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About TETRACOSACTIDE

TETRACOSACTIDE belongs to the group of medicines called pituitary hormones and analogues used instead of steroids to treat a number of conditions such as ulcerative colitis, Crohn's disease, rheumatoid arthritis, osteoarthrosis, acute exacerbations of multiple sclerosis, some types of seizures in children, skin diseases responsive to corticoids, and additional therapy in cancer patients to improve the tolerability of chemotherapy. It is also used as a test to check if pituitary and adrenal glands are working properly.

TETRACOSACTIDE contains Tetracosactide, which is similar to the hormone that the pituitary gland normally produces (called ACTH) to make the adrenal glands produce certain steroids. TETRACOSACTIDE works on the adrenal glands by telling them to produce more steroids.

TETRACOSACTIDE will be administered by a healthcare professional; do not self-administer. In some cases, TETRACOSACTIDE may cause headaches, increased appetite, stomach pain, increased sweating, and facial flushing. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.

Let the doctor know if you are allergic to any of the components in TETRACOSACTIDE. Consult the doctor if you are pregnant or breastfeeding. Avoid driving or operating heavy machinery if you experience dizziness or blurred vision. Keep the doctor informed about your health condition and medications to rule out any side effects/interactions.

Uses of TETRACOSACTIDE

Ulcerative colitis, Crohn's disease, rheumatoid arthritis, osteoarthrosis, acute exacerbations of multiple sclerosis, and some types of seizures in children. It is also used as a diagnostic agent to check if pituitary and adrenal glands are working properly.

Medicinal Benefits

TETRACOSACTIDE belongs to the group of medicines called pituitary hormones and analogues used in place of steroids to treat a number of conditions such as ulcerative colitis, Crohn's disease, rheumatoid arthritis, osteoarthrosis, acute exacerbations of multiple sclerosis, some types of seizures in children, skin diseases responsive to corticoids, and additional therapy in cancer patients to improve the tolerability of chemotherapy. It is also used as a test to check if pituitary and adrenal glands are working properly. TETRACOSACTIDE contains Tetracosactide, which is similar to the hormone that the pituitary gland normally produces (called ACTH) to make the adrenal glands produce certain steroids. TETRACOSACTIDE works on the adrenal glands by telling them to produce more steroids.

Directions for Use

TETRACOSACTIDE will be administered by a healthcare professional; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of TETRACOSACTIDE

  • Headache
  • Increased appetite
  • Stomach pain
  • Increased sweating
  • Facial flushing

In-Depth Precautions and Warning

Drug Warnings

Do not use TETRACOSACTIDE if you are allergic to any of its components, if you have asthma, serious mood or mental health disorders, tuberculosis, infections, hormone problems (Cushing’s syndrome or Addison’s disease), stomach or small intestinal ulcer, serious heart disease, primary adrenocortical insufficiency or adrenocongenital syndrome (a condition that limits hormone production in the adrenal glands). Inform the doctor if you have been vaccinated recently or are due to undergo vaccination, if you have immune function problems, disorder of the intestines, high blood pressure, blood clot, osteoporosis (thinning of bones), myasthenia gravis (muscle problems), underactive thyroid, serious liver or kidney disease, or ocular herpes simplex (viral infection of the eye). Consult the doctor if you are pregnant or breastfeeding. Let the doctor know if you are taking any other medicines, including supplements and herbal products.

Drug Interactions

Drug-Drug Interactions: Inform the doctor if you are taking medicines to treat high blood pressure, diabetes, convulsions (valproate, phenytoin, clonazepam, nitrazepam, phenobarbital or primidone), or contraceptives.

Drug-Food Interactions: No interactions found.

Drug-Disease Interactions: Inform the doctor if you have asthma, serious mood or mental health disorders, tuberculosis, infections, hormone problems, stomach or small intestinal ulcers, or serious heart disease.

Drug-Drug Interactions Checker List:

  • VALPROATE
  • PHENYTOIN
  • CLONAZEPAM
  • NITRAZEPAM
  • PHENOBARBITAL
  • PRIMIDONE
  • Safety Advice

    • Safety Warning

      Alcohol

      consult your doctor

      It is not known if alcohol affects TETRACOSACTIDE. Please consult your doctor.

    • Safety Warning

      Pregnancy

      caution

      Inform the doctor if you are pregnant or think you may be pregnant. Your doctor will discuss the benefits and risks of using TETRACOSACTIDE during pregnancy.

