A drop in white blood cells after ECF chemotherapy (Epirubicin, Cisplatin, and Fluorouracil) is common because these medicines affect the bone marrow, and a count of 4300 is mildly low but still needs monitoring. For the next cycle, your oncologist may reduce doses slightly, delay treatment to allow recovery, or add supportive injections like growth factors (G-CSF) to boost white cells and lower the risk of infection, depending on your overall health and how low your counts go. You can help by maintaining good nutrition, staying well hydrated, practising strict hygiene (like frequent handwashing and avoiding crowds or sick contacts), and reporting fever, sore throat, or weakness immediately, as infections can become serious when counts are low. The exact plan, including any dose adjustment, is individualised, so your doctor will balance effective cancer treatment with safety to minimise side effects.