For severe varicose veins, medications primarily help manage symptoms rather than cure the condition. Oral venoactive drugs, such as micronised purified flavonoid fraction (MPFF) or horse chestnut extract, can improve vein tone and reduce swelling. Over-the-counter pain relievers like ibuprofen can help manage discomfort and inflammation. Additionally, topical heparin-based gels may offer localised relief. For targeted treatment, a doctor might recommend sclerotherapy, which involves injecting a chemical solution like polidocanol directly into the veins to close them. Since medications are usually combined with compression stockings and lifestyle changes, please consult your healthcare provider to discuss the best personalised plan for you.