    • Safety Warning

      Breast Feeding

      caution

      Caution is advised while administering TETRACOSACTIDE to a nursing woman.

    • Safety Warning

      Driving

      caution

      TETRACOSACTIDE may cause dizziness and blurred vision. Drive or operate machinery only if you are alert.

    • Safety Warning

      Liver

      consult your doctor

      If you have a history of liver disease, inform your doctor before receiving TETRACOSACTIDE.

    • Safety Warning

      Kidney

      consult your doctor

      If you have a history of kidney disease, inform your doctor before receiving TETRACOSACTIDE.

    • Safety Warning

      Children

      caution

      TETRACOSACTIDE should be used with caution in children. The doctor may adjust the dose based on the child's age and disease condition.

    Habit Forming

    No

    Diet & Lifestyle Advise

    Seizures:

    • Meditation and yoga can help lower stress, decrease pain sensitivity and improve coping skills.

      Have a seizure response plan, and help those around you know what to do.

    • Prepare your living area; small changes may help reduce the risk of physical injury during a seizure.

    • Understand what triggers seizures and try reducing or avoiding them.

    • Please pay attention to overall health, as it can help reduce seizure activity.

    • Install an alarm or emergency device to get assistance during a seizure attack.

    Multiple sclerosis:

    • Avoid heavily processed foods and saturated fats.

    • Include fruits, vegetables, and whole grains in the diet.

    • Try to stay active. Choose moderate exercises.

    • Quit smoking.

    • Prevent stress by doing meditation or yoga.

    Osteoarthritis & Rheumatoid arthritis:

    • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30 minutes of walking or swimming would be helpful.

    • Performing yoga may also help in improving joint flexibility and pain management.

    • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

    • Get adequate sleep, as resting the muscles can help reduce inflammation and swelling.

    • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.

    • Acupuncture, massage and physical therapy may also be helpful.

    Ulcerative colitis & Crohn's disease:

    • Eat smaller meals more often.

    • Avoid smoking and alcohol consumption.

    • Maintain a healthy weight by regular exercising.

    • Avoid carbonated and caffeinated beverages.

    • Practise relaxation techniques and avoid stress by doing yoga or meditation.

    • Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda. 

    • Avoid deep-fried and spicy foods.

    • Foods containing probiotics may help in providing relief from gas and bloating.

    Patients Concern

    Disease/Condition Glossary

    Ulcerative colitis: It is a type of chronic inflammatory bowel disease that causes inflammation of the lining of the large intestine (colon) and produces ulcers on the lining of the colon, which may cause bleeding and discharge of pus and mucus. The common symptoms include bloody stools, stomach pain, rectal pain, diarrhoea, fever, and weight loss. 
    Crohn's disease: It is an inflammatory bowel disease that affects the lining of the digestive tract. Symptoms include diarrhoea, abdominal pain, fatigue, weight loss, abdominal pain, 
    Rheumatoid arthritis: It is an autoimmune disease (the body's immune system attacks its tissue) that leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities and loss of joint function.
    Osteoarthrosis: It is a joint disease in which the two ends of the joints come together due to the breakdown of a protective covering of cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms include pain, stiffness, inflammation and tenderness.
    Multiple sclerosis: It is an autoimmune disease (the body attacks itself by mistake) that affects the central nervous system (brain and spinal cord). The immune system damages the myelin sheath (protective covering that surrounds the nerve cells), leading to disrupted communication between the brain and the body.
    Seizures: Seizures, also known as fits or convulsions, are a single occurrence of abnormal electrical activity in the brain. Symptoms include muscle jerking, spasms, loss of balance, teeth clenching, rapid blinking or eye movements, biting the tongue, confusion, and loss of consciousness.

    FAQs

    How does TETRACOSACTIDE work?

    TETRACOSACTIDE works by stimulating the adrenal glands to increase the production of natural steroid hormones.

    Why has the doctor advised a low-salt diet?

    TETRACOSACTIDE may cause salt and water retention. Therefore, your doctor may advise a low-salt diet during treatment with TETRACOSACTIDE.

    Should I inform the doctor if I am due to undergo surgery?

    Inform the doctor if you suffer from an injury or have surgery during or within one year after the treatment, as dose adjustment may be needed or treatment may need to restart.

    Available Medicines for

    TETRACOSACTIDE