You should not switch from Ryzodeg 100 IU/ml Penfill to Afrezza 0.68 mg Inhalation Powder Kit on your own. Although both medicines contain insulin, they work differently and are not directly interchangeable. Ryzodeg contains a combination of long-acting insulin degludec and rapid-acting insulin aspart, which helps control blood sugar throughout the day and around meals. Afrezza is an inhaled rapid-acting human insulin that primarily controls blood sugar after meals and does not provide long-lasting insulin coverage. If your injections are painful, speak to your doctor before making any changes. The pain may be due to your injection technique, needle size, injection site, or the way the insulin is stored. Your doctor can help identify the cause, suggest ways to make injections more comfortable, or discuss other suitable treatment options if needed. Do not stop or replace your prescribed insulin without medical advice, as this may lead to poor blood sugar control.