, pastries, biscuits, and samosas. Choose omega 3 fatty acid-containing oils for daily cooking. You can use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil for frying.

  • Do not take stress as it may elevate your blood sugar level. You can adopt stress management techniques like mindfulness to control stress-related blood sugar changes.

  • Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, and cheese, etc.).

  • Keep your blood pressure as normal (120/80) as possible as it reduces the risk of cardiovascular diseases in diabetes patients.

Special Advise

You should have a test of Glycated haemoglobin (HbA1C) every 3 months to check your blood glucose level control.

Patients Concern

Disease/Condition Glossary

Type 2 Diabetes: It is a condition where the body cannot make sufficient insulin, or the insulin that it makes doesn't work properly or is utilized by our body. This can cause high blood sugar levels (hyperglycemia). Type 2 diabetes symptoms include increased thirst, frequent urination at night, slow wound healing, increased hunger, fatigue, and blurred vision. There may be weight gain in some cases, while in rare cases, weight loss may be observed. The complication of type 2 diabetes also includes neuropathy (nerve problems), nephropathy (kidney problems), and retinopathy (damaged retina of eyes or blindness), loss of limbs, sexual dysfunction, and increase the chance of heart attack or stroke.

FAQs

No, TENELIGLIPTIN is prescribed for only type 2 diabetes and not for type 1 diabetes. It is advised to take TENELIGLIPTIN with a meal.

There is no sufficient data on how TENELIGLIPTIN affects pregnancy. It is safe to seek medical advice before you start TENELIGLIPTIN if you are pregnant or get pregnant.

Do not stop taking TENELIGLIPTIN until your prescribed course is finished, even if you feel better.

If you miss a dose of TENELIGLIPTIN, you are advised to take it as soon as you remember. Do not double the dose as it may lead to a lowering of blood pressure. Take one daily at the same time.

Hypoglycemia refers to low blood sugar levels. TENELIGLIPTIN can cause hypoglycemia. The symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness. Hypoglycemia can occur if you miss or delay your food, drink alcohol, over-exercise, or take other antidiabetic medicine along with this medicine. People with diabetes are advised to keep a quick sugar source like glucose tablets, honey, or fruit juice.